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Update on classification,diagnosis,and management of immunoglobulin G4-related disease

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Chinese Medical Journal 2022年第4期135卷 381-392页

作者： Yu Chen Shaozhe Cai Lingli Dong hisanori Umehara Department of Rheumatology and Immunology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Rheumatology and Immunology Nagahama City HospitalOinuichoNagahamaShiga 526-0043Japan

Immunoglobulin G4-related disease(IgG4-RD)is a newly recognized chronic fibro-inflammatory autoimmune disease,and its recognition has been constantly increasing worldwide over the last few years.A correct and timely recognition,as well as appropriate intervention,is crucial for the treatment of *** certain subtypes of IgG4-RD,organ-specific criteria are formulated to make the diagnosis more *** biomarkers have emerged in the recent years to aid the disease diagnosis,its prognosis prediction,as well as therapy response *** recurrence is very common in IgG4-RD,glucocorticoid is still the first-line treatment for the majority of *** factors that affect the likelihood of disease relapse are *** selection strategy of various steroid-sparing agents is still being ***,when patients have special sites involvement leading to severe clinical conditions,surgical operation or interventional therapy should also be *** update on classification,diagnosis,and management of IgG4-RD is provided in the current study to fully elucidate the recommended clinical practice of this mysterious disease.

关键词： IgG4-related disease Review Update Management

Single and combined eff ects of fertilization,ectomycorrhizal inoculation,and drought on container-grown Japanese larch seedlings

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Journal of Forestry Research 2023年第4期34卷 1077-1094页

作者： Evgenios Agathokleous Mitsutoshi Kitao Masabumi Komatsu Yutaka Tamai hisanori Harayama Takayoshi Koike Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD) Nanjing University of Information Science and TechnologyNanjing 210044JiangsuPeople’s Republic of China Research Center for Global Changes and Ecosystem Carbon Sequestration and Mitigation School of Applied MeteorologyNanjing University of Information Science and TechnologyNanjing 210044JiangsuPeople’s Republic of China Hokkaido Research Center Forestry and Forest Products Research Institute(FFPRI)Forest Research and Management Organization7 HitsujigaokaSapporoHokkaido 062-8516Japan Department of Mushroom Science and Forest Microbiology Forestry and Forest Products Research Institute(FFPRI)Matsunosato 1Tsukuba 305-8687Japan Research Faculty of Agriculture Hokkaido UniversityKita 9 Nishi 9SapporoHokkaido 060-8589Japan Department of Plant Ecology Forestry and Forest Products Research Institute(FFPRI)Matsunosato 1Tsukuba 305-8687Japan

Climate change can intensify drought in many regions of the world and lead to more frequent drought events or altered cycles of soil water ***,it is important to enhance the tolerance to drought and thus health,vigor,and success of transplantation seedlings used in the forestry by modifying fertilization and promoting ***,we sowed seeds of Japanese larch(Larix kaempferi)in 0.2-L containers with 0.5 g(low fertilization;LF)or 2 g(high fertilization;HF)of slow-release fertilizer early in the growing *** month later,we irrigated seedlings with non-sterilized ectomycorrhizal inoculum(ECM)or sterilized solution(non-ECM),and after about 2 months,plants were either kept well watered(WW;500 mL water/plant/week)or subjected to drought(DR;50 mL water per plant/week)until the end of the growing *** largely stimulated plant growth and above-and belowground biomass production,eff ects that are of practical signifi cance,but caused a small decrease in stomatal conductance(Gs 390)and transpiration rate(E 390),which in practice is insignifi *** treatment resulted in moderate inhibition of seedling growth and biomass and largely canceled out the enhancement of biomass and foliar K content by *** caused a large decrease in CO 2 assimilation,and enhanced stomatal closure and induced *** also largely depleted foliar Mg and enriched foliar *** DR caused a large decrease in foliar P content in LF,it moderately increased P in ***,DR increased foliar K in HF but not in LF,and decreased foliar P in ECM plants but not in non-ECM ***,ECM plants exhibited a large enrichment in foliar P under WW and had a lower water potential under DR when grown in *** results indicate that the drought tolerance and health and vigor of Japanese larch seedlings can be modifi ed by soil fertility and soil *** study provides a basis for new multifactorial research programs aimed at producing seedlings of su

关键词： Drought Ectomycorrhizae Fertilizer eff ect Oxidative stress Stressor interactions

Ketone bodies and inflammation modulation:A mini-review on ketogenic diet’s potential mechanisms in mood disorders

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BIOCELL 2023年第8期47卷 1897-1906页

