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Efficacy of combination therapy with natriuretic and aquaretic drugs in cirrhotic ascites patients: A randomized study

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World Journal of Gastroenterology 2017年第45期23卷 8062-8072页

作者： Haruki Uojima hisashi hidaka Tsuyoshi Nakayama Ji Hyun Sung Chikamasa Ichita Shinnosuke Tokoro Sakue Masuda Akiko Sasaki Kazuya Koizumi Hideto Egashira Makoto Kako Department of Gastroenterology Shonan Kamakura General Hospital Department of Gastroenterology Internal MedicineKitasato University School of Medicine Department of Gastroenterology Shonan Atsugi Hospital

AIM To assess the effects of a combination therapy with natriuretic and aquaretic drugs in cirrhotic ascites *** A two-center,randomized,open-label,prospective study was conducted. Japanese patients who met the criteria were randomized to trial group and the combination diuretic group(received 7.5 mg of tolvaptan) or the conventional diuretic group(received 40 mg of furosemide) for 7 d in addition to the natriuretic drug which was used prior to enrolment in this study. The primary endpoint was the change in body weight from the baseline. Vital signs,fluid intake,and laboratory and urinary data were assessed to determine the pharmacological effects after administration of aquaretic and natriuretic *** A total of 56 patients were randomized to receive either tolvaptan(n = 28) or furosemide(n = 28). In the combination and conventional diuretic groups,the average decrease in body weight from the baseline was 3.21 ± 3.17 kg(P < 0.0001) and 1.75 ± 2.36 kg(P = 0.0006),respectively,when measured on the final dosing day. Following 1 wk of treatment,a significantly greater reduction in body weight was observed in the combination diuretic group compared to that in the conventional diuretic group(P = 0.0412).CONCLUSION Compared to a conventional diuretic therapy with only a natriuretic drug,a combination diuretic therapy with natriuretic and aquaretic drugs is more effective for patients with cirrhotic ascites.

关键词： Tolvaptan 肝肝硬化利尿的效果腹水肝的浮肿

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Relationship between response to lusutrombopag and splenic volume

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World Journal of Gastroenterology 2018年第46期24卷 5271-5279页

作者： Haruki Uojima Yoshitaka Arase Norio Itokawa Masanori Atsukawa Takashi Satoh Koji Miyazaki hisashi hidaka Ji Hyun Sung Makoto Kako Kota Tsuruya Tatehiro Kagawa Katsuhiko Iwakiri Ryouichi Horie Wasaburo Koizumi Department of Gastroenterology Shonan Kamakura General Hospital Department of Gastroenterology Internal MedicineKitasato University School of Medicine Division of Gastroenterology and Hepatology Department of Internal MedicineTokai University School of Medicine Department of Internal Medicine Division of GastroenterologyNippon Medical School Chiba Hokusoh Hospital Department of Internal Medicine Division of Gastroenterology and HepatologyNippon Medical School Division of Hematology Department of Medical Laboratory SciencesKitasato University School of Allied Health Sciences Division of Molecular Hematology Kitasato University Graduate School of Medical Sciences Department of Transfusion and Cell Transplantation Kitasato University School of Medicine

AIM To assess the correlation between the efficacy of lusutrom-bopag and clinical characteristics in patients with chronic liver *** In this retrospective, multicenter study, which conducted at four locations in Japan, 50 thrombocytopenic patients with chronic liver disease were enrolled. All patients received oral lusutrombopag(3.0 mg/d for 7 d) for chronic liver disease. We assessed the increase in platelet count after the trial drug administration. A treatment response was defined as a platelet count ≥ 5 × 104/μL and an increased platelet count ≥ 2 × 104/μL from baseline after drug administration. We evaluated the response to lusutrombopag compared to baseline clinical characteristics in patients with chronic liver *** The numbers of responders and non-responders were 40(80.0%) and 10(20.0%), respectively. The patients were divided into a responder and non-responder group, and we added factors that may correspond to successful treatment with lusutrombopag. Splenic volume and body weight were lower in the responder group than in the nonresponder group. White blood cell count and hemoglobin level were higher in responders compared with nonresponders. Using a logistic regression model to assess the relationship between response to lusutrombopag and clinical characteristics, multivariate analysis confirmed that splenic volume was an independent factor that predicted the response of platelet counts(P = 0.025; odds ratio = 11.2; 95% confidence interval: 1.354-103.0). Splenic volume negatively correlated to changes in platelet count(r =-0.524, P = 0.001).CONCLUSION Splenic volume influences the change in platelet counts after administration of lusutrombopag in patients with chronic liver disease.

