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Role of Multidetector CT in Staging of Gastric Carcinoma

Journal of Cancer Therapy 2019年第7期10卷 565-579页

作者： hisham mostafa kamel emam Ehab Mansour Mohammed Moussa Mohammed Abouelmaged Maha Ragab Ismail Ibrahim Radiodiagnosis Department Faculty of Medicine Assiut University Assiut Egypt Surgical Oncology Department South Egypt Cancer Institute Assiut Egypt

Background: Radiology plays an essential role in the diagnosis, staging and surveillance of oncology patients. CT is the most sensitive imaging modality in the workup of these patients. Aim of the Study: The aim of this work is to detect the role of MDCT (multidetector computed tomography) in the preoperative investigation of gastric adenocarcinoma patients according to TNM staging. Patients and Methods: This is a prospective study enrolling 20 patients who had histologically proven adenocarcinoma based upon an upper gastrointestinal endoscopic biopsy for MDCT staging of gastric carcinoma during the period from June 2016 to June 2017. The MSCT data were correlated and compared with the histopathological results. The study was conducted in the Radiology Department of Assiut University Hospital using 64-MDCT (Toshiba Aquilion). Results: According to our study results, the sensitivity of determining T1 stage on CT scan can’t be detected as there was only 1 case pathologically proved T1 and overstaged as T2 by MSCT;however, accuracy and specificity are quite high, which was 95% and 100% respectively. For T2 stage tumors (25.0% of cases), accuracy is 95%, sensitivity—100%, and specificity—93.7%. According to our results the accuracy and sensitivity of T3 staging are 75% and 100%, while those of T4 stage were 75% and 44.4% respectively. Tumor was correctly staged in 14 of 20 patients (the valid T staging rate was 70.0%). Tumor was under-staged in 5 of 20 patients (25.0%) (staged as T3, but pathologically proven to be T4a). As regards N staging accuracy found results for N0 (62.5%), N2 (87.5%) and N3 (75%), while N1 accuracy recorded 37.5%. As regards the nodal staging sensitivity which had a range from (0% for N4) to (66% for N2) this wide range of sensitivity demonstrates the problem of CT in nodal staging. As regards sensitivity of M0, accuracy was 100% and 85% respectively. While that of M1 was (62.5%) and (85%) respectively. Conclusion: MSCT can be the first choice fo

关键词： Multidetector CT Gastric Carcinoma

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Evaluation of natural radioactivity and radiological hazards in basement rocks from Gabel Abu El-Hassan in the North Eastern Desert of Egypt by multivariate statistical approach with remote sensing data

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Radiation Detection Technology and Methods 2021年第1期5卷 15-26页

作者： Atef El-Taher mostafa kamel Abdellah Tolba Ghada Salaheldin Physics Department Faculty of ScienceAl-Azhar UniversityAssiut 71452Egypt Geology Department Faculty of ScienceAl-Azhar UniversityAssiutEgypt Physics Department Faculty of ScienceAssiut UniversityAssiut 71516Egypt

Purpose The present work deals with the natural radioactivity levels of basement rocks from Gabel Abu El-Hassan in the North Eastern Desert of *** The activity concentrations of 226Ra,232Th and 40K in rock samples were measured using a gamma-ray spectrometry with an HPGe *** Enhanced Thematic Mapper Plus(ETM+)data were processed and interpreted to create rock forming radioactive *** and conclusion The activity concentrations of 226Ra,232Th and 40K varied from 28.2±9.4 to 259.6±38.6 Bq/kg,37.9±9.9 to 297.4±54.6 Bq/kg and 487.0±73.4 to 5514.6±786.0 Bq/kg,*** radiological hazard indices(gamma index),the annual effective dose rate and excess life-time cancer risk were estimated to assess the radiological hazards due to the use of rock samples as building *** sensing data were also used to integrate between radioactive analysis and Landsat-7(ETM+)data processing to detect radioactive anomalies and to identify the uraniferous alteration zones in Abu El-Hassan area.

