检索结果-南通市图书馆

Rikkunshi-to Partially Reverses Cancer Chemotherapy-Induced Decrease in Plasma Valproic Acid Concentration in a Patient with Malignant Lymphoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medicine 2011年第2期2卷 58-61页

作者： Masashi Ishihara Kiyoyuki Kitaichi Katsuhiko Matsuura Hiroshi Nakamura hisashi tsurumi Hisataka Moriwaki Yoshinori Itoh Department of Pharmacy Gifu University Hospital

A fifty-five-year-old male patient with malignant lymphoma who took oral valproic acid (VPA) tablets and itraconazole (ITZ) capsles received 3 courses of cancer chemotherapy, including 2 courses of a combination of rituximab/methotrexate/ifosphamide/etoposide/ carboplatin/ methylpredonisolon (R-IMVP16/CBDCA regimen) and subsequent one course of a combination of rituximab/ranimustine/citara bine/etoposide/merphalan (R-MEAM regimen). Plasma concentration of VPA dramatically decreased below the therapeutic concentration after the first and second chemotherapy and seizures appeared in both cases. Plasma concentration of ITZ was also lowered after the second chemotherapy course. At the third chemotherapy, Rikkunshi-to, a Japanese herbal medicine, was prescribed for 14 days. Plasma VPA concentration decreased, though to a lesser extent, after chemotherapy, in which the level was near the border of therapeutic concentration. No convulsion was observed. Therefore, care should be taken to monitor plasma drug concentration during cancer chemotherapy. Rikkunshi-to may be useful to alleviate the chemotherapy-induced decrease in plasma concentrations of orally administered drugs.

关键词： Cancer Chemotherapy Malignant Lymphoma Valproic Acid Therapeutic Drug Monitoring Convulsion Rikkunshi-to

Diagnosis of the jejunoileal lymphoma by double-balloon endoscopy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Endoscopy 2013年第3期5卷 111-116页

作者： Takashi Ibuka Hiroshi Araki Tomohiko Sugiyama Takayuki Nakanishi Fumito Onogi Masahito Shimizu Takeshi Hara Tsuyoshi Takami hisashi tsurumi Hisataka Moriwaki First Department of Internal Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Gastroenterology Gifu University School of MedicineGifu 501-1194Japan Department of Immunopathology Gifu University Graduate School of MedicineGifu 501-1194Japan

AIM:To investigate the feasibility of double-balloon endoscopy(DBE) to detect jejunoileal lymphoma,compared with fluorodeoxyglucose positron emission tomography(FDG-PET).METHODS:Between March 2004 and January 2011,we histologically confirmed involvement of malignant lymphoma of the jejunoileum in 31 patients by DBE and *** 20 patients of them,we performed with *** retrospectively reviewed the records of these 20 *** median age was 64 years(range 50-81).In the 20 patients,the pathological diagnosis of underlying non-Hodgkin's lymphoma(NHL) comprised follicular lymphoma(FL,n = 12),diffuse large B cell lymphoma(DLBCL,n = 4),mantle cell lymphoma(MCL,n = 2),enteropathy associated T cell lymphoma(ETL,n = 1) and anaplastic large cell lymphoma(ALCL,n = 1).RESULTS:Ten cases showed accumulation by FDGPET(50%).FDG-PET was positive in 3 of 12 FL cases(25%) while in 7 of 8 non-FL cases(88%,P < 0.05).Intestinal FL showed a significantly lower rate of positive FDG-PET,in comparison with other types of *** with endoscopically elevated lesions(n = 10) showed positive FDG-PET in 2(20%),but those with other type NHL did in 8 of 10(80%,P < 0.05).When the cases having elevated type was compared with those not having elevated type lesion,the number of cases that showed accumulation of FDG was significantly smaller in the former than in the ***:In a significant proportion,small intestinal involvement cannot be pointed out by ***,FL is difficult to evaluate by FDG-PET but essentially requires DBE.

关键词： Double-balloon endoscopy Non-Hodgkin’s lymphoma Jejunoileum Fluorodeoxyglucose positron emission tomography Follicular lymphoma

Garenoxacin Prophylaxis for Febrile Neutropenia after Chemotherapy in Hematological Malignancies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Internal Medicine 2016年第4期6卷 128-138页

作者： Nobuhiko Nakamura Takeshi Hara Soranobu Ninomiya Yuhei Shibata Takuro Matsumoto Hiroshi Nakamura Junichi Kitagawa Yasuhito Nannya Masahito Shimizu Nobuo Murakami hisashi tsurumi Department of Hematology Gifu University Graduate School of Medicine Gifu Japan

