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Down-Regulation of Claudin-1 Expression in Gastric Cancer Mucosa Is Correlated with Poor Prognosis

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Open Journal of Pathology 2014年第4期4卷 206-212页

作者： Eiichiro Hirakawa Yasunori Tokuhara Tatsuya Morinishi hiroyuki ohsaki Erika Uemura Yukari Miki Toru Matsunaga Yoshio Kushida Reiji Haba Laboratory of Pathology Department of Medical Technology Kagawa Prefectural University of Health Sciences Kagawa Japan Department of Medical Technology Ehime Prefectural University of Health Sciences Ehime Japan Department of Diagnostic Pathology Kagawa University Hospital Kagawa Japan Department of Medical Hygiene Technology Course Kochi Gakuen College Kochi Japan

Background: Cell adhesion molecule abnormalities are given as one reason for the occurrence of invasion and metastasis in various cancers. In this study, we conducted an immunohistochemical examination of cell adhesion molecule claudin-1 in mucosa and invasive front of gastric cancer, and investigated the correlation of claudin-1 expression and clinicopathological factors. Methods: Immunohistochemical examination was performed for 35 patients who underwent surgery be-tween January 2010 and October 2011, to assess the correlation of claudin-1 with primary gastric cancer. Results: The expression rate of claudin-1 was 48.6% (17/35) in 35 gastric carcinoma patients. The positive rates of claudin-1 were 42.9% (15/35) in mucosa and 28.6% (10/35) in invasive front of gastric cancer. The expression rate of claudin-1 in invasive front was lower than in mucosa. From comparing claudin-1 expression in mucosa, it was found that well-to moderately-differentiated adenocarcinoma had significantly more claudin-1 expression than poorly-differrentiated adenocarcinoma. Claudin-1 expression of well-to moderately-differentiated adenocar-cinoma decreased in the invasive front of gastric cancer. Expression of claudin-1 in mucosa was negative in many cases with advanced tumor invasion (T2, T3, T4) and positive in many cases with early tumor invasion (T1), with a significant difference between the two

关键词： Claudin-1 Immunohistochemistry Mucosa Invasive Front Gastric Cancer

Topology optimization of supporting structure for seismic response reduction of an arch

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Science China(Technological Sciences) 2016年第6期59卷 852-861页

作者： MIYAZU Yuji ohsaki Makoto TSUDA Seita Department of Architecture Hiroshima University Department of Architecture and Architectural Engineering Kyoto University Department of Design and Technology Okayama Prefectural University

A flexible supporting structure that reduces seismic response of an arch is proposed. Topology and cross-sectional areas of the supporting structure modeled as a truss structure are optimized through two steps of static and dynamic optimization problems. In the first step, a flexible supporting structure that has diagonal displacement at the top under horizontal load is obtained by solving static optimization problems. Then, in the second step, the cross-sectional area of the flexible member is optimized to minimize the seismic response acceleration of the arch evaluated by the complete quadratic combination(CQC) method. Time-history seismic response analysis is carried out to show that the response in the normal direction of the roof successfully decreases due to flexibility of the supporting structure; in addition, installing passive energy dissipation devices into the flexible supporting structure is very effective in reducing the tangential response of the arch.

关键词： topology optimization arch supporting structure truss nonlinear programming problem CQC method

Deep reinforcement learning-based critical element identification and demolition planning of frame structures

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Frontiers of Structural and Civil Engineering 2022年第11期16卷 1397-1414页

作者： Shaojun ZHU Makoto ohsaki Kazuki HAYASHI Shaohan ZONG Xiaonong GUO College of Civil Engineering Tongji UniversityShanghai 200092China Department of Architecture and Architectural Engineering Kyoto UniversityKyoto 615-8540Japan Tongji Lvjian Co. Ltd.Shanghai 200092China

This paper proposes a framework for critical element identification and demolition planning of frame *** quantitative indices considering the severity of the ultimate collapse scenario are proposed using reinforcement learning and graph *** action is defined as removing an element,and the state is described by integrating the joint and element features into a comprehensive feature vector for each *** establishing the policy network,the agent outputs the Q value for each action after observing the *** numerical examples,it is confirmed that the trained agent can provide an accurate estimation of the Q values,and handle problems with different action spaces owing to utilization of graph ***,different behaviors can be learned by varying hyperparameters in the reward *** comparing the proposed method and the conventional sensitivity index-based methods,it is demonstrated that the computational cost is considerably reduced because the reinforcement learning model is trained ***,it is proved that the Q values produced by the reinforcement learning agent can make up for the deficiencies of existing indices,and can be directly used as the quantitative index for the decision-making for determining the most expected collapse scenario,i.e.,the sequence of element removals.