作者： YAN ZHENG SIHUI MA KATSUHIKO SUZUKI hisanori KATO HUIJUAN JIA College of Physical Education Jilin UniversityChangchun130012China China Japan Union Hospital Jilin UniversityChangchun130012China Health Nutrition Graduate School of Agricultural and Life SciencesThe University of Tokyo1130032Japan Faculty of Sport Sciences Waseda UniversityTokorozawa3591192Japan

Mental disorders such as depression and anxiety inflict significant burdens on individuals and *** prescribed treatments often involve cognitive therapy and ***,for patients resistant to these conventional methods,alternative therapies like the Ketogenic Diet(KD)offer a promising *** and its key metabolite,β-hydroxybutyrate(BHB),have been hypothesized to alleviate mental disorders through antiinflammatory actions,a crucial pathway in the pathophysiology of *** mini-review examines 15 clinical trials exploring the influence of KD and BHB on inflammation and their potential roles in managing mental *** human and animal studies were scrutinized to elucidate possible cellular and molecular *** of the 15 trials,10 reported reduced levels of at least one inflammatory mediator or mRNA post KD or BHB treatment,while two observed an elevation in anti-inflammatory *** findings suggest that KD and BHB could modulate cellular inflammatory pathways,highlighting their potential for therapeutic application in mental disorders.

关键词： Ketone body Ketogenic diet Depression Anxiety Neuroinflammation

Gorenstein Q-homology projective planes

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Science China Mathematics 2015年第3期58卷 501-512页

作者： HWANG DongSeon KEUM JongHae OHASHI hisanori Department of Mathematics Ajou University School of Mathematics Korea Institute For Advanced Study Department of Mathematics Faculty of Science and Technology Tokyo University of Science

We present the complete list of all singularity types on Gorenstein Q-homology projective planes,i.e.,normal projective surfaces of second Betti number one with at worst rational double *** list consists of 58 possibl... 详细信息

关键词：投影机同源奇异性类型

Temperature-induced hormesis in plants

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Journal of Forestry Research 2019年第1期30卷 13-20页

作者： Evgenios Agathokleous Mitsutoshi Kitao hisanori Harayama Edward J.Calabrese Hokkaido Research Center Forestry and Forest Products Research Institute (FFPRI) Forest Research and Management Organization Research Faculty of Agriculture Hokkaido University Department of Environmental Health Sciences Morrill IN344 University of Massachusetts

Environmental change attracts particular attention by biologists concerned with the performance of biological systems under stress. To investigate these, dose–response relationships should be clarified. It was previously assumed that the fundamental nature of biological dose–responses follows a linear model, either with no threshold or with a threshold below which no effects are expected to occur in biological endpoints. However, substantial literature, including widespread documentation in plants, has revealed that hormesis commonly occurs. Hormesis is highly generalized and can be utilized as a quantitative measure of biological plasticity. Conditioning induced by adaptive responses also occurs in the framework of hormesis and is of particular importance to environmental change biology with regards to evolutionary *** paper presents additional evidence for hormetic dose responses induced by temperature in plants. The current understanding on hormesis provides a perspective for next generation environmental change research. Hormesis should have a central role in environmental change biology of vegetation.

关键词： Adaptive response Biological plasticity Dose response Hormesis Stress biology

Synthesis and TEM structural characterization of C60-flattened carbon nanotube nanopeapods

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Nano Research 2014年第12期7卷 1843-1848页

作者： Qing Wang Ryo Kitaura Yuta Yamamoto Shigeo Arai hisanori Shinohara Department of Chemistry & Institute for Advanced Research Nagoya University Nagoya 464-8602 Japan High Voltage Electron Microscope Laboratory Ecotopia Science Institute Nagoya University Nagoya 464-8602 Japan

充分弄平的碳 nanotube (FNT ) ， graphene nanoribbon (GNR ) 类似物，为做的 endohedral 在边提供一个空空格。由于 FNT 的空空间的唯一的形状，原子和分子的低维的安排的新奇类型能通过做进 FNT 的 endohedral 被获得，它提供 nanop... 详细信息

充分弄平的碳 nanotube (FNT ) ， graphene nanoribbon (GNR ) 类似物，为做的 endohedral 在边提供一个空空格。由于 FNT 的空空间的唯一的形状，原子和分子的低维的安排的新奇类型能通过做进 FNT 的 endohedral 被获得，它提供 nanopeapods 的一种新类型。基于 FNT 的 nanopeapods 通过 C 做的 endohedral 被综合了有传播电子显微镜学(TEM ) 的 60 , 和他们的结构的描述表现了。做 C 直到 FNT 的内部空空间的 60 经由煤气阶段的充满方法被执行了，在无限制的 FNT 在玻璃 ampoule 被封上并且在 723773 K 加热了二天的地方。TEM 观察显示出包含的 C 的那个大多数 60 个分子沿着 FNT 的边和 C 的那一些排列同样单个的分子的链 60 在 FNT 内形成二维的拥挤不堪的结构。

