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Clinicopathological characteristics of human epidermal growth factor receptor 2-positive Barrett's adenocarcinoma

World Journal of Gastroenterology 2012年第43期18卷 6263-6268页

作者： Takehiro Tanaka Atsushi Fujimura Koichi Ichimura hiroyuki yanai Yasuharu Sato Katsuyohi Takata hiroyuki Okada Seiji Kawano Shunsuke Tanabe Tadashi Yoshino Department of Pathology Okayama University Hospital Okayama 700-8558 Japan Department of Physiology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 700-8558 Japan Department of Pathology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 700-8558 Japan Department of Endoscopy Okayama University Hospital Okayama 700-8558 Japan Department of Gastroenterological Surgery Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 700-8558 Japan

AIM:To compare the clinicopathological characteristics of human epidermal growth factor receptor 2 (HER2)-positive and HER2-negative Barrett's adenocarcinoma in Japan. METHODS:We performed immunohistochemical analysis of HER2 in 30 samples taken from patients with Barrett's adenocarcinoma and dual color in situ hybridization in cases showing 2+ reactions. We compared the clinicopathological characteristics of HER2-positive and HER2-negative ***:HER2 positivity was identified in 8 (27%) carcinoma samples. We found that HER2 expression was associated with p53 overexpression (100% vs 52.6% in pT1 tumor; 100% vs 54.5% in all stage tumor, P < 0.05) and protruding lesions at the early disease stage. There was no association between the mucin phenotype of the carcinomas and prognosis. HER2 expression and low clinical stage were unexpectedly different between Barrett's adenocarcinoma patients and gastric cancer patients, but the macroscopic features may be associated with earlier diagnosis in these patients. CONCLUSION:Our results suggest that HER2-positive Barrett's adenocarcinomas are associated with p53 overexpression and lesion protrusion at the early disease stage.

关键词： Barrett's adenocarcinoma Human epidermal growth factor receptor 2 p53 Mucin phenotype

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Mechanism of gastrointestinal abnormal motor activity induced by cisplatin in conscious dogs

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World Journal of Gastroenterology 2014年第42期20卷 15691-15702页

作者： hiroyuki Ando Erito Mochiki Tetsuro Ohno Mitsuhiro yanai Yoshitaka Toyomasu Kyoichi Ogata Yuichi Tabe Ryuusuke Aihara Toshihiro Nakabayashi Takayuki Asao hiroyuki Kuwano Department of General Surgical Science Gunma University Graduate School of Medicine

AIM: To investigate whether 5-hydroxytryptamine (serotonin; 5-HT) is involved in mediating abnormal motor activity in dogs after cisplatin administration.

关键词： Cisplatin Emesis 5-hydroxytryptamine Abnormal motor activity Dog

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Application of EXSRF and artificaial neural networks to provenance studies of the archaeological pottery sherds during Neolithic Age in Gansu Province,China

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兰州大学学报（自然科学版） 2003年第1期39卷 47-53页

作者： MAQing-lin LEUNGPo-lau yanai-xia HUZhi-de CollegeofChemistryandChemicalEngineering LanzhouUniversityLanzhou730000China DepartmentofPhysicsandMaterialsScience CityUniversityofHongKongKowlooHongKong

EDXRF spectromerty was applied to provenance studies of Neolitic Age(from 6000 BCto 2000 BC)pottery sherds excavated from Gansu Province in north-west China。Major and trace components analysis of te pottery specimen was carried out,and the artificial neural networks has been used to classift the trace com-ponent of these pottery。The results shown that pottery exchange had been existed during 3000 BC in ancient Gansu Province,China。

关键词：新石器时代陶片分类研究甘肃能量色散x荧光光谱人工神经网络产地分析

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Sitagliptin in treatment of diabetes complicated by chronic hepatitis C

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Hepatobiliary & Pancreatic Diseases International 2010年第4期9卷 442-443页

作者： yanai H Department of Internal Medicine Kohnodai Hospital National Center for Global Health and Medicine

To the Editor: A high prevalence of glucose intolerance in patients with chronic hepatitis C has been reported, [1] and there is a significant association of chronic hepatitis C with diabetes mellitus (DM). [2] But DM... 详细信息

关键词： DPP Sitagliptin in treatment of diabetes complicated by chronic hepatitis C

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Influence of low dietary histamine on the seizure development of chemical kindling induced by pentylenetetrazol in rats

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Acta Pharmacologica Sinica 2005年第4期26卷 423-427页

