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Expression of Osteopontin and caudal-related homeobox gene 2:indications of phenotypes and prognosis in advanced gastric cancer

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福州总医院学报 2010年第4期17卷 212-217页

作者： Xia Zhang Tetsuya Tsukamoto Tsutomu Mizoshita ban hisayo Toyoda Takeshi Masae Tatematsu Division of Oncological Pathology Aichi Cancer Center Research Institute 1 - 1Kanokoden Chikusa-ku Nagoya Aichi 464-8681 Japan. Oncology department of Nanjing Command Fuzhou general hospital xi＇ er huan - lu156 Fuzhou 86-350025 China

Objective:To investigate the expression of osteopontin(OPN)and caudal-related homeobox gene 2(CDX2)in advanced gastric cancer,and to correlate them with clinicopathological ***:One-hundred and nine patients suffered from gastric cancer *** of OPN and CDX2 and other molecular markers were determined using immunohistochemistry ***:Total positive rate of OPN expression was 46.79%,and related with depth of cancer invasion and different phenotype(P<0.001),no association with the patient's age,gender,tumor histological type and lymph node *** different phenotypes of gastric cancers,OPN frequently expressed in CDX2-negative-expressed G and N type(16/109 and 21/109,respectively),and in CDX2-positive-expressed GI and I types expression level were *** expression reversely correlated with cdx-2 expression(P<0.001).Patients with OPN positive expression had worse 5-year survival,and patients with OPN negative,5-year survival time better(P<0.001).Further analysis revealed patients with OPN-/CDX2+ had better 5-year survival than other three groups including OPN+/CDX2-,OPN-/CDX2-and OPN+/CDX2+.With multivariate analysis for 5-year survival,it suggested that OPN was the most significant predictor of poor prognosis in gastric cancer(P =0.0043),with lymph node metastasis and tumor depth of invasion were also independent indicators(P =0.0359 and P =0.0315,respectively).Conclusion:Osteopontin is a useful prognostic marker in gastric cancer,and combined with CDX2,it may be much more useful for predicting the survival time in advanced gastric cancer *** it also gave us a clue that in gastric cancer,CDX2 may be a transcription factor modulating the expression of osteopontin.

关键词：胃癌肿瘤症状临床分析

Measurements and estimation of flow velocity in mobile bed rills

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International Journal of Sediment Research 2023年第1期38卷 97-104页

作者： Yunyun ban China Agricultural University Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences

Rills are primary sediment sources and hillslope water/sediment runoff transport channels. Water flow velocities in rills are easily affected by bed condition over eroding and non-eroding slopes, which is an important hydrodynamic process in soil erosion research. This research is done to demonstrate the poorly understood “feedback mechanism” related to slope independence of flow velocity to slope gradient. A series of experiments were done on silt loam soil slopes to measure water flow velocity in rills under nine unit width flow rates(q)(0.17 × 10-3, 0.33 × 10-3, 0.67 × 10-3, 1.33 × 10-3, 2.67 × 10-3,5.33 × 10-3, 10.67 × 10-3, 21.33 × 10-3, and 42.67 × 10-3m3/(s·m)) combined with four slope gradients(8.7%, 17.6%, 26.8%, and 36.4%), in which mobile bed rills were monitored. For unit flow velocity under q ≤ 1.33 × 10-3m2/s, independence of flow velocity to slope was obtained. However, the results indicated that slope gradient combined with a higher unit flow rate contributed to better velocity prediction and fitted with a segmented equation well(R2= 0.95). A feedback mechanism was able to verify that the increase in roughness directly dissipated flow energy to reduce flow velocity, but cannot completely counterbalances steep slope effect. The experimental results showed that erosion-caused morphological changes on soil slopes reduce flow velocity by half due to an increase in bed roughness. Therefore, the current experimental measurements considering a wide range of flow rate and slope gradient conditions is useful to reveal the steep slope effect in mobile bed rills. The analysis showed that, for the investigated conditions, the flow velocity is a slope gradient-and flow ratedependent parameter.

