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Gastric linitis plastica with autoimmune pancreatitis diagnosed by an endoscopic ultrasonography-guided fine-needle biopsy: A case report

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World Journal of Clinical Cases 2022年第31期10卷 11607-11616页

作者： Ryosuke Sato Kazuyuki Matsumoto Hiromitsu Kanzaki Akihiro Matsumi Kazuya Miyamoto Kosaku Morimoto hiroyuki terasawa Yuki Fujii Tatsuhiro Yamazaki Daisuke Uchida Koichiro Tsutsumi Shigeru Horiguchi Hironari Kato Gastroenterology and Hepatology Okayama University HospitalOkayama 700-8558Japan

BACKGROUND Gastric linitis plastica(GLP)is a subset of gastric cancer with a poor prognosis.It is difficult to obtain a definitive diagnosis by endoscopic mucosal biopsies,and the usefulness of an endoscopic ultrasonography-guided fine-needle biopsy(EUSFNB)for GLP has been recently reported.Meanwhile,autoimmune diseases are occasionally known to coexist with malignant tumors as paraneoplastic syndrome.We herein report the usefulness of an EUS-FNB for detecting GLP and the possibility of paraneoplastic syndrome coexisting with GLP.CASE SUMMARY An 81-year-old man was admitted to our hospital for a 1-mo history of epigastric pain that increased after eating.His laboratory data revealed high levels of serum carbohydrate antigen 19-9 and immunoglobulin-G4.Endoscopic examinations showed giant gastric folds and reddish mucosa;however,no epithelial changes were observed.The gastric lumen was not distensible by air inflation,suggesting GLP.Computed tomography showed the thickened gastric wall,the diffuse enlargement of the pancreas,and the peripancreatic rim,which suggested autoimmune pancreatitis(AIP)coexisting with GLP.Because the pathological findings of the endoscopic biopsy showed no malignancy,he underwent an EUSFNB and was diagnosed with GLP.He received chemotherapy for unresectable gastric cancer due to peritoneal metastasis,after which both the gastric wall thickening and diffuse enlargement of the pancreas were improved.CONCLUSION An EUS-FNB for GLP with a negative endoscopic biopsy is useful,and AIP may develop as a paraneoplastic syndrome.

关键词： Endoscopic ultrasound-guided fine needle aspiration Linitis plastica Autoimmune pancreatitis Paraneoplastic syndromes Case report

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Circulating tumor DNA dynamics analysis in a xenograft mouse model with esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2021年第41期27卷 7134-7143页

作者： hiroyuki terasawa Hideaki Kinugasa Kazuhiro Nouso Shumpei Yamamoto Mami Hirai Takehiro Tanaka Akinobu Takaki hiroyuki Okada Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 7008558Japan Department of Pathology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 7008558Japan

BACKGROUND It remains unclear which factors,such as tumor volume and tumor invasion,influence circulating tumor DNA(ctDNA),and the origin of ctDNA in liquid biopsy is always problematic.To use liquid biopsies clinically,it will be very important to address these questions.AIM To assess the origin of ctDNA,clarify the dynamics of ctDNA levels,assess ctDNA levels by using a xenograft mouse after treatment,and to determine whether tumor volume and invasion are related to ctDNA levels.METHODS Tumor xenotransplants were established by inoculating BALB/c-nu/nu mice with the TE11 cell line.Groups of mice were injected with xenografts at two or four sites and sacrificed at the appropriate time point after xenotransplantation for ctDNA analysis.Analysis of ctDNA was performed by droplet digital PCR,using the human telomerase reverse transcriptase(hTERT)gene.RESULTS Mice given two-site xenografts were sacrificed for ctDNA at week 4 and week 8.No hTERT was detected at week 4,but it was detected at week 8.However,in four-site xenograft mice,hTERT was detected both at week 4 and week 6.These experiments revealed that both tumor invasion and tumor volume were asso ciated with the detection of ctDNA.In resection experiments,hTERT was detected at resection,but had decreased by 6 h,and was no longer detected 1 and 3 d after resection.CONCLUSION We clarified the origin and dynamics of ctDNA,showing that tumor volume is an important factor.We also found that when the tumor was completely resected,ctDNA was absent after one or more days.