关键词： TEM观察碳纳米管结构表征 C60 扁平化豆荚合成透射电子显微镜

Rayleigh scattering studies on inter-layer interactions in structure-defined individual double-wall carbon nanotubes

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Nano Research 2014年第10期7卷 1548-1555页

作者： Sihan Zhao Tomoya Kitagawa Yuhei Miyauchi Kazunari Matsuda hisanori Shinohara Ryo Kitaura Department of Chemistry & Institute forAdvanced Research Nagoya University Nagoya 464-8502 Japan Institute of Advanced Energy Kyoto University Uji Kyoto 511-0011 Japan Japan Science and Technology Agency PRESTO Saitama 332-0012 Japan

尽管在分层的材料联合的夹层在决定二维的系统的物理性质由于它的重要性吸引了可观的兴趣，在一个维的系统联合的夹层上的研究到目前为止是有限的。双墙碳 nanotubes (DWCNT ) 是最基本、理想的模型系统之一学习在一个维的系统联合的夹... 详细信息

尽管在分层的材料联合的夹层在决定二维的系统的物理性质由于它的重要性吸引了可观的兴趣，在一个维的系统联合的夹层上的研究到目前为止是有限的。双墙碳 nanotubes (DWCNT ) 是最基本、理想的模型系统之一学习在一个维的系统联合的夹层。在这个工作，散布光谱学和传播电子显微镜学的瑞利被用来描绘电子转变在之间内部 -- 并且确切一样的单个 DWCNT 的 outer-nanotubes。我们发现联合的夹层是强壮的，导致在大多数与孤立的 CNT 相比的光转变精力(多达 0.2 eV ) 的换至较低排挡。我们也发现金属性的试管的存在导致更强壮的移动。库仑相互作用屏蔽的夹层是在解释观察结果的关键因素之一。

关键词：单壁碳纳米管库仑相互作用层间耦合瑞利散射结构定义透射电子显微镜双壁碳纳米管一维系统

Length-Sorted Semiconducting Carbon Nanotubes for High-Mobility Thin Film Transistors

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Nano Research 2011年第10期4卷 963-970页

作者： Yasumitsu Miyata Kazunari Shiozawa Yuki Asada Yutaka Ohno Ryo Kitaura Takashi Mizutani hisanori Shinohara Department of Chemistry and Institute for Advanced Research Nagoya University Nagoya 464-8602 Japan Department of Quantum Engineering Nagoya University Nagoya 464-8603 Japan

我们为 solution-processable 为碳 nanotubes 的化学纯化开发了一个过程有高活动性的薄电影的晶体管(TFT ) 。简单落下涂层制作的净化的碳 nanotubes 的电影象 164 cm2V1s1， 0.78 Sm1 的规范的跨导，和开／关电流一样高显示出搬运人... 详细信息

我们为 solution-processable 为碳 nanotubes 的化学纯化开发了一个过程有高活动性的薄电影的晶体管(TFT ) 。简单落下涂层制作的净化的碳 nanotubes 的电影象 164 cm2V1s1， 0.78 Sm1 的规范的跨导，和开／关电流一样高显示出搬运人活动性 106 的比率。如此的高效要求测微计长、高度净化的半导体的围单人赛的碳 nanotubes (SWCNT ) 的暂停的准备。我们的纯化过程包括长度并且用与表面活化剂的混合物再循环胶化过滤的 SWCNT 的电子类型的选择套住。结果提供一个重要里程碑向与 roll-to-roll 和墨水喷气设备制造打印了高速度、大区域的电子学。

关键词：半导体碳纳米管薄膜晶体管高流动性长度单壁碳纳米管排序载流子迁移率 SWCNTs

Regularities in the E. coli promoters composition in connection with the DNA strands interaction and promoter activity

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第12期7卷 969-973页

作者： BEREZHNOY Andrey Yu SHCKORBATOV Yuriy G. hisanori Kiryu National Scientific Center Kharkov Physical-Technical Institute Kharkov 61108 Ukraine Institute of Biology Kharkov National University Maidan Svobody 4 Kharkov 61077 Ukraine Computational Biology Research Center National Institute of Advanced Industrial Science and Technology Koto-ku Tokyo 135-0064 Japan)

The energy of interaction between DNA strands in promoters is of great functional importance. Visualization of the energy of DNA strands distribution in promoter sequences was achieved. The separation of promoters in groups by their energetic properties enables evaluation of the dependence of promoter strength on the energetic properties. The analysis of groups (clusters) of promoters distributed by the energy of DNA strands interaction in ?55, ?35, ?10 and +6 sequences indicates their connection with the transcriptional activity.

关键词： DNA序列启动强度 DNA链交互能量 DNA序列分类