关键词： Flow velocity Flow rate Slope gradient Model fitting Slope morphology

THE BOUNDARY INTEGRO-DIFFERENTIAL EQUATIONS OF A BIHARMONIC BOUNDARY VALUE PROBLEM

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Journal of Computational Mathematics 1999年第1期17卷 59-72页

作者： ban, HD Tang, WJ Inst Appl Phys & Computat Math Lab Computat Phys Beijing 100088 Peoples R China Tsing Hua Univ Dept Appl Math Beijing 100084 Peoples R China

In this paper, a new method of boundary reduction is proposed, which reduces the biharmonic boundary value problem to a system of integro-differential equations on the boundary and preserves the self-adjointness of the original problem. Moreover, a boundary finite element method based on this integro-differential equations is presented and the error estimates of the numerical approximations are given. The numerical examples show that this new method is effective.

关键词： boundary integro-differential equations biharmonic boundary value problem

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Connected Vehicle-Based Traffic Signal Coordination

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Engineering 2020年第12期6卷 1463-1472页

作者： Wan Li Xuegang ban Oak Ridge National Laboratory KnoxvilleTN 37932USA University of Washington SeattleWA 98195USA

This study presents a connected vehicles(CVs)-based traffic signal optimization framework for a coordinated arterial *** signal optimization and coordination problem are first formulated in a centralized scheme as a mixed-integer nonlinear program(MINLP).The optimal phase durations and offsets are solved together by minimizing fuel consumption and travel time considering an individual vehicle’s *** to the complexity of the model,we decompose the problem into two levels:an intersection level to optimize phase durations using dynamic programming(DP),and a corridor level to optimize the offsets of all *** order to solve the two-level model,a prediction-based solution technique is *** proposed models are tested using traffic simulation under various *** with the traditional actuated signal timing and coordination plan,the signal timing plans generated by solving the MINLP and the two-level model can reasonably improve the signal control *** considering varies vehicle types under high demand levels,the proposed two-level model reduced the total system cost by 3.8%comparing to baseline actuated *** reduced the system cost by 5.9%.It also suggested that coordination scheme was beneficial to corridors with relatively high demand *** intersections with major and minor street,coordination conducted for major street had little impacts on the vehicles at the minor street.

关键词： Connected vehicles Traffic signal coordination Dynamic programming Two-level optimization Mixed-integer nonlinear program

Joint Optimal Scheduling for Electric Vehicle Battery Swapping-charging Systems Based on Wind Farms

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CSEE Journal of Power and Energy Systems 2021年第3期7卷 555-566页

作者： Mingfei ban Jilai Yu Yiyun Yao College of Mechanical and Elec-trical Engineering Northeast Forestry UniversityHarbin 150040China Department of Electrical Engineering Harbin Institute of TechnologyHarbin 150001China National Renewable Energy Laboratory Golden 80401USA

Insufficiencies in charging facilities limit the broad application of electric vehicles(EVs).In addition,EV can hardly represent a green option if its electricity primarily depends on fossil *** these two problems,this paper studies a battery swapping-charging system based on wind farms(hereinafter referred to as W-BSCS).In a W-BSCS,the wind farms not only supply electricity to the power grid but also cooperate with a centralized charge station(CCS),which can centrally charge EV batteries and then distribute them to multiple battery swapping stations(BSSs).The operational framework of the W-BSCS is analyzed,and some preprocessing technologies are developed to reduce complexity in ***,a joint optimal scheduling model involving a wind power generation plan,battery swapping demand,battery charging and discharging,and a vehicle routing problem(VRP)is *** a heuristic method based on the exhaustive search and the Genetic Algorithm is employed to solve the formulated NP-hard *** results verify the effectiveness of the joint optimal scheduling model,and they also show that the W-BSCS has great potential to promote EVs and wind power.

