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World Journal of Gastroenterology 2014年第30期20卷 10512-10517页

作者： Hirotoshi Ishiwatari Tsuyoshi Hayashi Makoto Yoshida Michihiro Ono hiroyuki masuko Tsutomu Sato Koji Miyanishi Yasushi Sato Rishu Takimoto Masayoshi Kobune Atsushi Miyamoto Tomoko Sonoda Junji Kato Department of Medical Oncology and Hematology Sapporo Medical University School of MedicineSapporo 0600061Japan Department of Hospital Pharmacy Sapporo Medical University School of MedicineSapporo 0600061Japan Department of Public Health Sapporo Medical University School of MedicineSapporo 0600061Japan

AIM: To investigate the effectiveness of phenol for the relief of cancer pain by endoscopic ultrasound-guided celiac plexus neurolysis (EUS-CPN).

关键词： Celiac plexus neurolysis Celiac plexus blockade Endoscopic ultrasound Phenol Pain management Upper gastrointestinal cancer

Usefulness of Radiofrequency Ablation with the PVT-350BTP Probe for the treatment of Hepatocellular Carcinoma

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Open Journal of Medical Imaging 2011年第1期1卷 9-13页

作者： Naoki Hotta Kazuo masuko Department of Internal Medicine Division of Hepatology Masuko Memorial Hospital

Radiofrequency ablation (RFA) has been clinically employed in Japan, and its usefulness in the treatment of hepatocellular carcinoma (HCC) has been reported by many researchers. In the present study, the convex puncture probe PVT-350BTP, rather than a conventional convex probe, was used for RFA for the treatment of HCC and its usefulness was assessed. At the same time, evaluation of the therapeutic effect using ultrasound contrast agent was investigated. The subjects were 20 patients (16 men and 4 women) with 20 HCC nodules as confirmed by contrast CT or abdominal angiography. No nodules were ≤1.0 cm in diameter, 12 were 1.1 cm - 2.0 cm, and 8 were 2.1 cm - 3.0 cm. An Aplio diagnostic ultrasound system (Toshiba Medical Systems, Tokyo, Japan) and the PVT-350BTP probe (Toshiba) were employed for RFA. The PVT-350BTP supports puncture angles of 55, 70, 85, and 100 degrees. By mounting various types of puncture adapters on the probe, 13 G to 22 G puncture needles can be used. The needle can easily be attached and detached by operating a lever. Contrast echo studies with Levovist were performed before and after RFA, and the results were evaluated using the Advanced Dynamic Flow (ADF) imaging technique. Puncture was performed successfully using this probe for 20 cases with 20 nodules. It was confirmed that RFA with the PVT-350BTP permits percutaneous treatment to be performed more reliably than with a conventional probe.

关键词： Ultrasound RFA HCC PVT-350BTP

Usefulness of new live 3D ultrasound probe during radiofrequency ablation in a case of hepatocellular carcinoma

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Open Journal of Gastroenterology 2012年第1期2卷 15-17页

作者： Naoki Hotta Kazuo masuko Department of Internal Medicine Division of Hepatology Masuko Memorial Hospital Aichi Japan.

We report a case of hepatocellular carcinoma (HCC) with chronic hepatitis C virus (HCV) infection, suc-cessfully treated with percutaneous radiofrequency ablation (RFA) under new Live trhree-dimensional (3D) echo guidance for hearts probe before [1], but ,at the time, perform RFA with a new Live3D probe de- veloped flants. A 61 year-old Japanese man had a 3.5 cm in diameter HCC nodule in the liver S3 region. We applied the Live 3D ultrasonography during RFA therapy with a cool-tip needle electrode. The echo guidance facilitated an accurate approach for the needle puncture. The guidance was also useful for confirming, whether an adequate safety marging for the nodule had been obtained. Thus new Live 3D ul-trasonography echo technique appears to provide safe guidance of RFA needles via accurate targeting of HCC nodules, thereby allowing real-time visualize- tion when combined with echo contrast.

关键词： New Live 3D Probe HCC

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日本服装企业战略转型的双案例比较研究

日本服装企业战略转型的双案例比较研究

作者： masuko HIROSHI 上海交通大学

学位级别：硕士

随着互联网的不断发展,市场竞争全球化不断加剧,日本服装企业传统的商业文化难以适应,企业也面临着前所未闻的巨大挑战。同时,消费者对于服装的需求从高端奢侈品转变到低价高品质产品,催生了SPA运营、管理模式的服装品牌（文中简称“快... 详细信息