作者： Eiko SAKURAI Yoshinobu KISO Kazuhiko yanai Department of Pharmacology Tohoku University School of Medicine Sendai 980-8575 Japan Department of Pharmacology School of Medicine Zhejiang University Hangzhou 310031 China Department of Pharmacologv School of Medicine Zhejiang University Hangzhou 310031 China Department of Pharmacology Tohoku University School of Medicine Sendai 980-8575 Japan

Aim:To determine the role of dietary low histamine on the seizure development ofpentylenetetrazol (PTZ)-induced kindling in ***:After 14 d of feedingon a low histamine diet (LH,containing 0.145 μmol/g of histamine),the rats werechemically kindled by repeated intraperitoneal injection of a subconvulsant doseof PTZ (35 mg/kg) once every 48 h,and seizure activity of kindling was recordedfor 30 *** in brain samples was analyzed using a high performanceliquid chromatography system with a fluorescence ***:The LH diet induced an increase in seizure response (seizure susceptibility) to thefirst trial of PTZ,and resulted in facilitation of subsequent PTZ kindling process(seizure development).The histamine levels in the cortex,hippocampus,andhypothalamus of LH-treated rats decreased significantly and these changes cor-related well with seizure behavior (r=0.875,0.651,and 0.796,respectively).In addition,chronic kindled seizures resulted in a significant increase of the histamine contentin the cortex and hypothalamus in the LH-fed ***:These find-ings indicate that the histamine in daily food could influence the brain histaminer-gic function,and play an important role in regulating seizure susceptibility.

关键词： seizures pentylenetetrazol brain histamine diet

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Distributed and Parallel Component Library

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Wuhan University Journal of Natural Sciences 2005年第2期10卷 375-379页

作者： XUZheng-quan XUYang yanai-ping CollegeofComputerScienceandTechnology HuazhongUniversityofScienceandTechnologyWuhan430074HubeiChina

Software component library is the essential part of reuse-based softwaredevelopment. It is shown that making use of a single component library to store all kinds ofcomponents and from which components are searched is very inefficient. We construct multi-librariesto support software reuse and use PVM as development environments to imitate large-scale computer,which is expected to fulfill distributed storage and parallel search of components efficiently andimprove software reuse.

关键词： software reuse component library parallel virtual machine distributedstorage parallel search

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Nuclear heat shock protein 110 expression is associated with poor prognosis and hyperthermo-chemotherapy resistance in gastric cancer patients with peritoneal metastasis

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World Journal of Gastroenterology 2017年第42期23卷 7541-7550页

作者： Akiharu Kimura Kyoichi Ogata Bolag Altan Takehiko Yokobori Erito Mochiki Mitsuhiro yanai Norimichi Kogure Toru Yanoma Masaki Suzuki Tuya Bai hiroyuki Kuwano Department of General Surgical Science Gunma University Graduate School of Medicine Department of Oncology Clinical Development Gunma University Graduate School of Medicine Department of Molecular Pharmacology and Oncology Gunma University Graduate School of Medicine Department of Digestive Tract and General Surgery Saitama Medical CenterSaitama Medical University

AIM To investigate the significance of heat shock protein 110(HSP110) in gastric cancer(GC) patients with peritoneal metastasis undergoing *** Primary GC patients(n = 14) with peritoneal metastasis or positive peritoneal lavage cytology who underwent distal or total gastrectomy between April 2000 and December 2011 were enrolled in this study. The patients underwent postoperative intraperitoneal hyperthermo-chemotherapy using a Thermotron RF-8 heating device two weeks after surgery. We analyzed nuclear HSP110 expression in surgically resected tumors using immunohistochemistry. Additionally, the effect of HSP110 suppression on hyptherthermochemosensitivity was assessed in vitro in the MKN45 GC cell line using the HSP inhibitor KNK437. RESULTS HSP110 immnohistochemical staining in 14 GC patients showed that five(35.7%) samples belonged to the low expression group, and nine(64.3%) samples belonged to the high expression group. Progression-free survival was significantly shorter in the HSP110 high-expression group than in the low-expression group(P = 0.0313). However, no significant relationships were identified between HSP110 expression and the clinicopathological characteristics of patients. Furthermore, high HSP110 expression was not an independent prognostic factor in GC patients with peritoneal metastasis(P = 0.0625). HSP110 expression in MKN45 cells was suppressed by KNK437 at the hyperthermic temperature of 43 ℃ in vitro. Comparison of MKN45 cell proliferation in the presence and absence of KNK437 at 43 ℃, revealed that proliferation was significantly decreased when HSP110 was inhibited by KNK437. Additionally, HSP110 suppression via HSP inhibitor treatment increased cellular sensitivity to hyperthermo-chemotherapy in *** The expression of nuclear HSP110 in GC patients might be a new marker of chemosensitivity and a therapeutic target for patients who are tolerant to existing hyperthermo-chemotherapies.

