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Selection of treatment modality for hepatocellular carcinoma according to the modified Japan Integrated Staging score

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World Journal of Gastroenterology 2008年第1期14卷 58-63页

作者： Atsushi Nanashima Junichi Masuda Satoshi Miuma Yorihisa Sumida Takashi Nonaka Kenji Tanaka Shigekazu hidaka Terumitsu Sawai Takeshi Nagayasu Division of Surgical Oncology Department of Translational Medical Sciences Nagasaki University Graduate School of Biomedical Sciences 1-7-1 Sakamoto Nagasaki 852-8501 Japan Second Department of Internal Medicine Department of Translational Medical Sciences Nagasaki University Graduate School of Biomedical Sciences 1-7-1 Sakamoto Nagasaki 852-8501 Japan First Department of Internal Medicine Department of Translational Medical Sciences Nagasaki University Graduate School of Biomedical Sciences 1-7-1 Sakamoto Nagasaki 852-8501 Japan

AIM: To compare the prognosis of patients who underwent hepatectomy and ablation using the modified Japan Integrated Staging score (mJIS).METHODS: We examined the clinicopathologic records and patient outcomes in 278 HCC patients including 226 undergoing hepatectomy and 52 undergoing ablation ***: Cirrhosis was more frequent in the ablation group. Tumor size, number and presence of vascular invasion were significantly higher in the operation group compared to the ablation group. The local recurrence rate adjacent to treated lesions was significantly higher in the ablation group compared to the operation group (P < 0.05). The 3- and 5-year survival rates in the ablation and the operation group were 66% and 78%, and 50% and 63%, respectively, but not significantly different. Over 50% survival rates were observed in patients with a mJIS score of 0-2 in both groups. However, survival rates with a score of 3-5 in both groups were significantly ***: According to the mJIS system, both local treatments could be selected for patients with a score of 0-2. However, for patients with a score more than 3, liver transplantation might be a better option in patients with HCC.

关键词：肝细胞癌肝切除术改良日本综合分级评价肝移植

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Atomic force microscopy analysis of orientation and bending of oligodeoxynucleotides in polypod-like structured DNA

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Nano Research 2015年第12期8卷 3764-3771页

作者： Tomoki Shiomi Mengmeng Tan Natsuki Takahashi Masayuki Endo Tomoko Emura Kumi hidaka Hiroshi Sugiyama Yuki Takahashi Yoshinobu Takakura Makiya Nishikawa Department of Biopharmaceutics and Drug Metabolism Graduate School of Pharmaceutical Sciences Kyoto University Sakyo-ku Kyoto 606-8501 Japan Institute for Integrated Cell-Material Sciences (WPI-iCeMS) Kyoto University Sakyo-ku Kyoto 606-8501 Japan Department of Chemistry Graduate School of Science Kyoto University Sakyo-ku Kyoto 606-8502 Japan

我们以前证明象多足一样组织了 DNA，或 polypodna，与三或更构造了 oligodeoxynucleotides (ODN ) ，被象树枝状的房间和巨噬细胞那样的有免疫力的房间高效地收起，取决于它的结构的复杂性。包括 polypodna 的 ODN 应该弯曲形成象多足... 详细信息

我们以前证明象多足一样组织了 DNA，或 polypodna，与三或更构造了 oligodeoxynucleotides (ODN ) ，被象树枝状的房间和巨噬细胞那样的有免疫力的房间高效地收起，取决于它的结构的复杂性。包括 polypodna 的 ODN 应该弯曲形成象多足一样结构，并且可以那么由采用 bendtype 符合构造或跨类型的符合构造做。这里，我们试着阐明取向并且用原子力量显微镜学(AFM ) 在 polypodnas ODN 弯曲。我们设计了 pentapodnas 的二种类型(即，有五个豆荚的 polypodna ) 使用 60- 到 88 底 ODN，它然后在 DNA origami 上被使不能调动装裱。AFM 成像证明在 pentapodna 的 ODN 采用了拐弯类型符合构造。当他们在非强迫的条件下面在框架上被使不能调动时， Tetrapodna 和 hexapodna 也采用了拐弯类型符合构造。这些调查结果提供向协调设计的有用信息，和 structureactivity 关系为，许多 DNA nanostructures。

关键词：原子力显微镜分析反义寡核苷酸弯曲型结构 DNA 取向树突状细胞免疫细胞巨噬细胞

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A fucosynthase specifically introducing histo-blood group antigens Lewis a/x into type-1/2 chains

A fucosynthase specifically introducing histo-blood group an...

