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Protective effect of Irsogladine on monochloramineinduced gastric mucosallesions in rats:a comparative study with rebamipide

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World Journal of Gastroenterology 1999年第6期5卷 477-482页

作者： H yamamoto, M Umeda, H Mizoguchi, S Kato and K Takeuchi Kyoto Phamaceutical University 日本

AIM To examine the effect of irsogladine, a novel antiulcer drug, on the mucosal ulcerogenic response to monochloramine (NH 2Cl) in rat stomach, in comparison with rebamipide, another antiulcer drug with cytoprotective activity. METHODS AND RESULTS Oral administration of NH 2Cl (120*!mM) produced severe hemorrhagic lesions in unanesthetized rat stomachs. Both irsogladine ( 1*!mg/*!kg - 10*!mg/*!kg , po ) and rebamipide ( 30*!mg/*!kg - 100*!mg/*!kg , po ) dose dependently prevented the development of these lesions in response to NH 2Cl, the effect of irsogladine was significant at 3*!mg/*!kg or greater, and that of rebamipide only at 100*!mg/*!kg . The protective effect of irsogladine on NH 2Cl induced gastric lesions was significantly reduced by N G nitro L arginine methyl ester (L NAME) but not by indomethacin, while that of rebamipide was significantly mitigated by indomethacin but not by L NAME. Topical application of NH 2Cl (20*!mM) caused a marked reduction of potential difference (PD) in ex vivo stomachs. This PD reduction was not affected by mucosal application of irsogladine, but significantly prevented by rebamipide. The mucosal exposure to NH 4OH (120*!mM) also caused a marked PD reduction in the ischemic stomach (bleeding from the carotid artery), resulting in gastric lesions. These ulcerogenic and PD responses caused by NH 4OH plus ischemia were also significantly mitigated by rebamipide, in an indomethacin sensitive manner, while irsogladine potently prevented such lesions without affecting the PD response, in a L NAME sensitive manner. CONCLUSION These results suggest that ① NH 2Cl generated either exogenously or endogenously damages the gastric mucosa, ② both irsogladine and rebamipide protect the stomach against injury caused by NH 2Cl, and ③ the mechanism underlying the protective action of irsogladine is partly mediated by endogenous nitric oxide, while that of rebamipide is in part mediated by endogenous prostaglandins.

关键词： irsogladine rebamipide monochloramine gastric mucosal lesions rats comparative study

Validity of a Making Method for a Homogeneous Specimen Using Micro-wave

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Journal of Environmental Science and Engineering(A) 2014年第5期3卷 274-281页

作者： hisashi Suzuki Department of Civil and Environment Engineering Tokushima University Tokushima 770-8506 Japan

It is too difficult for a compacted specimen of unsaturated clay prepared and used in a laboratory test to have homogeneous water content and porosity. Although there have been many hydraulic and mechanical studies, there are few papers related to homogeneity of specimen. However, it is clear that homogeneity of specimen influences mechanical properties. In this paper, the use of micro-waves is proposed as method for making homogeneous specimens. The study results indicate that specimens made by micro-waves are more homogeneous than compacted specimens.

关键词： Micro-wave homogeneous specimen water content dry density.

Esophageal carcinoma originating in the surface epithelium with immunohistochemically proven esophageal gland duct differentiation: A case report

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World Journal of Gastroenterology 2017年第21期23卷 3928-3933页

作者： Hiromi Tamura Hirotsugu Saiki Takahiro Amano Masashi yamamoto Shiro Hayashi Hiroka Ando Reiko Doi Tsutomu Nishida Katsumi yamamoto Shiro Adachi Department of Pathology City Hospital of Toyonaka Department of Gastroenterology JCHO Osaka Hospital Department of Gastroenterology City Hospital of Toyonaka

A case of esophageal carcinoma exclusively composed of adenocarcinoma simulating an esophageal gland duct in a 61-year-old man is presented. The tumor arose as a slightly elevated lesion in the middle intrathoracic esophagus. It was almost completely overlaid with nonneoplastic stratified squamous epithelial cells. Beneath the overlying surface epithelium, an adenocarcinoma that was bilayered in structure diffusely invaded both the mucosal and submucosal layers. Although the tumor consisted exclusively of adenocarcinomatous cells, a keratinizing squamous cell carcinoma component was focally observed. The invasive carcinoma was focally continuous with the small area of the surface squamous epithelial layer, which was confirmed to be neoplastic by immunohistochemistry. Morphological and immunohistochemical examinations suggested that the adenocarcinomatous component arose from the esophageal surface epithelium and clearly differentiated into an esophageal gland duct. It is important to consider the possibility of this type of adenocarcinoma when diagnosing a ductal or glandular lesion of the esophagus in small biopsy specimens.