关键词： Natural radioactivity Radiological hazards Remote sensing Gabel Abu El-Hassan Egypt

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Radio Optical Network Simulation Tool (RONST)

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Computers, Materials & Continua 2022年第5期71卷 3685-3702页

作者： Yasmine IAbdelhak Fady kamel Moustafa Hafez Hussein EKotb Haitham AOmran Tawfik Ismail Hassan mostafa Department of Electronics and Communications Faculty of EngineeringMansoura UniversityDakahlia35516Egypt Nanotechnology and Nanoelectronics Program Zewail City of Science and TechnologyGiza12578Egypt Department of Electronics and Communications Faculty of EngineeringCairo UniversityGiza12613Egypt Department of Electronics and Communications Faculty of EngineeringAin Shams UniversityCairo11566Egypt Laboratory of Micro Optics Faculty of Information Engineering and TechnologyGerman University in Cairo11835CairoEgypt National Institute of Laser Enhanced Sciences Cairo UniversityGiza12613Egypt Wireless Intelligent Networks Center(WINC) Nile UniversityGiza12677Egypt

This paper presents a radio optical network simulation tool(RONST)for modeling optical-wireless *** a typical optical and electrical chain environment,performance should be optimized concurrently before system *** a result,simulating such systems turns out to be a multidisciplinary *** governing equations are incompatible with co-simulation in the traditional environments of existing software(SW)*** ultra-wideband(UWB)technology is an ideal candidate for providing high-speed short-range access for wireless *** limited wireless reach of this technology is a significant limitation.A feasible solution to the problem of extending UWB signals is to transmit these signals to endusers via optical *** concept implies the need for the establishment of a dependable environment for studying such ***,the essential novelty of the proposed SW is that it provides designers,engineers,and researchers with a dependable simulation framework that can accurately and efficiently predict and/or optimize the behavior of such systems in a single optical-electronic simulation ***,it is supported by a strong mathematical foundation with integrated algorithms to achieve broad flexibility and low computational *** validate the proposed tool,RONST was deployed on an ultra-wideband over fiber(UWBoF)*** bit error rate(BER)has been calculated over a UWBoF system,and there is good agreement between the experimental and simulated results.

关键词： Optical-wireless systems mathematical modelling techniques opto-electronic software tools ultra-wide band over fiber systems(UWBoF)

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Hepatitis C Virus RNA Strands Detection in Peripheral Blood Mononuclear Cells Legitimizes Virus Eradication in Negative Serum PCR Naive and Post-treatment Patients

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Journal of Clinical and Translational Hepatology 2017年第1期5卷 1-8页

作者： Mohamed Darwish Ahmed Abd Alla mostafa kamel El Awady Tropical Medicine Department Faculty of MedicineAl-Azhar UniversityCairoEgypt Department of Microbial Biotechnology National Research CenterCairoEgypt

Background and Aims:Hepatitis C virus(HCV)hepatotropism is associated with intra-peripheral blood mononuclear cell(PBMC)infection that causes post-treatment relapse in RNA seronegative *** understanding of the association of non-viremic hepatic fibrosis with positive anti-HCV IgG antibodies and active hepatocellular damage might be increased by PBMCs screening for intracellular ***,the goals of this study included evaluation of PBMCs PCR for diagnosing HCV infection,addressing PBMCs plus serum real-time(SRT)PCR benefits over SRT-PCR alone,studying intraPBMCs distribution of RNA sense and antisense strands,and identifying treatment feasibility in solitary intracellular ***:Enzyme-linked immunosorbent assay,SRT-PCR and PBMCs PCR were used to evaluate HCV infection in 401 *** patients were classified into groups of negative controls(n=30),positive controls(n=63),non-viremia post-treatment(experienced;n=166)and na(i)ve(n=49)cases,and non-viremia positive PBMCs PCR na(i)ve(n=35)and experienced(n=58)***:The diagnosis of true positive and negative by PBMCs PCR and SRT-PCR had 100%and 96.7%compatibility *** PCR detected intracellular HCV infection in 49 out of 215 non-viremia patients;among them,na(i)ve cirrhotics had significantly higher number of intracellular infection than the na(i)ve non-cirrhotic(P<0.001)and experienced patients(P<0.0001).Antisense and sense strands were respectively recognized in na(i)ve and experienced cases(P=0.01218).Intracellular HCV strands were detected in 18.02%of experienced *** of intracellular RNA strands showed significant decline in experienced compared to na(i)ve patients(P<0.05).Conclusion:PBMCs PCR is a valid diagnostic test that can diagnose intracellular HCV when SRT-PCR is *** and sense strands are respectively recognized more often in na(i)ve and experienced *** expected overall relapsing rate in our cohort was 18.02%.Int

关键词： HCV PBMCs RNA Strands

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Preemptive living donor kidney transplantation:Access,fate,and review of the status in

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World Journal of Nephrology 2023年第3期12卷 40-55页

