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Macrophage colony-stimulating factor expressed in non-cancer tissues provides predictive powers for recurrence in hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第39期22卷 8779-8789页

作者： Hiroshi Kono Hideki Fujii Shinji Furuya Michio Hara Kazuyoshi Hirayama Yoshihiro Akazawa Yuuki Nakata Masato tsuchiya Naohiro Hosomura Chao Sun First Department of Surgery Faculty of Medicine University of Yamanashi

AIM To investigate the role of macrophage colony-stimulating factor(M-CSF) in patients with hepatocellular carcinoma(HCC) after surgery. METHODS Expression of M-CSF, distribution of M2 macrophages(Mφs), and angiogenesis were assessed in the liver, including tumors and peritumoral liver tissues. The prognostic power of these factors was assessed. Mouse isolated hepatic Mφs or monocytes were cultured with media containing M-CSF. The concentration of vascular endothelial growth factor(VEGF) in media was assessed. Furthermore, the role of the M-CSF-matured hepatic Mφs on proliferation of the vascular endothelial cell(VEC) was investigated. RESULTS A strong correlation between the expressions of M-CSF and CD163 was observed in the peritumoral area. Also, groups with high density of M-CSF, CD163 or CD31 showed a significantly shorter time to recurrence(TTR) than low density groups. Multivariate analysis revealedthe expression of M-CSF or hepatic M2Mφs in the peritumoral area as the most crucial factor responsible for shorter TTR. Moreover, the expression of M-CSF and hepatic M2Mφs in the peritumoral area had better predictable power of overall survival. Values of VEGF in culture media were significantly greater in the hepatic Mφs compared with the monocytes. Proliferation of the VEC was greatest in the cells co-cultured with hepatic Mφs when M-CSF was present in *** M-CSF increases hepatocarcinogenesis, most likely by enhancing an angiogenic factor derived from hepatic Mφ and could be a useful target for therapy against HCC.

关键词： M2 macrophage Vascular endothelial growth factor Vascular endothelial cell Monocyte Angiogenesis

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Validation of the Japan Coma Scale for the prediction of mortality in children:analysis of a nationwide trauma database

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World Journal of Pediatric Surgery 2022年第2期5卷 23-28页

作者： Yuki Enomoto Yusuke Tsutsumi Asuka tsuchiya Takahiro Kido Koji Ishigami Masahito Togo Susumu Yasuda Yoshiaki Inoue Department of Emergency and Critical Care Medicine University of TsukubaTsukubaIbarakiJapan Department of Emergency and Critical Care Medicine Mito Medical CenterMitoIbarakiJapan Department of Emergency and Critical Care Medicine Tokai University School of Medicine Graduate School of MedicineIseharaKanagawaJapan Department of Clinical Epidemiology and Health Economics The University of TokyoBunkyo-kuTokyoJapan Department of Pediatrics University of Tsukuba HospitalTsukubaIbarakiJapan

Objective The Japan Coma Scale(JCS)is widely used in clinical practice to evaluate levels of consciousness in *** have been several studies on the usefulness of JCS in ***,its usefulness in evaluating children has not been ***,this study aimed to assess the usefulness of the JCS for the prediction of mortality in *** This is a multicenter cohort study which used data from a national trauma registry(Japan Trauma Data Bank).This study included patients under 16 years of age who were treated between 2004 and *** primary outcome measure was in-hospital *** models were used to examine each item of the Glasgow Coma Scale(GCS)and the *** A included the discrete levels of each *** model B,data regarding age,sex,vital signs on arrival to hospital,the Injury Severity Score,and blunt trauma were added to each *** effectivity of the JCS score was then evaluated using the area under the curve(AUC)for discrimination,a calibration plot,and the Hosmer-Lemeshow test for *** A total of 9045 patients were *** AUCs of the GCS and JCS were 0.929(95%confidence interval(CI)0.904 to 0.954)and 0.930(95%CI 0.906 to 0.954)in model A and 0.975(95%CI 0.963 to 0.987)and 0.974(95%CI 0.963 to 0.985)in model B,*** results of the Hosmer-Lemeshow test were 0.00(p=1.00)and 0.00(p=1.00)in model A and 4.14(p=0.84)and 8.55(p=0.38)in model B for the GCS and JCS,*** We demonstrated that the JCS is as valid as the GCS for predicting *** findings of this study indicate that the JCS is a useful and relevant tool for pediatric trauma care and future research.