随着互联网的不断发展,市场竞争全球化不断加剧,日本服装企业传统的商业文化难以适应,企业也面临着前所未闻的巨大挑战。同时,消费者对于服装的需求从高端奢侈品转变到低价高品质产品,催生了SPA运营、管理模式的服装品牌（文中简称“快销时尚服装品牌”）。日本服装企业如要在变化多端的服装市场持续发展,需要摆脱日本传统的组织文化,并进行战略转型;同时,快销时尚服装品牌也需要对经营模式进行创新。本文通过分析快销时尚服装品牌代表UNIQLO的经营管理模式,与岛田商事株式会社（文中简称“岛田商事”）的现状进行比较,对其当下问题的对策以及未来可能机遇做出探索。通过双案例比较研究,可以为日本同行业企业,特别是还在停留在传统的商业文化企业,提供些许借鉴。另外,从全球来看,日本商社是日本特有的商业性质,而对于快销时尚服装品牌来说,商社在近期的未来并是不必须的商业形式。本文证明,在供应链管理中商社可以与不同的供应商合作并为服装品牌和消费者带来成本和创新的附加价值。

关键词：战略转型经营模式日本企业组织文化

Effects of <i>γ</i>-Polyglutamic Acid on Blood Glucose and Caecal Short Chain Fatty Acids in Adult Male Mice

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Food and Nutrition Sciences 2020年第1期11卷 8-22页

作者： Motoi Tamura Sachiko Hori Atsuko Inose masuko Kobori Food Function Division Food Research Institute of National Agriculture and Food Research Organization Tsukuba Ibaraki Japan

γ-Polyglutamic acid (γ-PGA) is a major component of Natto. We hypothesized that γ-PGA could reduce postprandial glucose rise and plasma glucose levels. Mice were fed a 0.1% γ-PGA—containing diet or control diet for 91 days. Maltose and starch tolerance tests were performed, and plasma lipids, glucose levels, and caecal short chain fatty acids (SCFAs) were measured. Mice were co-administered γ-PGA and starch to suppress the initial rise in blood glucose levels. Blood glucose levels at 15 min were significantly lower in the PGA group than in the Con group (P 0.05). The plasma glucose level and NEFA level were also significantly lower in the PGA group (P 0.05), and caecal acetic acid/total caecal SCFAs ratio was significantly increased in the PGA group (P 0.05). Significant negative correlations existed between the caecal acetic acid/propionic acid ratio and the weight of visceral fat/BW (r =?-0.57, P = 0.0318). Our results suggest that γ-PGA may effectively prevent metabolic syndrome by lowering blood glucose levels.

关键词： γ-Polyglutamic Acid Mice Blood Glucose Short Chain Fatty Acids

Effect of Foot Self-Care Behavior According to Severity of Diabetic Neuropathy in Japanese Patients with Diabetes

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Health 2018年第9期10卷 1192-1199页

作者： masuko Sumikawa Yumi Kuwamura Yasuyuki Sumikawa Toshiko Fujiwara Chizuru Kamiya Department of Nursing School of Health Sciences Sapporo Medical University Sapporo Japan Department of Women’s Health Nursing Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan Department of Dermatology School of Medicine Sapporo Medical University Sapporo Japan Sapporo Medical University Hospital Sapporo Japan Kansai University of Nursing and Health Sciences Awaji Japan

PURPOSE: Diabetic patients with severe diabetic neuropathy often have hypoesthesia and numbness. This study evaluated foot self-care behavior according to severity of diabetic neuropathy. METHODS: We used a hand-held nerve conduction test device DPN check (HDN-1000, Omron) to evaluate severity of diabetic neuropathy. Foot self-care was evaluated using the Japanese SDSCA (the Summary of Diabetes Self-Care Activities measure). Foot self-care comprised visual inspection, washing, wiping interdigital areas, and checking shoes, and was scored according to the number of days self-care which was performed in the previous week. RESULTS: The study evaluated 103 diabetic patients (age: 65.7 years, diabetes duration: 13.9 years, HbA1c: 7.3%). Total scores (out of 28 points) for self-care behavior according to neuropathy severity were 11.8 (Normal: n = 54), 10.6 (Mild: n = 27), 13.3 (Moderate: n = 17), and 10.8 (Severe: n = 5). Foot self-care scores were low in all groups, with particularly low scores in those with severe neuropathy. However, no statistically significant differences were observed. CONCLUSIONS: Foot self-care is essential in diabetes because lesions are more likely to occur in severe neuropathy. Living alone and the presence of recurrent foot lesions are associated with poor survival prognosis. Accordingly, foot-care intervention must take neuropathy severity and lifestyle factors into account. The severity of diabetic neuropathy must be determined and foot-care intervention should take lifestyle factors into account.

关键词： Foot Self-Care Behavior Diabetic Patients Diabetic Neuropathy Nerve Conduction Velocity Nerve Conduction Amplitude

Changes in Water Soluble Carbohydrates Content of Timothy (<i>Phleum pretense</i>L.) in Pastures of TMR Centers over 4 Years

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American Journal of Plant Sciences 2019年第2期10卷 276-284页

作者： Michiko Okubo Daisuke Takahashi Fumiya Abe Hideshi Shinoda Kenzaburo Deguchi Norie Shio Takayoshi masuko Kousaku Souma Faculty of Bioindustry Tokyo University of Agriculture Hokkaido Japan Snow Brand Seed Co. Ltd. Technical Research Institute Hokkaido Japan Animal Research Center Hokkaido Research Organization Hokkaido Japan Souya Agriculture Extension Office Hokkaido Agricultural Administration Hokkaido Japan Uvas Co. Ltd. Hokkaido Japan

