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The Interacting Generalized Ricci Dark Energy Model in Non-Flat Universe

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Journal of Modern Physics 2015年第3期6卷 327-334页

作者： Masashi Suwa Koji Kobayashi hisashi oshima School of Pharmacy Nihon University Chiba Japan

We extend our previous analysis and consider the interacting holographic Ricci dark energy (IRDE) model in non-flat universe. We study astrophysical constraints on this model using the recent observations including the type Ia supernovae (SNIa), the baryon acoustic oscillation (BAO), the cosmic microwave background (CMB) anisotropy, and the Hubble parameter. It is shown that the allowed parameter range for the fractional energy density of the curvature is ?in the presence of the interactions between dark energy and matter. Without the interaction, the flat universe is observationally disfavored in this model.

关键词： Dark Energy Ricci Non-Flat

利用探针跳跃式扫描离子电导显微镜技术揭示结直肠癌单细胞层面对H_(2)O_(2)良性应激的动态响应

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Science Bulletin 2024年第12期69卷 1909-1919页

作者：王东 Emily Woodcock 杨羲 Hiromi Nishikawa Elena V.Sviderskaya Masanobu oshima Christopher Edwards 张彦军 Yuri Korchev WPI Nano Life Science Institute(WPI-Nano LSI) Kanazawa UniversityKanazawa 920-1192Japan Department of Medicine Imperial College LondonLondon W120NNUnited Kingdom Cell Biology Research Centre Molecular and Clinical Sciences Research InstituteSt George’sUniversity of LondonLondon SW170REUnited Kingdom

Colorectal cancer(CRC),a widespread malignancy,is closely associated with tumor microenvironmental hydrogen peroxide(H_(2)O_(2))*** clinical trials targeting H_(2)O_(2)for cancer treatment have revealed its paradoxical role as a promoter of cancer *** the dynamics of cancer cell H_(2)O_(2)eustress at the single–cell level is *** this study,non–contact hopping probe mode scanning ion conductance microscopy(HPICM)with high-sensitive Pt–functionalized nanoelectrodes was employed to measure dynamic extracellular to intracellular H_(2)O_(2)gradients in individual colorectal cancer Caco–*** explored the relationship between cellular mechanical properties and H_(2)O_(2)*** to 0.1 or 1 mmol/L H_(2)O_(2)eustress increased the extracellular to intracellular H_(2)O_(2)gradient from 0.3 to 1.91 or 3.04,***,cellular F–actin–dependent stiffness increased at 0.1 mmol/L but decreased at 1 mmol/L H_(2)O_(2)*** H_(2)O_(2)–induced stiffness modulated AKT activation positively and glutathione peroxidase 2(GPX2)expression *** findings unveil the failure of some H_(2)O_(2)-targeted therapies due to their ineffectiveness in generating H_(2)O_(2),which instead acts eustress to promote cancer cell *** research also reveals the complex interplay between physical properties and biochemical signaling in cancer cells'antioxidant defense,illuminating the exploitation of H_(2)O_(2)eustress for survival at the single–cell *** GPX and/or catalase(CAT)enhances the cytotoxic activity of H_(2)O_(2)eustress against CRC cells,which holds significant promise for developing innovative therapies targeting cancer and other H_(2)O_(2)-related inflammatory diseases.

关键词： SPM Nanoprobe Nanobiology SECM ROS Stiffness

Emotion Measurement Using Biometric Signal

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Health 2024年第5期16卷 395-404页

作者： Yukina Miyagi Saori Gocho Yuka Miyachi Chika Nakayama Shoshiro Okada Kenta Maruyama Taeyuki oshima College of Pharmacy Kinjo Gakuin University Nagoya Japan Graduate School of Medicine Aichi Medical University Nagakute Japan Department of Pharmacy Nagoya Ekisaikai Hospital Nagoya Japan Department of Pharmacy Gifu University of Medical Science Kani Japan

In recent years, research on the estimation of human emotions has been active, and its application is expected in various fields. Biological reactions, such as electroencephalography (EEG) and root mean square successive difference (RMSSD), are indicators that are less influenced by individual arbitrariness. The present study used EEG and RMSSD signals to assess the emotions aroused by emotion-stimulating images in order to investigate whether various emotions are associated with characteristic biometric signal fluctuations. The participants underwent EEG and RMSSD while viewing emotionally stimulating images and answering the questionnaires. The emotions aroused by emotionally stimulating images were assessed by measuring the EEG signals and RMSSD values to determine whether different emotions are associated with characteristic biometric signal variations. Real-time emotion analysis software was used to identify the evoked emotions by describing them in the Circumplex Model of Affect based on the EEG signals and RMSSD values. Emotions other than happiness did not follow the Circumplex Model of Affect in this study. However, ventral attentional activity may have increased the RMSSD value for disgust as the β/θ value increased in right-sided brain waves. Therefore, the right-sided brain wave results are necessary when measuring disgust. Happiness can be assessed easily using the Circumplex Model of Affect for positive scene analysis. Improving the current analysis methods may facilitate the investigation of face-to-face communication in the future using biometric signals.