关键词： Glasgow prediction nationwide

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Characteristics of Anomalous Radio Propagation before and after the 2011 Tohoku-Oki Earthquake as Seen by Oblique Ionograms

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Open Journal of Earthquake Research 2020年第2期9卷 100-112页

作者： Kiyoshi Igarashi Toshio tsuchiya Ken Umeno Department of Applied Mathematics and Physics Graduate School of Informatics Kyoto University Kyoto Japan

The characteristics of anomalous radio propagation in the frequency 1 - 30 MHz before and after the 2011 Tohoku-Oki earthquake are firstly revealed by using oblique ionograms for the pass from Wakkanai to Kokubunji which is closest to the epicenter. An oblique ionogram with a wavy-shape-trace was observed at 06:30 UTC on 11 March 2011 after the 2011 Tohoku-Oki earthquake. The velocity of northward-propagating disturbance caused this wavy-shape-trace is estimated to be 130 m/s. This wave-shape-trace shows very clear signature appearing in the oblique ionograms as the characteristic of strong ionospheric disturbances triggered by the earthquake. An oblique ionogram with a steep slopy-shape-trace was observed at 04:45 UTC on 11 March 2011 one hour before the 2011 Tohoku-Oki earthquake. This slopy-shape-trace is investigated as the signatures of preseismic ionospheric anomaly. This anomalous oblique ionogram with a slopy-shape-trace is examined with the slope ratio of virtual height to sweep-frequency, and the difference between monthly median foF2 and hourly value foF2 at Wakkanai and Kokubunji. These features appearing in oblique ionograms suggest that it is useful for studying the signatures of preseismic ionospheric anomaly.

关键词： Ionospheric Disturbances Oblique Ionogram Anomalous Radio Propagation Atmospheric Gravity Waves

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High total Joule heat increases the risk of post-endoscopic submucosal dissection electrocoagulation syndrome after colorectal endoscopic submucosal dissection

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World Journal of Gastroenterology 2021年第38期27卷 6442-6452页

作者： Masanori Ochi Ryosuke Kawagoe Toshiro Kamoshida Yukako Hamano Haruka Ohkawara Atsushi Ohkawara Nobushige Kakinoki Yuji Yamaguchi Shinji Hirai Akinori Yanaka Kiichiro tsuchiya Department of Gastroenterology Hitachi General HospitalHitachi City 317-0077IbarakiJapan Department of Gastroenterology Faculty of MedicineUniversity of TsukubaTsukuba 305-8576IbarakiJapan

BACKGROUND We hypothesized that thermal damage accumulation during endoscopic submucosal dissection(ESD)causes the pathogenesis of post-ESD electrocoagulation syndrome(PECS).AIM To determine the association between Joule heat and the onset of *** We performed a retrospective cohort study in patients who underwent colorectal ESD from May 2013 to March 2021 in *** developed a novel device that measures swift coagulation time with a sensor adjacent to the electrosurgical coagulation unit foot switch,which enabled us to calculate total Joule *** was defined as localized abdominal pain(visual analogue scale≥30 mm during hospitalization or increased by≥20 mm from the baseline)and fever(temperature≥37.5 degrees or white blood cell count≥10000μ/L).Patients exposed to more or less than the median Joule heat value were assigned to the high and low Joule heat groups,*** analyses included Mann-Whitney U and chisquare tests and logistic regression and receiver operating characteristic curve(ROC)*** We evaluated 151 *** PECS incidence was 10.6%(16/151 cases),and all patients were followed conservatively and discharged without severe *** multivariate analysis,high Joule heat was an independent PECS risk *** area under the ROC curve showing the correlation between PECS and total Joule heat was high[0.788(95%confidence interval:0.666-0.909)].CONCLUSION Joule heat accumulation in the gastrointestinal wall is involved in the onset of ***-related thermal damage to the peeled mucosal surface is probably a major component of the mechanism underlying PECS.

关键词： Post-endoscopic submucosal dissection electrocoagulation syndrome Joule heat Colorectal endoscopic submucosal dissection Colorectal neoplasms Electrocoagulation Gastrointestinal tract

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Emotion Judgment Method Using a Clustered EEG Feature Knowledge Base

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通讯和计算机（中英文版） 2015年第2期12卷 67-72页

作者： Seiji tsuchiya Mayo Morimoto MisakoImono Hirokazu Watabe Dept. of Intelligent Information Engineering and Science Faculty of Science and Engineering Doshisha University Kyo-Tanabe Kyoto 610-0321 Japan Dept. of Information and Computer Science Graduate School of Engineering Doshisha University Kyo-Tanabe Kyoto 610-0321 Japan

For a robot to converse naturally with a human, it must be able to accurately gauge the emotional state of the person. Techniques for estimating emotions of a person from facial expressions, intonation and speech content have been proposed. This paper presents a technique for judging the emotion of a person using EEGs, differing from the data used to date. Accuracy of emotion judgment was 33.0%, which is still low, but we believe we obtained sufficient clues that will lead to improved accuracy, such as the validity of knowledge base clustering.