关键词： Lusutrombopag Portal hypertension Splenic volume Thrombocytopenia Thrombopoietin receptor agonist

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Usefulness of autotaxin for the complications of liver cirrhosis

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World Journal of Gastroenterology 2020年第1期26卷 97-108页

作者： Xue Shao Haruki Uojima Toru Setsu Tomomi Okubo Masanori Atsukawa Yoshihiro Furuichi Yoshitaka Arase hisashi hidaka Yoshiaki Tanaka Takahide Nakazawa Makoto Kako Tatehiro Kagawa Katsuhiko Iwakiri Shuji Terai Wasaburo Koizumi Department of Gastroenterology Internal MedicineKitasato University School of MedicineSagamiharaKanagawa 252-0375Japan Department of Hepatopancreatobiliary Medic Department of Gastroenterology Shonan Kamakura General HospitalKamakuraKanagawa 247-8533Japan Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8510Japan Department of Internal Medicine Division of GastroenterologyNippon Medical School Chiba Hokusoh HospitalChiba 270-1694Japan Department of Internal Medicine Division of Gastroenterology and HepatologyNippon Medical SchoolTokyo 113-8603Japan Department of Gastroenterology and Hepatology Tokyo Medical University HospitalShinjukuTokyo 113-8510Japan Division of Gastroenterology and Hepatology Department of Internal MedicineTokai University School of MedicineKanagawa 259-1193Japan

BACKGROUND Autotaxin(ATX)has been reported as a direct biomarker for estimating the evaluation of liver *** available data on ATX as a useful biomarker for the complications of liver cirrhosis(LC)are *** To assess the clinical usefulness of ATX for assessing the complications of *** This multicenter,retrospective study was conducted at six locations in *** include patients with LC,n=*** ATX level was evaluated separately in men and women because of its high level in female *** assess the clinical usefulness of ATX for the complications of LC,the area under the curve(AUC)of ATX assessing for the severe complications was analyzed in comparison with the model for end-stage liver disease score,albumin-bilirubin(ALBI)score,fibrosis-4 index,and aspartate aminotransferase-to-platelet ratio *** The mean age was 68.4±11.4 years,240 patients(60.0%)were male.A total of 213(53.3%)and 187(46.8%)patients were compensated and decompensated,*** numbers of patients with varix rupture,hepatic ascites,and hepatic encephalopathy were 35(8.8%),131(32.8%),and 103(25.8%),*** AUCs of ATX in men for hepatic encephalopathy,hepatic ascites,and varix ruptures were 0.853,0.816,and 0.706,*** AUCs of ATX in women for hepatic encephalopathy,hepatic ascites,and varix rupture were 0.759,0.717,and 0.697,*** AUCs of ATX in men were higher than those in women,as were all the other biomarkers used to detect encephalopathy and varix ***,for detecting ascites,the AUC of ALBI in men was more effective than using *** ATX in men was more effective than any other biomarkers for detecting hepatic encephalopathy and varix ruptures.

关键词： Autotaxin Hepatic encephalopathy Hepatic ascites Liver fibrosis Biomarker

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Enzyme-linked immunosorbent assay of 3 Screen Islet Cell Autoantibody in patients with autoimmune thyroid disease

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World Journal of Diabetes 2024年第5期15卷 935-944页

作者： Eiji Kawasaki Hidekazu Tamai Takahiro Fukuyama Yoko Sagara Ryutaro hidaka Aira Uchida Masayuki Tojikubo Narihito Tatsumoto Yuko Akehi Yuji Hiromatsu The Diabetes Thyroid and Endocrine CenterShin-Koga HospitalKurume 830-8577Japan

