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The Effect of Loop Diuretics on Sarcopenia and Long-Term Prognosis in Patients with Refractory Hepatic Ascites Treated with Tolvaptan

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Open Journal of Gastroenterology 2018年第6期8卷 201-208页

作者： Masaaki Shimada Hiroaki Iwase Noboru Hirashima Masashi Saito hisashi kondo Noboru Urata Satoshi Unita Takashi kondo Daiki Tanaka Takuya Tsunekawa Department of Gastroenterology National Hospital Organization Nagoya Medical Center Nagoya Japan

We investigated sarcopenia, focusing on the dose of loop diuretics used in 70 patients with refractory hepatic ascites treated with tolvaptan. Bloating improved in 68.5% of patients, as determined using the Japanese version of the Support Team Assessment Schedule. The psoas muscle index (PMI) was used to define sarcopenia. A statistically significant difference was observed in the PMI between patients receiving low-dose (3.6 ± 1.2 cm2/m2) and high-dose furosemide (3.1 ± 1.2 cm2/m2) before tolvaptan treatment (P = 0.048). The PMI increased from 3.2 ± 1.1 cm2/m2 to 3.5 ± 1.3 cm2/m2 (P = 0.002) in responders, but decreased from 3.4 ± 1.2 cm2/m2 to 3.0 ± 1.0 cm2/m2 (P = 0.106) in non-responders before and after tolvaptan treatment, respectively. The long-term prognosis improved in responders compared with non-responders (mean survival time: 646 days vs. 228 days, P < 0.001). Early introduction of tolvaptan treatment is necessary to prevent the progression of sarcopenia.

关键词： Tolvaptan Hepatic Ascites Sarcopenia Loop Diuretics Long-Term Prognosis

Predictive Factors Differ between Hepatocellular Carcinoma Occurrence and Recurrence after Sustained Virological Responses by Direct-Acting Antivirals in Patients with Hepatitis C

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Open Journal of Gastroenterology 2020年第1期10卷 1-13页

作者： Noboru Hirashima Masaaki Shimada Noboru Urata Takuya Tsunekawa Satoshi Unita Takashi kondo Daiki Tanaka hisashi kondo Masashi Saito Hiroaki Iwase Department of Gastroenterology National Hospital Organization Nagoya Medical Center Nagoya Japan

Background: Interferon-free direct-acting antivirals (DAA) have markedly increased the sustained virological response (SVR) rate among patients with hepatitis C. Although DAA inhibit the development of hepatocellular carcinoma (HCC), predictive factors remain unclear. The aims of the present study were to investigate predictive factors for HCC occurrence and recurrence after SVR by DAA in prospectively followed patients with hepatitis C (HCV). Methods: One hundred and eighty-three HCV-infected patients treated with DAA and achieving SVR were prospectively followed up for more than one year. Among these patients, 166 had no history of HCC before DAA therapy, while 17 had a history of being treated for HCC by radiofrequency ablation or resection before the initiation of DAA. Liver stiffness (LS) measurements were conducted using transient elastography, and LS was assessed at the initiation of DAA (LS0), 24 weeks after the initiation of DAA (LS24), 48 weeks after (LS48), and every year after that. Results: HCC occurred in 7 out of 166 patients without a history of HCC (4.2%), and recurred in 9 out of 17 with a history of HCC (52.9%). Patients with a history of HCC were significantly older, mainly males, had higher alpha-fetoprotein (AFP) levels before DAA and at SVR24, higher Fib-4 levels, and higher LS0, 24, and 48 than those without a history of HCC. Age (p = 0.013) and AFP at SVR24 (p = 0.036) correlated with occurrence. LS48 (p = 0.043) correlated with recurrence. Conclusions: Predictive factors differed between HCC occurrence and recurrence after SVR by DAA in HCV patients. High recurrence rates were due to fibrosis in the liver being more advanced in patients with than in those without a history of HCC. Age and AFP at SVR24 were identified as predictive factors of HCC occurrence and LS48 of HCC recurrence.