关键词：情绪状态知识库脑电图特征集群面部表情机器人准确率

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University physical education classes and the acquisition of life skills

University physical education classes and the acquisition of...

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2008奥林匹克科学大会

作者： Takayama,Masako Hironobu tsuchiya Gakuin University Osaka University of Health and Sport Sciences

Introduction The purpose of this study was two-fold:(1) to conduct an experiment on an inclusive education program at a university and to investigate Freshmen psychological adjustment to this program (Research 1):(2) to explore how to improve life skills in university physical education classes (Research 2). Methods The questionnaire consisted of a Life Skill scale,a Social Support scale and an Adjustment scale. Students made a log before and after every physical education class.

关键词： University physical education classes and the acquisition of life skills

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Adjuvant and Neoadjuvant therapy for lung cancer in Japan

Adjuvant and Neoadjuvant therapy for lung cancer in Japan

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2000全国肿瘤学术大会

作者： Hirohito Tada Ryosuke tsuchiya Osaka City General Hospital Japan National Cancer Center Osaka City General Hospital Japan National Cancer Center

＜正＞Even completely resected lung cancer frequently relapsed at distant metastatic *** are many reports about adjuvant and neoadjuvant chemotherapy,but efficacy of these treatment modalities is still questionable.1986-1989,we performed phase Ⅲ study of adjuvant chemotherapy *** alone for completely resected stage Ⅲ non small lung cancer（reported by Ohta）.Patients were randomly assigned to either post operative CDDP+VDS chemotherapy or

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Cu behaviors and effects of mine drainage in Kosaka River,Hokuroku mining district,Northeast Japan

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Transactions of Nonferrous Metals Society of China 2014年第6期24卷 1880-1889页

作者：鹿晴晴 Takuto KANETSUKI Shin-ichi YAMASAKI Ryoichi YAMADA Takahiro WATANABE Noriyoshi tsuchiya Graduate School of Environmental Studies Tohoku University

Focusing on the origin of the heavy metal,this study aims to build an imputed method to estimate the heavy metal content in river water by making a distinction between the heavy metal of natural origins and that caused by human *** by GIS,Kosaka watershed within the Hokuroku basin was divided into several sub-watershed polygons and the outflows of water and Cu were calculated for each *** with the natural origin,the dominant Cu emissions affected the river water more significantly in *** on the mass balance closure,the heavy metal content of Cu in the Kosaka River was estimated by the conflux accumulation of tributaries and mine *** estimated Cu concentrations were checked by comparing with the actually measured values at monitoring points along the Kosaka River and the results are coincidence with each other in *** is revealed that the mainstream water quality could be estimated by seizing the water quality of upstream tributaries and human drainages.

关键词： mine drainage river water heavy metal geographic information system(GIS) Kosaka watershed

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Stability analysis of state-delay systems based on the characterization of state-transition operator

Stability analysis of state-delay systems based on the chara...

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Joint 48th IEEE Conference on Decision and Control and 28th Chinese Control Conference

作者： Akira Kojima Taro tsuchiya Faculty of System Design Tokyo Metropolitan University

Stability conditions for state-delay systems are derived based on the norm of semigroup, which describes the transition of the internal state. Introducing an exact calculation method of the semigroup norm, the conditions for the internal stability and the marginal stability are characterized by nonsingularity of a transcendental function. The conditions depend on the existence of time interval such that the semigroup turns to a contraction map and enable us to approach the necessary and sufficient condition by extending the interval. The feature of proposed method is discussed with numerical examples.

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A durable complete response resulting from treatment with nivolumab plus ipilimumab for metastatic collecting duct carcinoma of the kidney

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Asian Journal of Urology 2023年第3期10卷 376-378页

作者： Keisuke Funajima Sei Naito Takanobu Kabasawa Hayato Nishida Tomoyuki Kato Mitsuru Futakuchi Norihiko tsuchiya Department of Urology Yamagata University Faculty of Medicine2-2-2 Iida-nishiYamagataJapan Department of Pathology Yamagata University Faculty of Medicine2-2-2 Iida-nishiYamagataJapan

Dear Editor,Collecting duct carcinoma(CDC)or Bellini carcinoma originates in the distal collecting *** is a markedly aggressive subtype of renal cell carcinoma and accounts for less than 1%of all renal cell carcinomas[1].We described a patient with CDC and psoriasis,who showed complete response(CR)after being treated with combination therapy of nivolumab and ipilimumab(NI).The study was conducted in accordance with and approved by the Ethics Committee of Yamagata University Faculty of Medicine(approval no.2019-35).The need for patient consent was waived by the same institutional review board;all the patients provided written informed consents.

关键词： markedly nivolumab approval

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