关键词： Esophageal adenocarcinoma Bilayered structure Esophageal gland duct

Emerging therapeutic options in inflammatory bowel disease

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World Journal of Gastroenterology 2021年第48期27卷 8242-8261页

作者： Jesus K yamamoto-Furusho Norma N Parra-Holguín Gastroenterology Unit Inflammatory Bowel Disease ClinicInstituto Nacional de Ciencias Medicas y NutricionMexico City 14080Mexico

Inflammatory bowel disease(IBD)is a chronic disease that requires chronic treatment throughout the evolution of the disease,with a complex physiopathology that entails great challenges for the development of new and specific treatments for ulcerative colitis and Crohn's *** anti-tumor necrosis factor alpha therapy has impacted the clinical course of IBD in those patients who do not respond to conventional treatment,so there is a need to develop new therapies and markers of treatment *** pathways involved in the development of the disease are known and the new therapies have focused on blocking the inflammatory process at the gastrointestinal level by oral,intravenous,subcutaneous,and topical *** these new therapies can lead to more personalized treatments with higher success rates and fewer *** treatments have not only focused on clinical remission,but also on achieving macroscopic changes at the endoscopic level and microscopic changes by achieving mucosal *** treatments are mainly based on modifying signaling pathways,by blocking receptors or ligands,reducing cell migration and maintaining the integrity of the epithelial ***,this review presents the efficacy and safety of the new treatments that are currently under study and the advances that have been made in this area in recent years.

关键词： Inflammatory bowel disease Review Emerging Treatment Ulcerative colitis Crohn's disease

A sustainable way of agricultural livelihood:edible bird’s nests in Indonesia

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Ecosystem Health and Sustainability 2021年第1期7卷 332-341页

作者： Yutaka Ito Ken’ichi Matsumoto Aswin Usup Yuki yamamoto Faculty of Regional Policy The University of ShimaneMatsueJapan Faculty of Economics Toyo UniversityTokyoJapan Faculty of Agriculture University of Palangka RayaPalangkarayaIndonesia Graduate School of Fisheries and Environmental Sciences Nagasaki UniversityNagasakiJapan

Edible birds’nests(EBNs)have traditionally been produced in Southeast *** farmers construct buildings for swiftlets and harvest their *** farming does not directly degrade forest resources and is therefore considered a sustainable means of production,whereas the expansion of other agricultural activities often relies on the degradation of natural *** study examines the relationship between natural resources and agricultural livelihoods,focusing on Indonesian EBN *** survey data that we collected in 2017,combined with satellite information on the extent of the forest in Central Kalimantan,Indonesia,we measured production efficiency and identified the natural and social factors that enhance production *** results show that a forest extent ranging between 2,000 and 6,000 meters from nesting building is positively associated with the production efficiency of EBN farming,perhaps because extensive forest could help swiftlets to collect food and build ***,while EBN farming is a sustainable and profitable option,the initial costs of constructing buildings to house swiftlets may deter farmers from participating in the process.

关键词： Edible bird’s nest swiftlet Indonesia forest natural habitat ecosystem services satellite data

Establishment of a surveillance program for anal cancer in Crohn's disease

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World Journal of Gastroenterology 2024年第45期30卷 4844-4849页

作者： Hajime Kayano Ken-Ichi Okada Seiichiro yamamoto Kazuo Koyanagi Department of Gastroenterological Surgery Tokai University School of MedicineIsehara 259-1193KanagawaJapan

This letter discusses the incidence of anal cancer among Crohn's disease(CD)-related *** with CD have been demonstrated to be at a higher risk of developing small bowel and colorectal cancers than healthy *** CD-associated anal cancer is relatively rare,patients with CD accom-panied by anal or perianal lesions are at increased risk of anal ***-tionally,compared to ulcerative colitis,which is also an inflammatory disease,CD-related anal cancer is often detected at an advanced stage owing to the complexity of CD and is associated with a poor prognosis with frequent local ***,the detection of early-stage cancer is crucial for improving the ***,the surveillance methods recommended for CD-related malignancies in the United States and Europe are similar to those for ulcerative *** are not appropriate for detecting CD-related malignancies in the recto-anal ***,there is an urgent need for surveillance programs aimed at the early detection of malignant anorectal lesions in patients with CD.

