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Effects of duration of phenytoin administration on mRNA expression of cytochrome P450 and P-glycoprotein in the liver and small intestine of rats

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Asian Journal of Pharmaceutical Sciences 2016年第5期11卷 662-667页

作者： Atsushi Kawase hiroyuki tanaka Toru Otori Kenji Matsuyama Masahiro Iwaki Department of Pharmacy Faculty of PharmacyKindai University

Phenytoin(5,5-diphenylhydantoin;DPH) induces expression of cytochromes P450(CYPs). Interactions between DPH and tacrolimus suggested that the persistence of CYP induction after discontinuation of DPH is dependent on the history of administration and dosing period of DPH. However, the relationship between the duration of DPH administration and expression of CYPs in the liver and small intestine of rats is not known. Alterations in levels of P-glycoprotein(P-gp;MDR1;ABCB1) as well as CYPs cause drug interactions in the small intestine. We examined the effects of the duration of DPH administration on expression of CYPs and P-gp in the liver and small intestine of rats. Rats were treated with DPH(100 mg/kg,peroral(p.o.) twice a day(b.d.)) for 2, 4, 8, and 16 d. mRNA levels of CYPs and P-gp were examined using the total RNA extracted from the liver and duodenum 2 h and 24 h after the final administration of DPH. CYP3 A activities were determined using microsomes. DPH administration for 2 d and 4 d markedly increased m RNA levels of CYPs such as CYP3 A1, CYP3 A2,CYP2 B1, and CYP2 B2 in the liver. A relatively long duration of DPH administration(8 d and16 d) resulted in abolition of the induction of hepatic CYP but increased CYP3 A activities were maintained. These results suggest that the duration of DPH administration could be an important determinant of hepatic CYP induction.

关键词： Phenytoin Cytochromes P450 Microsomes mRNA Liver

Adsorption,selectivity,and phase behavior in organic nanopores for shale gas and oil development

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Petroleum Research 2021年第3期6卷 187-203页

作者： Jinrong Cao Yunfeng Liang Yoshihiro Masuda Kohei Tamura hiroyuki tanaka Tomoaki Ishiwata Yoshiharu Ito Toshifumi Matsuoka Department ofSystemsInnovation TheUniversityofTokyoTokyo113-8656Japan Japan Oil GasandMetalsNationalCorporation(JOGMEC)Chiba261-0025Japan Fukada GeologicalInstitute Tokyo113-0021Japan

In a shale gas and oil reservoir,hydrocarbon fluids are stored in organic nanopores with sizes on the order of~1-100 *** adsorption,selectivity,and phase behavior of hydrocarbons in the nanopores are crucial for estimating the gas-in-place and predicting the *** this study,to understand the characteristics of the phase behavior of multicomponent hydrocarbon systems in shale reservoirs,the phase behavior of a CH_(4)/n-C_(4)H_(10)binary mixture in graphite nanopores was investigated by Grand Ca-nonical Monte Carlo(GCMC)molecular *** method for determining the dew-point pressure and bubble-point pressure in the nanopores was *** condensation phenomenon was observed owing to the difference in the adsorption selectivities of the hydrocarbon molecules on the nanopore surfaces,and hence the dew-point pressure(and bubble-point pressure)of hydrocarbon mixtures in the nanopores significantly *** GCMC simulations reproduced both the higher and lower bubble-point pressures in nanopores in previous *** work highlights the crucial role of the selec-tivity in the phase behavior of hydrocarbons in nanopores.

关键词： Shale gas and oil Nanopores Adsorption Selectivity Phase behavior Bubble point pressure Dew point pressure Molecular simulation

A single atom photocatalyst co-doped with potassium and gallium for enhancing photocatalytic hydrogen peroxide synthesis

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Nano Research 2024年第8期17卷 7027-7038页

作者： Wenan Cai Yuichiro tanaka Xing Zhu Teruhisa Ohno Department of Applied Chemistry Faculty of EngineeringKyushu Institute of TechnologyKitakyushu 804-8550Japan College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXi’an 710021China

Polymer carbon nitride(PCN)is widely used in ***,pristine PCN has disadvantages such as insufficient visible light absorption and low photogenerated carrier separation efficiency that greatly limited the photocatalytic *** a non-toxic metal,gallium has the potential to solve the defects of *** ions coordinated with nitrogen in carbon nitride to form Ga-N active sites and improved the photocatalytic *** doped potassium ions form a transmission channel for charge redistribution and transfer between adjacent layers,which is beneficial for better separation of photoexcited *** this study,a series of PCN co-doped with gallium and potassium(Ga-K-PCN)were *** experimental results indicated photocatalytic generation of hydrogen peroxide proceeds through the 2e−oxygen reduction reaction ***,Nyquist plots and photocurrent results further proved that the presence of Ga-N sites and potassium ion doping could significantly improve the separation/transfer of intra-planar and interlayer charge carriers and thus enhance photocatalytic *** Ga10-K3-PCN photocatalysts promoted yield of H_(2)O_(2),with reactivity at 28.2μmol/(g·h)and solar-to-chemical conversion efficiency at 0.64%,surpassed that of a typical photo-catalyst based on PCN(0.18%).