Background: Febrile neutropenia is one of the most serious adverse events in patients with hematological malignancies and chemotherapy. The routine use of fluoroquinolone prophylaxis in patients with hematological malignancies is controversial. Therefore, we prospectively evaluated the efficacy and safety of prophylactic use of garenoxacin for febrile neutropenia. Patients and Methods: Consecutive adult patients with hematological malignancies who were at risk for chemotherapy-induced neutropenia lasting more than seven days were eligible for present study. They received oral garenoxacin (400 mg daily) from the neutrophil count decreased to less than 1000/μl and continued until the neutropenia had resolved. The primary endpoint was incidence of febrile neutropenia, and the secondary endpoints were the type and incidence of adverse events. Results: We enrolled 46 consecutive patients (median age, 59 years). The underlying diseases comprised acute myeloid leukemia (n = 17), acute lymphoblastic leukemia (n = 3), malignant lymphoma (n = 23), and multiple myeloma (n = 3). There were 23 febrile neutropenia episodes and 2 episodes of bacteremia. There were no grade 3 or 4 adverse events;however serum creatinine levels were significantly elevated after garenoxacin administration. The overall prophylactic efficacy of garenoxacin was 50%, and there were no infection-related deaths. Conclusions: Prophylactic use of garenoxacin is effective and safe in patients with hematological malignancies. (Clinical trial registration number: UMIN000004979).

关键词： Febrile Neutropenia Prophylaxis Garenoxacin Hematological Malignancies

Endoscopic Examination for Patients with Diarrhea after Allogeneic Stem Cell Transplantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Internal Medicine 2017年第4期7卷 105-114页

作者： Junichi Kitagawa Takuro Matsumoto Yuhei Shibata Nobuhiko Nakamura Hiroshi Nakamura Soranobu Ninomiya Yasuhito Nannya Masahito Shimizu Takeshi Hara Hiroshi Araki hisashi tsurumi Department of Hematology Graduate School of Medicine Gifu University Gifu Japan Department of Gastroenterology Graduate School of Medicine Gifu University Gifu Japan

Objective: Intestinal graft-versus-host disease (GVHD) represents one of the most serious complications of allogeneic stem cell transplantation (allo-SCT). Endoscopic and histological proof is required due to the number of differential diagnoses manifesting as diarrhea. We investigated the safety of endoscopic biopsies, and the role of conducting biopsies and inspections of the terminalileum. Patients: Thirty two colonoscopic examinations and 29 biopsies were performed for 19 patients after allo-SCT in our institute between October 2011 and May 2015. Results: Endoscopic examinations and biopsies were performed safely under the policy of transfusing platelets for thrombocytopenia (3/μL). For biopsied cases, the diagnostic consistency rate with endoscopic findings was 60%, with a tendency toward negative correlations with early examinations after diarrhea onset (25% for 0 - 1 days;62.5% for later) or low-grade GVHD according to Freiburg criteria (41.2% for grade 1, 66.7% for grade 2, 100% for higher). The terminal ileum was inspected with colonoscopy in 13 cases. Endoscopic diagnoses of the ileum were provided in 11 cases and histological diagnoses in 9 cases. Diagnostic consistency for diagnosis of the terminal ileum between endoscopy and histology was 77.8%. Conclusion: Because endoscopic and histopathological findings do not always match, caution is required when focusing on endoscopic findings alone, as there is a risk of misdiagnosis. Extensive inspection of the terminal ileum with biopsy appears useful to identify otherwise undetected lesions. Our data thus support invasive endoscopic examinations for gastrointestinal complications, including ileac inspection and biopsies under appropriate management.

关键词： Intestinal GVHD Endoscopic Evaluation Ileoscopy Colonoscopy

Development of High Strength Steel Designed for Carbonitriding with High Nitrogen Content to Be Used for Automatic Transmission Gears

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

材料热处理学报 2004年第5期25卷 382-385页

作者： Youichi Watanabe Nissan Motor Co. Ltd. 6-1 Dalkoku-cho Tsurumi-ku Yokohama Japan

To downsize and lighten automatic transmission components, the gears installed must be strengthened in terms of pitting endurance and/or wear resistance. The most important metallurgical factor affecting fractures is well known to be resistance to softening when steel is tempered at approximately 573 K. Carbonitriding with a high amount of nitrogen is a very effective production technique because nitrogen increases the resistance during tempering. However, structural anomalies begin to appear in the surface layer when the nitrogen content exceeds 0.6 mass% in the chromium steel generally used. To address this, we have developed new high-strength chromium steel with an optimized chemical composition that effectively inhibits anomalies even when Carbonitriding with a nitrogen content of more than 0.6 mass%. We performed a drivetrain durability test on an automatic transmission component designed to have excellent contact fatigue strength and a tooth root bending impact and fatigue strength. We found that the developed steel that was carbonitrided with a content of about 0.9 mass%, and then shot peened hard, has a pitting life of roughly 4.5 times that of conventionally manufactured steel.

