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Open Journal of Psychiatry 2018年第2期8卷 120-130页

作者： Yukiko horiuchi Akira Sakamoto Kumiko Akiyama Akiyo Shoun Naoyuki Nishimura Kikunori Shinohara Yasunobu Komoto Taku Sato Hitoshi Ishida Nobuo Makino Letters and Education Ochanomizu University Tokyo Japan Faculty of Core Research Human Science Division Ochanomizu University Tokyo Japan The Nikkoso Foundation for Safe Society Tokyo Japan Graduate School of Humanities and Sciences Ochanomizu University Tokyo Japan Recovery Support Network Okinawa Japan Tokyo University of Science SUWA Nagano Japan Yoshino Hospital Tokyo Japan Naruse Mental Clinic Tokyo Japan Japan Women’s University Tokyo Japan

To understand the reality of gambling disorder caused by playing pachinko/pachislot, a national pachinko/pachislot survey was conducted. Based on the survey result, we examined the appearance ratio and the characteristics of individuals with a suspected pachinko-pachislot playing disorder. The analysis result indicated that approximately 0.4% of survey respondents were suspected to have the disorder. This appearance ratio was comparable to the prevalence of gambling disorder in the general population. Those who had a suspected disorder were likely to be divorced, and have no savings. Meanwhile, no distinctive characteristics were found in their gender, annual household income, or the highest educational attainment.

关键词： Gambling Disorder Pachinko/Pachislot Playing Disorder National Survey Japan

Pancreatic paraganglioma with draining vessels

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World Journal of Gastroenterology 2015年第31期21卷 9442-9447页

作者： Yoshitsugu Misumi Toshio Fujisawa Hirotsugu Hashimoto Koichi Kagawa Tamaki Noie Hideyuki Chiba Hajime horiuchi Yasushi Harihara Nobuyuki Matsuhashi Department of Gastroenterology NTT Medical Center Tokyo Department of Pathology NTT Medical Center Tokyo Department of Surgery NTT Medical Center Tokyo Department of Gastroenterology Omori Red Cross Hospital

A pancreatic paraganglioma is a rare neoplasm that is difficult to distinguish from a pancreatic neuroendocrine tumour. Here we present a case of pancreatic paraganglioma that was surgically resected following preoperative diagnosis of a pancreatic neuroendocrine tumour. Careful evaluation of the endoscopic ultrasonography findings revealed abundant draining ves-sels,which could have led to a correct preoperative diagnosis of pancreatic paraganglioma.

关键词： Paraganglioma Neuroendocrine tumour Draining vesse

载脂蛋白E-基因敲除鼠VLDL和IDL在动脉硬化中的作用

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南京大学学报（自然科学版） 1999年第2期35卷 180-185页

作者：张春妮 Hakamata Hideki Sakaguchi hisashi Suzuki Hirosh Miyazaki Akira 庄一义 horiuchi Seikoh 南京大学医学院临床学院南京军区南京总医院解放军医学检验中心日本熊本大学医学部日本中外药物研究所

探讨载脂蛋白Ｅ（ａｐｏＥ）－基因敲除鼠极低密度脂蛋白（ＶＬＤＬ）和中间密度脂蛋白（ＩＤＬ）组分（ａｐｏＥｋｏ－ＶＬＤＬ／ＩＤＬ）致动脉硬化作用．采用超离法从ａｐｏＥ－基因敲除鼠血浆中分离ＶＬＤＬ和ＩＤＬ组分，与鼠腹腔... 详细信息

探讨载脂蛋白Ｅ（ａｐｏＥ）－基因敲除鼠极低密度脂蛋白（ＶＬＤＬ）和中间密度脂蛋白（ＩＤＬ）组分（ａｐｏＥｋｏ－ＶＬＤＬ／ＩＤＬ）致动脉硬化作用．采用超离法从ａｐｏＥ－基因敲除鼠血浆中分离ＶＬＤＬ和ＩＤＬ组分，与鼠腹腔巨噬细胞共育，观察ａｐｏＥｋｏ－ＶＬＤＬ／ＩＤＬ与巨噬细胞的相互作用．ＡｐｏＥｋｏ－ＶＬＤＬ／ＩＤＬ导致细胞胆固醇酯含量显著增加．其诱导的细胞［３Ｈ］胆固醇油酸脂量高达１５．１ｎｍｏｌ／ｍｇ细胞蛋白，是天然低密度脂蛋白的８．４倍．形态学观察显示，经ａｐｏＥｋｏ－ＶＬＤＬ／ＩＤＬ处理的巨噬细胞与苏丹黑Ｂ呈阳性染色．细胞结合实验表明，１２５Ｉ－ａｐｏＥｋｏ－ＶＬＤＬ／ＩＤＬ与巨噬细胞的总结合可被非标记配基取代８０％以上，特异结合呈一饱和图形．同时细胞缔合和细胞内降解实验也显示相似结果．

关键词： VLDL IDL 载脂蛋白E 基因敲除动脉硬化

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可用于地震早期预警的家用地震仪

世界地震译丛 2012年第4期43卷 30-36页

作者： S.horiuchi Y.horiuchi S.Yamamoto H.Nakamura Changjiang Wu P.A.Rydelek M.Kachi 王蕤(译) 吕春来(校) 不详北京市地震局