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The 12th Japan-China-Korea Joint Symposium on Enzyme Engineering

作者： Haruko Sakurama Shinya Fushinobu Erina Yoshida Yuji Honda Masafumi hidaka hisashi Ashida Motomitsu Kitaoka Hidehiko Kumagai Kenji Yamamoto Takane Katayama Research Institute for Bioresources and Biotechnology Ishikawa Prefectural University Department of Biotechnology The University of Tokyo

Introduction Lewis a/x antigens[Galβ1-3/4(Fucα1-4/3)GlcNAc-,Le]play fundamental roles in various biological processes such as cell-to-cell communication in mammals and host-pathogen ***,establishing a method for synthesizing the antigens is important for functional glycomics ***,regiospecific synthesis of glycosidic bonds,especiallyα-L-fucosyl linkages,is quite difficult to control

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Perceptions of Reducing HIV-Preventive Behaviors among Men Who Have Sex with Men Living with HIV in Japan

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Health 2018年第12期10卷 1719-1733页

作者： Yuka Matsutaka Junko Koyano Yasuharu hidaka Department of Social and Clinical Psychology Faculty of Contemporary Culture Hijiyama University Hiroshima Japan Matsuhama Hospital Niigata Japan Takarazuka University School of Nursing Osaka Japan

Sexual health and behavior among HIV-positive men who have sex with men (MSM) have attracted attention in Japan and elsewhere. It has been reported that perceptions about sex are one factor leading to a reduction in HIV-preventive behaviors. This study investigated types of perceptions, termed self-talk, which allow HIV-positive Japanese MSM to permit themselves to participate in unprotected anal intercourse (UAI). A package of internet surveys for MSM including 20 items assessing self-talk on UAI and condom usage in anal intercourse was administered in 2014. Data from 479 HIV-positive Japanese MSM were analyzed. Exploratory factor analysis was conducted to reveal the factor structure of the self-talk. In addition, using the Kruskal-Wallis test, we examined the relationship between the types of self-talk and the tendency to have UAI. Factor analysis of 20 items assessing self-talk on UAI produced four dimensions: “Diversion/Desire for Stimulation,” “Optimism/Defiant Attitude,” “Denial of Concern of Transmitting,” and “Concern about Relationships.” The score of the subscale “Diversion/Desire for Stimulation” was significantly higher than the other three subscales. It was shown that there was a tendency for the self-talk assessed to be associated with the UAI frequency. The types of perceptions permitting UAI and the psychological stress of being an HIV-positive MSM in Japan were discussed. This study was the first to reveal the factorial structure of perceptions in reducing HIV-preventive behaviors among HIV-positive MSM in Japan. We found positive associations between certain types of self-talk and risky sexual behaviors. We provided recommendations for psychosocial support and HIV risk-reduction intervention for HIV-positive MSM.

关键词： HIV Prevention Safe Sex Men Who Have Sex with Men Perceptions about Sex Psychological Stress

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Effects of an oral iron chelator, deferasirox, on advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第40期22卷 8967-8977页

作者： Issei Saeki Naoki Yamamoto Takahiro Yamasaki Taro Takami Masaki Maeda Koichi Fujisawa Takuya Iwamoto Toshihiko Matsumoto Isao hidaka Tsuyoshi Ishikawa Koichi Uchida Kenji Tani Isao Sakaida Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine Yamaguchi 755-8505 Japan Yamaguchi University Health Administration Center Yamaguchi 755-8511 Japan Department of Oncology and Laboratory Medicine Yamaguchi University Graduate School of Medicine Yamaguchi 755-8505 Japan Department of Human Nutrition Faculty of Nursing and Human Nutrition Yamaguchi 755-8502 Japan Center of Research and Education for Regenerative Medicine Yamaguchi University Graduate School of Medicine Yamaguchi Prefectural University Yamaguchi 755-8505 Japan Department of Veterinary Surgery Joint Faculty of Veterinary Medicine Yamaguchi University Yamaguchi 755-8511 Japan

