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Using a novel hemostatic peptide solution to prevent bleeding after endoscopic submucosal dissection of a gastric tumor

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World Journal of Gastrointestinal Endoscopy 2024年第3期16卷 168-174页

作者： Kuniyo Gomi Yorimasa Yamamoto Erika Yoshida Misako Tohata Masatsugu nagahama Department of Gastroenterology Showa University Fujigaoka HospitalYokohama 227-8501KanagawaJapan

BACKGROUND Endoscopic mucosal dissection has become the standard treatment for early gastric ***,post-endoscopic submucosal dissection(ESD)ulcer occurs in 4.4%of *** study hypothesized whether applying PuraStat,a novel hemostatic peptide solution,prevents post-ESD *** To investigate the preventive potential of PuraStat,a hemostatic formulation,against bleeding in post-ESD gastric *** Between May 2022 and March 2023,101 patients(Group P)underwent ESD for gastric diseases at our hospital and received PuraStat(2 mL)for post-ESD *** retrospectively compared this group with a control group(Group C)com-prising 297 patients who underwent ESD for gastric diseases at our hospital between April 2017 and March 2021.P values<0.05 on two-sided tests indicated *** Post-ESD bleeding occurred in 6(5.9%)(95%CI:2.8-12.4)and 20(6.7%)(95%CI:4.4-10.2)patients in Groups P and C,respectively,with no significant between-group *** relative risk was 1.01(95%CI:0.95-1.07).The lesser curvature or anterior wall was the bleeding site in all 6 patients who experienced postoperative bleeding in Group *** multivariate analysis,the odds ratios for resection diameter≥50 mm and oral anticoagulant use were 6.63(95%CI:2.52-14.47;P=0.0001)and 4.04(1.26-0.69;P=0.0164),*** adjusted odds ratio of post-ESD bleeding and PuraStat was 1.28(95%CI:0.28-2.15).CONCLUSION PuraStat application is not associated with post-ESD ***,the study suggests that gravitational forces may affect the effectiveness of applied PuraStat.

关键词： Endoscopic submucosal dissection PuraStat Bleeding Gastric cancer hemostatic forceps Proton pump inhibitor hemostatic peptide solution

Benefits of endoscopic gallbladder stenting following percutaneous transhepatic gallbladder drainage

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2902-2909页

作者： Fumitaka Niiya Naoki Tamai Masataka Yamawaki Jun Noda Tetsushi Azami Yuichi Takano Fumiya Nishimoto Masatsugu nagahama Division of Gastroenterology Department of Internal MedicineShowa University Fujigaoka HospitalYokohama 227-8501KanagawaJapan

BACKGROUND Endoscopic transpapillary gallbladder drainage is challenging because of the complexity of the procedure and high incidence of adverse events(AEs).To overcome these problems,endoscopic gallbladder stenting(EGBS)after percutaneous transhepatic gallbladder drainage(PTGBD)can be effective,as it mitigates inflammation and *** To examine the benefits of EGBS after PTGBD to assess its efficacy and impact on *** We retrospectively analyzed data from 35 patients who underwent EGBS after PTGBD at a single center between January 2016 and December *** primary outcomes were technical success and AEs,and the rate of recurrent cholecystitis was *** addition,the reasons for the failure of the procedure were *** Among the 35 patients,the technical success rate was 77.1%and the final contrast of the cystic duct was successful in 97.1%of *** incidence of early AEs was relatively low(11.4%),with no instances of cystic duct *** rate of recurrent cholecystitis was 3.7%,and no other biliary events were *** EGBS after PTGBD may be significantly beneficial,with a substantial success rate and minimal AEs in both short-and long-term follow-ups.

