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Randomized controlled trial of pancreatic stenting to prevent pancreatitis after endoscopic retrograde cholangiopancreatography

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World Journal of Gastroenterology 2012年第14期18卷 1635-1641页

作者： Yoshiaki Kawaguchi Masami Ogawa Fumio Omata hiroyuki ito Tooru Shimosegawa Tetsuya Mine Division of Gastroenterology Tokai University School of MedicineIsehara 259-1193Japan Division of Gastroenterology Tohoku University Graduate School of Medicine1-1 Seiryo-machiAobakuSendai CityMiyagi 980-8574Japan

AIM:To determine the effectiveness of pancreatic duct(PD) stent placement for the prevention of pancreatitis after endoscopic retrograde cholangiopancreatography(ERCP) in high risk ***:Authors conducted a single-blind,randomized controlled trial to evaluate the effectiveness of a pancreatic spontaneous dislodgement stent against post-ERCP pancreatitis,including rates of spontaneous dislodgement and *** defined high risk patients as having any of the following:sphincter of Oddi dysfunction,difficult cannulation,prior history of post-ERCP pancreatitis,pre-cut sphincterotomy,pancreatic ductal biopsy,pancreatic sphincterotomy,intraductal ultrasonography,or a procedure time of more than 30 *** were randomized to a stent group(n = 60) or to a non-stent group(n = 60).An abdominal radiograph was obtained daily to assessspontaneous stent ***-ERCP pancreatitis was diagnosed according to consensus ***:The mean age(± standard deviation) was 67.4 ± 13.8 years and the male:female ratio was 68:*** the stent group,the mean age was 66 ± 13 years and the male:female ratio was 33:27,and in the non-stent group,the mean age was 68 ± 14 years and the male:female ratio was 35:*** were no significant differences between groups with respect to age,gender,final diagnosis,or type of endoscopic *** frequency of post-ERCP pancreatitis in PD stent and non-stent groups was 1.7%(1/60) and 13.3%(8/60),*** severity of pancreatitis was mild in all *** frequency of post-ERCP pancreatitis in the stent group was significantly lower than in the non-stent group(P = 0.032,Fisher's exact test).The rate of hyperamylasemia were 30%(18/60) and 38.3%(23 of 60) in the stent and non-stent groups,respectively(P = 0.05,χ2 test).The placement of a PD stent was successful in all 60 *** rate of spontaneous dislodgement by the third day was 96.7%(58/60),and the median(range) time to dislodgement was 2.1(2-

关键词： Endoscopic retrograde cholangiopancreatography Pancreatitis Postoperative complications Prophylaxis Stents

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Amenorrhea as a rare drug-related adverse event associated with everolimus for pancreatic neuroendocrine tumors

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World Journal of Gastroenterology 2014年第42期20卷 15920-15924页

作者： Yoshiaki Kawaguchi Atsuko Maruno Yohei Kawashima hiroyuki ito Masami Ogawa Tetsuya Mine Department of Gastroenterology Tokai University School of Medicine

The patient was an asymptomatic 43-year-old woman. Abdominal ultrasonography and enhanced computed tomography showed a tumor lesion accompanied by multiple cystic changes in the liver and the pancreatic tail. Endoscopic ultrasound-fine needle aspiration was performed on the pancreatic tumor lesion and revealed pancreatic neuroendocrine tumor(PNET). As it was unresectable due to multiple liver metastases, the decision was made to initiate treatment with everolimus and transcatheter arterial chemoembolization. The patient ceased menstruating after the start of everolimus administration. When the administration was discontinued due to interstitial lung disease, menstruation resumed, but then again stopped with everolimus resumption. An association between everolimus and amenorrhea was highly suspected. Amenorrhea occurred as a rare adverse event of everolimus. As the younger women might be included in PNETs patients, we should put this adverse event into consideration.

关键词： Amenorrhea Everolimus Neuroendocrine tumor Pancreas Adverse event

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Risk factors for proximal migration of biliary tube stents

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World Journal of Gastroenterology 2014年第5期20卷 1318-1324页

作者： Yoshiaki Kawaguchi Masami Ogawa Yohei Kawashima Hajime Mizukami Atsuko Maruno hiroyuki ito Tetsuya Mine Department of Gastroenterology Tokai University School of Medicine

AIM: To analyze the risk factors for biliary stent migration in patients with benign and malignant strictures.

