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Multiple intrahepatic artery aneurysms during the treatment for IgG4-related sclerosing cholangitis:A case report

World Journal of Hepatology 2024年第12期16卷 1505-1514页

作者： Hotaka Tamura Yoshinori Ozono Keisuke Uchida Naomi Uchiyama Hiroshi Hatada Souichiro Ogawa hisayoshi iwakiri Hiroshi Kawakami Division of Gastroenterology and Hepatology Department of Internal MedicineFaculty of MedicineUniversity of MiyazakiMiyazaki 889-1692Japan

BACKGROUND The purpose of this case report is to describe a case of multiple intrahepatic artery aneurysms during treatment for IgG4-related sclerosing cholangitis(IgG4-SC)and to provide information for daily *** SUMMARY A 64-year-old Japanese woman was diagnosed with IgG4-SC five years prior and was receiving maintenance treatment with prednisolone 7.5-10 mg/*** developed abdominal pain and a sudden onset of black stool and was admitted to our *** contrast-enhanced computed tomography(CT)and ultra-sonography(US)revealed multiple intrahepatic artery aneurysms that developed during the treatment for *** transarterial embolization for mu-ltiple hepatic artery aneurysms was *** artery aneurysms disappeared on contrast-enhanced CT and US,the progression of anemia ceased,and the melena ***,hemostasis was *** Hepatic artery aneurysms should be considered poor prognostic complications of IgG4-SC.

关键词： Hepatic artery aneurysm Pseudoaneurysm IgG4-related sclerosing cholangitis Embolization Melena Atherosclerosis Case report

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Monocyte-derived fibrocytes elimination had little contribution on liver fibrosis

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 348-353页

作者： Yoshinori Ozono Kotaro Shide Fumiyo Toyoshima Yuuka Takaishi Mai Tsuchimochi Ayako Kamiunten Takuro Kameda Kenichi Nakamura Tadashi Miike Kazunori Kusumotoa hisayoshi iwakiri Satoru Hasuikea Kenji Nagata Akira Sawaguchi Kazuya Shimoda Department of Gastroenterology and Hematology Faculty of MedicineUniversity of Miyazaki5200 KiharaKiyotakeMiyazaki 889-1601Japan Department of Anatomy Ultrastructural Cell BiologyFaculty of MedicineUniversity of Miyazaki5200 KiharaKiyotakeMiyazaki 889-1601Japan Department of Liver disease University of Miyazaki HospitalMiyazakiJapan

Background:Monocyte-derived fibrocytes play an important role in the progression of fibrosis in the skin,lungs,heart and ***,the contribution of fibrocytes to liver fibrosis is *** aim of this study was to investigate whether fibrocytes contributed to fibrosis progression in the livers of carbon tetrachloride(CCl 4)-treated ***:C57BL/6J mice were divided into 4 groups:normal control group,CCl 4-treated group,CCl 4+control liposome-treated group,and CCl 4+clodronate liposome-treated *** the elimination of systemic monocyte and monocyte-derived fibrocyte,one group was treated with clodronate liposome,and another group with control liposome as a *** 4 weeks of treatment,hepatic mononuclear cells were subjected to immunofluorescent(IF)staining and fluorescence-activated cell sorter(FACS)analysis to detect *** of collagen-positive Sirius red stained area and collagen-I mRNA expression in the liver were performed to evaluate the degree of liver fibrosis ***:In the liver of the CCl 4-treated and CCl 4+control liposome-treated groups,the number of fibrocytes,the area positive for Sirius red staining and collagen-I mRNA expression significantly increased compared with those in the normal control *** the liver of the CCl 4+clodronate liposome-treated group,few fibrocytes was observed as in the normal control group,but Sirius red staining positive area and collagen-I mRNA expression were increased and equivalent to the CCl 4-treated and CCl 4+control liposome-treated ***:Monocyte-derived fibrocytes play a minimal role in CCl 4-induced liver *** other than fibrocytes such as hepatic stellate cells play a central role in liver fibrosis.

关键词： Fibrocytes Liver fibrosis Carbon tetrachloride Clodronate Collagen-I

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Efficacy and safety of sofosbuvir and ledipasvir in Japanese patients aged 75 years or over with hepatitis C genotype 1

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World Journal of Hepatology 2017年第36期9卷 1340-1345页

作者： Yoshinori Ozono Kenji Nagata Satoru Hasuike hisayoshi iwakiri Kenichi Nakamura Mai Tsuchimochi Yuri Yamada Yuka Takaishi Mitsue Sueta Tadashi Miike Yoshihiro Tahara Shojiro Yamamoto Kotaro Shide Tomonori Hidaka Yoko Kubuki Kazunori Kusumoto Toshimasa Ochiai Junya Kato Naoto Komada Shuichi Hirono Kazuo Kuroki Masafumi Shigehira Kazuya Shimoda Department of Gastoroenterology and Hematology Faculty of Medicine University of Miyazaki Department of Liver Disease University of Miyazaki Hospital Department of Internal Medicine Koga General Hospital Department of Internal Medicine National Hospital Organization Miyakonojo Medical Center Department of Internal Medicine Hirono Naika Clinic Department of Internal Medicine Kushima Municipal Hospital Department of Internal Medicine Shigehira Clinic

AIM To evaluate the efficacy and safety of a regimen containing sofosbuvir(SOF) and ledipasvir(LDV) in Japanese patients aged ≥ 75 years with hepatitis C genotype *** This multicenter, retrospective study consisted of 246 Japanese patients with HCV genotype 1 at nine centers in Miyazaki prefecture in Japan. Demographic, clinical, virological, and adverse effects(AE)-related data obtained during and after SOF/LDV therapy were collected from medical records. These patients were divided into two groups, younger(aged < 75 years) and elderly(aged ≥ 75 years). Virological data and AEs were analyzed by age *** The sustained virological response(SVR) rates at 12 wk after treatment were 99.2%, 99.4%, and 98.7% in the overall population and in patients aged < 75 and ≥ 75 years, respectively. Common AEs during therapy were headache, pruritus, constipation, and insomnia. These occurred in fewer than 10% of patients, and their incidence was not significantly different between the younger and elderly groups. Two patients discontinued treatment, one due to a skin eruption and the other due to cerebral bleeding. CONCLUSION Compared with younger patients, elderly patients had a similar virological response and tolerance to SOF/LDV therapy.

关键词： Chronic hepatitis C Sofosbuvir Ledipasvir Sustained virological response Direct acting antivirals

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