关键词： progressive collapse alternate load path demolition planning reinforcement learning graph embedding

A Piecewise Linear Isotropic-Kinematic Hardening Model with Semi-Implicit Rules for Cyclic Loading and Its Parameter Identification

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Computer Modeling in Engineering & Sciences 2016年第4期111卷 303-333页

作者： M.ohsaki T.Miyamura J.Y.Zhang Department of Architecture and Architectural Engineering Kyoto UniversityKyoto-Daigaku KatsuraNishikyoKyoto 615-8540Japan Department of Computer Science Nihon University1 NakagawaraTokusadaTamuraKoriyama 963-8642Japan Department of Architecture and Urban Design Nagoya City University2-1-10 Kita-ChigusaChigusaNagoya 464-0083Japan

A simple constitutive model,called semi-implicit model,for cyclic loading is proposed for steel materials used for structures such as building frames in civil *** constitutive model is implemented in the E-Simulator,which is a software package for large-scale seismic response *** constitutive relation is defined in an algorithmic manner based on the piecewise linear combined isotropic-kinematic *** rules are used for the first and subsequent loading states to incorporate characteristics such as yield plateau and Bauschinger effect of rolled mild steel *** optimization method is also presented for parameter identification from the results of cyclic and monotonic loading ***,the proposed model is readily applicable to practical elastoplastic analysis of building *** of the model is demonstrated in an example of a cantilever subjected to various types of cyclic loading.

关键词： Combined isotropic-kinematic hardening Piecewise linear hardening Steel material Parameter optimization Cyclic load

MULTIOBJECTIVE OPTIMIZATION FOR FORCE DESIGN OF TENSEGRITY STRUCTURES

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MULTIOBJECTIVE OPTIMIZATION FOR FORCE DESIGN OF TENSEGRITY S...

Optimization of Flexible Structures by Using Liapunov Stability Theory

The Fourth China-Japan-Korea Joint symposium on Optimization of Structural and Mechanical Systems

作者： Makoto ohsaki Dept.of Architecture ＆ Architectural Engineering Kyoto University Kyoto-Daigaku KatsuraNishikyoKyoto615-8540Japan

＜正＞In this paper, we present a multiobjective optimization approach for force design of tensegrity structures, where their geometries are assumed to be determined a priori;we search for the optimal distribution of member forces that leads to the maximum stiffness, and that is closest to the target values assigned by the designers as well. The Pareto optimal solutions of the problem are presented for a tensegrity grid as an example to demonstrate the methodology.

关键词： Tensegrity Structure Force Design Optimization Stiffness

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Optimization of Flexible Structures by Using Liapunov Stabil...

Surgical Treatment of Idiopathic Multiple Pulmonary Arteriovenous Malformation Identified at the Onset of Cerebral Infarction: A Case Report

The Sixth World Congress on Computational Mechanics in Conjunction with the Second Asian-Pacific Congress on Computational MechanicsⅠ

作者： M. ohsaki Department of Architecture and Architectural Engineering Kyoto University Kyoyo 606-8501 Japan

The approaches for designing structures against static and dynamic loads are divided into two categories;i. e. stiff structure and flexible structure. For the stiff structure approach, buckling is a critical design constraint for column-type and dome-type structures as well as shell-type mechanical parts and structures. In some situations, however, large deformation can be allowed so far as no failure or yielding occurs and the undeformed initial state can be recovered after releasing the external loads.

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Open Journal of Respiratory Diseases 2017年第2期7卷 62-67页

作者： Masahiro Kitada Shunsuke Yasuda Nana Takahashi Satoshi Okazaki Kei Ishibashi Satoshi Hayashi Yoshinobu ohsaki Department of Respiratory Center Asahikawa Medical University Hokkaido Japan

Pulmonary arteriovenous malformation (PAVM), which is asymptomatic in most cases, is often identified in patients with central nervous system disorders such as brain abscesses and/or cerebral infarctions. We have reported a patient with idiopathic multiple PAVM identified at the onset of cerebral infarction. A 69-year-old woman visited the Department of Neuropathic Internal Medicine at our hospital with chief complaints of numbness in her left hand and a feeling of weakness. The patient was given a diagnosis of subacute cerebral infarction. Multiple old lacunar infarctions were also observed in the deep white matter of the left frontal lobe. Chest computed tomography showed multiple nodular structures, mainly in the right lower lung field (S8), as well as continuous arteries and veins at the site;thus, the patient was finally diagnosed with multiple PAVM. Right lower thoracoscopic lobectomy was performed, as is typical surgical practice in such cases. The patient had a favorable postoperative course, and had no recurrence of cerebral infarction. Although the patient’s lesions were mainly restricted to S8, the fact that there were multiple lesions deemed a lobectomy as the appropriate course of treatment. This case emphasizes that attention should be paid to cases of multiple PAVM since cerebral infarction may arise from the disease.