日本气象厅(JMA)已开始推出一项地震早期预警(EEW)的实际服务,预计在不久的未来,将非常密集地布设安装信号接收装置。地震早期预警的接收/预警装置配有中央处理器和内存,并通过互联网进行连接。再加上一个便宜的地震仪和模数(A/D)转换器... 详细信息

日本气象厅(JMA)已开始推出一项地震早期预警(EEW)的实际服务,预计在不久的未来,将非常密集地布设安装信号接收装置。地震早期预警的接收/预警装置配有中央处理器和内存,并通过互联网进行连接。再加上一个便宜的地震仪和模数(A/D)转换器,该装置就变成了一个实时的地震观测系统,我们称之为家用地震仪(Home Seismometer)。如果这种家用地震仪与地震早期预警的标准接收装置相连接,那么地震观测系统的数量就会极大地增多。在房间里,由人的活动所引起的背景噪声可能非常大,为此我们专门编写了软件,从而能够使用该家用地震仪进行现场预警。我们对软件做了检验,发现该软件能够准确地将噪声和地震分辨开来,并适用于几乎所有的地震事件。

关键词：早期预警地震仪家用地震观测系统接收装置背景噪声日本气象厅中央处理器

Constitutively Active Soluble Form of Erythropoietin Receptor Suppresses Growth and Angiogenesis of Xenografts of Transfected Cancer Cell Lines

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Journal of Cancer Therapy 2011年第1期2卷 40-53页

作者： Yoshiko Yasuda Yasuhiro Maeda Satoshi Hara Motoyoshi Tanaka Eiji Koike Yoh Watanabe Seiji Masuda Harufumi Yamasaki Katsumi Okumoto Hiroyoshi Konishi Yoshitaka horiuchi Hiroshi Hoshiai 不详

We examined the effect of blocking the erythropoietin (Epo) signaling using an anti-Epo antibody, soluble form of Epo receptor (sEpoR) capable of binding to Epo or EpoR antagonist, and proved to be effective against xenografts of female reproductive organ malignancies and of cancer cell lines in nude mice. We transfected seven cancer cell lines of various origins to express constitutively active sEpoR, and examined their tumorigenesis in nude mice. Suppression of the tumor growth, decrease in viable and proliferating cells and reduction of vascular density were seen individually in all xenografts of transfected cell lines compared with the controls. Quantitative RT-PCR analyses showed that expression levels of Epo, EpoR, ?1A-adrenaline receptor (?1A-ADR) and muscalinic acetylcholine receptor subunit 3 mRNAs (m3-AchR) were higher in the majority of the wild-type xenografts than in the corresponding cell lines except for A549. In some of the transfected xenografts, EpoR, ?1A-ADR and m3-AchR mRNAs were down-regulated. Western blot analyses revealed that the constitutively activated ERK1/2MAPK was discernible in the majority of non-transfected cell lines and was reduced in the transfected cell lines. However, it was regained after exposure to acetylcholine and/or noradrenaline. These findings suggest that constitutively active sEpoR can effectively destroy the xenografts but signals from the autonomic neurotransmitters of the host produced under stress may interfere with this antitumor activity.

关键词： Erythropoietin Erythropoietin Receptor Soluble Form of Erythropoietin Receptor ERK1/2/MAPK Adrenoreceptor Acetylcholine Receptor Immunohistochemistry Western Blot Real-Time RT-PCR Nude Mice

α-Particle Condensation in Nuclear Systems

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α-Particle Condensation in Nuclear Systems

日光性角化病中苏木素着色的巨大透明角质颗粒:采用抗Ted-H-1抗体和抗兜甲蛋白抗体进行免疫组化比较(英文)

International Summer School on Subatomic Physics 2006

作者： Y. Funaki H. horiuchi A. Tohsaki T. Yamada P. Schuck G. Rpke The Institute of Physical and Chemical Research （RIKEN） Wako Saitama 351-0198Japan Research Center for Nuclear Physics （RCNP） Osaka University IbarakiOsaka 567-0047Japan Research Center for Nuclear Physics （RCNP） Osaka University IbarakiOsaka 567-0047Japan Laboratory of Physics Kanto Gakuin University Yokohama 236-8501Japan Institut de Physique Nucléaire 91406 Orsay Cedex France Institut für Physik Universitt Rostock D-18051 RostockGermany

＜正＞Quantum condensates in nuclear matter are treated beyond mean-field approximation. Due to Pauli blocking, the formation of an α-like condensate is limited to the low-density region. Consequences for finite nuclei are considered. In particular, excitations of self-conjugate 4-n nuclei near the n α threshold are candidates for the formation of such condensate. We repeat some results and discuss the consequences.