关键词： Migration Endoscopic biliary stent Risk factor Endoscopic retrograde cholangiopancreatography Retrieval

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Small serotonin-positive pancreatic endocrine tumors caused obstruction of the main pancreatic duct

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World Journal of Gastroenterology 2012年第45期18卷 6669-6673页

作者： Masami Ogawa Yoshiaki Kawaguchi Atsuko Maruno hiroyuki ito Toshio Nakagohri Kenichi Hirabayashi Hiroshi Yamamuro Tomohiro Yamashita Tetsuya Mine Department of Gastroenterology Tokai University School of Medicine143 ShimokasuyaIsehara 259-1193Japan Department of Gastroenterological Surgery Tokai University School of Medicine143 ShimokasuyaIsehara 259-1193Japan Department of Pathology Tokai University School of Medicine143 ShimokasuyaIsehara 259-1193Japan Department of Radiology Tokai University School of Medicine143 ShimokasuyaIsehara 259-1193Japan

We report 2 cases of pancreatic endocrine tumors that caused obstruction of the main pancreatic duct(MPD).A 49-year-old asymptomatic man was referred to our institution because dilation of the MPD was revealed by abdominal ultrasonography(US).No tumor was detected by endoscopic ultrasonography,computed tomography(CT),and magnetic resonance imaging(MRI).The diameter of the MPD was > 20 mm at the body,and no dilation was noted at the *** malignancy was not confirmed through cytology or imaging,pancreatic cancer was strongly ***-denectomy was *** and immunohistochemical examination revealed a 5 mm × 3 mm serotonin-positive endocrine *** was present around the MPD and seemed to cause stricture.A 32-year-old asymptomatic man had elevated serum amylase,and US demonstrated dilation of the *** tumor was detected by CT and *** cancer was suspected due to stricture and dilation of the *** of middle part of pancreas was *** and immunohistochemical examination revealed a serotonin-positive endocrine tumor sized 5 mm × 4 *** report 2 cases of serotonin-positive pancreatic endocrine tumors that caused stricture of the MPD in spite of the small size of the tumor.

关键词： Serotonin Pancreatic endocrine tumor Main pancreatic duct Obstruction Dilatation

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Direct-acting antivirals for hepatitis C virus-infected patients with hepatocellular carcinoma

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World Journal of Hepatology 2022年第6期14卷 1190-1199页

作者： Kazuto Tajiri hiroyuki ito Kengo Kawai Yoshiro Kashii Yuka Hayashi Aiko Murayama Masami Minemura Terumi Takahara Yukihiro Shimizu Ichiro Yasuda Department of Gastroenterology Toyama University HospitalToyama 930-0194Japan Department of Gastroenterology Takaoka Municipal HospitalTakaoka 933-8550Japan Gastroenterology Center Nanto Municipal HospitalNanto 932-0211Japan Department of Gastroenterology Saiseikai Toyama HospitalToyama 931-8533Japan

BACKGROUND Hepatocellular carcinoma(HCC)in hepatitis C virus(HCV)-infected patients has a high risk of *** eradication of HCV is expected to reduce this risk,the risk in patients with a history of HCC may be high after treatment with direct-acting antivirals(DAAs).AIM To determine the risk factors for HCC recurrence in patients with HCV and a history of *** The risk of HCC recurrence in patients with a history of HCC and/or of HCC occurrence in patients without a history of HCC after DAA therapy was retrospectively analyzed in 311 HCV patients treated at our institution and several neighboring *** frequency and predictors of HCC recurrence/occurrence after DAA treatment were included in these *** clinical course of HCC before and after DAA treatment was also *** HCV patients with a history of HCC were older and had greater progression of liver fibrosis and diabetes than patients without a history of *** recurrence-free survival(RFS)was 1092 d in patients with a history of HCC,and post-DAA HCC recurrence/occurrence was observed in 29 patients(53.7%)with and 5(1.9%)without a history of HCC over 6 years(P<0.001).RFS in patients with a history of HCC did not differ significantly before and after DAA *** frequency of HCC recurrence/occurrence in patients with a history of HCC was lower after than before DAA *** analysis showed that the incidence rate of HCC recurrence/occurrence before DAA treatment was the only independent predictor of HCC recurrence/occurrence after DAA *** function was well preserved and clinical course was good in patients with HCC recurrence/occurrence after DAA *** DAA therapy in patients infected with HCV is also effective in patients with a history of *** treatment for HCC is desirable before DAA *** frequency of HCC recurrence/occurrence before DAA therapy was associated with a significantly increased risk of H

