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Actin filaments localization on the sorting endosomes

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Actin filaments localization on the sorting endosomes

Clinical benefit of radiation therapy and metallic stenting for unresectable hilar cholangiocarcinoma

Third Congress of the Asian-Pacific Organization for Cell Biology

作者： hiroyuki nakagawa Shigeaki Miyamoto Dept.of Biochem. Eng. & Sci. Kyushu Inst. of Tech.IizukaFukuoka 820Japan

By immunofluorescence microscopic observation, monoclonal and polyclonal antibodies against a synthetic actin

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World Journal of Gastroenterology 2012年第19期18卷 2364-2370页

作者： hiroyuki Isayama Takeshi Tsujino Yousuke Nakai Takashi Sasaki Keiichi nakagawa Hideomi Yamashita Taku Aoki Kazuhiko Koike Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Radiology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Division of Hepato-Biliary-Pancreatic and Transplantation Surgery Department of SurgeryGraduate School of MedicineUniversity of TokyoTokyo 113-8655Japan

AIM： To determine the efficacy of external beam radiotherapy （EBRT）, with or without intraluminal brachytherapy （ILBT）, in patients with non-resected locally advanced hilar cholangiocarcinoma.METHODS： We analyzed 64 patients with locally advanced hilar cholangiocarcinoma, including 25 who underwent resection （17 curative and 8 non-curative）, 28 treated with radiotherapy, and 11 who received best supportive care （BSC）. The radiotherapy group received EBRT （50 Gy, 30 fractions）, with 11 receiving an ad- ditional 24 Gy （4 fractions） ILBT by iridium-192 with remote after loading. ILBT was performed using percu-taneous transhepatic biliary drainage （PTBD） route. Uncovered metallic stents （UMS） were inserted into nonresected patients with obstructive jaundice, with the exception of four patients who received percutaneous transhepatic biliary drainage only. UMS were placed endoscopically or percutaneously, depending on the initial drainage procedure. The primary endpoints were patient death or stent occlusion. Survival time of patients in the radiotherapy group was compared with that of patients in the resection and BSC groups. Stent patency was compared in the radiotherapy and BSC groups.RESULTS： No statistically significant differences in patient characteristics were found among the resection, radiotherapy, and BSC groups. Three patients in the radiotherapy group and one in the BSC group did not receive UMS insertion but received PTBD alone; cholangitis occurred after endoscopic stenting, and patients were treated with PTBD. A total of 16 patients were administered additional systemic chemotherapy （5-fluorouracil-based regimen in 9, S-1 in 6, and gemcitabine in 1）. Overall survival varied significantly among groups, with median survival times of 48.7 mo in the surgery group, 22.1 mo in the radiotherapy group, and 5.7 mo in the BSC group. Patients who underwent curative resection survived significantly longer than those who were not candidates for surgery （P = 0.0076）

关键词： Hilar cholangiocarcinoma Radiotherapy Intra-luminal brachytherapy Biliary metallic stent Ob-structive jaundice

A weeding-duration model for Abies sachalinensis plantations in Hok-kaido, northern Japan

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Journal of Forestry Research 2013年第1期24卷 131-136页

作者： Masahiko nakagawa Doto Station Forestry Research InstituteHokkaido Research OrganizationShintoku-choHokkaido081-0038Japan

I developed a weeding-duration model for Sakhalin fir （Abies sachalinensis （Fr. Schmidt） Masters） plantations that employs a generalized linear model. The number of years following planting that weeding is necessary is the response variable, and elevation, slope steepness, maximum snow depth, annual precipitation, geology, soil, site index, slope aspect, and vegetation type are explanatory variables. Among the explanatory variables, geology, soil, slope aspect, and vegetation type are categorical data. A Poisson distribution is assumed for the response variable, with a log-link function. Elevation, slope steepness, maximum snow depth, annual precipitation, site index, and vegetation type had a significant effect on weeding duration. Among the eight models with the smallest Akaike information criterion （AIC）, I chose the model with no multicollinearity among the explanatory variables. The weeding-duration model includes site index, maximum snow depth, slope steepness （angle） and vegetation type as explanatory variables; elevation and annual precipitation were not included in the selected model because of multicollinearity with maximum snow depth. This model is useful for cost-benefit analyses of afforestation or reforestation with Abies sachalinensis.

关键词： Abies sachalinensis plantation snow depth site index weeding

On the Numerical Modeling of the Deep Mantle Water Cycle in Global-Scale Mantle Dynamics:The Effects of the Water Solubility Limit of Lower Mantle Minerals

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Journal of Earth Science 2017年第4期28卷 563-577页

作者： Takashi nakagawa Department of Mathematical Science and Advanced Technology Japan Agency for Marine-Earth Science and TechnologyYokohama 236-0001Japan

Water is the most important component in Earth system evolution. Here, I review the current understanding of the fate of water in the mantle dynamics system based on high-pressure and temperature experiments, geochemical analyses, seismological and geomagnetic observations, and nu- merical modeling of both regional- and giobal-scale mantle dynamics. In addition, as a numerical ex- ample, I show that the water solubility of the deep mantle is strongly sensitive to global-scale water cir- culation in the mantle. In a numerical example shown here, water solubility maps as functions of tem- perature and pressure are extremely important for revealing the hydrous structures in both the mantle transition zone and the deep mantle. Particularly, the water solubility limit of lower mantle minerals should be not so large as ~100 ppm for the mantle transition zone to get the largest hydrous reservoir in the giobal-scale mantle dynamics system. This result is consistent with the current view of mantle water circulation provided by mineral physics, which is also found as a hydrous basaltic crust in the deep mantle and the water enhancement of the mantle transition zone simultaneously. In this paper, I also discuss some unresolved issues associated with mantle water circulation, its influence on the onset and stability of plate motion, and the requirements for developing Earth system evolution in mantle dy- namics simulations.