作者： Rabea Ahmed Gadelkareem Amr mostafa Abdelgawad Ahmed Reda Nashwa mostafa Azoz Mohammed Ali Zarzour Nasreldin Mohammed hisham Mokhtar Hammouda Mahmoud Khalil Department of Urology Assiut Urology and Nephrology HospitalFaculty of MedicineAssiut UniversityAssiut 71515Egypt Department of Internal Medicine Assiut University HospitalFaculty of MedicineAssiut UniversityAssiut 71515Egypt

BACKGROUND Preemptive living donor kidney transplantation(PLDKT)is recommended as the optimal treatment for end-stage renal *** To assess the rate of PLDKT among patients who accessed KT in our center and review the status of PLDKT in *** We performed a retrospective review of the patients who accessed KT in our center from November 2015 to November *** addition,the PLDKT status in Egypt was reviewed relative to the *** Of the 304 patients who accessed KT,32 patients(10.5%)had preemptive access to KT(PAKT).The means of age and estimated glomerular filtration rate were 31.7±13 years and 12.8±3.5 mL/min/1.73 m2,***-nine patients had KT,including 3 PLDKTs only(5.1%of total KTs and 9.4%of PAKT).Twenty-nine patients(90.6%)failed to receive PLDKT due to donor unavailability(25%),exclusion(28.6%),regression from donation(3.6%),and patient regression on starting dialysis(39.3%).In multivariate analysis,known primary kidney disease(P=0.002),patient age(P=0.031)and sex(P=0.001)were independent predictors of achievement of KT in our ***,PAKT was not significantly(P=0.065)associated with the achievement of *** of the literature revealed lower rates of PLDKT in Egypt than those in the *** Patient age,sex,and primary kidney disease are independent predictors of achieving living donor *** its non-significant effect,PAKT may enhance the low rates of *** main causes of non-achievement of PLDKT were patient regression on starting regular dialysis and donor unavailability or exclusion.

关键词： Access to kidney transplantation Donor regression Kidney transplantation Living donors Preemptive kidney transplantation Transplantation

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Reasons and effects of the decline of willing related potential living kidney donors

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World Journal of Transplantation 2023年第5期13卷 276-289页

作者： Rabea Ahmed Gadelkareem Amr mostafa Abdelgawad Nasreldin Mohammed Ahmed Reda Nashwa mostafa Azoz Mohammed Ali Zarzour hisham Mokhtar Hammouda Mahmoud Khalil Department of Urology Assiut Urology and Nephrology HospitalFaculty of MedicineAssiut UniversityAssiut 71515Egypt Department of Internal Medicine-Nephrology Unit Assiut University HospitalFaculty of MedicineAssiut UniversityAssiut 71515Egypt

BACKGROUND Although the availability of related living donors(LDs)provides a better chance for receiving kidney transplantation(KT),the evaluation protocols for LD selection remain a safeguard for the LD’s *** protocols are variable from one center to another,resulting in variable rates of decline of the potential LDs(PLDs).The decline of willing PLDs may occur at any stage of evaluation,starting from the initial contact and counseling to the day of *** To identify the causes of the decline of PLDs,the predictors of PLD candidacy,and the effect on achieving *** A retrospective study was performed on the willing PLDs who attended our outpatient clinic for kidney donation to their related potential recipients between October 2015 and December *** variables influencing their candidacy rate and the fate of their potential recipients were *** groups of PLDs were compared:Candidate PLDs after a completed evaluation vs non-candidate PLDs with a complete or incomplete evaluation.A multivariate logistic regression was performed to assess the factors contributing to the achievement of PLD *** Of 321 willing PLDs,257 PLDs(80.1%)accessed the evaluation to variable extents for 212 potential recipients,with a mean age(range)of 40.5±10.4(18-65)years,including 169 females(65.8%).The remaining 64 PLDs(19.9%)did not access the *** 58 PLDs(18.1%)succeeded in donating,but 199 PDLs(62.0%)were declined;exclusion occurred in 144 PLDs(56.0%)for immunological causes(37.5%),medical causes(54.9%),combined causes(9.7%),and financial causes(2.1%).Regression and release occurred in 55 PLDs(17.1%).The potential recipients with candidate PLDs were not significantly different from those with non-candidate PLDs,except in age(P=0.041),rates of completed evaluation,and exclusion of PLDs(P<0.001).There were no factors that independently influenced the rate of PLD *** patients who failed to have KT after the decline of their P

关键词： Donor decline Donor evaluation Donor exclusion Kidney transplantation Living kidney donors Related living donors

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Efficacy of the combination of tadalafil and tamsulosin versus tadalafil alone as a medical expulsive therapy for stone L1/3 ureter 10 mm or less: A prospective comparative placebo-controlled study