关键词： Inflammatory bowel disease Crohn's disease Colorectal cancer Perianal disease Anal cancer surveillance

Numerical Simulation of Ice Accretion Phenomena on Rotor Blade of Axial Blower

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Journal of Thermal Science 2012年第4期21卷 322-326页

作者： Taiki Matsuura Masaya Suzuki Makoto yamamoto Shinichiro Shishido Takeshi Murooka Hiroshi Miyagawa Graduate School of Mechanical Engineering Tokyo University of Science 1-14-6 Kudankita Chiyoda-ku Department of Mechanical Engineering Tokyo University of Science 1-14-6 Kudankita Chiyoda-ku Research and Engineering Division IHI Corporation 229 Tonogaya Mizuho-cho Nishitama-gun

Ice accretion is the phenomenon that super-cooled water droplets impinge and accrete on a body. It is well known that ice accretion on blades and airfoils leads to performance degradation and severe accidents. For this reason, experimental investigations have been carried out using flight tests or icing tunnels. However, it is too expensive, dangerous, and difficult to set actual icing conditions. Hence, computational fluid dynamics is useful to predict ice accretion. A rotor blade is one of jet engine components where ice accretes. Therefore, the authors focus on the ice accretion on a rotor blade in this study. Three-dimensional icing phenomena on the rotor blade of a commercial axial blower are computed here, and ice accretion on the rotor blade is numerically investigated.

关键词： Icing Computational Fluid Dynamics Euler-Lagrangian Coupling Rotor Blade Axial Blower

An anomaly in persistent right umbilical vein of portal vein diagnosed by ultrasonography

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World Journal of Gastroenterology 2005年第8期11卷 1179-1181页

作者： Shigeo Nakanishi Katsuya Shiraki Kouji yamamoto Mutsumi Koyama Takeshi Nakano First Department of Internal Medicine Matsusaka Central General Hospital of Medicine

AIM: To detect the anomaly in the persistent right umbilical vein (PRUV) of portal vein (PV) with deviation of the ligamentum tere and left-sided gallbladder. METHODS: A total of 5783 candidates for routine analysis were evaluated for hepatic vascular abnormalities by ultrasonography. RESULTS: Ten candidates (0.17%) had a portal vein anomaly with a rightward-deviated ligamentum tere. The blood-flow velocity in the PRUV of the portal vein (17.7±3.0 cm/s) of the 10 cases was similar to that of the right anterior portal trunk (17.6±4.1 cm/s). However, the vessel diameter of the PRUV (φ12.4±4.4 mm) was larger than the right anterior portal trunk (φ6.1?.9 mm). Therefore, flow volume in the anomalous portion (0.97±0.30 L/min) was more than that in the right anterior portal trunk (0.18±0.05 L/min). CONCLUSION: The anomaly plays an important role in intra-hepatic PV flow.

关键词： PV anomaly Persistent right umbilical vein Ultrasonography

CONCURRENT PRODUCTION ENGINEERING SYSTEM FOR BUFFER SIZE AND FLEXIBLE TRANSFER LINE LAYOUT DESIGN

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Journal of Systems Science and Systems Engineering 2008年第2期17卷 187-203页

作者： Hidehiko yamamoto Jaber ABU QUDEIRI M.Anouar JAMALI Intelligent Manufacturing Systems Laboratory Gifu UniversityJapan Department of Industrial Engineering University of Quebec at Trois-Rivers(UQTR)Canada

In this paper we propose a COncurrent Production Engineering System （COPES） for the flexible transfer line （FTL） layout design in a restricted area. COPES first determines the buffer size in front of the bay of each machine tool in the FTL and then initializes a computer aided design （CAD） system to draw the FTL in a restricted area. We develop a set of modules systems which have been integrated into a single framework, in accordance with the practice of concurrent engineering. Concurrent engineering involves the cooperation of these activities. It＇s expected that the developed COPES can improve the cooperation between production engineers＇ and the plant designer. This can be done by enabling the production engineers＇ to make better decision regarding FTL buffer size.

关键词： Concurrent engineering flexible transfer line layout design production simulator buffer size CAD