关键词： photocatalysis gallium oxygen reduction reaction H_(2)O_(2) production

Fabrication of Mie-resonant silicon nanoparticles using laser annealing for surface-enhanced fluorescence spectroscopy

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Microsystems & Nanoengineering 2024年第2期10卷 133-141页

作者： Tatsuya Fukuta Ryo Kato Takuo tanaka Taka-aki Yano Institute of Post-LED Photonics Tokushima University2-1 Minami-JosanjimaTokushima770-8506Japan Innovative Photon Manipulation Research Team RIKEN Center for Advanced PhotonicsWakoSaitama351-0198Japan Metamaterials Laboratory RIKEN Cluster for Pioneering ResearchWakoSaitama351-0109Japan

Silicon nanostructures with unique Mie resonances have garnered considerable attention in the field of ***,we present a simple and efficient method for the fabrication of silicon(Si)nanoparticle substrates using continuous-wave(CW)laser *** resulting silicon nanoparticles exhibit Mie resonances in the visible region,and their resonant wavelengths can be precisely ***,laser-annealed silicon nanoparticle substrates show a 60-fold enhancement in *** tunable and fluorescence-enhancing silicon nanoparticle platform has tremendous potential for highly sensitive fluorescence sensing and biomedical imaging applications.

关键词： nanoparticles annealing resonant

Metabolomics in liver diseases: A novel alternative for liver biopsy?

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World Journal of Hepatology 2024年第1期16卷 12-16页

作者： Yasuo tanaka Department of Gastroenterology National Center for Global Health and MedicineTokyo 162-8655Japan

Hepatitis C virus(HCV)remains a significant public health problem as it can cause acute and chronic *** HCV infection is a major cause of liver fibrosis,and evaluation of liver fibrosis is essential because the prognosis of patients with chronic HCV infection is closely related to the stage of *** fibrosis is traditionally evaluated based on pathological analysis of biopsy specimens,which is considered the gold ***,liver biopsy is invasive and susceptible to sampling error and inter-and intraobserver variation in pathological interpretation;it is also ***,noninvasive diagnostic investigations have been developed,including the use of fibrotic markers,scoring systems based on routine blood tests,and transient elastography with magnetic resonance imaging or ***,metabolomics,an emerging technology,has been used to detect the fibrosis *** this editorial,I comment on the article titled“Metabolomics in chronic hepatitis C:Decoding fibrosis grading and underlying pathways”by Ferrasi et al published in the recent issue of the World Journal of Hepatology.I discuss previous studies on the use of metabolome analysis for the diagnosis of HCV-related liver fibrosis and the potential development of biopsy-free diagnostic techniques.

关键词： Metabolomics Hepatitis C virus Liver fibrosis Liver cirrhosis Serum biomarker

Simulation Vacuum Preloading Method by Tri-Axial Apparatus

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International Journal of Geosciences 2012年第1期3卷 211-221页

作者： Ngo Trung Duong Wanchai Teparaksa hiroyuki tanaka Department of Civil Engineering Faculty of Engineering Chulalongkorn University Bangkok Thailand

It is very important to control any risk of instability of embankment during vacuum construction, the simulation vacuum preloading method using tri-axial apparatus is proposed to predict the behavior of soft soil improvement in the laboratory, as well as to make this method become familiar and easier in the future. The tri-axial apparatus is used instead of the large-scale one, which has been performed by Bergado (1998) and Indaratna (2008). The tri-axial test on small size specimen can be carried out in one week compared to the large-scale apparatus takes one month for big specimen. In addition, the lateral deformation as well as the shear strength increase with time can determine accurately.