关键词： Liquid biopsy Circulating tumor DNA Xenograft Esophageal squamous cell carcinoma Dynamics of circulating tumor DNA

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Comparison of Fitness Tracking Using Three Different Smartwatches during Free Activities in Daily Life

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Open Journal of Nursing 2023年第10期13卷 625-640页

作者： Eriko terasawa Yoshihiro Asano Makiko Aoki Hisayo Okayama Doctorial Program in Nursing Graduate School of Comprehensive Human Sciences University of Tsukuba Ibaraki Japan School of Medicine Department of Health Sciences Shinshu University Nagano Japan Faculty of Health Science of Nursing Juntendo University Shizuoka Japan Nursing Science and Engineering/Women’s Health Nursing Institute of Medicine University of Tsukuba Ibaraki Japan

Background: Young women of reproductive age experience various physiological changes, which they measure and track using various devices, including fitness trackers and smartwatches. However, fitness tracking assessment methods are ambiguous because they may differ from model to model. Objective: This study aimed to compare the stress level, heart rate, sleep time, number of steps, and distance traveled, which were calculated using fitness tracking methods for daily-life free activity installed in various smartwatches. Materials and Methodology: Healthy women in their 20s to 30s were recruited for this study, which was conducted from December 2021 to June 2022. The finalized participants wore three different smartwatch models (Mi smartband 6, vivosmart®4, and Band 6) simultaneously on their person for 48 hours and performed their daily activities and recorded them on an hour-based activity chart. Each smartwatch’s measured data (e.g., age, height, weight, and oral medications) were extracted into five datasets: heart rate, stress level, number of steps, distance, and sleep time. Data analyses were conducted using Spearman’s rank correlation coefficient ρ (for comparing heart rates) and Bland-Altman plots (for assessing heart rate agreement). The smartwatches’ fitness trackers were compared using the mean absolute percentage error. Results: The correlation coefficient showed that vivosmart®4 and Band 6 had a higher heart rate agreement (ρ = 0.684). The Bland-Altman plots showed high agreement between Band 6, Mi smartband 6, and vivosmart®4. The heart rate measurement method used under free movement was found to be consistent. The examined smartwatches were able to measure heart rate at the same level even under daily-life free movements. Conclusion: Several different smartwatches’ calculated measured values for heart rate had a high agreement. The smartwatches provided accurate heart rate measurements under daily-life free movement conditions. Furthermore, the calculation methods f

关键词： Wearable Device Fitness Tracking Daily Life Smartwatches

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Effectiveness of an Educational Intervention for Postpartum Depression in a Pre-Parent Classroom

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Open Journal of Nursing 2023年第8期13卷 455-486页

作者： Taeko Unno Eriko terasawa Kiyoko Naito Mayuko Niida Yoshihiro Asano Hisayo Okayama Graduate Course of Midwifery Kyoto Koka Women’s University Kyoto Japan Doctorial Program in Nursing Graduate School of Comprehensive Human Sciences University of Tsukuba Ibaraki Japan Department of Child Studies Faculty of Education and Welfare Biwako-Gakuin University Shiga Japan Healthcare Division LEBER Inc. Ibaraki Japan School of Medicine Department of Health Sciences Shinshu University Nagano Japan Nursing Science and Engineering/Women’s Health Nursing Institute of Medicine University of Tsukuba Ibaraki Japan

The global incidence of postpartum depression is estimated at approximately 10% - 20%. A lack of partner support is a key factor associated with perinatal depression. This study examined the effects of an educational intervention that provided information for the prevention and early detection of postpartum depression to first-time mothers and fathers who participated in a “First-Time Parent Class.” The study was utilized quasi-experimental research, conducted first with the control group and followed by an assessment of the intervention group. Mothers were assessed using the Edinburgh Postpartum Depression Scale and the Japan Child and Family Research Institute Child-Rearing Support Questionnaire. Fathers’ assessments were conducted using the Japan Child and Family Research Institute Child-Rearing Support Questionnaire for Fathers and were based on responses to questions regarding their coping strategies. Data were obtained from 158 data (72 interventions, 86 controls) couples analyzed. No significant difference was found between mothers’ child-rearing difficulty and depression score rates in the first month after childbirth. There was a difference among fathers in the control group and those in the intervention group regarding their responses to maternal depression: the “consult family” (p = 0.035), “consult friends” (p = 0.033), and “consult the city health center” (p = 0.047) variables were higher in the intervention group;however, the effect size was small. Providing first-time parents with information during pregnancy to prevent and detect postpartum depression will deepen parents’ understanding and help them cope with postpartum depression.