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Current Urology 2024年第4期18卷 278-282页

作者： Ahmed Reda mostafa kamel Mohamed Loay Yaser M.Abdelsalam Mohamed A.Zarzour Department of Urology Assiut University HospitalAssiutEgypt

Background The lifetime occurrence of urinary stones is approximately 1%–15%,and the peak age of occurrence is 30 *** one fifths of urinary tract stones are found in the ureter,of which two thirds are in the distal *** drugs,including phosphodiesterase-5 inhibitors(PDE5Is)andα-blockers,are used to relax the smooth muscles in medical expulsive therapy(MET).We aimed to compare the combination of tadalafil and tamsulosin versus tadalafil alone as MET for stones in the L1/3 ureter of 10 mm or *** and methods A total of 150 patients with L1/3 ureteric stones measuring 10 mm or less were enrolled in the study and randomly assigned to one of 3 equal groups using a computer-generated random *** in group A prescribed tadalafil 10 mg/***,those in group B were prescribed tamsulosin 0.4 mg and tadalafil 10 mg/d,whereas those in group C received a placebo once *** expulsion rate and pain recurrence were evaluated after 14 *** The stone expulsion rate was significantly higher in the tadalafil and tamsulosin groups and the tamsulosin group than in the placebo group in the current study by 68%in the combination group,64%in the tadalafil alone group,and 42%in the placebo group(p=0.019).In the current study,a combination was associated with lower pain recurrence than tadalafil alone or placebo,with means of 1.06,1.9,2.98(with a p value of 0.001).Stone size was not effective in any *** The combination of PDE5Is andα-blockers effectively increases the expulsion of lower ureteric stones(5–10 mm),but with the same effect as PDE5Is alone,with the advantage of decreasing pain *** size did not affect the expulsion rate in patients who received MET for stones less than 1 cm in size.

关键词： Tadalafil Tamsulosin Ureteric stone

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Occult HCV Infection (OCI) Diagnosis in Cirrhotic and Non-cirrhotic Naive Patients by Intra-PBMC Nested Viral RNA PCR

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Journal of Clinical and Translational Hepatology 2017年第4期5卷 319-326页

作者： Mohamed Darwish Ahmed Abd Alla Saleh Ahmed Elibiary George Y.Wu mostafa kamel El-Awady Tropical Medicine Department Faculty of MedicineAl-Azhar UniversityCairoEgypt Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA Department of Microbial Biotechnology National Research CenterCairoEgypt

Background and Aims:Occult HCV infections(OCIs)include IgG antibody seronegative cryptogenic(COCIs),as well as seropositive secondary na(i)ve(SNOCIs)and experienced(SEOCIs)*** used peripheral-blood-mononuclear-cell(PBMC)-PCR to evaluate COCIs and SNOCIs prevalence,serum HCV spontaneous disappearance(SCSD)in na(i)ve cirrhotics and non-cirrhotics,intra-PBMC HCV-RNA strands in relation to cirrhosis density in na(i)ve non-viremia cases,and HCV-RNA seroconversion after 1 year of solitary naive intra-PBMC ***:The anti-HCV IgG antibodypositive na(i)ve-patients(n=785)were classified into viremic(n=673)and non-viremic[n=112,including non-cirrhotics(n=55)and cirrhotics(n=57)],and 62 controls without evidence of *** and post-HCV non-viremia cases(n=62+112=174)were submitted to hepatic FibroscanElastography *** subjects(n=847)were screened for intra-PBMC HCV-RNA sense and antisense strands by ***:Na(i)ve-OCI cases(4.84%)that were diagnosed by PBMC-PCR significantly raised the total numbers of HCV-infection to 714(p=0.01).The percent positivity of SNOCIs(34.82%)was significantly higher than for asymptomatic-COCIs(3.125%,p=0.0001).Comparing PBMC-PCR with single-step-reverse-transcription(SRT)-PCR for identification of SCSD in na(i)ve IgG antibody-positive nonviremia patients(n=112)revealed a decline in SCSD prevalence by PBMC-PCR(from 14.27%to 9.3%),regardless of presence of hepatic cirrhosis(p=0.03).SCSD was found to be higher by PBMC-PCR in non-cirrhotics compared to cirrhotics(p=0.0001),with an insignificant difference when using SRT-PCR(p=0.45).Intra-PBMC HCV-RNA infection was significantly more frequent in cirrhotics compared to both non-cirrhotics and controls(p<0.0005).An increased hepatic fibrosis density was recognized in intra-PBMC HCV-RNA infection with sense(p=0.0001)or antisense strand(p=0.003).HCV-RNA seroconversion was associated with intra-PBMC infection when both sense and antisense strands were dete

