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Visual and refractive outcomes of posterior chamber phakic IOL in stable keratoconus

International Journal of Ophthalmology(English edition) 2019年第5期12卷 840-843页

作者： Sherif H Emerah Moataz M Sabry hisham a saad Waleed A Ghobashy Ophthalmology Department Research Institute of Ophthalmology Magrabi Eye Hospital Ophthalmology Department Tanta University Ophthalmology Department Suez Canal University

We evaluated the visual and refractive outcomes after phakic visian toric implantable collamer lens(ICL) insertion in stable keratoconus(KC). This retrospective study investigated toric ICL implantation in 14 eyes of 8 patients with stable KC. After 6 mo, the mean uncorrected distance visual acuity improved significantly from 0.77 to 0.15 logMAR. The mean best corrected distance visual acuity(BCDVA) improved from 0.18±0.1 to 0.15±0.1 logMAR. Fifty percent of eyes maintained their preoperative BCDVA; 42.8% gained one line. There was no statistical difference in high order or coma aberration. The mean refractive manifest spherical equivalent(MSE), mean refractive manifest spherical error, mean manifest astigmatism decreased significantly postoperatively. At 6 mo postoperatively, our achieved mean spherical equivalent was approximately 74%. No intraoperative or postoperative complications occurred. Toric ICL implantation was effective, predictable and safe to correct refractive error and improve visual acuity in patients with stable KC.

关键词： coma keratoconus lens implantation intraocular

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Transcriptome changes in stages of non-alcoholic fatty liver disease

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World Journal of Hepatology 2022年第7期14卷 1382-1397页

作者： Jihad Aljabban Michael Rohr saad Syed Kamal Khorfan Vincent Borkowski hisham Aljabban Michael Segal Mohamed Mukhtar Mohammed Mohammed Maryam Panahiazar Dexter Hadley Ryan Spengler Erin Spengler Department of Medicine University of Wisconsin Hospital and ClinicsMadisonWI 53792United States Department of Medicine University of Central Florida College of MedicineOrlandoFL 32827United States Department of Medicine Northwestern Memorial HospitalChicagoIL 60611United States Department of Gastroenterology and Hepatology University of California San Francisco-FresnoFresnoCA 93701United States Department of Medicine Barry UniversityMiamiFL 33161United States Department of Medicine Michigan State University College of Human MedicineEast LansingMI 49503United States Department of Medicine Windsor University School of MedicineSaint Kitts 1621CayonSaint Kitts and Nevis Department of Surgery University of California San FranciscoSan FranciscoCA 94305United States Department of Artificial Intelligence PathologyUniversity of Central Florida College of MedicineOrlandoFL 32827United States Department of Gastroenterology and Hepatology University of Wisconsin Hospital and ClinicsMadisonWI 53792United States

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease in the United States and *** currently understood model of pathogenesis consists of a‘multiple hit’hypothesis in which environmental and genetic factors contribute to hepatic inflammation and *** To examine the genetic expression of NAFLD and non-alcoholic steatohepatitis(NASH)tissue samples to identify common pathways that contribute to NAFLD and NASH *** We employed the Search Tag Analyze Resource for Gene Expression Omnibus platform to search the The National Center for Biotechnology Information Gene Expression Omnibus to elucidate NAFLD and NASH *** NAFLD,we conducted meta-analysis of data from 58 NAFLD liver biopsies and 60 healthy liver biopsies;for NASH,we analyzed 187 NASH liver biopsies and 154 healthy liver *** Our results from the NAFLD analysis reinforce the role of altered metabolism,inflammation,and cell survival in pathogenesis and support recently described contributors to disease activity,such as altered androgen and long non-coding RNA *** top upstream regulator was found to be sterol regulatory element binding transcription factor 1(SREBF1),a transcription factor involved in lipid *** of SREBF1,we observed upregulation in CXCL10,HMGCR,HMGCS1,fatty acid binding protein 5,paternally expressed imprinted gene 10,and downregulation of sex hormone-binding globulin and insulin-like growth factor *** molecular changes reflect low-grade inflammation secondary to accumulation of fatty acids in the *** results from the NASH analysis emphasized the role of cholesterol in *** canonical pathways,disease networks,and disease functions were related to cholesterol synthesis,lipid metabolism,adipogenesis,and metabolic *** upstream regulators included proinflammatory cytokines tumor necrosis factor and IL1B,PDGF BB,and *** of beta-estradiol