关键词：碳氮共渗传动齿轮喷丸硬化接触疲劳高强度钢

维普期刊数据库

Three New Anamorph of <i>Ceramothyrium</i>from Fallen Leaves in Vietnam

在线全文

学校读者我要写书评

暂无评论

Advances in Microbiology 2018年第4期8卷 314-323页

作者： Le Thi Hoang Yen Yasuhisa tsurumi Duong Van Hop Katsuhiko Ando Institute of Microbiology and Biotechnology Vietnam National University Ha Noi Vietnam National Institute of Technology and Evaluation Kisarazu Japan

Three new anamorph of Ceramothyrium aquaticum sp. nov., Ceramothyrium exiguum sp. nov., and Ceramothyrium phuquocense sp. nov. are described and illustrated. These fungi were isolated from submerged decaying leaves collected from Phu Quoc National Park, Phu Quoc province, Viet Nam. The phylogeny based on ITS region and D1/D2 of the 28S rDNA gene showed that these fungi nested in the Ceramothyrium. Morphologically, C. aquaticum, C. phuquocense sp. nov. and C. exiguum sp. nov. are characterized;they were different from known anamorph species of Ceramothyrium by having one main axis and two lateral arms with 70 - 90, 33.5 - 72.5 and 70 - 130 μm long main axis, respectively. The table to compare Ceramothyrium anamorph is also given.

关键词： Aquatic Fungi Annamorph Telemorph Litter Fungi

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

燃料电池用质子电解质的研究进展

化工新型材料 2009年第3期37卷 34-36页

作者：李永生耿浩然 Kazunori tsurumi 张昭良王飞贾婧济南大学材料科学与工程学院济南250022 田中贵金属工业株式会社神奈川254-0076

目前,作为燃料电池的重要部件的质子电解质主要分为有机、有机-无机复合、无机三类。有机质子电解质接近商业化程度,但其价格昂贵,中温导电性差;复合质子电解质是以前者为基础掺杂增湿组分,使燃料电池性能有一定程度的增强;提高工作温... 详细信息

目前,作为燃料电池的重要部件的质子电解质主要分为有机、有机-无机复合、无机三类。有机质子电解质接近商业化程度,但其价格昂贵,中温导电性差;复合质子电解质是以前者为基础掺杂增湿组分,使燃料电池性能有一定程度的增强;提高工作温度是解决燃料电池中催化剂CO中毒和提高燃料转化效率的有效办法,因此能在中高温环境中工作的无机质子导电材料已成为研究热点之一。

关键词：燃料电池电解质焦磷酸锡

维普期刊数据库

阻塞性睡眠呼吸暂停对急性冠状动脉综合征患者经皮冠状动脉介入后的临床和血管造影结果的影响

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘(心脏病学分册) 2007年第6期 10-11页

作者： Yumino D tsurumi Y Takagi A 郭俊 Japan Dr. Tokyo Women’ s Medical University Department of Cardiology The Heart Institute of Japan

越来越多的证据表明阻塞性睡眠呼吸暂停(OSA)与心血管系统发病有关。作者推测,OSA可影响急性冠状动脉综合征(ACS)患者经皮冠状动脉介入(PCI)后的

关键词：阻塞性睡眠呼吸暂停 OSA 急性冠状动脉综合征经皮冠状动脉介入患者血管造影

MICROALGAE CULTIVATION IN A TUBULAR BIOREACTOR AND UTILIZATION OF THEIR CELLS

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Oceanology and Limnology 1998年第S1期16卷 75-83页

作者： Koyu Hon-nami Shunji Kunito(Energy and Environment R&D Center, Tokyo Electric Power Co. 4-1 Egasaki-cho, tsurumi - ku, Yokohama 230, Japan)(E - mail: T0707125 @ pmail. tepco. co.jp) 1. Energy and Environment R&D Center Tokyo Electric Power Co. 4-1 Egasaki-cho Tsurumi-ku 230 Yokohama Japan

In this study on the possiblities of microalgae technology as an option for CO2 mitiga-tion, many microalgae were isolated from seawater. Some species of the isolates, Chlamydomonas *** YA-SH-1, which accumulates starch in cells under light and ferment ethanol in dark and anaerobiccondition, was grown outdoors by using 50-L tubular bioreactors in batch cultivation and harvested. Usingthese cells, the performance of ethanol production was examined quantitatively in a 0.5-L scale fermen-tor. Another species, Tetraselmis sp. strain Tt-1, was cultivated in a semi-batch manner by a similar typeof tubular bioreactor indoors and examined for its utilization. Tests showed these cells could be used aspartial substitute for wood and kenaf pulp for processing into paper. With the idea of making microalgaeproduce cellulose by genetic engineering in their minds, the authors studied the structure of bacterial cel-lulose synthase genes and the low temperature-induced, reversible flocculation in a thermophilic bluegreen alga (Cyanobacterium), Synechocystis vulcanus in order to examine the feasibility of using thesegenes as gene source and the cynanobacterium as host.

关键词： microalgae tubular bioreactor Tetraselmis Chlamydomonas

维普期刊数据库