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Questionnaire survey regarding the current status of superextended lymph node dissection in Japan

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World Journal of Gastrointestinal Oncology 2016年第9期8卷 707-714页

作者： Shinji Morita Takeo Fukagawa Hisataka Fujiwara hitoshi Katai Department of Surgical Oncology National Cancer Center HospitalChuo-kuTokyo

AIM To verify the current status of super-extended lymph node dissection for advanced gastric cancer according to a questionnaire *** One-hundred and five institutions responded to the *** survey included the following items: Number of experiences,whether performed prophylactically and/or therapeutically,whether preoperative chemotherapy was provided,number of preoperative chemotherapy rounds,and therapeutic options after *** Eighty-seven of the 105 institutions(83%) had performed D3 gastrectomy in the past or continued to perform D3 gastrectomy at ***,D3 gastrectomy was rarely performed prophylactically in clinical ***-eight institutions(74%) indicated that preoperative chemotherapy with curative intent was required for patients suspected of having para-aortic node(PAN) *** chemotherapy,a D3 gastrectomy was scheduled for patients with a complete or partial response,stable disease,and progressive disease at 36(46%),28(36%),and 13(17%) of the institutions,*** For patients with apparent PAN metastasis,a D3 gastrectomy is typically planned if a few courses of preoperative chemotherapy yield at least a stable disease condition.

关键词： Questionnaire survey Advanced gastric cancer Radical surgery Para-aortic nodal dissection Preoperative chemotherapy

Study on adsorption behavior of cesium using ammonium tungstophosphate(AWP)-calcium alginate microcapsules

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Science China Chemistry 2012年第9期55卷 1719-1725页

作者： WU Yan MIMURA hitoshi NIIBORI Yuichi OHNISHI Takashi KOYAMA Shinichi WEI YueZhou School of Nuclear Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Graduate School of Engineering Tohoku University Aramaki-Aza-Aoba 6-6-01-2Sendai980-8579Japan Japan Atomic Energy Agency 4002 NaritaO-arai-machiIbaraki311-1393Japan

A functional microcapsule was prepared by encapsulating the fine crystalline ammonium tungstophosphate （AWP） in calcium alginate polymer （CaALG）. The characterization of AWP-CaALG microcapsule was examined by SEM and EPMA. The ad- sorption behavior of Cs（Ⅰ）, Rb（Ⅰ）, Sr（Ⅱ）, Pd（II）, Ru（Ⅲ）, Rh（Ⅲ）, La（Ⅲ）, Ce（Ⅲ）, Dy（Ⅲ） and Zr（IV） was investigated by the batch method. The batch experiments were carried out by varying the shaking times, HNO3 concentration, and initial concen- tration of metal ions. Relatively large K＋ values above 105 cm3/g for Cs（I） were obtained in the range of 0.1-5 M HNO3, re- sulting in a separation factor of Cs/Rb exceeding 102. In contrast, the K＋ values of Sr（II）, Pd（II）, Ru（Ⅲ）, La（Ⅲ）, Dy（Ⅲ）, Ce（Ⅲ） and Zr（IV） were considerably lower than 50 cm3/g. The K＋ value of Cs（1） decreased in the order of the coexisting ions, H＋〉 Na＋〉〉 NH4＋, and a linear relationship with a slop of about -1 was obtained between log Kd and log [NH4＋] （[NH4＋] 〉 0.01 M） The adsorption of Cs（I） was found to be controlled by chemisorption mechanism, and followed a Langmuir-type adsorption equation. A high uptake percentage of 99.4% for Cs（I） was obtained by using the dissolved solutions of spent fuel from FBR-JOYO （JAEA）.

关键词： cesium high level liquid waste (HLLW) ammonium tungstophosphate alginate microcapsule adsorption

Effects of 0.4% ripasudil hydrochloride hydrate on morphological changes in rabbit eyes

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International Journal of Ophthalmology(English edition) 2019年第10期12卷 1637-1642页

作者： Bundit Limratchatamorn Ken Asakawa Kimiyo Mashimo Shigekazu Uga hitoshi Ishikawa Department of Ophthalmology Priest HospitalDepartment ofMedical ServicesMinistry of Public HealthBangkok10400Thailand Department of Ophthalmology School of MedicineKitasatoUniversityKanagawa252-0374Japan Department of Orthoptics and Visual Science School of AlliedHealth SciencesKitasato UniversityKanagawa252-0373Japan

We evaluated the cellular structure changes after continuous use of ripasudil hydrochloride hydrate in rabbit eyes which might affect its own efficacy and adverse effects. Two pigmented Dutch rabbits and 1 Japanese white rabbit were instilled with 0.4% ripasudil hydrochloride hydrate to the left eye twice daily. The right eye was observed as the control. Both eyes of all 3 rabbits were then enucleated for histopathologic examination by light and electron microscope at 1 mo in 1 of the pigmented Dutch rabbits, 3 mo in the other pigmented Dutch rabbit, and in the Japanese white rabbit after instillation. Microscopic observations showed increase intercellular space in trabecular meshwork, ciliary body, and iris stoma, increase pigmented granule number and size in iris epithelial cells, and decrease actin filament in iris muscle fiber cells. Consequently, ripasudil hydrochloride hydrate decreases the intraocular pressure by improving the conventional outflow and may also facilitate the unconventional outflow via intercellular space widening without serious side effects.

