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Glycogen synthase kinase 3b biology in bone and soft tissue sarcomas

Journal of Cancer Metastasis and Treatment 2020年第1期6卷 660-674页

作者： Kensaku Abe Shingo Shimozaki Takahiro Domoto Norio Yamamoto hiroyuki tsuchiya Toshinari Minamoto Department of Orthopaedic Surgery Graduate School of Medical SciencesKanazawa UniversityKanazawa 920-8641Japan Division of Translational and Clinical Oncology Cancer Research InstituteKanazawa UniversityKanazawa 920-0934Japan Shimozaki Orthopaedic Hospital HakusanIshikawa 924-0802Japan

Bone and soft tissue sarcomas are malignant neoplasms probably originating from musculoskeletal and mesenchymal progenitor *** than 80 different histopathological subtypes are encountered in *** standard of care for sarcoma patients involves a multidisciplinary combination of surgery,anthracycline-based multiagent chemotherapy and ***,these are associated with adverse events and occasionally disappointing *** genomic-,biologically-,and immunologically-based therapies are still under evaluation in early-phase clinical ***,there are strong barriers to the development and clinical translation of new therapeutic *** is due to the rarity of these diseases,the broad spectrum of tumor subtypes with genetic and biological heterogeneity,and the wide variability in clinical manifestation,response to treatment and prognosis.A potential approach toward overcoming this barrier is to identify therapeutic targets that cover multiple sarcoma *** synthase kinase 3b(GSK3b)has emerged as a common therapeutic target in more than 25 different cancer *** we review the evidence for tumor-promoting roles of GSK3b in the major types of bone and soft tissue sarcomas including osteosarcoma,rhabdomyosarcoma,synovial sarcoma,and *** this review,we describe the therapeutic effects of inhibiting GSK3b in these sarcoma types,while also protecting healthy cells and tissues from detrimental effects associated with conventional therapies,such as doxorubicin-induced ***,we highlight GSK3b as a potential therapeutic target spanning multiple sarcoma types.

关键词： Osteosarcoma rhabdomyosarcoma synovial sarcoma fibrosarcoma glycogen synthase kinase 3b

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Long-term survival in a patient with Hutchinson-Gilford progeria syndrome and osteosarcoma:A case report

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World Journal of Clinical Cases 2021年第4期9卷 854-863页

作者： Katsuhiro Hayashi Norio Yamamoto Akihiko Takeuchi Shinji Miwa Kentaro Igarashi Yoshihiro Araki Hirotaka Yonezawa Sei Morinaga Yohei Asano hiroyuki tsuchiya Department of Orthopaedic Surgery Kanazawa UniversityKanazawa 9208641Japan

BACKGROUND Hutchinson-Gilford progeria syndrome(HGPS)is an extremely rare disease characterized by the rapid appearance of aging with an onset in *** cardiovascular complications can be life-threatening events for affected patients and the cause of early *** we report a HGPS patient with osteosarcoma hat was successfully managed and is alive 13 years after the *** is the first report describing the detailed surgical procedure and long-term follow-up of osteosarcoma in a patient with *** SUMMARY The patient was diagnosed with HGPS at 5 years of age with typical features and was referred to our department with a suspected bone tumor of the left proximal tibia at the age of *** biopsy of the tibial bone tumor revealed a conventional fibroblastic *** have developed and performed a freezing technique using liquid nitrogen for tumor *** technique overcame the small size of the tibia for megaprosthesis and avoided amputation and limb salvage was achieved 13 years *** the patient had a number of surgical site complications,such as wound dehiscence,and superficial and deep infections due to vulnerable skin in HGPS,no recurrence or metastases were detected for 13 years,and she walks assisted by *** general health was good at the latest follow-up at 31 years of *** A HGPS patient with osteosarcoma was successfully managed and she was alive 13 years after the diagnosis.