关键词： Predictive Factor HCC Occurrence and Recurrence SVR DAA

Stage IV malignant transformation of mature cystic teratoma palliatively treated with concurrent chemoradiotherapy:A case report

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World Journal of Clinical Cases 2025年第1期13卷 56-61页

作者： Saori kondo Takashi Suzuki Kanato Yoshiike Sakura Yamanaka Kenta Sonehara Hiroshi Nabeshima Osamu Oguchi Department of Obstetrics and Gynecology Saku Central Hospital Advanced Care CenterSaku City 385-0051NaganoJapan

BACKGROUND Malignant transformation(MT)of mature cystic teratoma(MCT)has a poor prognosis,especially in advanced *** chemoradiotherapy(CCRT)has an inhibitory effect on *** SUMMARY Herein,we present a case in which CCRT had a reduction effect preoperatively.A 73-year-old woman with pyelonephritis was referred to our *** tomography revealed right hydronephrosis and a 6-cm pelvic *** ultrasound-guided fine-needle biopsy(EUS-FNB)revealed squamous cell *** patient was diagnosed with MT of *** to her poor general con-dition and renal malfunction,we selected CCRT,expecting fewer adverse *** CCRT,her performance status improved,and the tumor size was reduced;surgery was *** months postoperatively,the patient developed dis-semination and lymph node *** chemotherapy was *** died 18 months after treatment *** EUS-FNB was useful in the diagnosis of MT of MCT;CCRT suppressed the disea-se and improved quality of life.

关键词： Mature cystic teratoma Malignant transformation Squamous cell carcinoma Concurrent chemoradiotherapy Endoscopic ultrasound-guided fine-needle biopsy Case report

Immunological role of sulfatide in the pathogenesis of multiple sclerosis

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Neural Regeneration Research 2023年第9期18卷 1950-1951页

作者： Mio Hamatani Takayuki kondo Institute for the Advanced Study of Human Biology Kyoto UniversityKyotoJapan Department of Neurology Kansai Medical University Medical CenterMoriguchiJapan

Multiple sclerosis(MS) is a chronic inflammatory demyelinating disease of the central nervous system.A certain population of patients with MS present with a relapse-remitting disease course(RRMS) during the early phase and eventually advance to a progressive course(PMS).While immune modulation therapies have recently seen tremendous success in RRMS,our limited knowledge of pathogenesis hampers the development of effective treatments for PMS.

关键词： pathogenesis sclerosis eventually

Hepatitis C infected patients need vitamin D3 supplementation in the era of direct acting antivirals treatment

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World Journal of Gastroenterology 2017年第8期23卷 1325-1327页

作者： Yasuteru kondo Department of Hepatology Sendai Kousei HospitalAobaSendai City 980MiyagiJapan

It has been reported that the serum level of vitamin D3(Vit D3) could affect the natural course of chronic hepatitis C(CH-C) and the response to treatment with pegylated interferon(Peg-IFN) and ribavirin. Although several mechanisms for the favorable effects of Vit D3 supplementation were reported, the total effect of Vit D3 supplementation remains unclear. Previously, we reported that supplementation with 1(OH)Vit D3 could enhance the Th1 response inducing not only a favorable immune response for viral eradication but also HCC control. Recently, the main treatment of CH-C should be direct acting antivirals(DAAs) without PegIFN. Peg-IFN is a strong immune-modulator. Therefore, an immunological analysis should be carried out to understand the effect of Vit D3 after treatment of DAAs without Peg-IFN. The induction of a favorable immune response by adding Vit D3 might be able to suppress the hepatocarcinogenesis after achieving SVR, especially in children and elderly patients with severe fibrosis lacking sufficient amounts of VitD 3.

关键词： Vitamin D Hepatitis C virus Direct acting antivirals Hepatocarcinogenesis Immune response

Metal-free catalytic reduction of aldehydes,ketones,aldimines,and ketimines

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Chinese Chemical Letters 2010年第11期21卷 1314-1317页

作者： Hiroaki Matsuoka Kazuhiro kondo Graduate School of Medical Sciences Nagoya City University Graduate School of Pharmaceutical Sciences Nagoya City University

The metal-free combination of catalytic amounts of PPh3,B（C6F5）3,and PhSiH_3 can efficiently hydrosilylate aldehydes, ketones,aldimines and ketimines to afford the corresponding reduction products in good yields.