关键词： Battery swapping station electric vehicle vehicle routing problem wind power

A Composite Adaptive Fault-Tolerant Attitude Control for a Quadrotor UAV with Multiple Uncertainties

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Journal of Systems Science & Complexity 2022年第1期35卷 81-104页

作者： WANG ban ZHANG Youmin ZHANG Wei School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China Department of Mechanical Industrial and Aerospace EngineeringConcordia UniversityMontreal H3G 1M8QCCanada

In this paper,a composite adaptive fault-tolerant control strategy is proposed for a quadrotor unmanned aerial vehicle(UAV)to simultaneously compensate actuator faults,model uncertainties and external *** assuming knowledge of the bounds on external disturbances,a baseline sliding mode control is first designed to achieve the desired system tracking performance and retain insensitive to ***,regarding actuator faults and model uncertainties of the quadrotor UAV,neural adaptive control schemes are constructed and incorporated into the baseline sliding mode control to deal with ***,in terms of unknown external disturbances,a disturbance observer is designed and synthesized with the control law to further improve the robustness of the proposed control ***,a series of comparative simulation tests are conducted to validate the effectiveness of the proposed control strategy where a quadrotor UAV is subject to inertial moment variations and different level of actuator *** capabilities and advantages of the proposed control strategy are confirmed and verified by simulation results.

关键词： Actuator fault composite adaptive fault-tolerant control external disturbance model uncertainty quadrotor UAV

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Metal-organic framework-based CO2 capture: from precise material design to high-efficiency membranes

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Frontiers of Chemical Science and Engineering 2020年第2期14卷 188-215,F0004页

作者： Yujie ban Meng Zhao Weishen Yang State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China

A low-carbon economy calls for CO capture *** separations represent an energy-efficient and environment-friendly process compared with distillations and solvent ***-organic frameworks(MOFs),as a novel type of porous materials,are being generated at a rapid and growing pace,which provide more opportunities for high-efficiency CO *** this review,we illustrate a conceptional framework from material design and membrane separation application for CO capture,and emphasize two importance themes,namely(i)design and modification of CO-philic MOF materials that targets secondary building units,pore structure,topology and hybridization and(ii)construction of crack-free membranes through chemical epitaxy growth of active building blocks,interfacial assembly,ultrathin two-dimensional nanosheet assembly and mixed-matrix integration strategies,which would give rise to the most promising membrane performances for CO capture,and be expected to overcome the bottleneck of permeability-selectivity limitations.

关键词： CO2 capture CO2-philic MOFs crack-free membranes

Procedural simulation method for aggregating charging load model of private electric vehicle cluster

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Journal of Modern Power Systems and Clean Energy 2015年第2期3卷 170-179页

作者： Mingfei ban Jilai YU Harbin Institute of Technology Harbin 150001HLJChina

The usage of each private electric vehicle(PrEV)is a repeating behavior process composed by driving,parking,discharging and charging,in which PrEV shows obvious procedural *** analyze the procedural characteristics,this paper proposes a procedural simulation *** method aggregates the behavior process regularity of the PrEV cluster to model the cluster’s charging ***,the basic behavior process of each PrEV is constructed by referring the statistical datasets of the traditional private non-electric ***,all the basic processes are set as a simulation starting point,and they are dynamically reconstructed by several *** simulation continues until the steady state of charge(SOC)distribution and behavior regularity of the PrEV cluster are ***,based on the obtained SOC and behavior regularity information,the PrEV cluster’s behavior processes are simulated again to make the aggregating charging load model *** for several scenarios show that the proposed method can improve the reliability of modeling by grasping the PrEV cluster’s procedural characteristics.

关键词： Electric vehicle(EV) Private electric vehicle(PrEV) Charging load model State of charge(SOC) Procedural simulation Cluster

Toward multicomponent mesoporous single-crystalline metal oxides

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National Science Review 2024年第5期11卷 92-93页

作者： Minkyeong ban Jinwoo Lee Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology (KAIST)

Mesoporous metal oxide materials have attracted significant interest due to their porous frameworks and large surface areas, finding applications in sensors, catalysis and energy storage [1]. The performance of these ... 详细信息

关键词： single metal crystalline mesoporous multicomponent oxides toward