AIM To evaluate the inhibitory effects of deferasirox(DFX) against hepatocellular carcinoma(HCC) through basic and clinical *** In the basic study, the effect of DFX was investigated in three hepatoma cell lines(Hep G2, Hep3 B, and Huh7), as well as in an N-nitrosodiethylamine-induced murine HCC model. In the clinical study, six advanced HCC patients refractory to chemotherapy were enrolled. The initial dose of DFX was 10 mg/kg per day and was increased by 10 mg/kg per day every week, until the maximum dose of 30 mg/kg per day. The duration of a single course of DFX therapy was 28 consecutive days. In the event of dose-limiting toxicity(according to the Common Terminology Criteria for Adverse Events v.4.0), DFX dose was *** Administration of DFX inhibited the proliferation of hepatoma cell lines and induced the activation of caspase-3 in a dose-dependent manner in vitro. In the murine model, DFX treatment significantly suppressed the development of liver tumors(P < 0.01), and significantly upregulated the mR NA expression levels of hepcidin(P < 0.05), transferrin receptor 1(P < 0.05), and hypoxia inducible factor-1α(P < 0.05) in both tumor and non-tumor tissues, compared with control mice. In the clinical study, anorexia and elevated serum creatinine were observed in four and all six patients, respectively. However, reduction in DFX dose led to decrease in serum creatinine levels in all patients. After the first course of DFX, one patient discontinued the therapy. We assessed the tumor response in the remaining five patients; one patient exhibited stable disease, while four patients exhibited progressive disease. The one-year survival rate of the six patients was 17%.CONCLUSION We demonstrated that DFX inhibited HCC in the basic study, but not in the clinical study due to dose-limiting toxicities.

关键词：肝肿瘤 Hepatocellular 癌先进舞台 Iron-chelator Deferasirox

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Interaction between Peptide Pheromone or Its Truncated Derivatives and Pheromone Receptor of the Fission Yeast <i>Schizosaccharomyces pombe</i>Examined by a Force Spectroscopy Study and a GFP Reporter Assay

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Journal of Surface Engineered Materials and Advanced Technology 2013年第4期3卷 36-42页

作者： Sho hidaka Osamu Nikaido Shoichi Kiyosaki Atsushi Ikai Toshiya Osada Department of Life Science Graduate School of Bioscience and Biotechnology Tokyo Institute of Technology Yokohama Japan Innovation Laboratory Tokyo Institute of Technology Yokohama Japan.

In our previous study, the specific interaction between P-factor, a peptide pheromone and its receptor, Mam2, on the cell surface of the fission yeast Schizosaccharomyces pombe was investigated by two methods, an atomic force microscope (AFM) and a GFP reporter assay. The removal of Leu at C-terminal of P-factor resulted in an inactivation of P-factor function to bind Mam2 and induce the signal transduction pathway. Here, we used truncated P-factor derivatives lacking N-terminal of P-factor (P12 ~ P22: 12 ~ 22 amino acid residues from C-terminal) as ligands for Mam2. From the dose-dependent analysis of the GFP reporter assay ranging from 1 nM to 100 μM of the peptide concentration, the peptides can be classified into three groups based on EC50 and maximal GFP production level, group1 (P-factor), group2 (P17 ~ 22), and group3 (P12 ~ P16). At 0.1 μM, only P-factor induced the signal transduction pathway. At 1 μM, peptides from group2 partially induced the pathway and peptides from group3 induced the pathway a little. At 10 μM, all peptides induced the pathway mostly depending on the length of peptides. We also performed AFM experiments using P-factor and peptides from group3 to investigate the interaction between the peptides and Mam2 for comparison between the two methods.

关键词： GPCR Mam2 Pheromone GFP AFM Yeast

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Is there any correlation between Iiver graft regeneration and recipient's pretransplant skeletal muscle mass?-a study in extended Ieft Iobe graft Iiving-donor Iiver transplantation

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Hepatobiliary Surgery and Nutrition 2020年第2期9卷 183-194页

作者： Riccardo Pravisani Akihiko Soyama Shinichiro Ono Umberto Baccarani Miriam Isola Mitsuhisa Takatsuki Masaaki hidaka Tomohiko Adachi Takanobu Hara Takashi Hamada Florian Pecquenard Andrea Risaliti Susumu Eguchi Department of Surgery Nagasaki University Graduate School of Biomedical SciencesNagasakiJapan Liver-Kidney Transplant Unit Department of MedicineUniversity of UdineUdineItaly Division of Medical Statistic Department of MedicineUniversity of UdineUdineItaly