关键词： numerical modeling mantle convection water cycle water solubility limit.

Inflammation-and stress-related signaling pathways in hepatocarcinogenesis

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World Journal of Gastroenterology 2012年第31期18卷 4071-4081页

作者： Hayato nakagawa Shin Maeda Department of Gastroenterology University of TokyoTokyo 113-8655Japan Department of Gastroenterology Yokohama City UniversityYokohama 236-0004Japan

It has been established that cancer can be promoted and exacerbated by *** carcinoma(HCC) is the fifth most common cancer worldwide,and its long-term prognosis remains *** HCC is a complex and heterogeneous tumor with several genomic mutations,it usually develops in the context of chronic liver damage and inflammation,suggesting that understanding the mechanism(s) of inflammation-mediated hepatocarcinogenesis is essential for the treatment and prevention of *** liver damage induces a persistent cycle of necroinflammation and hepatocyte regeneration,resulting in genetic mutations in hepatocytes and expansion of initiated cells,eventually leading to HCC ***,several inflammation-and stress-related signaling pathways have been identified as key players in these processes,which include the nuclear factor B,signal transducer and activator of transcription,and stress-activated mitogen-activated protein kinase *** these pathways may suggest potential therapeutic targets,they have a wide range of functions and complex crosstalk occurs among *** review focuses on recent advances in our understanding of the roles of these signaling pathways in hepatocarcinogenesis.

关键词： Hepatocellular carcinoma Inflammation Nuclear factor-~B Mitogen-activated protein kinase Signal transducer and activator of transcription c-JunNH2-terminal kinase p38 Transforming growth factor-activated kinase 1 Apoptosis signal-regulating kinase 1

Statistical Theory of Turbulence by the Late Lamented Dr. Shunichi TsugéCase Study on Flow through a Grid in Wind Tunnel

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Open Journal of Applied Sciences 2012年第4期2卷 18-21页

作者： Takeo nakagawa hiroyuki Iida School of Information Science Japan Advanced Institute of Science and Technology Nomi Japan Takeo nakagawa Hiroyuki Iida School of Information Science Japan Advanced Institute of Science and Technology Nomi Japan

This paper is concerned with statistical theory of turbulence by the late lamented Dr. Shunichi Tsugé.? The theory has been applied to the primary flow through a grid fixed vertically with respect to the horizontal axis of the wind tunnel.?The first analytical solution has been obtained and explained the well-known “the inverse-linear decay law” of the turbulent intensity.? It is believed that the present result is the first exact solution in the theory of turbulence.

关键词： grid-produced turbulence exact solution turbulent intensity statistical theory of turbulence applied mathematics

Promoting functional recovery by inhibition of repulsive guidance molecule-a after spinal cord injury

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Neural Regeneration Research 2018年第6期13卷 981-982页

作者： Hiroshi nakagawa Masahiko Takada Sobell Department of Motor Neuroscience and Movement Disorders Institute of Neurology University College London Systems Neuroscience Section Primate Research Institute Kyoto University

Spinal cord injury（SCI）leads to permanent disability with motor and sensory *** mature mammalian central nervous system（CNS）possesses a limited capacity to regenerate/regrow after injury.

关键词： Promoting functional recovery by inhibition of repulsive guidance molecule-a after spinal cord injury SCI

Certainty of patient survival with reference to game information dynamic model

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Open Journal of Preventive Medicine 2012年第4期2卷 490-498页

作者： hiroyuki Iida Takeo nakagawa Nathan Nossal School of Information Science Japan Advanced Institute of Science and Technology Nomi Japan

This paper is concerned with Hepato-Cellular Carcinoma (HCC) patients treated naturopathic agents. Patients treated with ≥4 agents survived significantly longer than patients treated with ≤3 agents. The great effect is seen in patients treated with at least 4 agents that include Cordyceps sinensis. This greater certainty of patient survival without toxic side effects is significant benefit comparing with the conventional therapy. Treatment of HCC with a regimen of ≥4 agents prepared from natural products is associated with greater certainty of patient survival in a substantial portion of patients. The information dynamic model for certainty of patient survival is derived based on fluid mechanics, where a series of approximate solutions of the flow between two parallel flat walls, one of which is at rest, the other is suddenly accelerated from the rest to a constant velocity are used. The kinetic energy of certainty of patient survival decreases with increasing time, while the potential energy increases with increasing time. Total mechanical energy of patients treated with 4 or more agents is smaller than that treated with 3 or fewer agents. The kinetic energy (potential energy) of patients treated with 4 or more agents decreases (increases) more slower than the kinetic energy (potential energy) of patients treated with 3 or fewer agents.

关键词： Certainty of Patient Survival Game Information Dynamic Model Naturopathic Therapy Herbal Treatment Natural Antioxidants Hepato-Cellular Carcinoma

Taming heterogeneous rhenium catalysis for the production of biomass-derived chemicals

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Chinese Chemical Letters 2020年第5期31卷 1071-1077页

作者： Keiichi Tomishige Yoshinao nakagawa Masazumi Tamura Department of Applied Chemistry School of EngineeringTohoku UniversityMiyagi 980-857Japan

Rhenium is one of important components for heterogeneous catalysts,which has been recently used for the catalytic reactions related to the production of biomass-derived chemicals such as deoxydehydration of vicinal OH groups,C-O hydrogenolysis,and hydrogenation of carboxylic acids,and so *** oxidation state of Re as a catalytic active species is strongly dependent on the catalytic *** control of the oxidation state of Re species on the catalysts is crucial on the catalyst development.

关键词： Rhenium Oxidation state Deoxydehydration Hydrogenolysis Hydrogenation