关键词： Postpartum Depression First-Time Parents Educational Intervention

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Effect of Cold-Rolling on Precipitation Phenomena in Sensitized Type 316L and 304L Austenitic Stainless Steels

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材料热处理学报 2004年第5期25卷 217-222页

作者： H.Tsubakino A.Yamamoto T.Yamada L.Liu M.terasawa S.Nakahigashi H.Harada GraduateSchoolofEngineering UniversityofHyogoHimejiHyogoJapan GraduateStudent UniversityofHyogoHimejiHyogoJapan JapanPowerEngineeringandInspectionCo. YokohamaKanagawaJapan Koyo-SeikoCo.Ltd. KashiwaraOsakaJapan

Precipitation phenomena in Type 316L and 304L stainless steels were studied mainly by transmission electron microscopic (TEM) observations after cold-rolling ranging from 0% (as solution annealed) to 80% reduction in thickness, and then by sensitization treatment. Precipitates were identified by electron diffraction analysis and EDS analysis. Precipitates observed in sensitized 316L stainless steel were sigma and chi phases, whereas carbide and sigma were observed in sensitized 304L stainless steel. Recrystallized grains were formed in 30% cold-rolled and sensitized 304L. However, the tendency toward recrystallization in sensitized 316L was much lower than in 304L. Precipitation of sigma and chi phases was accelerated by cold-rolling and they were observed at grain boundaries in lower cold-rolling; they were also seen, in grain interiors in higher cold-rolling. Higher deformation induced partially recrystallization combined with precipitation, resulting in the formation of heterogeneous microstructures.

关键词：冷轧 316L 304L 奥氏体不锈钢 TEM

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固体气泡损伤探测器阈起源的实验判别

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核技术 2002年第7期25卷 506-510页

作者：郭士伦李丽 Doke T Kikuchi J terasawa K Hara K Sakuma N Yasuda N Murakami T 中国原子能科学研究院核物理研究所北京102413 Advanced Research Institute for Science and Engineering Waseda University National Institute of Radiological Science

用 5 0 0MeV/u56Fe,6 5 0MeV/u40Ar ,6 0 0MeV/u2 8Si和 180MeV/u4He对固体气泡损伤探测器 (T- 12型 )进行了实验研究 ,实验结果表明 ,固体气泡损伤探测器的阈特性可用临界能量损失率表征。在一般条件下 ,限定能量损失率在不同重离子产... 详细信息

用 5 0 0MeV/u56Fe,6 5 0MeV/u40Ar ,6 0 0MeV/u2 8Si和 180MeV/u4He对固体气泡损伤探测器 (T- 12型 )进行了实验研究 ,实验结果表明 ,固体气泡损伤探测器的阈特性可用临界能量损失率表征。在一般条件下 ,限定能量损失率在不同重离子产生径迹时不具有相同临界值 ,因此。

关键词：固体气泡损伤探测器阈起源临界能量损失率限定能量损失率

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0.3微米移相掩模光刻

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半导体情报 1992年第4期29卷 59-64页

作者： Tsuneo terasawa 王育中

用移相掩模提高i线步进曝光的分辨率,这是本文讨论的问题。文中研究了重复线条,也研究了孤立线和孔状图形。为在光刻孤立窗口时,得到窄细亮线,在掩模主体狭缝的两侧附加辅助狭缝。辅助狭缝的宽度小于镜头的临界值。主体狭缝与辅助狭缝... 详细信息