关键词： Hutchinson-Gilford progeria syndrome Osteosarcoma Frozen autograft Biological reconstruction Case report Thyroid cancer

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Dedifferentiated chondrosarcoma of the middle finger arising from a solitary enchondroma:A case report

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World Journal of Clinical Cases 2022年第10期10卷 3297-3305页

作者： Hirotaka Yonezawa Norio Yamamoto Katsuhiro Hayashi Akihiko Takeuchi Shinji Miwa Kentaro Igarashi Sei Morinaga Yohei Asano Shiro Saito Yasunori Tome Hiroko Ikeda Takayuki Nojima hiroyuki tsuchiya Department of Orthopaedic Surgery Graduate School of Medical SciencesKanazawa UniversityKanazawa 920-8641IshikawaJapan Department of Orthopedic Surgery Graduate School of MedicineUniversity of the RyukyusNishihara 903-0215OkinawaJapan Department of Diagnostic Pathology Kanazawa University HospitalKanazawa 920-8641IshikawaJapan

BACKGROUND Dedifferentiated chondrosarcoma(DDCS)accounts for 10%of all chondrosarcomas and has the poorest outcome,with a 5-year survival rate of 7%-25%.DDCS commonly occurs in the femur and pelvis,whereas DDCS of the finger is extremely ***,the histological findings of preexisting solitary enchondroma samples are important and valuable for diagnosing malignant *** SUMMARY We report our experience with DDCS in the proximal phalanx of the left middle finger of an 87-year-old *** had undergone surgery for enchondroma,with curettage and artificial bone grafting,11 years ago,in the same *** years after the primary surgery,the left middle finger gradually started to enlarge,and the growth speed increased in the past *** radiographs showed an expansive osteolytic lesion with calcifications and residual grafting *** to the suspicion of malignancy,we performed ray *** findings revealed an abrupt transition between the low-grade chondrosarcoma and dedifferentiated sarcoma *** dedifferentiated components showed the features of a high-grade undifferentiated pleomorphic *** patient was diagnosed with DDCS arising from a preexisting *** had no local recurrence or distant metastasis and died of pneumonia 6 years and 10 months after the second *** The histological findings of a precursor lesion showed a typical enchondroma,suggesting that DDCS can arise from enchondroma.

关键词： Dedifferentiated chondrosarcoma Enchondroma Finger Phalanx Ray amputation Case report

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The Accuracy of Initial Bone Cutting in Total Knee Arthroplasty

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Open Journal of Orthopedics 2015年第10期5卷 297-304页

作者： Takaaki Ohmori Toru Maeda Tamon Kabata Yoshitomo Kajino Shintaro Iwai hiroyuki tsuchiya Department of Orthopedic Surgery Graduate School of Medical Science Kanazawa University Kanazawa Japan Department of Orthopedic Surgery Kanazawa Red Cross Hospital Kanazawa Japan

Background: The aim of this study was to evaluate the accuracy of initial bone cutting of the distal femur and the proximal tibia in TKA using an image-free navigation system. Methods: From February 2006 to March 2013, we evaluated 60 knees in 50 patients using an image-free navigation system (Navigation: Stryker Navigation Cart System;Software: Stryker Knee Navigation;Ver2.0: Stryker Orthopaedics US NJ Mahwah). First, we measured the angle shown by the navigation system before cutting, at the time we set the jig. Second, we measured the angles shown by navigation after the bone was cut using the jig. Then, we compared these two angles for each patient to determine the bone cutting error. Results: In the distal femur, 37 of 60 knees were cut in an extended position in the sagittal plane, and 26 of 60 knees were cut in a varus in the coronal plane. In the proximal tibia, 29 of 60 knees were cut with decreased posterior slope in the sagittal plane, and 26 of 60 knees were cut in a valgus. Conclusions: In this study, the distal femur tended to be cut in an extended and a varus position and the proximal tibia did with decreased posterior slope and in a valgus position after initial bone cutting. It is necessary to note the initial cutting error in TKA. Since cutting errors affect postoperative outcome, we should cut bones several times. And as the reasons of the cause of the error, we propose new reason that cutting bone is not parallel with accuracy to AP axis.

