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Portal hypertensive colopathy in patients with liver cirrhosis

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World Journal of Gastroenterology 2005年第20期11卷 3127-3130页

作者： Keiichi Ito Katsuya Shiraki Takahisa Sakai hitoshi Yoshimura Takeshi Nakano First Department of Internal Medicine Mie University School of Medicine 2-174 Edobashi Tsu Mie 514-8507Japan

AIM: In patients with liver cirrhosis and portal hypertension, portal hypertensive colopathy is thought to be an important cause of lower gastrointestinal hemorrhage. In this study, we evaluated the prevalence of colonic mucosal changes in patients with liver cirrhosis and its clinical significance. METHODS: We evaluated the colonoscopic findings and liver function of 47 patients with liver cirrhosis over a 6-year period. The main cause of liver cirrhosis was post-viral hepatitis (68%) related to hepatitis B (6%) or C (62%) infection. All patients underwent upper gastrointestinal endoscopy to examine the presence of esophageal varices, cardiac varices, and congestive gastropathy, as well as a full colonoscopy to observe changes in colonic mucosa. Portal hypertensive colopathy was defined endoscopically in patients with vascular ectasia, redness, and blue vein. Vascular ectasia was classified into two types: type 1, solitary vascular ectasia; and type 2, diffuse vascular ectasia. RESULTS: Overall portal hypertensive colopathy was present in 31 patients (66%), including solitary vascular ectasia in 17 patients (36%), diffuse vascular ectasia in 20 patients (42%), redness in 10 patients (21%) and blue vein in 6 patients (12%). As the Child-Pugh class increased in severity, the prevalence of portal hypertensive colopathy rose. Child-Pugh class B and C were significantly associated with portal hypertensive colopathy. Portal hypertensive gastropathy, esophageal varices, ascites and hepatocellular carcinoma were not related to occurrence of portal hypertensive colopathy. Platelet count was significantly associated with portal hypertensive colopathy, but prothrombin time, serum albumin level, total bilirubin level and serum ALT level were not related to occurrence of portal hypertensive colopathy. CONCLUSION: As the Child-Pugh class worsens and platelet count decreases, the prevalence of portal hypertensive colopathy increases in patients with liver cirrhosis. A colonoscopi

关键词： Portal hypertensive colopathy Liver cirrhosis

Common carotid arterial thrombosis associated with ulcerative colitis

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World Journal of Gastroenterology 2007年第11期13卷 1755-1757页

作者： hitoshi Nogami Tsuneo Iiai Satoshi Maruyama Tatsuo Tani Katsuyoshi Hatakeyama Division of Digestive and General Surgery Department of Surgery Niigata University Niigata Japan

A 26-year-old woman with ulcerative colitis was transferred to our hospital with left hemiparesis due to cerebral infarction. Cervical ultrasonography and magnetic resonance imaging angiography revealed thrombosis at the right common carotid artery and the right internal carotid artery. Antithrombotic and anticoagulant therapies were commenced. After about 2 wk of the treatment, the frequency of her diarrhea increased. She underwent emergency subtotal colectomy, but 10 d later an abundant hemorrhage from the remnant rectum occurred, so the remnant rectum was resected and an ileal pouch anal anastomosis was performed. Antithrombotic and anticoagulant therapies were continued, but neither her neurological status nor magnetic resonance imaging angiography findings showed subsequent changes. She was discharged 3 mon after operation. This is a rare case of common carotid arterial thrombosis occurring as a complication of ulcerative colitis, in which antithrombotic and anticoagulant therapies are considered to provoke a deterioration of the patient’s bowel disease.

关键词： Thrombus at the common carotid artery Antithrombotic therapy Anticoagulant therapy Bleeding from the remnant rectum Ulcerative colitis

Suppression of postprandial blood glucose elevation by buckwheat(Fagpopyrum esculentum) albumin hydrolysate and identification of the peptide responsible to the function

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Food Science and Human Wellness 2022年第4期11卷 992-998页

作者： Kazumi Ninomiya Yusuke Yamaguchi Fumie Shinmachi hitoshi Kumagai Hitomi Kumagai Department of Food Science and Nutrition Kyoritsu Women’s University2-2-1 HitotsubashiChiyoda-kuTokyo 101-8347Japan College of Bioresource Sciences Nihon University1866 KameinoFujisawa-shi 252-0880Japan