关键词： Pulmonary Arteriovenous Malformation (PAVM) Brain Abscesses Cerebral Infarctions

Efficacy of 5-Fluorouracil and High-Concentration Cisplatin Suspended in Lipiodol by Short-Term Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis

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Journal of Cancer Therapy 2015年第13期6卷 1151-1161页

作者： Yutaka Yata Masashi Namikawa Tatsuya Ohyama Takashi ohsaki Daisuke Kanda Takeshi Hatanaka Kei Shibuya Jun Kubota Hitoshi Takagi Terumi Takahara Teruo Yoshinaga Department of Gastroenterology Saiseikai Maebashi Hospital Maebashi-City Japan Department of Radiology Saiseikai Maebashi Hospital Maebashi-City Japan Third Department of Internal Medicine Toyama University Toyama-City Japan

Background: Since advanced hepatocellular carcinoma (HCC) is potentially fatal, and patients’ quality of life (QOL) often deteriorates during their treatment, improving the prognosis and QOL of patients given chemotherapy is very important. In addition, cost-effective treatments are highly desirable when chemotherapy must be given repeatedly. The aim of this study was to evaluate the efficacy and usefulness of 5-fluorouracil (5-FU) and high-concentration cisplatin by short-term hepatic arterial infusion chemotherapy (3-day FPL) in advanced HCC patients. Methods: Thirty patients with unresectable advanced HCC were enrolled. The patients underwent hepatic arterial infusion chemotherapy via the implanted port system with 5-FU on days 1 - 3 and a fine-powder formulation of cisplatin in suspended pre-warmed lipiodol on day 2 every 4 to 10 weeks. Tumor response was assessed one month later with CT. Results: All patients had evidence of portal vein invasion (Vp2-4). Four patients achieved a complete response (CR), 8 patients achieved a partial response (PR), and 7 patients had stable disease (SD). The median progression-free survival (PFS) and overall survival (OS) were 198 days and 452 days, respectively. The OS was significantly longer in the successful disease control group (CR, PR, and SD) than in the progressive disease group (P < 0.005). Conclusions: Three-day FPL was effective and tolerable in advanced HCC patients due to its shorter time of administration than conventional FP therapy. Therefore, repetitive 3-day FPL appears useful and contributes to improving the prognosis and QOL of patients with advanced HCC. In addition, this protocol is a cost-effective treatment.

关键词： Advanced Hepatocellular Carcinoma (HCC) Portal Vein Tumor Thrombosis (PVTT) Hepatic Arterial Infusion Chemotherapy (HAIC) 5-FU a Fine-Powder Formulation of Cisplatin Quality of Life (QOL) Cost-Effective Treatment

基于非线性分析方法以及优化技术的张拉整体结构的自由形态设计方法（英文）

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空间结构 2015年第3期21卷 92-96页

作者：张景耀大崎纯名古屋市立大学建筑与设计学院广岛大学建筑系京都大学建筑工程系

由于张拉整体结构内部存在预应力,其形状必须处于自平衡状态而不能随意设计.因此,在张拉整体结构的研究领域中,自由形态设计一直是一个相对热点的课题.到目前为止已经有很多相关研究,并取得了不少进展,但仍然没有一种方法能得到大家的公... 详细信息

由于张拉整体结构内部存在预应力,其形状必须处于自平衡状态而不能随意设计.因此,在张拉整体结构的研究领域中,自由形态设计一直是一个相对热点的课题.到目前为止已经有很多相关研究,并取得了不少进展,但仍然没有一种方法能得到大家的公认.通过研究,作者发现非线性分析以及优化方法对于张拉整体结构的找形问题都是非常有效的方法.在本文中,这两种不同的方法被糅合在一起,以找到尽可能接近设计者所期待的自平衡形状.算例显示,该方法对于张拉整体结构的自平衡形状具有很好的控制能力.因此,该方法可适用于张拉整体结构的自由形态设计.

关键词：张拉整体结构自由形态设计找形非线性分析优化