关键词： Total Knee Arthroplasty Bone Cutting Errors Distal Femur Proximal Tibia Navigation

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Reconstruction Using a Free Vascularized Fibular Graft after Frozen Autograft Reconstruction for Osteosarcoma of the Distal Tibia: A Case Report

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Modern Plastic Surgery 2013年第1期3卷 47-50页

作者： Seigo Suganuma Kaoru Tada Norio Yamamoto Toshiharu Shirai Katsuhiro Hayashi Akihiko Takeuchi hiroyuki tsuchiya Department of Orthopaedic Surgery Graduate School of Medical Science Kanazawa University Kanazawa Japan

Recently we have been performing biological reconstruction for malignant bone tumors of the extremities using frozen autografts. Here we present a case treated with free vascularized fibular graft (FVFG) after this method. A 23-year-old man developed osteosarcoma in his left distal tibia. There was nonunion after frozen autograft reconstruction, which we treated with FVFG. Twenty-four months later, bridging between the host bone and the frozen autograft was achieved. Our department has achieved bone union in almost all cases, but we sometimes encounter cases of nonunion after this method because of delayed blood supply. In these instances, reconstruction using FVFG may represent an attractive choice for salvage treatment.

关键词： Free Vascularized Fibular Graft Frozen Autograft Reconstruction Malignant Bone Tumor

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FN1基因表达与人纤维肉瘤肺转移的相关性

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中华肿瘤杂志 2007年第1期29卷 14-16页

作者：龚明上田善道金泽芳光土屋弘行马一盖中日友好医院血液科北京100029 日本金泽医科大学病理病态学

目的研究纤维连接蛋白1（FN1）基因表达与人纤维肉瘤肺转移的相关性。方法将HT1080细胞经裸鼠尾静脉注射接种，采集肿瘤浸润组与正常对照组肺组织RNA，合成cDNA，以含1176个人肿瘤相关基因的芯片行cDNA微阵列分析，以实时定量RT-PCR法... 详细信息

目的研究纤维连接蛋白1（FN1）基因表达与人纤维肉瘤肺转移的相关性。方法将HT1080细胞经裸鼠尾静脉注射接种，采集肿瘤浸润组与正常对照组肺组织RNA，合成cDNA，以含1176个人肿瘤相关基因的芯片行cDNA微阵列分析，以实时定量RT-PCR法测定两组FN1表达。利用激光捕获法采集实验组小鼠肿瘤浸润肺组织及周围组织RNA，分别以实时定量RT-PCR法测定FN1表达。结果肺转移组与对照组相比，表达差异基因31个，占2．3％，其中表达下调的基因占0．3％，表达上调的基因占2．3％，FN1表达明显上调。肿瘤浸润肺组织与周围组织相比，FN1表达明显上调。结论FN1基因高表达可能与人纤维肉瘤肺转移有关。

关键词：人纤维肉瘤肺肿瘤肿瘤转移 FN1基因

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应用深低温技术进行恶性骨肿瘤的灭活再植重建

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中华医学信息导报 2003年第24期18卷 15-页

作者： hiroyuki tsuchiya 汤小东 Restorative Medicine of Neuro-Musculoskeletal System Graduate School of MedicineKanazawa University MDPhD

本文将介绍应用液氮深低温冷冻处理恶性骨肿瘤,进行灭活再植保肢治疗的新方法。18例患者(7例骨肉瘤、3例尤文肉瘤、2例软骨肉瘤、2例软组织肉瘤骨侵犯、1例恶性纤维组织细胞瘤)应用本方法进行肿瘤切除和灭活重建。

关键词：灭活再植骨肿瘤深低温

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Ab Initio Two-Phase Molecular Dynamics on the Melting Curve of SiO_2

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Journal of Earth Science 2010年第5期21卷 801-810页

作者： Yusuke Usui Taku tsuchiya Geodynamics Research Center Ehime University

Ab initio two-phase molecular dynamics simulations were performed on silica at pressures of 20-160 GPa and temperatures of 2 500-6 000 K to examine its solid-liquid phase boundary. Results indicate a melting temperature （Tin） of 5 900 K at 135 GPa. This is 1 100 K higher than the temperature considered for the core-mantle boundary （CMB） of about 3 800 K. The calculated melting temperature is fairly consistent with classical MD （molecular dynamics） simulations. For liquid silica, the O-O coordination number is found to be 12 along the Tm and is almost unchanged with increasing pressure. The self-diffusion coefficients of O and Si atoms are determined to be 1.3×10^-9-3.3×10^-9 m2/s, and the viscosity is 0.02-0.03 Pa＇s along the Tin. We find that these transport properties depend less on pressure in the wide range up of more than 135 GPa. The eutectic temperatures in the MgO-SiO2 systems were evaluated and found to be 700 K higher than the CMB temperature, though they would decrease considerably in more realistic mantle compositions.