关键词： Biometric Signals Electroencephalogram Electrocardiogram Emotion Communication

SEPARATION OF METAL IONS AS CHELATES OF 1N2,7O3,6S IN THE PRESENCE OR ABSSENCE OF TBA^+ BY CAPILLARY ELECTROPHORESIS

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Journal of Wuhan University of Technology(Materials Science) 1999年第2期14卷 40-45页

作者： Mitsuko oshima Okayama University

Separation and determination of metal ions based on the formation of chelate anions with 1-Nitroso-2, 7-dihydrexynaphthalene-3, 6-disulfonic acid (1N2, 7O3, 6S) was studied by rising HPCE of the nine metal ions examined, the ions that can be detected sensitively with 1-Nitroso-2, 7-dihydrexynaphthalene-3, 6-disulfonic acid were Fe2+, Co2+, Cu2+, Ni2+, Zn2+ and Pd2+. The cobalt chelate could exist in two oxidation states of cobalt. When TBA(+) were added in electrophoretic solutions, the drastic changes in elertrophoretic mobilities of chelate were observed, which was due to the ion association between chelates anions and TBA(+). The ion association constants of chelate anions with TBA(+) were determined by using the change in electrophoretic mobilities of chelates, metal ions tested were separated within 10 min using 30cm silica capillary (50 m i. d).

关键词： high-performance capillary electrophoresis 1-Nitroso-2,7-dihydrozynaphthalene-3,6-disulfonic acid metal ions

Shedding new light on the dislocation-mediated plasticity in wurtzite ZnO single crystals by photoindentation

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Journal of Materials Science & Technology 2023年第25期156卷 206-216页

作者： Yan Li Xufei Fang Eita Tochigi Yu oshima Sena Hoshino Takazumi Tanaka Hiroto Oguri Shigenobu Ogata Yuichi Ikuhara Katsuyuki Matsunaga Atsutomo Nakamura Department of Mechanical Science and Bioengineering Osaka University1-3 Machikaneyama-choToyonaka 560-8531Japan Department of Materials and Earth Sciences Technical University of Darmstadt64287 DarmstadtGermany Institute of Industrial Science The University of Tokyo4-6-1 KomabaMeguro-kuTokyo 153-8505Japan PRESTO Japan Science and Technology Agency (JST)4-1-8HonchoKawaguchi-shiSaitama 332-0012Japan Department of Materials Physics Nagoya UniversityFuro-choChikusa-kuNagoya 464-8603Japan Institute of Engineering Innovation The University of Tokyo2-11-16 YayoiBunkyo-kuTokyo 113-8656Japan

Dislocation-mediated plasticity in inorganic semiconductors and oxides has attracted increasing research interest because of the promising mechanical and functional properties tuned by *** this study,we investigated the effects of light illumination on the dislocation-mediated plasticity in hexagonal wurtzite ZnO,a representative third-generation semiconductor material.A(0001)45o off sample was specially designed to preferentially activate the basal slip on(0001)*** types of nanoindentation tests were performed under four different light conditions(550 nm,334 nm,405 nm,and darkness),including low-load(60μN)pop-in tests,high-load(500μN)nanoindentation tests,and nanoindentation creep *** maximum shear stresses at pop-in were found to approximate the theoretical shear strength regardless of the light *** activation volume at pop-ins was calculated to be larger in light than in ***-sectional transmission electron microscope images taken from beneath the indentation imprints showed that all indentation-induced dislocations were located beneath the indentation imprint in a thin-plate shape along one basal slip *** indentation-induced dislocations could spread much deeper in darkness than in light,revealing the suppressive effect of light on dislocation *** analytical model was adopted to estimate the elastoplastic stress field beneath the *** was found that dislocation glide ceased at a higher stress level in light,indicating the increase in the Peierls barrier under light ***,nanoindentation creep tests showed the suppression of both indentation depth and creep rate by *** creep also yielded a larger activation volume in light than in darkness.

关键词： Photoindentation Compound semiconductors Oxides Crystal plasticity Dislocations

Mutant p53 in colon cancer

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Journal of Molecular Cell Biology 2019年第4期11卷 267-276页

作者： Mizuho Nakayama Masanobu oshima Division of Genetics Cancer Research Institute Kanazawa University Kanazawa 920-1192 Japan WPI-Nano Life Science Institute Kanazawa University Kanazawa 920-1192 Japan

The accumulation of genetic alterations in driver genes is responsible for the development and malignant progression of colorectal cancer. Comprehensive genome analyses have revealed the driver genes, including APC, KRAS, TGFBR2, and TP53, whose mutations are frequently found in human colorectal cancers. Among them, the p53 mutation is found in ~60% of colorectal cancers, and a majority of mutations are missense-type at ‘hot spots’, suggesting an oncogenic role of mutant p53 by ‘gain-of-function’ mechanisms. Mouse model studies have shown that one of these missense-type mutations, p53 R270H (corresponding to human R273H), causes submucosal invasion of intestinal tumors, while the loss of wild-type p53 has a limited effect on the invasion process. Furthermore, the same mutant p53 promotes metastasis when combined with Kras activation and TGF-β suppression. Importantly, either missense-type p53 mutation or loss of wild-type p53 induces NF-κB activation by a variety of mechanisms, such as increasing promoter accessibility by chromatin remodeling, which may contribute to progression to epithelial–mesenchymal transition. These results indicate that missense-type p53 mutations together with loss of wild-type p53 accelerate the late stage of colorectal cancer progression through the activation of both oncogenic and inflammatory pathways. Accordingly, the suppression of the mutant p53 function via the inhibition of nuclear accumulation is expected to be an effective strategy against malignant progression of colorectal cancer.