关键词： Endoscopy Gallbladder Stents Drainage Adverse events Cholecystitis Follow-up Cystic duct

Genetic polymorphisms in glutathione S-transferase T1 affect the surgical outcome of varicocelectomies in infertile patients

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Asian Journal of Andrology 2009年第3期11卷 333-341页

作者： Kentaro Ichioka Kanji nagahama Kazutoshi Okubo Takeshi Soda Osamu Ogawa hiroyuki Nishiyama Department of Urology Kyoto University Graduate School of Medicine Kyoto 606-8507 Japan

Glutathione S-transferases （GSTs）, superoxide dismutase 2 （SOD2） and NAD（P）H：quinone oxidoreductase 1 （NQO1） are anti-oxidant enzyme genes. Polymorphisms of GSTs, SOD2 and NQO1 have been reported to influence individual susceptibility to various diseases. In an earlier study, we obtained preliminary findings that a subset of glutathione S-transferase 7：1 （GSTT1）-wt patients with varicocele may exhibit good response to varicocelectomy. In this study, we extended the earlier study to determine the distribution of genotype of each gene in the infertile population and to evaluate whether polymorphism of these genes affects the results of surgical treatment of varicocele. We analyzed 72 infertile varicocele patients, 202 infertile patients without varicocele and 101 male controls. Genotypes of GSTs were determined by polymerase chain reaction （PCR）. Genotyping of SOD2 and NQO1 was performed using the PCR-restriction fragment length polymorphism （PCR-RFLP） method. A significantly better response to varicocelectomy was found in patients with the GSTTI-wt genotype （63.2%） and NQO1-Ser/Ser genotype （80.0%） than in those with GSTTI-null genotype （35.3%） and NQO1-Pro/Pro or NQO1- Pro/Ser genotype （45.2%）, respectively. The frequencies of glutathione S-transferase M1/T1, SOD2 and NQO1 genotypes did not differ significantly among the varicocele patients, idiopathic infertile patients and male controls. GSTT1 genotype is associated with improvement of semen parameters after varicocelectomy. As the number of patients with NQO1-Ser/Ser genotype was not sufficient to reach definite conclusions, the association of NQO1 genotype with varicocelectomy requires further investigation.

关键词： genetic polymorphism GSTM1 GSTT1 male infertility NQO1 SOD2 varicocele testis

Impact of next-nearest leading vehicles on followers’ driving behaviours and traffic stability in mixed traffic

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第1期7卷 42-51页

作者： Akihito nagahama Daichi Yanagisawa Katsuhiro Nishinari Ritsumeikan Global Innovation Research Organization Ritsumeikan UniversityKusatsu 525-8577Japan Research Center for Advanced Science and Technology The University of TokyoTokyo 153-8904Japan

There has been an increase in the number of on-road vehicles of all types,especially in some developing *** rise of traffic heterogeneity causes larger mixed traffic conge *** study examines the impact of next-nearest leading vehicles on the driving of following drivers in mixed *** previous studies reported that traffic stability can be improved with the introduction of followers’anticipatory driving that refers to multiple leaders,the effect of anticipatory driving on mixed traffic has not yet been *** data collected from experiments conducted with groups of two and three vehicles,we found that operational delay,maximum acceleration and deceleration of the followers were affected by the presence of next-nearest *** addition,we developed regression models of the affected followers’behaviours with respect to the next-nearest leaders and identified the factors affecting these *** example,the followers’deceleration is directly affected by the height of the next-nearest leading ***,the model parameters for determining the deceleration of following vehicles should take the height of the next-nearest leading vehicle into ***,based on the regression models,we estimated values of parameters in the intelligent driver model when the type of the next-nearest leader was *** analysis based on these estimated parameters implied that a tall or short next-nearest leader with a large engine power would stabilise traffic when anticipatory driving of followers is possible.

关键词： Transportation engineering Mixed traffic Car-following behaviour Next-nearest leader Traffic stability Intelligent driver model

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Pod1 is involved in the sexual differentiation and gonadal development of the Nile tilapia

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Science China(Life Sciences) 2011年第11期54卷 1005-1010页

作者： LI JianZhong LIU ShaoJun nagahama Yoshitaka Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education College of Life Sciences Hunan Normal Univer sity Changsha 410081 China Laboratory of Reproductive Biology National Institute for Basic Biology Okazaki 444-8585 Japan

Pod1 is a member of the basic helix-loop-helix(bHLH) family of transcription factors that have been implicated in the regulation of sexual differentiation and gonadal development in ***,to date,little is known about the role of Pod1 in nonmammalian vertebrate *** cloned and characterized the Pod1 gene from *** tilapia Pod1 gene contains an open reading frame(ORF) of 525 nucleotides which potentially codes for a protein with 174 amino *** alignment revealed that the deduced tilapia protein sequence shared high homology(79.5% to 90.5%) with the Pod1 sequences of other *** tissue distribution of Pod1 revealed by RT-PCR showed that it had varied expression patterns in adult *** situ hybridization was performed to examine the temporal and spatial expression patterns of Pod1 during tilapia sexual differentiation and gonadal *** the undifferentiated gonad,Pod1 was expressed in the somatic cells of both ***,Pod1 expression in tilapia persisted in differentiated juvenile and adult ovary and *** data indicate for the first time that Pod1 is not only necessary for the onset of sexual differentiation,but also plays an important role in gonadal development in the teleost.