关键词： Ab Initio Two-Phase Molecular Dynamics on the Melting Curve of SiO2 SiO CMB MgO than

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Crystal orientation-dependent fatigue characteristics in micrometer-sized single-crystal silicon

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Microsystems & Nanoengineering 2016年第1期2卷 154-162页

作者： Tsuyoshi Ikehara Toshiyuki tsuchiya National Institute of Advanced Industrial Science and Technology(AIST) 1-2 NamikiTsukubaIbaraki 305-8564Japan Department of Micro Engineering Graduate School of EngineeringKyoto UniversityKyotodaigaku-Katsura C3Nishikyo-kuKyoto 615-8540Japan

Repetitive bending fatigue tests were performed using five types of single-crystal silicon specimens with different crystal orientations fabricated from{100}and{110}*** lifetimes in a wide range between 100 and 1010 were obtained using fan-shaped resonator test *** surface observation via scanning electron microscope(SEM)revealed that the{111}plane was the primary fracture *** crack propagation exponent n was estimated to be 27,which was independent of the crystal orientation and dopant concentration;however,it was dependent on the surface conditions of the etched *** fatigue strengths relative to the deflection angle were orientation dependent,and the ratios of the factors obtained ranged from 0.86 to *** strength factors were compared with those obtained from finite element method stress *** calculated stress distributions showed strong orientation dependence,which was well-explained by the elastic *** comparison of the strength factors suggested that the first principal stress was a good criterion for fatigue *** include comparisons with specimens tested in our previous report and address the tensile strength,initial crack length,volume effect,and effects of surface roughness such as scallops.

关键词： fatigue fracture lifetime MEMS reliability resonator single-crystal silicon

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Expanding-contracting Earth

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Geoscience Frontiers 2013年第3期4卷 341-347页

作者： Taku tsuchiya Kenji Kawai Shigenori Maruyama Geodynamic Research Center Ehime UniversityMatsuyamaEhime 790-8577Japan Department of Earth and Planetary Sciences Tokyo Institute of TechnologyMeguroTokyo 152-8551Japan Department of Earth Science University of CaliforniaSanta Barbara 93106CAUSA

The Earth was born from a giant impact at 4.56 Ga. It is generally thought that the Earth subsequently cooled, and hence shrunk, over geologic time. However, if the Earth＇s convection was double-layered, there must have been a peak of expansion during uni-directional cooling. We computed the expansion- contraction effect using first principles mineral physics data. The result shows a radius about 120 km larger than that of the present Earth immediately after the consolidation of the magma-ocean on the surface, and subsequent shrinkage of about 110 km in radius within about 10 m.y., followed by gradual expansion of 11 km in radius due to radiogenic heating in the lower mantle in spite of cooling in the upper mantle in the Archean. This was due to double-layered convection in the Archean with final collapse of overturn with contraction of about g km in radius, presumably by the end of the Archean. Since then, the Earth has gradually cooled down to reduce its radius by around 12 km. Geologic evidence supports the late Archean mantle overturn ca. 2.6 Ga, such as the global distribution of super-liqnidus flood basalts on nearly all cratonic fragments （〉35 examples）. If our inference is correct, the surface environment of the Earth must have undergone extensive volcanism and emergence of local landmasses, because of the thin ocean cover （3-5 km thickness）. Global unconformity appeared in cratonic fragments with stromatolite back to 2.9 Ga with a peak at 2.6 Ga. The global magmatism brought extensive crustal melting to yield explosive felsic volcanism to transport volcanic ash into the stratosphere during the catastrophic mantle overturn. This event seems to be recorded by sulfur mass-independent fractionation （SMIF） at 2.6 Ga. During the mantle overturn, a number of mantle plumes penetrated into the upper mantle and caused local upward doming of by ca. 2-3 km which raised local landmasses above sea-level. The consequent increase of atmospheric oxygen enabled life evolutio

关键词： Mantle overturn Expanding Earth Global unconformity Nutrients Eukaryotes

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