关键词： colon cancer missense-type mutant p53 gain-of-function mouse model NF-κB multistep tumorigenesis organoids

Performance analysis for power generating system by using matrix method

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中国科学：技术科学英文版 2011年第7期54卷 1689-1696页

作者： Kanji oshima Yohji UCHIYAMA Department of Risk Engineering Graduate School of Systems and Information Engineering University of Tsukuba

We verified that the matrix method, a process analysis method used mainly for life cycle inventory analysis, has several advantages in the analysis of power systems, which have recently become more complex to enhance efficiency and to reduce CO 2 emissions. While designing a conceptual thermodynamic model of a complex power system, the matrix method provides a definite procedure and facilitates calculations, even if there is a recursive loop between the upstream and downstream processes. Similarly, in the case of partial modification to the constructed model, the matrix method can potentially reduce the time and effort required to calculate the thermodynamic balances, even if the constructed model is designed by others. In this study, we obtained mass flow and energy balances of example model power systems by the matrix method from the common thermodynamic conditions including temperatures and pressures which are set on the basis of an existing industrial steam power system. While analyzing the environmental impact of complex multiproduct power systems, such as carbon emissions, the matrix method can be used to easily derive the environmental impact of each final product. We could verify the efficacy of the matrix method in accurately deriving that of an example model power system.

关键词：性能分析发电系统二氧化碳排放量生命周期清单分析蒸汽动力系统热力学模型电力系统矩阵方法

Significance of regenerating islet-derived type Ⅳ gene expression in gastroenterological cancers

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World Journal of Gastroenterology 2012年第27期18卷 3502-3510页

作者： Masakatsu Numata Takashi oshima Department of Gastroenterological Surgery Kanagawa Cancer Center1-1-2 NakaoAsahi-kuYokohamaKanagawa 241-0815Japan Gastroenterological Center Yokohama City University Medical Center4-57 Urafune-choMinami-kuYokohamaKanagawa 232-0024Japan

The regenerating islet-derived members (Reg ),a group of small secretory proteins,which are involved in cell proliferation or differentiation in digestive organs,are upregulated in several gastrointestinal cancers,functioning as trophic or antiapoptotic *** islet-derived type Ⅳ (RegⅣ ),a member of the Reg gene family,has been reported to be overexpressed in gastroenterological *** overexpression in tumor cells has been associated with carcinogenesis,cell growth,survival and resistance to *** tissue expressing RegⅣ is generally associated with more malignant characteristics than that without such expression,and RegⅣ is considered a novel prognostic factor as well as diagnostic marker in some gastroenterological *** previously investigated the expression levels of RegⅣ mRNA of 202 surgical colorectal cancer specimens with quantitative real-time reverse-transcriptase polymerase chain reaction and reported that a higher level of RegⅣ gene expression was a significant independent predictor of colorectal *** biologic functions of RegⅣ protein in cancer tissue,associated with carcinogenesis,antiapoptosis and invasiveness,are being elucidated by molecular investigations using transfection techniques or neutralizing antibodies of RegⅣ,and the feasibility of antibody therapy targeting RegⅣ is being *** studies may lead to novel therapeutic strategies for gastroenterological cancers expressing RegⅣ .This review article summarizes the current information related to biological functions as well as clinical importance of RegⅣ gene to clarify the significance of RegⅣ expression in gastroenterological cancers.

关键词：胃肠道肿瘤基因表达胰岛类型再生生物学功能聚合酶链反应预测因子

Acoustic CT system for temperature distribution measurement

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仪器仪表学报 2008年第5期29卷 897-902页

作者： Shinji Ohyama Toyofumi Oga Kazuo oshima Junya Takayama Graduate School of Science and Engineering Tokyo Institute of Technology 2-12-1 O-okayama Meguro-ku Tokyo 152-8552 Japan Research and Development Headquarters NTT FACILITIES INC. Minato-ku Tokyo Japan

In this paper, a measurement method for cross-sectional temperature distribution is addressed. A novel method based on an acoustic CT technique is proposed. Specifically, the temperature distributions are estimated using the time of flight data of several ultrasonic propagation paths. The times of the flight data contain both temperature and wind effect, and the method to select only temperature component is introduced. A filtered back projection method is applied to reconstruct the temperature distributions from the time of flight data. An experimental system was designed and fabricated to realize simultaneous temperature and wind velocity distribution measurements. Through this system, the effectiveness of the proposed measurement method is confirmed.

关键词：声波CT技术温度分布测量方法超声波