用移相掩模提高i线步进曝光的分辨率,这是本文讨论的问题。文中研究了重复线条,也研究了孤立线和孔状图形。为在光刻孤立窗口时,得到窄细亮线,在掩模主体狭缝的两侧附加辅助狭缝。辅助狭缝的宽度小于镜头的临界值。主体狭缝与辅助狭缝的光相位相反。辅助狭缝的作用在于减小亮线的宽度,使其小于镜头的线扩展函数值。主体狭缝及周围的四个辅助狭缝,也同样适用于小孔图形光刻。文中对移相掩模和普通掩模在片子上的光强分布进行了计算对比,并用额定分辨率为0.55μm的i线步进曝光机,将图形制作在片子上。用移相掩模光刻,0.3μm线条/间隔、0.3μm孤立窗口及0.4μm孔图形都可以分辨。而用普通掩模光刻,其图形不能分辨。对辅助狭缝光相位的变化作用,本文也进行了讨论。光强计算及实验结果表明,改变狭缝的光相位,能够控制最佳聚焦位置。

关键词：集成电路掩模移相微米光刻

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固体气泡探测器-固体核径迹探测器的新类别

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核技术 2005年第9期28卷 659-662页

作者：郭士伦 Doke T 李丽陈宝流张东海 Kikuchi J terasawa K Komiyama M Hara K Fuse T Yasuda N Murakami T 中国原子能科学研究院北京102413 Advanced Research Institute for Science and Engineering Waseda University 山西师范大学现代物理研究所临汾041004 The Institute of Physical and Chemical Research National Institute of Radiological Sciences

利用高能重离子p、He、C、Si、Ar、Fe、Kr和Xe对固体气泡探测器的性质进行了研究。结果表明,固体气泡探测器具有许多与固体核径迹探测器相似的性质,且具有显影主动性、实时记录性、体径迹显示能力等多方面普通固体核径迹探测器所不具有... 详细信息

利用高能重离子p、He、C、Si、Ar、Fe、Kr和Xe对固体气泡探测器的性质进行了研究。结果表明,固体气泡探测器具有许多与固体核径迹探测器相似的性质,且具有显影主动性、实时记录性、体径迹显示能力等多方面普通固体核径迹探测器所不具有的性能。可以得出结论:固体气泡探测器是固体核径迹探测器的一种新类别。

关键词：固体气泡探测器固体核径迹探测器高能重离子探测

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生产L——异亮氨酸的新方法

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氨基酸杂志 1991年第2期13卷 43-45页

作者： MASATO terasawa 刘红湖南省微生物研究所情资室

前言现在,已有许多生产L-异亮氨酸的报导,但是,由于菌株生长过程中需要大量消耗碳源,而且转化率很低,所以,这些方法的效果很差。本文描述了一种具有高产潜力的L-异亮氨酸的新生产方法。

关键词： L-异亮氨酸生产工艺

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活细胞反应生产L—异亮氨酸工艺中附产物形成的抑制

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氨基酸杂志 1993年第2期15卷 47-50页

作者： Masato terasawa Masayuki Inui 翟颐华武汉大学生物系90级

在用黄色短杆菌(Brevibacterium flavum)AB—07,采用活细胞反应生产L—异亮酸的新工艺中,副产两种非天然的和不需要的氨基酸—正缬氨酸(Nva)和O—乙基高丝氨酸(O—EH)。正缬氨酸的形成可被AB—07的亮氨酸营养缺陷突变株(AB—07—Leu—2... 详细信息

在用黄色短杆菌(Brevibacterium flavum)AB—07,采用活细胞反应生产L—异亮酸的新工艺中,副产两种非天然的和不需要的氨基酸—正缬氨酸(Nva)和O—乙基高丝氨酸(O—EH)。正缬氨酸的形成可被AB—07的亮氨酸营养缺陷突变株(AB—07—Leu—2)所抑制。并发现Nva的形成与亮氨酸的生物合成紧密联系着。O—乙基高丝氨酸的形成可被向反应混合物中加入L—蛋氨酸所抑制。但是AB—07—Leu—2菌中的高丝氨酸—O—乙酰转移酶并不因加入L—蛋氨酸而被抑制或阻遏。推测L—蛋氨酸阻遏了O—EH形成酶催化O—乙酰高丝氨酸向O—EH的转化。

关键词：异亮氨酸生产工艺活细胞发酵

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