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Metastatic basaloid-squamous cell carcinoma of the esophagus treated by 5-fluorouracil and cisplatin

World Journal of Gastroenterology 2007年第26期13卷 3634-3637页

作者： Yoshihiro Shibata Eishi Baba Hiroshi Ariyama Ryusuke Miki Nobumichi Ogami Shuji Arita Baoli Qin hitoshi kusaba Kenji Mitsugi Hirokazu Noshiro Takashi Yao Shuji Nakano First Department of Internal Medicine and Department of Biosystemic Science of Medicine Graduate School of MedicineKyushu UniversityFukuokaJapan Department of Surgery and Oncology Graduate School of Medical SciencesKyushu UniversityJapan Department of Anatomic Pathology Graduate School of Medical SciencesKyushu UniversityJapan

Basaloid squamous cell carcinoma （BSC） of the esophagus is a rare malignant disease. We report here a patient with recurrent esophageal BSC, who was successfully treated by systemic chemotherapy containing 5-fluorouracil （5-FU） and cisplatin （CDDP）. A 57-year-old woman was diagnosed as having SCluamous cell carcinoma of the esophagus upon endoscopic examination. Curative esophagectomy with lymph node dissection was performed under the thoracoscope. The pathological diagnosis of the surgical specimen was BSC. Five months after operation, the patient was diagnosed as having a recurrence of the BSC with metastases to the liver and spleen, and a right paraclavicular lymph node. She was given systemic chemotherapy consisting of continuous infusion of 800 mg/d of 5-FU and 3 h infusion of 20 mg/d of CDDP for 5 consecutive days every 4 wk. The metastatic lesions in the spleen and right paraclavicular lymph node disappeared, and the liver metastasis was apparently reduced in size after 2 courses of chemotherapy. The tumor regression was seen over 6 courses, with progression afterwards. Although subsequent treatment with CPT-11 and CDDP was not effective, docetaxel and vinorelbine temporarily controlled the tumor growth for 2 mo. 5-FU and CDDP combination may be useful for the patients with advanced BSC.

关键词： Basaloid-squamous cell carcinoma Esophagus Chemotherapy

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Analysis of a Questionnaire Survey regarding Current Conditions against Exposure to Anticancer Drugs and Reports of Cancer Chemotherapy at Outpatient Departments in Japan

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Pharmacology & Pharmacy 2017年第5期8卷 140-152页

作者： Tsuyoshi Shirakawa Tomoko Hara Kojiro Hata Kojiro Hata Kimitaka Suetsugu Hideki Kakimoto Kentaro Ogata Yousuke Ikari Hidenori Sasaki Makoto Takahashi Masaru Fukahori Miyuki Uoi Taito Esaki Mikako Hiraike Toshinobu Hayashi Akira Tokunaga Norio Ureshino Tsuneo Kuwamura hitoshi kusaba Kenji Mitsugi Eishi Baba Department of Pharmacy National Hospital Organization Kyushu Medical Center Fukuoka Japan Department of Oncology Miyazaki Prefectural Miyazaki Hospital Miyazaki Japan Department of Internal Medicine Fukuoka Wajiro Hospital Fukuoka Japan Department of Pharmacy Hamanomachi Hospital Fukuoka Japan Department of Pharmacy Kyushu University Hospital Fukuoka Japan Department of Pharmacy Fukuoka University Hospital Fukuoka Japan Department of Practical Pharmaceutical Science Faculty of Pharmaceutical Sciences Fukuoka University Fukuoka Japan Division of Medical Oncology Hematology and Infection Diseases Fukuoka University Hospital Fukuoka Japan Department of Pharmacy Kurume University Hospital Fukuoka Japan Division of Gastroenterology Kurume University Department of Medicine Fukuoka Japan Department of Pharmacy National Kyushu Cancer Center Fukuoka Japan Department of Gastrointestinal and Medical Oncology National Kyushu Cancer Center Fukuoka Japan Department of Pharmacy National Hospital Organization Kyushu Medical Center Fukuoka Japan Department of Pharmacy Saga-Ken Medical Centre Koseikan Saga Japan Department of Medical Oncology Saga-Ken Medical Centre Koseikan Saga Japan Department of Pharmacy Japan Community Healthcare Organization Kyushu Hospital Fukuoka Japan Department of Medicine and Comprehensive Biosystemic Science Kyushu University Graduate School of Medical Sciences Fukuoka Japan Department of Medical Oncology Hamanomachi Hospital Fukuoka Japan Department of Comprehensive Clinical Oncology Faculty of Medical Sciences Kyushu University Fukuoka Japan