BACKGROUND In recent years,the emergence of multiplex technology that can simultaneously measure multiple anti-islet autoantibodies has become particularly valuable for the staging and early diagnosis of immune-mediated type 1 diabetes(T1D).While it has been established that 20%-30%of T1D patients suffer from autoimmune thyroid disease(AITD),there is limited available data regarding the presence of anti-islet autoantibodies in AITD *** commercially available anti-islet autoantibodies,glutamic acid decarboxylase 65 autoantibodies(GADAs)are often the first marker measured in general clinical *** To investigate the frequency of anti-islet autoantibodies in AITD *** Our study involved four hundred ninety-five AITD patients,categorized into three distinct groups:AITD with T1D(n=18),AITD with phenotypic type 2 diabetes(T2D)(n=81),and AITD without diabetes(n=396),and the enzyme-linked immunosorbent assay(ELISA)was employed to determine the frequencies of 3 Screen Islet Cell Autoantibody(3 Screen ICA),GADA,insulinoma-associated antigen-2 autoantibodies(IA-2As),and zinc transporter 8 autoantibodies(ZnT8As)within these *** The frequency of 3 Screen ICA in AITD patients with T1D,T2D,and those without diabetes were 88.9%,6.2%,and 5.1%,respectively,with no significant difference seen between the latter two ***,the frequency of 3 Screen ICA was 11.1%higher in AITD patients with T1D,1.3%higher in AITD patients with T2D,and 1.1%higher in AITD patients without diabetes compared to GADA,***,12.5%,20.0%,and 20.0%of the 3 Screen ICA-positive patients were negative for ***,1.3%of the AITD patients who tested negative for 3 Screen ICA in both the AITD with T2D and non-diabetic AITD groups were found to be positive for individual *** the 3 Screen ICA-positive patients,there was a significantly higher proportion of individuals with multiple autoantibodies in AITD patients with T1D com

关键词： Anti-islet autoantibodies Autoimmune thyroid disease Real-world practice Retrospective study Type 1 diabetes

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Olmesartan for non-alcoholic steatohepatitis complicated with hypertension: An open-label study

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Open Journal of Gastroenterology 2013年第2期3卷 128-133页

作者： hisashi hidaka Makoto Ohbu Yasuhiro Matsumoto Tsutomu Minamino Juichi Takada Yoshiaki Tanaka Yusuke Okuwaki Masaaki Watanabe Takahide Nakazawa Akitaka Shibuya Wasaburo Koizumi Department of Gastroenterology Kitasato University School of Medicine Sagamihara Kanagawa Japan Department of Pathology Kitasato University School of Allied Health Science Sagamihara Kanagawa Japan

Aim: We evaluated the long-term effects of olmesartan, an angiotensin type 1 receptor blocker, in patients with non-alcoholic steatohepatitis (NASH) complicated with hypertension. Methods: All patients were given a standard calorie diet and exercise counseling more than 3 months before the treatment. Seven patients with NASH received olmesartan treatment for 1 year. Liver biopsy, clinical parameters and blood markers of hepatic fibrosis, including serum hyaluronic acid, type IV collagen, and procollagen III N-terminal propeptide levels, were also examined at the beginning and the end of the study. Results: The median dose of the final administration was 20 mg (range, 10 - 40 mg). Olmesartan reduced MAP by –11.3 ± 13.0% (P = 0.046) after 1 year. In the laboratory data, serum AST, ALT, and ferritin significantly decreased after a year of administration (AST, 62 ± 24 vs. 39 ± 20 IU/L, P = 0.018;ALT, 106 ± 79 vs. 55 ± 35 IU/L, P = 0.043;ferritin, 323.8 ± 252.8 vs. 202.3 ± 194.1 ng/ml, P = 0.028). Furthermore, fasting glucose significantly decreased. However, transforming growth factor-beta1, the serum concentration of the fibrosis markers, and all histological features were unchanged at the end of the study. No side effects of the treatment were noted at any time during the study. Conclusion: Olmesartan significantly reduced blood pressure, fasting glucose, aminotransferase, and serum ferritin but could not suppress the hepatic fibrosis markers or histological features after 1 year. Therefore, olmesartan is advisable only for its anti-inflammatory effect in patients with NASH-complicated hypertension.