关键词： Peritoneal metastasis Hyperthermia Hyperthermo-chemotherapy Heat shock protein 110 Gastric cancer Drug resistance

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法治与引领:第七次全国县级以上公共图书馆评估定级回望与思考

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四川图书馆学报 2024年第2期 10-18页

作者：王洁陶丽霞袁珍珍杜艳爱南开大学商学院天津300071 长治医学院健康管理系山西长治046013

文章立足《中华人民共和国公共图书馆法》和高质量、专业化强引领的新环境,从评估标准研制、评估宣讲培训、正式评估工作、评估工作总结的评估全流程出发,对第七次评估工作进行了回望与反思,总结了此次评估工作所取得的成就,肯定了评估... 详细信息

文章立足《中华人民共和国公共图书馆法》和高质量、专业化强引领的新环境,从评估标准研制、评估宣讲培训、正式评估工作、评估工作总结的评估全流程出发,对第七次评估工作进行了回望与反思,总结了此次评估工作所取得的成就,肯定了评估工作在缩小图书馆事业区域发展差异、创新评估工作手段中发挥的作用,同时希望评估结果能够得到充分应用,评估工作可以不断创新,继续助力我国公共图书馆事业发展腾飞。

关键词：法治环境第七次评估公共图书馆图书馆评估评估思考

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Role of colonoscopy in patients with persistent acute diverticulitis

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World Journal of Gastroenterology 2008年第17期14卷 2763-2766页

作者： Adi Lahat Henit yanai Emad Sakhnini Yoram Menachem Simon Bar-Meir Department of Gastroenterology ChaimSheba Medical Center and Sackler School of Medicine Tel AvivUniversity

AIM： To identify patients with persistent acute diverticulitis who might benefit from an early colonoscopy during their first hospitalization. METHODS： All patients hospitalized between July 2000 and December 2006 for acute diverticulitis who underwent colonoscopy were included in the study. Patients were followed during hospitalization and after discharge. Patients were considered to have a persistent course of acute diverticulitis if symptoms continued after 1 wk of conventional treatment with 1V antibiotics, or if symptoms recurred within 2 mo after discharge. Patients were considered to benefit from an early colonoscopy if the colonoscopy was therapeutic or if it changed a patient＇s outcome. RESULTS： Three hundred and six patients were hospitalized between July 2000 and December 2006 with the diagnosis of acute diverticulitis. Two hundred and twenty four of these were included in the study group. Twenty three patients （10.3%） fulfilled the criteria for a persistent course of acute diverticulitis. Of them, four patients （17.4%） clearly benefited from an early colonoscopy; these patients＇ clinical course is described. None of the patients with a regular non-persistent course demonstrated any benefit from colonoscopy. CONCLUSION： Early colonoscopy detected other significant pathology, which accounted for the clinical presentation in 17% of patients with persistent acute diverticulitis. Therefore, we believe an early colonoscopy should be considered in all patients with a persistent clinical course.

关键词： Persistent acute diverticulitis Early colonoscopy Clinical course

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集成电路虚拟仿真实验教学平台的设计

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集成电路应用 2024年第7期41卷 54-57页

作者：朱俊樊国梁王延来李天天内蒙古大学物理科学与技术学院内蒙古010021

阐述针对集成电路实践课程教学中的问题及原因,从选题内容、层次设计、平台建设和学生考核方面,提出集成电路虚拟仿真实验教学平台建设的实施细则。并注重集成电路设计环节,引入翻转课堂模式,与工程实训进行虚实互补,借助马赛克成绩分... 详细信息

阐述针对集成电路实践课程教学中的问题及原因,从选题内容、层次设计、平台建设和学生考核方面,提出集成电路虚拟仿真实验教学平台建设的实施细则。并注重集成电路设计环节,引入翻转课堂模式,与工程实训进行虚实互补,借助马赛克成绩分布图考察学习过程和实验细节,深化集成电路相关实践课程的教学改革。

关键词：集成电路虚拟仿真实验教学平台

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