关键词： ripasudil hydrochloride hydrate actin filament side effect rabbit

Improving conditional random field model for prediction of protein-RNA residue-base contacts

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Frontiers of Electrical and Electronic Engineering in China 2018年第2期6卷 155-162页

作者： Morihiro Hayashida Noriyuki Okada Mayumi Kamada hitoshi Koyano Department of Electrical Engineering and Computer Science National Institute of Technology Matsue College Shimane 690- 8518 Japan Graduate School of Medicine Kyoto University Kyoto 606-8507 Japan Riken Quantitative Biology Center Hyogo 650-0047 Japan

Background： For understanding biological cellular systems, it is important to analyze interactions between protein residues and RNA bases. A method based on conditional random fields （CRFs） was developed for predicting contacts between residues and bases, which receives multiple sequence alignments for given protein and RNA sequences, respectively, and learns the model with many parameters involved in relationships between neighboring residue-base pairs by maximizing the pseudo likelihood function. Methods： In this paper, we proposed a novel CRF-based model with more complicated dependency relationships between random variables than the previous model, but which takes less parameters for the sake of avoidance of overfitting to training data. Results： We performed cross-validation experiments for evaluating the proposed model, and took the average of AUC （area under receiver operating characteristic curve） scores. The result suggests that the proposed CRF-based model without using Ll-norm regularization （lasso） outperforms the existing model with and without the lasso under several input observations to CRFs. Conclusions： We proposed a novel stochastic model for predicting protein-RNA residue-base contacts, and improved the prediction accuracy in terms of the AUC score. It implies that more dependency relationships in a CRF could be controlled by less parameters.

关键词： protein-RNA interaction residue-base contact conditional random field

Usefulness of biopsying the major duodenal papilla to diagnose autoimmune pancreatitis:A prospective study using IgG4-immunostaining

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World Journal of Gastroenterology 2006年第13期12卷 2031-2033页

作者： Terumi Kamisawa Yuyang Tu hitoshi Nakajima Naoto Egawa Kouji Tsuruta Atsutake Okamoto Department of Internal Medicine Tokyo Metropolitan Komagome Hospital 3-18-22 Honkomagome Bunkyo-ku Tokyo Japan Department of Surgery Tokyo Metropolitan Komagome Hospital 3-18-22 Honkomagome Bunkyo-ku Tokyo Japan

AIM： TO examine the histological and immunohistochemical findings of biopsy specimens taken from the major duodenal papilla of autoimmune pancreatitis （AIP） patients. METHODS： The major duodenal papilla in the resected pancreas of 3 patients with AIP and of 5 control patients [pancreatic carcinoma （n = 3） and chronic alcoholic pancreatitis （17 = 2）] was immunostained using anti-CD4-T cell, CD8-T cell and IgG4 antibodies. Forceps biopsy specimens taken from the major duodenal papilla of 2 patients with AIP and 5 control patients with suspected papillitis were prospectively taken during duodenoscopy and immunohistochemically examined. RESULTS： Moderate or severe Iymphoplasmacytic in- filtration including many CD4-positive or CD8-positive T lymphocytes and IgG4-positive plasma cells （≥10/HPF）, was observed in the major duodenal papilla of all 3 patients with AIR The same findings were also detected in the biopsy specimens taken from the major duodenal papilla of 2 patients with/kiP, but in controls, there were only a few （≤3/HPF） IgG4-positive plasma cells infiltrating the major duodenal papilla. CONCLUSIONS： An abundant infiltration of IgG4-positive plasma cells is specifically detected in the major duodenal papilla of patients with A/P. Although this is a preliminary study, IgG4-immunostaining of biopsy specimens taken from the major duodenal papilla may support the diagnosis of AIR

关键词： Autoimmune pancreatitis IgG4 Major duo-denal papilla

Rectal angiolipoma diagnosed after surgical resection: A case report

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World Journal of Gastroenterology 2007年第3期13卷 467-469页

作者： Mitsuru Ishizuka hitoshi Nagata Kazutoshi Takagi Toru Horie Akihito Abe Keiichi Kubota Department of Gastroenterological Surgery Dokkyo University School of Medicine Tochigi Japan

Angiolipoma is a common benign tumor with a char- acteristic vascular component that usually occurs in subcutaneous tissue. Although lipomas are frequently encountered at colonoscopy as submucosal tumors, an- giolipomas are rarely found in the gastrointestinal tract including the large intestine. Here we report a 77-year old Japanese man who underwent transanal resection of a tumor that was diagnosed tentatively as a leiomyoma. Histologically, the tumor consisted of mature fat cells and blood vessels. Immunohistochemically, the tumor cells were negative for c-kit and HMB-45, which are consis- tently expressed in tumors such as gastrointestinal stro- mal tumor and angiomyolipoma. The tumor was there- fore diagnosed as an angiolipoma. This is thought to be the first case report of a surgically resected angiolipoma of the rectum.