[Background] Medical staff have many occasions to be exposed to anticancer drugs (ACDs) in the process of performing cancer chemotherapy. Although guidelines for the safe handling of ACDs have been published, actual measures against exposure to ACDs differ between hospitals, and no surveillance data regarding the conditions of each hospital in relation to performing chemotherapy in Japan are available. [Methods] To understand current measures against exposure to ACDs and problems related to cancer chemotherapy at outpatient departments, we conducted a questionnaire survey on doctors, pharmacists, and nurses in 10 leading hospitals for cancer chemotherapy in Japan. [Results] Responses were received from all 10 institutions. The hospital pharmacists prepared all ACDs for outpatients in each institution. All hospitals took basic measures against ACD exposure, such as using personal protective equipment and penetration-resistant waste containers. Conditions against exposure to ACDs generally improved between 2012 and 2015, especially in terms of conveyance of ACDs and use of a closed-system drug transfer device. However, no measures linking ACDs with administration routes or injection sites were commonly taken in any of the hospitals in 2015. [Conclusions] Conditions against ACD exposure improved between 2012 and 2015, possibly because new guidelines were issued. To improve measures for ACD exposure in Japan, preparing more appropriate manuals and offering more opportunities to medical staff for continuing education are considered important.

关键词： Exposure Anticancer Drugs Measurement Personal Protective Equipment Outpatient Service

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Effects of elafibranor on liver fibrosis and gut barrier function in a mouse model of alcohol-associated liver disease

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World Journal of Gastroenterology 2024年第28期30卷 3428-3446页

作者： Aritoshi Koizumi Kosuke Kaji Norihisa Nishimura Shohei Asada Takuya Matsuda Misako Tanaka Nobuyuki Yorioka Yuki Tsuji Koh Kitagawa Shinya Sato Tadashi Namisaki Takemi Akahane hitoshi Yoshiji Department of Gastroenterology Nara Medical UniversityKashihara 634-8521Japan

BACKGROUND Alcohol-associated liver disease(ALD)is a leading cause of liver-related morbidity and mortality,but there are no therapeutic targets and modalities to prevent ALD-related liver *** proliferator activated receptor(PPAR)α and δ play a key role in lipid metabolism and intestinal barrier homeostasis,which are major contributors to the pathological progression of ***,elafibranor(EFN),which is a dual PPARαand PPARδagonist,has reached a phase III clinical trial for the treatment of metabolic dysfunctionassociated steatotic liver disease and primary biliary ***,the benefits of EFN for ALD treatment is *** To evaluate the inhibitory effects of EFN on liver fibrosis and gut-intestinal barrier dysfunction in an ALD mouse *** ALD-related liver fibrosis was induced in female C57BL/6J mice by feeding a 2.5% ethanol(EtOH)-containing Lieber-DeCarli liquid diet and intraperitoneally injecting carbon tetrachloride thrice weekly(1 mL/kg)for 8 ***(3 and 10 mg/kg/day)was orally administered during the experimental *** and molecular analyses were performed to assess the effect of EFN on steatohepatitis,fibrosis,and intestinal barrier *** EFN effects on HepG2 lipotoxicity and Caco-2 barrier function were evaluated by cell-based *** The hepatic steatosis,apoptosis,and fibrosis in the ALD mice model were significantly attenuated by EFN *** promoted lipolysis and β-oxidation and enhanced autophagic and antioxidant capacities in EtOH-stimulated HepG2 cells,primarily through PPARα***,EFN inhibited the Kupffer cell-mediated inflammatory response,with blunted hepatic exposure to lipopolysaccharide(LPS)and toll like receptor 4(TLR4)/nuclear factor kappa B(NF-κB)*** improved intestinal hyperpermeability by restoring tight junction proteins and autophagy and by inhibiting apoptosis and proinflammatory *** protective effect on intestinal bar

关键词： Liver fibrosis Ethanol Gut barrier function Apoptosis Autophagy Peroxisome proliferator activated receptor

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Direct visualization of postoperative aortobronchial fistula on computed tomography

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World Journal of Radiology 2024年第8期16卷 337-347页

作者： Nanae Tsuchiya hitoshi Inafuku Satoko Yogi Yuko Iraha Gyo Iida Mizuki Ando Takaaki Nagano Shotaro Higa Tatsuya Maeda Yuya Kise Kojiro Furukawa Koji Yonemoto Akihiro Nishie Department of Radiology Graduate School of Medical ScienceUniversity of the RyukyusOkinawa 903-0215Japan Department of Thoracic and Cardiovascular Surgery Graduate School of Medical ScienceUniversity of the RyukyusOkinawa 903-0215Japan Department of Biostatistics School of Health SciencesFaculty of MedicineUniversity of the RyukyusOkinawa 903-0215Japan