关键词： Pod1 somatic cells sexual differentiation gonadal development tilapia

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Reactions of Benzo[b]cyclobuta[d]pyran-3-one Derivatives with Sulfur Ylide

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复旦学报(自然科学版) 2005年第5期 285-286页

作者： Masayuki Yamashita,Yadav Navnath D.,Masaki nagahama,Tomoki Inaba,Ikuo Kawasaki,Shunsaku Ohta Kyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 Japan Kyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 Japan Kyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 Japan Kyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 Japan Kyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 Japan Kyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 Japan

Reactions of Benzo[b]cyclobuta[d]pyran-3-one Derivatives with Sulfur Ylide

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复旦学报（自然科学版） 2005年第5期44卷 895-896页

作者： Masayuki Yamashita Yadav Navnath D. Masaki nagahama Tomoki Inaba Ikuo Kawasaki Shunsaku Ohta Kyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 JapanKyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 JapanKyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 JapanKyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 JapanKyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 JapanKyoto Pharmaceutical University Misasagi-Nakauchicho 5 Yamashinaku Kyoto 607-8414 Japan

Small ring size cycloalkanes such as cyclopropanes and cyclobutanes have been found as a basic structuralconstituent in a wide rang of natural products[1]. In organic synthesis, their cycloalkanes also play an impor-t... 详细信息

关键词：立体收敛反应光化学叶立德加氢催化吡喃

超滤技术在碱性果胶酶浓缩工艺中的应用(英文)

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膜科学与技术 2001年第6期21卷 53-58页

作者：丁凤平,Hidetaka Noritomi,Kunio nagahama 东京都立大学工学研究院应用化学系东京都立大学工学研究院应用化学系东京都立大学工学研究院应用化学系东京日本东京日本东京日本

运用从自然界中分离得到的一株具有产生特效高活性碱性果胶酶的软腐欧文氏菌株ErwiniaCarotovoraIFO 3830 ,通过发酵得到了含有高活性碱性果胶酶的发酵液 .由于果胶酶在该发酵液中浓度极低 ,仅为数 μg/g左右 .为了从大量的但含有目的... 详细信息

运用从自然界中分离得到的一株具有产生特效高活性碱性果胶酶的软腐欧文氏菌株ErwiniaCarotovoraIFO 3830 ,通过发酵得到了含有高活性碱性果胶酶的发酵液 .由于果胶酶在该发酵液中浓度极低 ,仅为数 μg/g左右 .为了从大量的但含有目的酶浓度却极低的溶液中将目的酶分离出来 ,一般所使用的化工浓缩方法由于其操作温度较高使酶产品失活而无法运用 .目前被普遍用于酶浓缩的硫酸铵沉淀法 ,不仅化学药品的消耗极大 ,而且后处理工艺又比较复杂 ;回收得到的沉淀酶制品中因混入了大量的培养基和其他杂质 ,导致后处理工序的更加复杂 .本研究采用截留分子量为 5 0 0 0和 10 0 0 0 (道尔顿 )的超滤平面膜组件 ,可以直接从去除了菌体的发酵液中浓缩回收了目的产物碱性果胶酶 ,在浓缩率在 2 0倍的条件下 ,取得了98.3%的高回收率 .此外 ,还对超滤过程的表观阻力、浓缩率、渗透流束和浓缩液浓度等随着超滤过程的进行的变化规律进行了较为详细的研究

关键词：超滤碱性果胶酶浓缩动力学

Multicenter study of endoscopic preoperative biliary drainage for malignant distal biliary obstruction

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World Journal of Gastroenterology 2016年第14期22卷 3793-3802页