The objective of this study is to evaluate the suppressive effect of buckwheat-albumin hydrolysate on postprandial hyperglycemia and identify the peptide responsible to the function. Buckwheat-albumin hydrolysate was prepared by using digestive enzymes and was orally administered to rats together with soluble starch. The blood was taken from the tail vein up to 90 min after oral administration to measure blood-glucose and plasma-insulin levels. The peptide with α-amylase inhibitory activity was purified from the buckwheathydrolysate by gel-filtration chromatography, α-amylase affinity chromatography, and high performance liquid chromatography(HPLC). The amino-acid sequence of the peptide was identified by a protein sequencer and was compared with that in the buckwheat-genome database. Buckwheat-albumin hydrolysate significantly suppressed the elevation of blood glucose level 15 min after starch administration. The amino-acid sequence of the peptide with α-amylase inhibitory activity was YVEPDCGNLGCCYHC in the parental protein of molecular mass 17.8 k Da and theoretical pI 4.77. The amino-acid sequence, molecular weight, and pI of the parental protein in buckwheat albumin were different from those of α-amylase inhibitor in wheat albumin. This study suggests that the novel α-amylase inhibitor identified in buckwheat albumin is a potential candidate for a functional food material to suppress postprandial blood glucose elevation.

关键词： Buckwheat-albumin hydrolysate Bioactive peptide α-Amylase inhibitor Postprandial hyperglycemia Type 2 diabetes

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Transporter-Mediated Organ Toxicity

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毒理学杂志 2005年第S1期 173-174页

作者： hitoshi Endou,Yoshikatsu Kanai Department of Pharmacology and Toxicology Kyorin University School of Medicine 6-20-2 Shinkawa Mitaka Tokyo 181-8611 Japan Department of Pharmacology and Toxicology Kyorin University School of Medicine 6-20-2 Shinkawa Mitaka Tokyo 181-8611 Japan

Transporter-Mediated Organ Toxicity

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毒理学杂志 2005年第A3期19卷 173-174页

作者： hitoshi Endou Yoshikatsu Kanai Department of Pharmacology and Toxicology Kyorin University School of Medicine 6-20-2 Shinkawa Mitaka Tokyo 181-8611 Japan Department of Pharmacology and Toxicology Kyorin University School of Medicine 6-20-2 Shinkawa Mitaka Tokyo 181-8611 Japan

The absorption, distribution and excretion of most of xenobiotics, drugs, environmental toxins and their metabolites are mediated by membrane transporters.

关键词：环境毒素调节机构输送机构分子水平

Role of nuclear receptor CAR in carbon tetrachloride-induced hepatotoxicity

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World Journal of Gastroenterology 2005年第38期11卷 5966-5972页

作者： Yuichi Yamazaki Satoru Kakizaki Norio Horiguchi hitoshi Takagi Masatomo Mori Masahiko Negishi Department of Medicine and Molecular Science Pharmacogenetics Section

AIM： To investigate the precise roles of CAR in CCI4- induced acute hepatotoxicity. METHODS： To prepare an acute liver injury model, CCI4 was intraperitoneally injected in CAR＋/＋ and CAR-/- mice. RESULTS： Elevation of serum alanine aminotransferase and extension of centrilobular necrosis were slightly inhibited in CAR-/- mice compared to CAR＋/＋ mice without PB. Administration of a CAR inducer, PB, revealed that CCl4-induced liver toxicity was partially inhibited in CAR-/- mice compared with CAR＋/＋ mice. On the other hand, androstanol, an inverse agonist ligand, inhibited hepatotoxicity in CAR＋/＋ but not in CAR./. mice. Thus, CAR activation caused CCl4 hepatotoxicity while CAR inhibition resulted in partial protection against CCl4-induced *** were no differences in the expression of CYP2E1, the main metabolizing enzyme for CCl4, between CAR＋/＋ and CAR./. mice. However, the expression of other CCI4-metabolizing enzymes, such as CYP2B10 and 3All, was induced by PB in CAR＋/＋ but not in CAR-/- mice. Although the main pathway of CCl4-induced acute liver injury is mediated by CYP2E1, CAR modulates its pathway via induction of CYP2B10 and 3All in the presence of activator or inhibitor. CONCLUSION： The nuclear receptor CAR modulates CCl4- induced liver injury via induction of CCl4-metabolizing enzymes in the presence of an activator. Our results suggest that drugs interacting with nuclear receptors such as PB might play critical roles in drug-induced liver injury or drug- drug interaction even though such drugs themselves are not hepatotoxic.

