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Osteoporosis in adult Sri Lankan inflammatory bowel disease patients

World Journal of Gastroenterology 2009年第28期15卷 3528-3531页

作者： Arjuna Priyadarsin de silva Aranjan Lionel Karunanayake Thalahitiya Gamaralalage Iruka Dissanayaka Anuradha Supun Dassanayake Hewa Kattadi Kankanamgae Tilak Duminda Arunasalam Pathmeswaran Ananda Rajitha Wickramasinghe hithanadura janaka de silva department of Medicine Culty of Medicine University of Kelaniya PO Box 6 Thalagolla Road Ragama GQ11010 Sri Lanka department of Anatomy Faculty of Medicine University of Kelaniya PO Box 6Thalagolla Road Ragama GQ11010 Sri Lanka department of Pharmacology Faculty of Medicine University of Kelaniya PO Box 6 Thalagolla Road Ragama GQ11010 Sri Lanka department of Public Health Faculty of Medicine University of Kelaniya PO Box 6Thalagolla Road Ragama GQ11010 Sri Lanka Faculty of Medicine University of Kelaniya PO Box 6 Thalagolla Road Ragama GQ11010 Sri Lanka

AIM:To determine if inflammatory bowel disease(IBD) is a risk factor for osteoporosis in adult Sr Lankans.METHODS:We identified eligible subjects from among consecutive patients diagnosed with IBD who attended our outpatient clinic.We included only patients aged between 20 and 70 years.Patients who were pregnant, had significant comorbidity, or were on calcium supplements or treatment for osteoporosis within the past 6 mo, were excluded.Healthy, ageand sex-matched controls were also recruited, ina control to patient ratio of 3:1.Both groups were screened for osteoporosis using peripheral dual energy X-ray absorptiometry scanning.RESULTS:The study population consisted of 111 IBD patients(male:female = 43:68;mean age 42.5 years) and 333 controls(male:female = 129:204;mean age 43.8 years).The occurrence of osteoporosis among IBD patients(13.5%) was significantly higher than among controls(4.5%)(P = 0.001).The frequency of osteoporosis was not significantly different between ulcerative colitis(14.45%) and Crohn's disease(10.7%).However, on multivariate analysis, only age(P = 0.001), menopause(P = 0.024) and use of systemic steroids(P dependently with the occurrence of osteoporosis, while IBD, severity of disease, number of relapses, duration of illness or treatment other than systemic steroids were not.CONCLUSION:IBD does not appear to be an independent risk factor for the occurrence of osteoporosis in this population.However, the use of systemic steroids was a risk factor.

关键词：骨质疏松症斯里兰卡患者炎症成人肠

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Genetic associations of inflammatory bowel disease in a South Asian population

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World Journal of Clinical Cases 2018年第15期6卷 908-915页

作者： Madunil Anuk Niriella Isurujith Kongala Liyanage Senerath Kuleesha Kodisinghe Arjuna Priyadarsin de silva Nimna Rajapakshe Sunali D Nanayakkara Dunya Luke Thilakshi silva Metthananda Nawarathne Ranjith K Peiris Udaya P Kalubovila Sujeewa R Kumarasena Vajira Harshadeva Weerabaddana Dissanayake Rohan W Jayasekara hithanadura janaka de silva Faculty of Medicine University of Kelaniya Faculty of Medical Sciences University of Sri Jayewardenepura University Medical Unit Colombo North Teaching Hospital Gastroenterology Unit National Hospital of Sri Lanka Gastroenterology Unit Colombo South Teaching Hospital Gastroenterology Unit Teaching Hospital Kandy Gastroenterology Unit Teaching Hospital Karapitiya Human Genetics Unit Faculty of Medicine University of Colombo

AIM To estimate prevalence and phenotypic associations of selected inflammatory bowel disease(IBD)-associated genetic variants among Sri Lankan patients. METHODS A case study of histologically confirmed ulcerative colitis(UC) or Crohn's disease(CD) patients with ≥ 1 year disease duration, who were compared to unrelated, gender-matched, healthy individuals as controls, was conducted at four major centers in Sri Lanka. Phenotypic data of the cases were obtained and all participants were genotyped for 16 selected genetic variants: IL12 B :rs1045431, IL23 R :rs11805303, ARPC2 :rs12612347, IRGM :rs13361189, IL26/IL22 :rs1558744, CDH1 :rs1728785, IL10 :rs3024505, FCGR2 A :rs3737240, PTGER4 :rs4613763, IL17 REL/PIM3 :rs5771069, HNF4 a :rs6017342, STAT3 :rs744166, SMURF1 :rs7809799, LAMB1 :rs886774, HLA-DRB5, DQA1, DRB1, DRA :rs9268853, MST1, UBA7, and APEH :rs9822268. The genotypes of all variants were in Hardy-Weinberg Equilibrium(P > 10^(-3)). To account for multiple hypothesis testing, P-values dered significant.RESULTS A total of 415 patients and 465 controls were recruited. Out of the single nucleotide polymorphisms(SNPs) tested, the majority were not associated with IBD in Sri Lankans. Significant positive associations were noted between rs886774(LAMB1-gene) and UC(odds ratio(OR) = 1.42, P = 0.001). UC patients with rs886774 had mild disease(OR = 1.66, P described in South Asians.

关键词： Inflammatory bowel disease Genetics of inflammatory bowel disease Ulcerative colitis Crohn’s disease LAMB1 gene mutation IL-12B gene mutation

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实时信息管理系统i-Booth的开发与应用

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工程质量 2011年第2期29卷 85-86页

作者：孙鹏北京市汉龙实业有限公司北京100078

如果信息能以需要的形式在恰当的时间传递到需要的地点,则这样的信息就是最有价值的。针对建筑施工过程中信息与通讯的混乱,卡尔加里大学于2006年开发了一种实时信息管理系统i-Booth。介绍了i-Booth系统的建立与确认过程。

关键词：建筑施工实时信息管理系统

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