关键词： Angiolipoma Angiomyolipoma Gastrointestinal stromal tumor

Development of cancer-initiating cells and immortalized cells with genomic instability

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World Journal of Stem Cells 2015年第2期7卷 483-489页

作者： Ken-ichi Yoshioka Yuko Atsumi hitoshi Nakagama Hirobumi Teraoka Division of Carcinogenesis and Cancer Prevention National Cancer Center Research Institute Department of Pathological Biochemistry Medical Research InstituteTokyo Medical and Dental University

Cancers that develop after middle age usually exhibit genomic instability and multiple mutations. This is in direct contrast to pediatric tumors that usually develop as a result of specific chromosomal translocations andepigenetic aberrations. The development of genomic instability is associated with mutations that contribute to cellular immortalization and transformation. Cancer occurs when cancer-initiating cells(CICs), also called cancer stem cells, develop as a result of these mutations. In this paper, we explore how CICs develop as a result of genomic instability, including looking at which cancer suppression mechanisms are abrogated. A recent in vitro study revealed the existence of a CIC induction pathway in differentiating stem cells. Under aberrant differentiation conditions, cells become senescent and develop genomic instabilities that lead to the development of CICs. The resulting CICs contain a mutation in the alternative reading frame of CDKN2A(ARF)/p53 module, i.e., in either ARF or p53. We summarize recently established knowledge of CIC development and cellular immortality, explore the role of the ARF/p53 module in protecting cells from transformation, and describe a risk factor for genomic destabilization that increases during the process of normal cell growth and differentiation and is associated with the downregulation of histone H2 AX to levels representative of growth arrest in normal cells.

关键词： ARF/p53 module Cancer stem cells Cancerinitiatingcells Differentiation Genomic instability H2AX

Clinical outcomes of endoscopic ultrasonography-guided transmural drainage using plastic stent and nasocystic drain for pancreatic and peripancreatic collections

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Hepatobiliary & Pancreatic Diseases International 2019年第1期18卷 96-99页

作者： Katsuya Kitamura Akira Yamamiya Yu Ishii Yuta Mitsui hitoshi Yoshida Division of Gastroenterology Department of Medicine Showa University School of Medicine

To the Editor:Pancreatic and peripancreatic collections(PCs)develop from acute pancreatitis(AP),chronic pancreatitis,surgery,or *** 2012 revised Atlanta classification[1]of AP classified local complications into the following 4 PC types:acute peripancreatic fluid collection(<4 weeks after the onset of acute interstitial edematous pancreatitis),acute necrotic collection(<4 weeks after the onset of acute necrotizing pancreatitis),pancreatic pseudocyst(PPC;≥4 weeks after the onset of acute interstitial edematous pancreatitis),and walled-off necrosis(WON;≥4 weeks after the onset of acute necrotizing pancreatitis).Endoscopic ultrasonographyguided transmural drainage(EUS-TD)has been reported to be a minimally invasive procedure for patients with PCs[2–4].This study aimed to investigate the clinical outcomes of EUS-TD for PCs.

关键词： peripancreatic EUS-TD

Churg-Strauss syndrome complicated by colon erosion, acalculous cholecystitis and liver abscesses

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World Journal of Gastroenterology 2005年第33期11卷 5248-5250页

作者： Msahiro Suzuki Kazuo Nabeshima Mitsukazu Miyazaki hitoshi Yoshimura Shinsei Tagawa Katsuya Shiraki Internal Medicine Mie Prefectual Shima Hospital Japan First Department of Internal Medicine University School of Medicine Tsu 514-8507 Japan

We report on a case of Churg-Strauss syndrome (CSS)with colon erosion, cholecystitis and liver abscesses. A 21-year-old woman with a history of bronchial asthma for 3 years was admitted with a complaint of abdominal pain. Laboratory findings included remarkable leukocytosis and eosinophilia, and a colonoscopy revealed erosion from the rectum to the ileocecal region. In addition, a colonic biopsy specimen showed necrotizing vasculitis and marked eosinophilic infiltration. On the basis of the clinical features and histopathological findings, she was diagnosed with CSS and subsequently treated with oral prednisolone,after which the eosinophilia and abdominal pain disappeared. However, on the 15th d in hospital she developed cholecystitis and liver abscesses. She was therefore treated with antibiotics and as a result went into clinical remission.

关键词： Churg-Strauss syndrome Cholecystitis Liverabscesses