作者： Naoki Sasahira Tsuyoshi Hamada Osamu Togawa Ryuichi Yamamoto Tomohisa Iwai Kiichi Tamada Yoshiaki Kawaguchi Kenji Shimura Takero Koike Yu Yoshida Kazuya Sugimori Shomei Ryozawa Toshiharu Kakimoto Ko Nishikawa Katsuya Kitamura Tsunao Imamura Masafumi Mizuide Nobuo Toda Iruru Maetani Yuji Sakai Takao Itoi Masatsugu nagahama Yousuke Nakai hiroyuki Isayama Department of Gastroenterology JCHO Tokyo Takanawa HospitalTokyo 108-8606Japan Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Gastroenterology Saitama International Medical CenterSaitama Medical UniversitySaitama 350-1298Japan Department of Gastroenterology and Hepatology Saitama Medical University International Medical CenterSaitama 350-8550Japan Department of Gastroenterology Kitasato UniversityKanagawa 252-0375Japan Department of Gastroenterology Jichi Medical UniversityTochigi 329-0498Japan Department of Gastroenterology Tokai UniversityKanagawa 259-1193Japan Department of Gastroenterology Asahi General HospitalChiba 289-2511Japan Department of Internal Medicine Japanese Red Cross Ashikaga HospitalTochigi 326-0843Japan Department of Gastroenterology Kimitsu Central HospitalChiba 292-8535Japan Department of Gastroenterology Yokohama City University Medical CenterKanagawa 232-0024Japan Department of Gastroenterology Showa University Northern Yokohama HospitalKanagawa 242-0032Japan Department of Gastroenterology Saitama City HospitalSaitama 336-8522Japan Department of Gastroenterology Ageo Central General HospitalSaitama 362-8588Japan Division of Gastroenterology Department of MedicineShowa University School of MedicineTokyo 142-8666Japan Department of Gastroenterology Toranomon HospitalTokyo 105-0001Japan Department of Gastroenterology Gunma UniversityGunma 371-0034Japan Department of Gastroenterology Mitsui Memorial HospitalTokyo 101-8643Japan Division of Gastroenterology and Hepatology Department of Internal MedicineToho University Ohashi Medical CenterTokyo 153-0044Japan Department of Gastroenterology Chiba UniversityChiba 260-0856Japan Department of Gastroenterology Tokyo Medical UniversityTokyo 160-0023Japan Department of Gastroenterology Showa University Fujigaoka HospitalKanagawa 227-8501Japan

AIM: To determine the optimal method of endoscopic preoperative biliary drainage for malignant distal biliary ***: Multicenter retrospective study was conducted in patients who underwent plastic stent (PS) or nasobiliary catheter (NBC) placement for resectable malignant distal biliary obstruction followed by surgery between January 2010 and March 2012. Procedure-related adverse events, stent/catheter dysfunction (occlusion or migration of PS/NBC, development of cholangitis, or other conditions that required repeat endoscopic biliary intervention), and jaundice resolution (bilirubin level < 3.0 mg/dL) were evaluated. Cumulative incidence of jaundice resolution and dysfunction of PS/NBC were estimated using competing risk analysis. Patient characteristics and preoperative biliary drainage were also evaluated for association with the time to jaundice resolution and PS/NBC dysfunction using competing risk regression ***: In total, 419 patients were included in the study (PS, 253 and NBC, 166). Primary cancers included pancreatic cancer in 194 patients (46%), bile duct cancer in 172 (41%), gallbladder cancer in three (1%), and ampullary cancer in 50 (12%). The median serum total bilirubin was 7.8 mg/dL and 324 patients (77%) had ≥ 3.0 mg/dL. During the median time to surgery of 29 d [interquartile range (IQR), 30-39 d]. PS/NBC dysfunction rate was 35% for PS and 18% for NBC [Subdistribution hazard ratio (SHR) = 4.76; 95%CI: 2.44-10.0, P < 0.001]; the pig-tailed tip was a risk factor for PS dysfunction. Jaundice resolution was achieved in 85% of patients and did not depend on the drainage method (PS or NBC).CONCLUSION: PS has insufficient patency for preoperative biliary drainage. Given the drawbacks of external drainage via NBC, an alternative method of internal drainage should be explored.

关键词： Endoscopic preoperative biliary drainage Malignant distal biliary obstruction Periampullary cancer Plastic stent Nasobiliary drainage