BACKGROUND Postoperative aortobronchial fistula(ABF)is a rare complication that can occur in 0.3%-5.0%of patients over an extended period of time after thoracic aortic *** visualization of the fistula via imaging is *** To investigate the relationship between computed tomography(CT)findings and the clinical signs/symptoms of ABF after thoracic aortic *** Six patients(mean age 71 years,including 4 men and 2 women)with suspected ABF on CT(air around the graft)at our hospital were included in this retrospective study between January 2004 and September *** CT findings included direct confirmation of ABF,peri-graft fluid,ring enhancement,dirty fat sign,atelectasis,pulmonary hemorrhage,and bronchodilation,and the clinical course were retrospectively *** proportion of each type of CT finding was *** ABF detection after surgery was found to have a mean and median of 14 and 13 years,*** signs and symptoms were asymptomatic in 4 patients,bloody sputum was found in 1 patient,and fever was present in 1 *** complications of ABF included graft infection in 2 patients and graft infection with hemoptysis in 2 *** the 6 patients,3 survived,2 died,and 1 was lost to *** locations of the ABFs were as follows:1 in the ascending aorta;1 in the aortic arch;2 in the aortic arch leading to the descending aorta;and 2 in the descending *** were directly confirmed by CT in 4/6(67%)***-graft dirty fat(4/6,67%)and peri-graft ring enhancement(3/6,50%)were associated with graft infection,endoleaks and pseudoaneurysms were associated with hemoptysis(2/6,33%).CONCLUSION Asymptomatic ABF after thoracic aortic surgery can be confirmed on chest *** is useful for the diagnosis of ABF and its complications.

关键词： Peri-graft air Aortobronchial fistula Chest computed tomography Postoperative Thoracic endovascular aortic repair Complication Thoracic aorta surgery

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Acetylene Vacuum Carburizing

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材料热处理学报 2004年第5期25卷 370-374页

作者： hitoshi Iwata JH CORPORATION Aichi Japan

Almost 30 years has passed since the publication of materials on vacuum carburizing technology, and is attracting a great deal of attention as a technology capable of being used as a substitute for gas carburizing technology. However, the technology was not popular except in specific fields. The main reason for this is due to a variety of harmful influences accompanying the sooting problems caused by CH4 or C3H8. We have succeeded in that the occurrence of sooting was suppressed by utilizing acetylene, at extremely low pressure for carburizing (below 1 kPa). This process is now showing the excellent quality and prospects for this technology in terms of quality, economy and safety. At present almost 70 practical mass production furnaces are used in production lines, in Japan and abroad. At this time, we will report summary of the present acetylene vacuum carburizing process and the actual results obtained by these acetylene vacuum carburizing furnaces for mass production.

关键词：乙炔真空渗碳大量生产低压

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The Fefferman-Stein-Type Inequality for the Kakeya Maximal Operator Ⅱ

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Acta Mathematica Sinica,English Series 2002年第3期18卷 447-454页

作者： hitoshi TANAKA Department of Mathematics Gakushuin University 1-5-1 Mejiro Toshima-ku Tokyo 171-8588 Japan

Let K, 0 ±1, be the Kakeya maximal operator defined as the supremum of averages over tubes of the eccentricity . The (so-called) Fefferman-Stein-type inequality: $|| {K_\delta f} ||_{L^d({{\rm R}^d,w})} \le C_d ({1 \over \delta})^{(d - 2)/2d}(\log ({1 \over \delta } ))^{\alpha_d} || f ||_{L^d ({\rm R}^d,K_{\delta}w})}$is shown, where Cd and d are constants depending only on the dimension d and w is a weight. The result contains the exponent (d-2)/2d which is smaller than the exponent (d-2)(d-1)/d(2d-3) obtained in [7].