Timothy (Phleum pretense L.) pastures of 3 Total mixed ration (TMR) centers in Hokkaido were selected, the first cutting grasses were continuously collected from the same pastures on different harvest days over 4 years (2011-2014), and changes in the water soluble carbohydrates (WSC) content were analyzed to investigate the relationship with weather conditions. The harvest days in the 4-year period were June 17-22, June 24-26, June 27-30, and July 2-5, and grasses on these dates were designated as the harvest date groups. The weather data during the cutting period in each year were utilized. The WSC content tended to change yearly and it was significantly lower in the 4 groups (67.3 - 82.1 g/kg DM) in 2011 than in the groups (101.5 - 130.3 g/kg DM) in 2013 excluding the June 24-26 group (P < 0.05, P < 0.01). The WSC content tended to increase as the harvest date progressed in 2011-2013 and it significantly increased even though the harvest date was delayed only in 2013 (P < 0.01). It was suggested that differences in the WSC content among the years were related to the weather condition and dry matter yield of the grass.

关键词： Grass Harvest Dates Hokkaido Timothy TMR Center Water Soluble Carbohydrates

新型广谱内吸杀菌剂——苯氧苯烷氧亚胺基乙脒

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江苏农药 1995年第1期 26-28页

作者： M.masuko 王宁

苯氧苯烷氧亚胺基乙脒是日本 shinogi公司的 *** 等人以先导化合物孢子素 A(Slrobuherin A)的结构发明的,其实验代号为 SSF-126,化学名称为:(E)-2-甲氧亚胺基-N-甲基-2-(2-苯氧苯基)乙脒,其化学结构如下:

关键词：杀菌剂广谱内吸杀菌剂苯氧苯烷氧亚胺基乙脒

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青贮期间硝酸盐消失与微生物群落的关系

草学 1983年第4期 90-96+14页

作者： Takayoshi masuko 侯发远

引言关于牧草青贮期间硝酸盐的消失情况,我们一直在进行研究。在早先所报道的有关试验中,我们曾发现以下趋势: (1) 在贮藏期间加葡萄糖的青贮料,其乳酸发酵加快,质量优良,而且其中的硝酸盐含量下降不明显。 (2) 贮前经过凋萎,含中等水... 详细信息

引言关于牧草青贮期间硝酸盐的消失情况,我们一直在进行研究。在早先所报道的有关试验中,我们曾发现以下趋势: (1) 在贮藏期间加葡萄糖的青贮料,其乳酸发酵加快,质量优良,而且其中的硝酸盐含量下降不明显。 (2) 贮前经过凋萎,含中等水分的青贮料,质量佳,但其中的硝酸盐含量显著下降。

关键词：青贮料葡萄糖含水量 pH 右旋糖己糖含水率硝酸还原硝酸盐含量青贮过程水溶性碳水化合物微生物群落

肺部非典型腺瘤性增生可能是发生肺部腺癌的前兆

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世界医学杂志 2001年第12期5卷 15-22页

作者： masuko Mori Sudha K Rao 等

越来越多的研究提出，肺部非典型腺瘤性增生（atypical adenomatous hyperplasia,AAH)可能是肺腺癌的前兆。世界卫生组织现在已承认AAH的存在，并指出，AAH可能不易与非粘液型细支气管肺泡癌鉴别，令人遗憾的是，目前尚无普遍认同的诊断... 详细信息

越来越多的研究提出，肺部非典型腺瘤性增生（atypical adenomatous hyperplasia,AAH)可能是肺腺癌的前兆。世界卫生组织现在已承认AAH的存在，并指出，AAH可能不易与非粘液型细支气管肺泡癌鉴别，令人遗憾的是，目前尚无普遍认同的诊断AAH的形态学标准，本文综述探讨了AAH的流行病学、大体外观，光镜下所见，形态测量，免疫组化和分子学特征，并提出一系列组织病理学特征，从而可能有助于临床病理医师识别这种诡异的病变，这些特征包括：沿肺泡框架扩散的局灶性不典型细胞增生，增生灶边缘不规则；细胞为立方至低柱状肺泡细胞，呈不同程度的不典型性，但不如在腺癌中见到的不典型严重，细胞体积和核－浆比增加，核深染和有明显的核仁，通常不典型细胞间连接完整，偶在这些细胞之间见有空隙，细胞构成不增多，也不成簇或呈乳头状结构；被AAH细胞散布的肺泡壁轻微增厚，有一些纤维组织增生，但无瘢痕形成，周围肺细胞也无明显的慢性炎症，有些研究指出，AAH是一种与肺腺癌密切相关的病变，认为AAH可能是复杂的肺腺癌多步骤癌变过程的早期。

关键词：肺腺癌肺部非典型腺瘤性增生 AAH 前驱病变分子学流行病学病理形态免疫组织化学方法动物模型