关键词： CAR Phenobarbital Cytochrome P450 CCl4 Drug-induced liver injury

Primary hepatic leiomyosarcoma with liver metastasis of rectal cancer

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World Journal of Gastroenterology 2012年第38期18卷 5479-5484页

作者： Kiyoto Takehara Hideki Aoki Yuko Takehara Rie Yamasaki Kohji Tanakaya hitoshi Takeuchi Department of Gastroenterological Surgery Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 700-8558 Japan Department of Surgery National Hospital Organization Iwakuni Clinical Center Yamaguchi 740-8510 Japan Department of Clinical Examination National Hospital Organization Iwakuni Clinical Center Yamaguchi 740-8510 Japan

Primary hepatic leiomyosarcoma is a particularly rare tumor with a poor prognosis. Curative resection is currently the only effective treatment, and the efficacy of chemotherapy is unclear. This represents the first case report of a patient with primary hepatic leiomyosarcoma co-existing with metastatic liver carcinoma. We present a 59-year-old man who was diagnosed preoperatively with rectal cancer with multiple liver metastases. He underwent a curative hepatectomy after a series of chemotherapy regimens with modified FOLFOX6 consisting of 5-fluorouracil, leucovorin and oxaliplatin plus bevacizumab, FOLFIRI consisting of 5-fluorouracil, leucovorin and irinotecan plus bevacizumab, and irinotecan plus cetuximab. One of the liver tumors showed a different response to chemotherapy and was diag-nosed as a leiomyosarcoma following histopathological examination. This case suggests that irinotecan has the potential to inhibit the growth of hepatic leiomyosarcomas. The possibility of comorbid different histological types of tumors should be suspected when considering the treatment of multiple liver tumors.

关键词： Leiomyosarcoma Rectal cancer Metastasis Chemotherapy Surgery

Strategies for gastric cancer in the modern era

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World Journal of Gastrointestinal Oncology 2010年第9期2卷 335-341页

作者： Satoru Takayama Takehiro Wakasugi hitoshi Funahashi Hiromitsu Takeyama Department of Gastroenterological Surgery Nagoya City University Graduate School of Medical Sciences

Gastric cancer is one of the most common neoplasms in Japan, and it is also the second leading cause of cancer-related deaths worldwide. Nowadays, infection with Helicobacter pylori (H. pylori) is a known risk factor for the development of gastric cancer. Therefore, gastric cancer should be considered as an infectious disease, and in fact, prophylactic eradication of H. pylori may prevent the development of metachronous gastric carcinoma. Before the role of H. pylori was understood, a different approach was used. Recently even after the cancer has developed, some newer therapeutic approaches have been pursued. These newer treatments have been summarized as "minimally invasive therapies" and use endoscopic or laparoscopic techniques. In addition, robotic approaches are being developed that seem to hold a great potential to change the surgical approach. Since basic understanding and treatment of the disease have both changed signif icantly over the last decade, we present a review of current advances in gastric cancer research and therapy.

关键词： Helicobacter pylori Endoscopic submucosal dissection Laparoscopy-assisted distal gastrectomy Gastric cancer Robot

Immunological effect of local ablation combined with immunotherapy on solid malignancies

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Chinese Journal of Cancer 2017年第6期36卷 252-257页

作者： Yusuke Takahashi Noriyuki Matsutani Takashi Nakayama hitoshi Dejima Hirofumi Uehara Masafumi Kawamura Department of General Thoracic Surgery Teikyo University School of Medicine

Recent comprehensive investigations clarified that immune microenvironment surrounding tumor cells are deeply involved in tumor progression,metastasis,and response to ***,several immunotherapeutic trials have achieved successful results,and the immunotherapeutic agents are available in clinical *** enhance their demonstrated efficacy,combination of immunotherapy and ablation has begun to *** ablations have considerable advantages as an alternative therapeutic option,especially its minimal *** addition,local ablations have shown immune-regulatory effect in preclinical and clinical *** the corresponding mechanisms are still unclear,the local ablations combined with immunotherapy have been suggested in the treatment of several solid *** article aims to review the published data on the immune-regulatory effects of local ablations including stereotactic body radiotherapy,cryoablation,radiofrequency ablation,and high-intensityfocused *** also discuss the value of local ablations combined with *** ablations have the potential to improve future patient outcomes;however,the effectiveness and safety of local ablations combined with immunotherapy should be further investigated.

关键词：免疫治疗剂免疫效应实体瘤免疫调节作用高强度聚焦超声肿瘤细胞临床实践综合调查

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