关键词： Maximal functions Weighted inequalties

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特朗普政府及新冠疫情对全球经济的影响回顾——聚焦中美关系

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日本研究 2024年第1期 74-87页

作者： [日]平川均张帅(译) 日本名古屋大学南开大学辽宁大学《日本研究》编辑部沈阳110136

由于美国前总统特朗普的“美国优先”对华政策,2018年开始的中美贸易战以及随后的新冠疫情促使中美贸易摩擦尖锐化。这场因贸易逆差引发的冲突不仅升级为两国之间的关税争端,还扩大到知识产权争端、不公平产业政策、技术霸权、国家安全... 详细信息

由于美国前总统特朗普的“美国优先”对华政策,2018年开始的中美贸易战以及随后的新冠疫情促使中美贸易摩擦尖锐化。这场因贸易逆差引发的冲突不仅升级为两国之间的关税争端,还扩大到知识产权争端、不公平产业政策、技术霸权、国家安全风险、人权问题、国家体制和意识形态问题等。2021年上台的美国拜登政府尝试扩展以民主价值观为纽带的联盟体系,制衡发展中的中国。另一方面,中国希望通过自身努力实现国内产业结构升级,提出“一带一路”倡议推动国际合作。世界经济正朝着形成独立经济集团的方向发展,中美两国在争夺先进战略产业和企业的同时,也有可能诞生一个新的经济集团。政治上意识形态的冲突将加剧,但在全球经济领域,中美两国之间的竞争将推动围绕“一带一路”倡议的非洲—欧亚经济基础设施的发展。

关键词：中美贸易战 “特朗普交易” 贸易逆差知识产权技术霸权

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On systematic development of FSI solvers in the context of particle methods

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Journal of Hydrodynamics 2022年第3期34卷 395-407页

作者： Abbas Khayyer hitoshi Gotoh Yuma Shimizu Department of Civil and Earth Resources Engineering Kyoto UniversityKyotoJapan

This paper presents a review on state-of-the-art of developments corresponding to fluid-structure interaction(FSI)solvers developed within the context of particle *** paper reviews and highlights the potential robustness of entirely Lagrangian meshfree FSI solvers in reproducing FSI corresponding to extreme events and portrays the future perspectives for systematic developments towards reliable engineering applications with respect to rapid advances in technology and emergence of so-called advanced materials that can result in complex and highly non-linear structural ***,the paper highlights the necessity for reproduction of comprehensive structural responses,including viscoelastic,elastoplastic and progressive damages/failures,by the advanced FSI solvers developed within the context of particle *** this regard,extensions of the structure model are suggested to be conducted in a variationally consistent framework to ensure stability,accuracy and physical reliability including thermodynamic *** paper reviews basics of mathematical and numerical modelling for entirely Lagrangian meshfree hydroelastic FSI solvers and presents a brief background on extensions of such solvers towards reproducing viscoelastic structural *** preliminary numerical results on structural viscoelasticity achieved by an extended Hamiltonian SPH(HSPH)model are *** vision paper also concisely portrays the future perspectives for systematic development of particle-based FSI solvers.

关键词： Fluid-structure interaction(FSI) entirely Lagrangian meshfree smoothed particle hydrodynamics(SPH) Hamiltonian SPH(HSPH) viscoelasticity

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Morrey Spaces for Non-doubling Measures

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Acta Mathematica Sinica,English Series 2005年第6期21卷 1535-1544页

作者： Yoshihiro SAWANO hitoshi TANAKA Graduate. School of Mathematical Sciences The University of Tokyo 3-8-1 KomabaMeguro-ku Tokyo 153-8914 Japan

The authors give a natural definition of Morrey spaces for Radon measures which may be non-doubling but satisfy certain growth condition, and investigate the boundedness in these spaces of some classical operators in ... 详细信息

关键词： Morrey space non-doubling measure vector-valued

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Comparison of the effects of submerged laser peening,cavitation peening and shot peening on the improvement of the fatigue strength of magnesium alloy AZ31

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Journal of Magnesium and Alloys 2023年第5期11卷 1592-1607页

作者： hitoshi Soyama Chieko Kuji Yiliang Liao Department of Finemechanics Tohoku University6-6-01 AobaAramakiAoba-kuSendai 980-8579Japan Department of Industrial and Manufacturing Systems Engineering Iowa State University2529 Union Dr.AmesIA 50011United States of America

To investigate the improvement in the fatigue strength of magnesium alloy by peening methods,magnesium alloy AZ31 was treated by submerged laser peening(SLP),cavitation peening(CP),and shot peening(SP),and the fatigue properties were evaluated by a plane bending fatigue *** the case of SLP,both the impact induced by laser ablation(LA)and that caused by laser cavitation(LC),which developed after LA,were *** the present study,the fatigue life at a constant bending stress was examined to determine the suitable *** was found that the fatigue strengths at N=10^(7)for the SLP,CP,and SP specimens treated by each optimum condition were 56%,18%,and 16%higher,respectively,than that of the non-peened(NP)specimen,which was 97 *** key factors in the improvement of fatigue strength by peening methods were work hardening and the introduction of compressive residual stress.

关键词： Magnesium alloy Fatigue strength Laser peening Cavitation peening Shot peening

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