关键词： nuclear matter α-matter superfluidity Bose-Einstein condensation strongly coupled systems

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世界核心医学期刊文摘（皮肤病学分册） 2006年第2期2卷 32-33页

作者： Takahashi M. horiuchi Y. Tezuka T. 焦婷 Institute for Health Sciences Tokushima BunriUniversity Yamashiro Tokushima 770 8514 Japan

Background: Our previous study showed that large keratohyaline granules (KHG) in molluscum contagiosum that stained with haematoxylin also reacted with anti- Ted- H- 1 monoclonal antibody (mAb), but not with antifilaggrin mAb or antiloricrin polyclonal antibody (pAb). This finding indicated that the Ted- H- 1 antigenic protein is a haematoxylin- stainable protein in KHG. Objectives: To clarify the identity of the major component protein of the large KHG in solar keratosis, another disorder in which large KHG are observed. Methods An enzyme immunohistochemical study was performed using antifilaggrin mAb, anti- Ted- H- 1 mAb and antiloricrin pAb. Immunofluorescent double staining and immunoelectron microscopic analyses were performed using anti- Ted- H- 1 mAb and antiloricrin pAb. Results: Antifilaggrin mAb, anti- Ted- H- 1 mAb and antiloricrin pAb reacted with normal KHG in nonlesional skin of solar keratosis, while only anti- Ted- H- 1 mAb reacted with the large KHG in the lesions of solar keratosis. Antifilaggrin mAb did not react with large KHG. Antiloricrin pAb reacted with the cell membrane of the stratum granulosum, but not with large KHG. Conclusions: These findings suggest that the haematoxylin- stainable protein in the large KHG would be a Ted- H- 1 antigen protein which was neither filaggrin nor loricrin.

关键词：兜甲蛋白透明角质颗粒 Ted-H-1 日光性角化病苏木素中间丝相关蛋白传染性软疣色蛋白酶

SECONDARY BONE GRAFTING FOR REPAIR OF RESIDUAL CLEFT DEFECTS IN THE ALVEOLAR PROCESS—SURGICAL PROCEDURE

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SECONDARY BONE GRAFTING FOR REPAIR OF RESIDUAL CLEFT DEFECTS...

谷胱甘肽耗竭与微囊藻毒素-LR细胞毒性的关系初探

第二届中国国际暨第五届全国口腔颌面外科学术会议

作者： M．IINO K．SETO K.KITAGAWARA K.MURAKAMI T.horiuchi K.NIITSU H．ISHII DEPT.OF DENTISTRY AND ORAL SURGERY SAKU CENTRAL HOSPITAL NAGANO JAPAN 1ST DEPT.OF OMFS TSURUMI UNIVERSITY YOKOHAMA JAPAN DEPT.OF DENTISTRY AND ORAL SURGERY SAKU CENTRAL HOSPITAL NAGANO JAPAN DEPT.OF DENTISTRY AND ORAL SURGERY SAKU CENTRAL HOSPITAL NAGANO JAPAN DEPT.OF DENTISTRY AND ORAL SURGERY SAKU CENTRAL HOSPITAL NAGANO JAPAN DEPT.OF DENTISTRY AND ORAL SURGERY SAKU CENTRAL HOSPITAL NAGANO JAPAN 1ST DEPT.OF OMFS TSURUMI UNIVERSITY YOKOHAMA JAPAN

Secondary bone grafting for repair of alveolar clefts has become a well-accepted procedure used in the occlusal rehabilitation of the cleft lip/palate *** of secondary alveolar bone grafting are 1)improving of bone su... 详细信息

关键词： SECONDARY BONE GRAFTING FOR REPAIR OF RESIDUAL CLEFT DEFECTS IN THE ALVEOLAR PROCESS SURGICAL PROCEDURE

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应用预防医学 2008年第3期14卷 129-131页

作者：农清清竹内亨张志勇何敏 Masahisa horiuchi 广西医科大学公共卫生学院南宁530021 日本鹿儿岛大学环境医学研究室广西医科大学医学科学实验中心南宁530021

目的探讨谷胱甘肽耗竭与微囊藻毒素-LR(MCLR)细胞毒性的关系。方法不同剂量的MCLR作用人肝癌细胞HepG2后,采用四甲基偶氮噻唑蓝法检测细胞毒性,并用二硫硝基苯甲酸法测定细胞内还原型谷胱甘肽(GSH)的含量。结果细胞存活率随处理剂量的... 详细信息

目的探讨谷胱甘肽耗竭与微囊藻毒素-LR(MCLR)细胞毒性的关系。方法不同剂量的MCLR作用人肝癌细胞HepG2后,采用四甲基偶氮噻唑蓝法检测细胞毒性,并用二硫硝基苯甲酸法测定细胞内还原型谷胱甘肽(GSH)的含量。结果细胞存活率随处理剂量的增加而降低,抗氧化剂N-乙酰半胱氨酸明显减轻MCLR诱导的细胞毒性。细胞内GSH含量显著降低,处理剂量与GSH水平之间呈现剂量-反应和时间-反应关系。结论谷胱甘肽耗竭可能是微囊藻毒素-LR引起细胞毒性的原因之一。

关键词：微囊藻毒素-LR 谷胱甘肽耗竭细胞毒性

TAMOXIFEN REDUCES BONE TURNOVER IN OVARIECTOMIZED RATS

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TAMOXIFEN REDUCES BONE TURNOVER IN OVARIECTOMIZED RATS