Background:The end-stage liver disease causes a metabolic dysfunction whose most prominent clinical feature is the loss of skeletal muscle mass(SMM).In living-donor liver transplantation(LDLT),liver graft regeneration(GR)represents a crucial process to normalize the portal hypertension and to meet the metabolic demand of the *** data are available on the correlation between pre-LDLT low SMM and ***:Retrospective study on a cohort of 106 LDLT patients receiving an extended left liver lobe *** skeletal muscle index(SMI)at L3 level was used for muscle mass measurement,and the recommended cut-off values of the Japanese Society of Hepatology guidelines were used as criteria for defining low *** was evaluated as rate of volume increase at 1 month post-LT[graft regeneration rate(GRR)].Results:The median GRR at 1 month post-LT was 91%(IQR,65-128%)and a significant correlation with graft volume-to-recipient standard liver volume ratio(GV/SLV)(rho-0.467,P<0.001),graft-to-recipient weight ratio(GRWR)(rho-0.414,P<0.001),donor age(rho-0.306,P=0.001),1 month post-LT cholinesterase serum levels(rho 0.397,P=0.002)and pre-LT low muscularity[absent *** GRR 97.5%(73.1-130%)vs.83.5%(45.2-110.9%),P=0.041]was *** in male recipients,but not in women,it was shown a direct correlation with pre-LT SMI(rho 0.352,P=0.020)and inverse correlation with 1 month post-LT SMI variation(rho-0.301,P=0.049).A low GRR was identified as an independent prognostic factor for recipient overall survival(HR 6.045,P<0.001).Conclusions:Additionally to the hemodynamic factors of portal circulation and the quality of the graft,the metabolic status of the recipients has a significant role in the GR process.A pre-LT low SMM is associated with impaired GRR and this negative impact is more evident in male recipients.

关键词： Liver regeneration living-donor liver transplantation(LDLT) skeletal muscle mass index sarcopenia malnutrition

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Perceived Difficulties Regarding HIV/AIDS Services among Public Health Nurses in the Kinki Region of Western Japan: Implications for Public Health Nursing Education in Japan

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Open Journal of Nursing 2017年第3期7卷 419-434页

作者： Yumiko H. Nishimura Mieko Iwai Akiyo Ozaki Asuka Waki Yasuharu hidaka School of Nursing Kansai University of Nursing and Health Sciences Hyogo Japan HRD Training & Consulting Office Double Eyes Hyogo Japan Ikeda-Shiritsu Shibutani Junior High School Osaka Japan School of Nursing Senri Kinran University Osaka Japan Takarazuka University School of Nursing Osaka Japan

Objective: To determine the perceived difficulties in providing HIV/AIDS services among public health nurses and to identify their correlates, we carried out a cross-sectional study in the Kinki region of western Japan. Methods: Structured self-administered questionnaires were distributed to all public health nurses in the region, and 1535 valid questionnaires were retrieved (valid response rate 78.7%). Results: More than half of the participants (52.8%) reported difficulties with HIV/AIDS services. The factors associated with perceived difficulties were having a negative attitude towards consultations on sexual matters (adjusted odds ratio [AOR] 2.2, p p = 0.002 and AOR 1.8, p p p = 0.016), and low permissiveness of the diversity of sexual behavior (AOR 2.0, p Conclusions: Overall, our results suggest that nursing and public health nursing education in Japan should cover sexual issues and HIV/AIDS in a more systematic way.

关键词： Perceived Difficulties HIV/AIDS Public Health Nursing Education Sexual Diversity

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Gait speed may predict development of Type 2 diabetes: A pilot study among elderly Japanese

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Journal of Diabetes Mellitus 2014年第1期4卷 38-43页

作者： Shuhei Nakanishi Gen Takezawa Yasuyuki Taooka Katsuko Kikkawa Naoko Matsumoto Toru hidaka Department of Internal Medicine Aki-Ota Hospital Hiroshima Japan Department of Molecular and Internal Medicine Graduate School of Biomedical & Health Sciences Hiroshima University Hiroshima Japan Department of Surgery Aki-Ota Hospital Hiroshima Japan Fitness Club Company Hiroshima Japan Welfare Division Health and Social Welfare Department Aki-Ota Town Government Hiroshima Japan