关键词： Angiotensin Type 1 Receptor Blocker Hepatic Fibrosis TGF-Beta1

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Performances and Acoustic Noise of Micro Multi-blade Fan

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Journal of Thermal Science 2008年第4期17卷 343-348页

作者： Ryotaro hidaka Toshiaki Kanemoto Tetsuya Sunada Kyushu Institute of Technology

在这篇论文，表演和传统的类型的声学的噪音，微多片扇子试验性地并且数字地被调查，到为居民情形优化扇子的说明。声学的噪音水平减少，但是效率随 impeller 的片数字的增加稍微败坏。而且，声学的噪音随在 impeller 插头和涡囊舌头之... 详细信息

在这篇论文，表演和传统的类型的声学的噪音，微多片扇子试验性地并且数字地被调查，到为居民情形优化扇子的说明。声学的噪音水平减少，但是效率随 impeller 的片数字的增加稍微败坏。而且，声学的噪音随在 impeller 插头和涡囊舌头之间的距离的增加减少，在随输入的增加和扇子效率的恶化伴随。

关键词：鼓风机热风扇子研究

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Thermal Runaway of Lithium-Ion Batteries Employing Flame-Retardant Fluorinated Electrolytes

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Energy & Environmental Materials 2023年第1期6卷 333-339页

作者： Junxian Hou Li Wang Xuning Feng Junpei Terada Languang Lu Shigeaki Yamazaki Anyu Su Yoshiko Kuwajima Yongjiang Chen Tomoya hidaka Xiangming He Hewu Wang Minggao Ouyang State Key Laboratory of Automotive Safety and Energy Tsinghua UniversityBeijing 100084China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China Daikin Industries Ltd.1-1Nishi-HitotsuyaSettsu Osaka 566-8585Japan Sichuan New Energy Vehicle Innovation Center Yibin 644002China

Fluorinated electrolytes possess good antioxidant capacity that provides high compatibility to high-voltage cathode and flame retardance;thus,they are considered as a promising solution for advanced lithium-ion batteries carrying both high-energy density and high ***,the fluorinated electrolytes are widely used to form stable electrolyte interphase,due to their chemical reactivity with lithiated graphite or ***,the influence of this reactivity on the thermal safety of batteries is seldom ***,we demonstrate that the flame-retardant fluorinated electrolytes help to reduce the flammability,while the lithium-ion batteries with flame-retardant fluorinated electrolytes still undergo thermal runaway and disclose their different thermal runaway pathway from that of battery with conventional *** reduction in fluorinated components(e.g.,LiPF 6 and fluoroethylene carbonate(FEC))by fully lithiated graphite accounts for a significant heat release during battery thermal *** 13%of total heat is sufficient to trigger the chain reactions during battery thermal *** study deepens the understanding of the thermal runaway mechanism of lithium-ion batteries employing flame-retardant fluorinated electrolytes,providing guidance on the concept of electrolyte design for safer lithium-ion batteries.

关键词： battery safety flame retardance fluorinated electrolytes lithium-ion battery thermal runaway

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Effect of calcium on phytochrome-mediated synthesis of amaranthin in Amaranthus caudatus seedlings

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Chinese Science Bulletin 1995年第17期40卷 1469-1473页

作者：马力耕周君莉安宜崔国军孙大业 hidakaHiroyoshi hidaka Hiroyoshi Department of Biology Hebei Normal University. Shijiazhuang 050016 China) Department of Pharmacology College of Medicine Nagoya University Nagoya 466. Japan)

Light plays a critical role in the regulation of plant morphogenetic and physiologicalresponses. As one of the extracellular signals, light signa1 is first received by the plantcells, then it affects the physiological and biochemical status of the cells and the expressionof genetic characters through signal transduction. Tong has pointed out that until recentlythere had been little progress in the intersteps between phytochrome activation and

关键词： calcium phytochrome Amaranthus caudatus amaranthin synthesis.