关键词： Direct-acting antivirals Hepatitis C virus Hepatocellular carcinoma Recurrence Liver fibrosis Curative treatment

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Tubulointerstitial Nephritis Complicated with Primary Sjogren’s Syndrome under Treatment for Type 2 Diabetes Mellitus

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Open Journal of Nephrology 2012年第4期2卷 105-108页

作者： Shinichi Antoku hiroyuki ito Mizuo Mifune Hiroko Nawata Masahiro Kato Department of Diabetes Metabolism and Kidney DiseaseEdogawa HospitalTokyoJapan Department of Internal Medicine Edogawa HospitalTokyoJapan Department of Neurology Edogawa HospitalTokyoJapan

Tubulointerstitial nephritis complicated by primary Sj?gren’s syndrome in a patient under treatment for type 2 diabetes mellitus was diagnosed in the early stage of the disease by renal biopsy. The symptoms of primary Sj?gren’s syndrome, such as thirst and polydipsia, were masked by the characteristic symptoms of type 2 diabetes mellitus. An association between sicca symptoms and diabetes mellitus (types 1 and 2) has been previously reported. Hence, it is possible that there are common underlying immunological mechanisms between primary Sj?gren’s syndrome and diabetes mellitus of both types. Intervention with steroids in a timely manner appears to have prevented or slowed the progression of re- nal impairment.

关键词： Tubulointerstitial Nephritis Sjogren’s Syndrome Type 2 Diabetes Mellitus

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Long-Term Durability and Reactivation of Thermochemical Heat Storage Driven by the CaO/Ca(OH)<sub>2</sub>Reversible Reaction

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Journal of Materials Science and Chemical Engineering 2017年第11期5卷 23-32页

作者： Kazuki Kuwata Takehiro Esaki Daichi Iwase hiroyuki ito Shijie Li Xixian Yang Hongyu Huang Noriyuki Kobayashi Nagoya University Nagoya Japan Integrated Technology Center Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Guangzhou China

Thermochemical heat storage is a promising technology for improving thermal energy efficiency. To investigate the durability of the CaO/Ca(OH)2 reaction and develop a reactivation method, repetitive charging/discharging operation of a packed bed reactor with a thick packed bed was conducted, and variations in the discharging behavior, final conversion, and reactant activity were investigated. Owing to the formation of a deactivated sintered reactant block, the discharging time halved and the final conversion ratio decreased by the 53rd discharging operation. To enhance durability, a reactivation method using high-pressure vapor was implemented during the 54th discharging operation. Following reactivation, the final conversion increased 15%, and the discharging time tripled when compared with the discharging operation before reactivation, confirming the success of this simple reactivation method.

关键词： Thermochemical Heat Storage Durability Repetitive Reaction Reactivation CaO/Ca(OH)2 Reaction

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Environmentally Friendly Syntheses of Imines Applying the Pressure Reduction Technique: Reaction Cases of Less Reactive Amines and Studies by Computational Chemistry

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Green and Sustainable Chemistry 2020年第1期10卷 1-17页

作者： Shoko Suzuki hiroyuki ito Motoyoshi Noike Shinji Ishizuka Risehiro Nonaka Kenji Funaki Takeshi Kodama Shujiro Sakaki Tomomichi Nishino Mina ito Toranosuke Takahasi Yasuo Yokoyama Faculty of Education Kyoto University of Education Kyoto Japan Department of Chemical and Biological Engineering National Institute of Technology Akita College Akita Japan Institute of Natural Medicine University of Toyama Toyama Japan Department of Applied Chemistry National Institute of Technology Akita College Akita Japan