关键词： OCIs PBMCs Na(i)ve Cirrhosis

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Systematic Analysis of Safety and Security Risks in Smart Homes

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Computers, Materials & Continua 2021年第7期68卷 1409-1428页

作者： Habib Ullah Khan Mohammad kamel Alomari Sulaiman Khan Shah Nazir Asif Qumer Gill Alanoud Ali Al-Maadid Zaki Khalid Abu-Shawish mostafa Kamal Hassan Department of Accounting and Information Systems College of Business and EconomicsQatar UniversityDohaQatar Department of Computer Science University of SwabiSwabiPakistan School of Software University of Technology SydneySydneyAustralia Department of Finance&Economics College of Business&EconomicsQatar UniversityDohaQatar

The revolution in Internet of Things(IoT)-based devices and applications has provided smart applications for *** applications range from healthcare to traffic-flow management,to communication devices,to smart security devices,and many *** particular,government and private organizations are showing significant interest in IoT-enabled applications for smart *** the perceived benefits and interest,human safety is also a key *** research is aimed at systematically analyzing the available literature on smart homes and identifying areas of concern or risk with a view to supporting the design of safe and secure smart *** this systematic review process,relevant work in the most highly regarded journals published in the period 2016–2020(a section of 2020 is included)was analyzed.A final set of 99 relevant articles(journal articles,book sections,conference papers,and survey papers)was analyzed in this *** analysis is focused on three research questions and relevant *** systematic analysis results and key insights will help researchers and practitioners to make more informed decisions when dealing with the safety and security risks of smart homes,especially in emergency situations.

关键词： Smart buildings IoT smart homes systematic literature review prototype model

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HCV Therapy Follow-up Fractionation (CTF2) by Intra-PBMC Nested RNA PCR Recognizes Early Virologic Response and Relapse

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Journal of Clinical and Translational Hepatology 2018年第2期6卷 147-154页

作者： Mohamed Darwish Ahmed Abd Alla Saleh Ahmed Elibiary Ramy Hassan Elshaboury George Y.Wu Reham M.Dawood mostafa kamel El Awady Tropical Medicine Department Faculty of MedicineAl-Azhar UniversityCairoEgypt Department of Pharmacy Massachusetts General HospitalBostonMAUSA Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterHartfordCTUSA Department of Microbial Biotechnology National Research CenterCairoEgypt

Background and Aims:Sustained virologic response is evaluated by single-step reverse transcription(SRT)PCR as-say,which assesses hepatitis C virus(HCV)clearance from plasma but not from tissues such as peripheral blood mono-nuclear cells(PBMCs).Persistence of HCV RNA in PBMCs beyond end of treatment(EOT)is associated with *** goal was to measure intra-PBMC HCV RNA levels during oral antiviral therapy according to the HCV therapy follow-up fractionation(CTF2)***:Compen-sated chronic HCV patients(n=278 SRT-PCR positive)were scheduled to receive oral antiviral *** were followed-up by SRT and intra-PBMCs HCV RNA PCR at the end of the 2nd,6th,10th,14th,18th and 24th weeks to evaluate virus clearance from plasma and PBMCs,*** CTF2 protocol evaluated SRT and PBMC PCR status at each follow-up point for determining therapy continuation or inter-ruption to address cost ***:All patients tested negative by SRT PCR after therapy for 2 ***-cation of the CTF2 protocol revealed:a)increasing HCV clear-ance rate from 75.9%at the end of 10th week to 90.3%at the end of 24th week(p<0.00001);b)faster clearance of HCV from plasma compared to PBMCs at each point of follow-up until the 18th week(p<0.05);c)higher viral elimination rates diagnosed by PBMC HCV RNA PCR(?)compared to PBMC HCV RNA PCR(+)from the 6th to 24th week of treatment(p<0.0001);d)higher over-time increase curve of combined plasma and PBMC HCV RNA determined negativity compared to the decline in positivity curves by PBMC PCR at the 6th-18th week compared to the 24th week(p<0.01)—these results validated treatment continuation;and e)solitary evaluation of EOT sustained HCV infection and relapses by PBMC HCV RNA(p<0.001).Conclusions:Early elimination of serum and tissue(PBMC)HCV infection by oral antiviral therapy can be achieved and evaluated during a cost-effective CTF2 pro-tocol application.

关键词： CTF2 protocol HCV PBMCs PCR Cost-effectiveness

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