关键词： Metal-free hydrosilylation Reduction Ketone Ketimine

Immune checkpoint and inflammation as therapeutic targets in pancreatic carcinoma

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World Journal of Gastroenterology 2016年第33期22卷 7440-7452页

作者： Shiro Kimbara Shunsuke kondo Department of Experimental Therapeutics National Cancer Center Hospital

Pancreatic adenocarcinoma(PAC) is one of the most deadly malignant neoplasms,and the efficacy of conventional cytotoxic chemotherapy is far from satisfactory. Recent research studies have revealed that immunosuppression and inflammation are associated with oncogenesis,as well as tumor development,invasion,and metastasis in PAC. Thus,immunosuppressionrelated signaling,especially that involving immune checkpoint and inflammation,has emerged as novel treatment targets for PAC. However,PAC is an immuneresistant tumor,and it is still unclear whether immune checkpoint or anti-inflammation therapies would be an ideal strategy. In this article,we will review immune checkpoint and inflammation as potential targets,as well as clinical trials and the prospects for immunotherapy in PAC.

关键词： Immune checkpoint Therapeutic anticancer target Inflammation Randomized clinical trial Pancreatic adenocarcinoma

Analysis of molten metal spreading and solidification behaviors utilizing moving particle full-implicit method

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Frontiers in Energy 2021年第4期15卷 959-973页

作者： Ryo YOKOYAMA Masahiro kondo Shunichi SUZUKI Koji OKAMOTO Department of Nuclear Engineering and Management The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan Research Center for Computational Design of Advanced Functional materials(CD-FMat) Department of Materials and ChemistryNational Institute of Advanced Industrial Science and Technology(AIST)Central 21-1-1UmezonoTsukubaIbaraki 305-8568Japan Institute of Engineering Innovation School of EngineeringThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan Nuclear Professional School The University of Tokyo2-22 ShirakataTokai-muraIbaraki 319-1188Japan

To retrieve the fuel debris in Fukushima Daiichi Nuclear Power Plants(1F),it is essential to infer the fuel debris *** particular,the molten metal spreading behavior is one of the vital phenomena in nuclear severe accidents because it determines the initial condition for further accident scenarios such as molten core concrete interaction(MCCI).In this study,the fundamental molten metal spreading experiments were performed with different outlet diameters and sample amounts to investigate the effect of the outlet for spreading-solidification *** the numerical analysis,the moving particle full-implicit method(MPFI),which is one of the particle methods,was applied to simulate the spreading *** the MPFI framework,the melting-solidification model including heat transfer,radiation heat loss,phase change,and solid fraction-dependent viscosity was developed and *** addition,the difference in the spreading and solidification behavior due to the outlet diameters was reproduced in the *** simulation results reveal the detailed solidification procedure during the molten metal *** is found that the viscosity change and the solid fraction change during the spreading are key factors for the free surface condition and solidified ***,it is suggested that the MPFI method has the potential to simulate the actual nuclear melt-down phenomena in the future.

关键词： molten metal spreading solidification particle method severe accident fuel debris decommissioning

Direct effects of hepatitis C virus on the lymphoid cells

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World Journal of Gastroenterology 2013年第44期19卷 7889-7895页

作者： Yasuteru kondo Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai City Miygai 980-0873 Japan

It has been reported that the direct binding of hepatitis C virus(HCV)and/or the replication of HCV in the extrahepatic organs and,especially,lymphoid cells,might affect the pathogenesis of extrahepatic diseases with HCV *** than one decade ago,several reports described the existence of HCV-RNA in peripheral blood mononuclear ***,many reports describing the existence of HCV in B lymphocytes and B cell lymphoma have been *** addition to B lymphocytes,it was reported that HCV replication could be detected in T lymphocytes and T cell *** the extrahepatic diseases with HCV infection,mixed cryoglobulinemia-related diseases and autoimmunerelated diseases are important for understanding the immunopathogensis of HCV persistent ***,HCV persistent infection can cause malignant *** biological significance of lymphotropic HCV has not yet become ***,several candidates have been considered for a long *** is that lymphotropic HCV is an HCV reservoir that might contribute to the recurrence of HCV infection and difficultto-treat disease *** other important issue is the carcinogenesis of the lymphoid cells and disturbances of the immune ***,the extrahepatic diseases might be induced by direct interaction between HCV and lymphoid *** this article,we summarize various studies showing the direct effect of HCV on lymphoid cells and discuss the biological significance of lymphotropic HCV.

关键词： Hepatitis C virus Lymphotropism T cell B cell Immunology