关键词： Soft Soil Soil Improvement Vacuum Preloading Degree of Consolidation

Application of Green Fluorescent Protein in Immunoassays

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Advances in Bioscience and Biotechnology 2014年第6期5卷 557-563页

作者： Seiichi Sakamoto Yukihiro Shoyama hiroyuki tanaka Satoshi Morimoto Department of Pharmacognosy Faculty of Pharmaceutical Sciences Nagasaki International University Nagasaki Japan Department of Pharmacognosy Graduate School of Pharmaceutical Sciences Kyushu University Fukuoka Japan

Green fluorescent protein (GFP) is a protein that emits green fluorescence when exposed to a radiation of ultraviolet wavelength range, even without the addition of substrate and cofactor. Because of such characteristics, the usage of GFP is widespread in both in vivo and in vitro applications. In addition, recent advances in biotechnology have enabled GFP to be expressed in various hosts, including bacteria, yeast, plants, animals, and even living-cells, for multiple purposes. Currently, GFP is a subject of great interest in the analytical sciences, especially in immunoassays for qualitative and quantitative analyses, when it is fused with an antibody because of the high sensitivity of GFP and antigen-binding specificity of antibodies. Recently the fluobody, which is a fusion protein of GFP with single-chain variable fragment antibody (scFv), has become a useful tool in various fields. We review here the applications of GFP as fluobodies in immunoassays.

关键词： GFP Immunoassay Fluobody

Exploiting fly models to investigate rare human neurological disorders

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Neural Regeneration Research 2025年第1期20卷 21-28页

作者： Tomomi tanaka Hyung-Lok Chung Department of Neurology Houston Methodist Research InstituteHoustonTXUSA Department of Neurology Weill Cornell Medical CollegeNew YorkNYUSA

Rare neurological diseases,while individually are rare,collectively impact millions globally,leading to diverse and often severe neurological *** attributed to genetic mutations that disrupt protein function or structure,understanding their genetic basis is crucial for accurate diagnosis and targeted *** investigate the underlying pathogenesis of these conditions,researchers often use non-mammalian model organisms,such as Drosophila(fruit flies),which is valued for their genetic manipulability,cost-efficiency,and preservation of genes and biological functions across evolutionary *** tools available in Drosophila,including CRISPR-Cas9,offer a means to manipulate gene expression,allowing for a deep exploration of the genetic underpinnings of rare neurological *** boasts a versatile genetic toolkit,rapid generation turnover,and ease of large-scale experimentation,making it an invaluable resource for identifying potential drug *** can expose flies carrying disease-associated mutations to various compounds,rapidly pinpointing promising therapeutic agents for further investigation in mammalian models and,ultimately,clinical *** this comprehensive review,we explore rare neurological diseases where fly research has significantly contributed to our understanding of their genetic basis,pathophysiology,and potential therapeutic *** discuss rare diseases associated with both neuron-expressed and glial-expressed *** cases include mutations in CDK19 resulting in epilepsy and developmental delay,mutations in TIAM1 leading to a neurodevelopmental disorder with seizures and language delay,and mutations in IRF2BPL causing seizures,a neurodevelopmental disorder with regression,loss of speech,and abnormal *** we explore mutations in EMC1 related to cerebellar atrophy,visual impairment,psychomotor retardation,and gain-of-function mutations in ACOX1 causing Mitchell ***-of-fun

关键词： ACOX1 Drosophila melanogaster glia lipid metabolism model organisms neuroinflammation neurologic disorders neuron rare disease VLCFA

Veno-Venous Extracorporeal Membrane Oxygenation for Acute Lung Injury after Surgery for Aortic Dissection: A Case Report

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World Journal of Cardiovascular Surgery 2017年第12期7卷 156-163页

作者： Takanori Kono Takeshi Oda Keiichi Akaiwa Katsuhiko Nakamura hiroyuki tanaka Department of Cardiovascular Surgery Omura Municipal Hospital Nagasaki Japan Department of Surgery Kurume University School of Medicine Fukuoka Japan

Acute respiratory failure after surgery for aortic dissection is a serious complication that has been associated with increased mortality and morbidity. Veno-venous (VV) extracorporeal membrane oxygenation (ECMO) is reported as one of the treatments for this life-threatening complication. A 78-year-old male patient was admitted to our hospital for Stanford type A acute aortic dissection. He underwent emergency replacement of the ascending aorta, after which he developed acute lung injury. It was difficult to maintain oxygenation with a respirator mask. Therefore, VV-ECMO was initiated on postoperative day 1. The oxygenation gradually improved, and VV-ECMO was continued until postoperative day 13. On postoperative day 25, mechanical ventilation was withdrawn. The patient was discharged from the hospital on postoperative day 149. We report a case of successful treatment of acute lung injury with VV-ECMO initiated after surgery for aortic dissection. VV-ECMO can be considered as a treatment option for severe acute lung injury after surgery for aortic dissection.

关键词： Acute Aortic Dissection Cardiopulmonary Bypass Cardiothoracic Surgery Acute Lung Injury Extracorporeal Membrane Oxygenation