Aims: Epidemiologic evidence suggests that physical activity is associated with reduced risk of Type 2 diabetes. Walking is simple, effective, and by far the most prevalent physical activity among older adults. However, it is difficult to recognize and evaluate performance-based parameters of physical activity. The purpose of this study was to evaluate the importance of performance-based gait speed among several physical measurements in the development of Type 2 diabetes using long-term community-based data on elderly Japanese persons. Methods: 10 baseline physical measurements, including habitual (HGS) and fast (FGS) gait speed, were examined in 102 elderly Japanese persons living independently in the community (mean age: 71.1 years old) who were not previously diagnosed with diabetes. The subjects then participated in a daily exercise program consisting of walking, stretching, muscle strengthening, and balance exercises and were followed for an average of 4.16 years. Using Cox proportional hazards models with adjustment for age, sex, and category of fasting glucose status, we investigated whether gait speed and/or other physical measurements are associated with development of Type 2 diabetes. Results: 9 subjects developed Type 2 diabetes. Among the 10 physical parameters examined, prolongation of HGS and FGS per second was the only statistically significant factors, with hazard ratios 1.83 (1.15 - 2.89, P = 0.010) and 2.93 (1.43 - 6.03, P = 0.003), respectively. Conclusions: We found a negative association between the development of Type 2 diabetes and gait speed among elderly Japanese people. We conclude that encouraging physical activity and preserving walking capacity may be beneficial for preventing Type 2 diabetes.

关键词： Gait Speed Type 2 Diabetes Japanese Elderly Population

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Prion Protein Binds to Aldolase A Produced by Bovine Intestinal M Cells

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Open Journal of Veterinary Medicine 2015年第3期5卷 43-60页

作者： Yuya Nagasawa Yu Takahashi Wataru Itani Hitoshi Watanabe Yusuke hidaka Shotaro Morita Kei Suzuki Kouichi Watanabe Shyuichi Ohwada Haruki Kitazawa Morikazu Imamura Takashi Yokoyama Motohiro Horiuchi Suehiro Sakaguchi Shirou Mohri Michael T. Rose Tomonori Nochi hisashi Aso Cellular Biology Laboratory Tohoku University Sendai Japan Food Immunology Group Tohoku University Sendai Japan Prion Disease Research Center National Institute of Animal Health Tsukuba Japan Laboratory of Veterinary Hygiene Hokkaido University Sapporo Japan Institute for Enzyme Research The University of Tokushima Tokushima Japan Institute of Biological Environmental and Rural Sciences Aberystwyth University Aberystwyth UK

Microfold (M) cells are a kind of intestinal epithelial cell in the follicle-associated epithelium (FAE) of Peyer’s patches. They can transport antigens and microorganisms to lymphoid tissues. Bovine spongiform encephalopathy (BSE) is a fatal neurodegenerative disorder in cattle. It is linked to variant Creutzfeldt-Jakob disease in humans. Although it is thought that M cells transport the BSE agent, the exact mechanism by which it crosses the intestinal barrier is not clear. We have bovine intestinal epithelial cell line (BIE cells), which can differentiate into the M cell type in vitro after stimulation, and which is able to transport the BSE agent. We show here that M cells are able to incorporate large numbers of PrP coated magnetic particles into intracellular vesicles, which we collected. The results of 2-DE show a specific protein associated with the PrP-coated particles, compared with non-coated particles. This protein was identified as aldolase A, a glycolytic pathway enzyme, using LC-MS/MS analysis. Aldolase A was synthesized and secreted by BIE cells, and increased during M cell differentiation. In the villi of the bovine intestine, aldolase A was detected on the surface of the epithelium and in the mucus droplet of goblet cells. In the FAE of bovine jejunal and ileal Peyer’s patches, aldolase A was localized on the surface and the apical part of the M cells. The binding of rbPrP to aldolase A was clearly detected and inhibited by pre-treatment of anti-aldolase A antibody. Aldolase A was co-stained with incorporated PrPSc in M-BIE cells. These results suggest that bovine M cells and goblet cells synthesize aldolase A, and that aldolase A may have the ability to bind PrP and associate with PrP in cellular vesicles. Therefore, aldolase A-positive M cells may play a key role in the invasion of BSE into the body.

关键词： Peyer’s Patch M Cell BIE Cells Aldolase A PrP Binding Protein

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