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Bioinformatics AKT inhibitor Therapy

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Dissecting novel mechanisms of hepatitis B virus related hepatocellular carcinoma using meta-analysis of public data

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World Journal of Gastrointestinal Oncology 2022年第9期14卷 1856-1873页

作者： Jihad Aljabban Michael Rohr saad Syed Eli Cohen Naima Hashi Sharjeel Syed Kamal Khorfan hisham Aljabban Vincent Borkowski Michael Segal Mohamed Mukhtar Mohammed Mohammed Emmanuel Boateng Mary Nemer Maryam Panahiazar Dexter Hadley Sajid Jalil Khalid Mumtaz Department of Medicine University of Wisconsin Hospital and ClinicsMadisonWI 53792United States Department of Medicine University of Central Florida College of MedicineOrlandoFL 32827United States Department of Medicine Northwestern Memorial HospitalChicagoIL 60611United States Department of Medicine Vanderbilt Medical CenterNashvilleTN 37232United States Department of Medicine Mayo ClinicRochesterMN 55905United States Department of Medicine University of Chicago HospitalsChicagoIL 60637United States Department of Gastroenterology and Hepatology University of California San Francisco-FresnoFresnoCA 93701United States Department of Medicine Barry UniversityMiamiFL 33161United States Department of Medicine Michigan State University College of Human MedicineLansingMI 49503United States Department of Medicine Windsor University School of MedicineFrankfortIL 60423United States Department of Surgery University of California San FranciscoSan FranciscoCA 94143United States Department of Pathology University of Central Florida College of MedicineOrlandoFL 32827United States Department of Gastroenterology and Hepatology Ohio State University Wexner Medical CenterColumbusOH 43210United States

BACKGROUND Hepatitis B virus(HBV) is a cause of hepatocellular carcinoma(HCC). Interestingly, this process is not necessarily mediated through cirrhosis and may in fact involve oncogenic processes. Prior studies have suggested specific oncogenic gene expression pathways were affected by viral regulatory proteins. Thus, identifying these genes and associated pathways could highlight predictive factors for HCC transformation and has implications in early diagnosis and *** To elucidate HBV oncogenesis in HCC and identify potential therapeutic *** We employed our Search, Tag, Analyze, Resource platform to conduct a meta-analysis of public data from National Center for Biotechnology Information’s Gene Expression Omnibus. We performed meta-analysis consisting of 155 tumor samples compared against 185 adjacent nontumor samples and analyzed results with ingenuity pathway *** Our analysis revealed liver X receptors/retinoid X receptor(RXR) activation and farnesoid X receptor/RXR activation as top canonical pathways amongst others. Top upstream regulators identified included the Ras family gene rab-like protein 6(RABL6). The role of RABL6 in oncogenesis is beginning to unfold but its specific role in HBV-related HCC remains undefined. Our causal analysis suggests RABL6 mediates pathogenesis of HBV-related HCC through promotion of genes related to cell division, epigenetic regulation, and Akt signaling. We conducted survival analysis that demonstrated increased mortality with higher RABL6 expression. Additionally, homeobox A10(HOXA10) was a top upstream regulator and was strongly upregulated in our analysis. HOXA10 has recently been demonstrated to contribute to HCC pathogenesis in vitro. Our causal analysis suggests an in vivo role through downregulation of tumor suppressors and other *** This meta-analysis describes possible roles of RABL6 and HOXA10 in the pathogenesis of HBV-related HCC. RABL6 and HOXA10 represent potent

关键词： Hepatitis B virus Hepatocellular carcinoma Genomics Meta-analysis

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