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Heparin-induced thrombocytopenia occurring early after living donor liver transplantation:a case report

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Emergency and Critical Care Medicine 2023年第4期3卷 198-202页

作者： Naoya Iwasaki Motohiro Sekino Takanobu Hara Akihiko Soyama Masaaki hidaka Yusuke Kasai Miki Suzumura Hiroshi Araki Rintaro Yano Sojiro Matsumoto Taiga Ichinomiya Ushio Higashijima Susumu Eguchi Tetsuya Har Department of Anesthesiology and Intensive Care Medicine Nagasaki University Graduate School of Biomedical SciencesNagasakiJapan Department of Surgery Nagasaki University Graduate School of Biomedical SciencesNagasakiJapan

Background:Thrombocytopenia commonly occurs early after liver ***,usually administered as anticoagulant ther-apy for thrombosis,a common complication after liver transplantation,may cause heparin-induced ***-induced thrombocytopenia is a rare but life-threatening complication,and its diagnosis after liver transplantation is *** presentation:We report a case of heparin-induced thrombocytopenia after living donor liver transplantation with a good out-come because of early diagnosis and discontinuation of *** liver transplantation,the platelet count usually reaches a nadir on postoperative days 3–5 and gradually *** contrast,heparin-induced thrombocytopenia typically occurs 5–10 days after heparin administration;therefore,if heparin is started intraoperatively,then thrombocytopenia will occur on postoperative days 5–***:Monitoring the trend and timing of thrombocytopenia and detailed examination for thrombosis may help confirm the diag-nosis of heparin-induced thrombocytopenia in the early stage after liver transplantation.

关键词： Case report Heparin Heparin-induced thrombocytopenia Liver transplantation Thrombocytopenia Thrombosis

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MUC5AC/β-catenin expression and KRAS gene alteration in laterally spreading colorectal tumors

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World Journal of Gastroenterology 2012年第39期18卷 5551-5559页

作者： Kosaburo Nakae Hiroyuki Mitomi Tsuyoshi Saito Michiko Takahashi Takashi Morimoto Yasuhiro hidaka Naoto Sakamoto Takashi Yao Sumio Watanabe Department of Gas-troenterology Juntendo University School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-8421Japan Department of Human Pathology Juntendo University School of Medicine1-1-19 HongoBunkyo-kuTokyo 113-0033Japan

AIM:To clarify differences in mucin phenotype, prolif-erative activity and oncogenetic alteration among subtypes of colorectal laterally spreading tumor (LST). METHODS:LSTs, defined as superficial elevated lesions greater than 10 mm in diameter with a low vertical axis, were macroscopically classified into two subtypes:(1) a granular type (Gr-LST) composed of superficially spreading aggregates of nodules forming a flat-based lesion with a granulonodular and uneven surface; and (2) a non-granular type (NGr-LST) with a flat smooth surface and an absence of granulonodular formation. A total of 69 LSTs, comprising 36 Gr-LSTs and 33 NGr-LSTs, were immunohistochemically stained with MUC2, MUC5AC,MUC6, CD10 (markers of gastrointestinal cell lineage), p53, β-catenin and Ki-67 antibodies, and examined for alteration in exon 1 of v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) and exon 15 of v-raf murine sarcoma viral oncogene homologue B1 (BRAF) by poly-merase chain reaction followed by direct sequencing. RESULTS:Histologically, 15 Gr-LST samples were adenomas with low-grade dysplasia (LGD), 12 were high-grade dysplasia (HGD) and 9 were adenocarcinomas invading the submucosa (INV), while 12 NGr-LSTs demonstrated LGD, 14 HGD and 7 INV. In the proximal colon, MUC5AC expression was significantly higher in the Gr-type than the NGr-type. MUC6 was expressed only in NGr-LST. MUC2 or CD10 did not differ. P53 expression demonstrated a significant stepwise increment in progression through LGD-HGD-INV with both types of LST. Nuclear β-catenin expression was significantly higher in the NGr-type. Ki-67 expression was signifi-cantly higher in the Gr-type in the lower one third zone of the tumor. In proximal, but not distal colon tumors, the incidence of KRAS provided mutation was signifi-cantly higher in the Gr-type harboring a specific mutational pattern (G12V). BRAF mutations (V600E) were detected only in two Gr-LSTs. CONCLUSION:The two subtypes of LST, especially in the pro

关键词：基因变异肠肿瘤细胞外信号调节激酶传播 RAS基因免疫组化染色聚合酶链反应 CD10

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