Recently, the development of environmentally friendly syntheses of imine derivatives, which were attracting great attention for their reactivity and structure in various fields, progressed rapidly because the concept of green chemistry had deeply penetrated into society. In our previous work, we had reported new synthetic methods of imine derivatives using some active amines under solvent- and catalyst-free reaction conditions. This synthetic reaction proceeded smoothly and target compounds were obtained in excellent yields. In this system, when less reactive amines were used as substrates, the synthetic reaction was not finished in the short reaction time, and the corresponding compounds were given in moderate yields. In order to solve this point, we tried to improve the reaction conditions of this method. Through this improvement, it was found that pure target compounds could be obtained in excellent yields by using 1.1 equivalents of less reactive amines to aldehydes and extending the reaction time compared with our previous work. In this paper, we will introduce the detail of this study, and also report the result of the investigation of the reaction property by computational chemistry.

关键词： Solvent-Free Catalyst-Free Pressure Reduction Technique Imine Computational Chemistry

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Parotid lymph node metastasis in a patient with tongue cancer

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Case Reports in Clinical Medicine 2014年第1期3卷 23-27页

作者： Kenji Yamagata Naomi Ishibashi Kanno hiroyuki ito Shogo Hasegawa Toru Yanagawa Kojiro Onizawa Hiroki Bukawa Department of Oral and Maxillofacial Surgery Faculty of Medi-cine University of Tsukuba Tsukuba Japan

Parotid lymph node (LN) metastasis occurs most commonly from cutaneous squamous cell carcinoma (CSCC) of the head and neck, but rarely from oral squamous cell carcinoma (OSCC). Here, we present a rare case of metastasis to the parotid LN in a patient with tongue cancer. Although usual extent of modified radical neck dissection that includes resection of the tail of the parotid gland is below the line of the mandibular angle and the mastoid process was performed, the parotid LN metastasis occurred. The patient was treated with partial parotidectomy and chemoradiotherapy. One year and two months later, there was no evidence of local recurrence, although multiple lung metastases were observed. We also review the literature on parotid LN metastasis from OSCC.

关键词： Oral Squamous Cell Carcinoma (OSCC) Parotid Lymph Node Metastases Tongue Cancer

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Reduced endogenous insulin secretion in diabetic patients with low-titer positive antibodies against GAD

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Journal of Diabetes Mellitus 2012年第1期2卷 96-100页

作者： Yuichiro Takeuchi hiroyuki ito Koshiro Oshikiri Shinichi Antoku Mariko Abe Mizuo Mifune Michiko Togane Masahiro Kato Department of Diabetes Metabolism and Kidney Disease Edogawa Hospital Tokyo Japan

Aim: To investigate the clinical characteristics of diabetic patients with a low-titer positive for the anti-glutamic acid decarboxylase 65 antibody (GAD antibody). Methods: The subjects were 420 diabetic inpatients. The endogenous insulin secretion was estimated on the basis of the C-peptide immunoreactivity from a 24 h urine collection (uCPR). Clinical variables were compared between patients negative for the GAD antibody (GAD antibody titer < 1.5 U/mL), a low-titer positive GAD antibody (1.5 U/mL ≤ GAD antibody titer < 10 U/mL) and a high-titer positive GAD antibody (10 U/mL ≤ GAD antibody titer). Results: The low and high-titer positive GAD antibodies were found in 25 and 10 patients, respectively. The uCPR was significantly lower in both the patients with a low (37 ± 33 ug/24h) and high-titer (39 ± 27 ug/24h) positive GAD antibodies than in those negative for GAD antibodies (71 ± 52 ug/24h). The uCPR level was significantly lower in the low-titer positive GAD antibody group (29 ± 22 ug/24h) than in the negative group (67 ± 55 ug/24h) among the patients not taking insulin secretagogues. The difference disappeared in the subjects taking insulin secreagogues. In the stepwise multiple regression analysis, a low-titer positive GAD antibody was independently associated with the uCPR level. Conclusions: Endogenous insulin secretion is reduced in diabetic patients positive for GAD antibodies, even if the titer is low. Earlier initiation of insulin therapy might therefore protect the pancreatic β-cell function in diabetic patients with a low-titer positive GAD antibody.

关键词： GAD Antibody Endogenous Insulin Secretion Urinary C-Peptide SPIDDM LADA

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