检索结果-南通市图书馆

Relationship between clinicopathological features and mucin phenotypes of advanced gastric adenocarcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第22期16卷 2764-2770页

作者： Fumiaki Toki Atsushi Takahashi Ryusuke Aihara Kyoichi Ogata hiroyuki Ando Tetsuro Ohno Erito Mochiki hiroyuki kuwano Department of General Surgical Science (Surgery I) Gunma University Graduate School of Medicine

AIM: To investigate a relationship between the clinicopathological features and mucin phenotypes in advanced gastric adenocarcinoma (AGA). METHODS: Immunohistochemical staining was performed to determine the mucin phenotypes in 38 patients with differentiated adenocarcinomas (DACs), 9 with signet-ring cell carcinomas (SIGs), and 48 with other diffuse-type adenocarcinomas (non-SIGs) of AGA. The mucin phenotypes were classified into 4 types: gastric (G), gastrointestinal (GI), intestinal, and unclassified. RESULTS: The G-related mucin phenotypes were highly expressed in all the histological subtypes of AGA. The expression of the GI phenotype in SIG patients was lower than that in DAC patients (P = 0.02), and this phenotype was observed in 56% of the non-SIG patients in the intramucosal layer. Among non-SIG cases, the expression of the GI phenotype was significantly higherin patients with extended adenocarcinomas and those with positive rates of lymph node metastasis. There was no difference between the expressions of the G and other GI phenotypes factors. Among DAC and non-SIG patients, there were no differences between the survival rates of the corresponding patient groups. CONCLUSION: The GI phenotype might possess more invasive characteristics than the G phenotype in nonSIG. Neither of the phenotypes indicated a poor prognosis of DAC and non-SIG.

关键词： Mucins Phenotype Diffuse type Undifferentiated type Gastric neoplasms Adenocarcinoma Prognosis

Extracapsular invasion as a risk factor for disease recurrence in colorectal cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第15期17卷 2003-2006页

作者： Takaaki Fujii Yuichi Tabe Reina Yajima Satoru Yamaguchi Soichi Tsutsumi Takayuki Asao hiroyuki kuwano Depart ment of General Surgical Science Graduate School of Medicine Gunma University Gunma 371-8511 Japan

AIM: To evaluate the presence of extracapsular invasion (ECI) in positive nodes as a predictor of disease recurrence disease in colorectal cancer. METHODS: Two hundred and twenty-eight consecutive patients who underwent colorectal resection were identified for inclusion in this study, of which 46 had positive lymph nodes. Among 46 cases with stage Ⅲcolorectal cancer, 16 had ECI at positive nodes and 8 had disease recurrence. The clinical and pathological features of these cases were reviewed. RESULTS: In the univariate analysis, the number of positive lymph nodes and depth of tumor invasion were significantly associated with the presence of ECI at positive nodes. Multivariate analysis demonstrated that only ECI was a predictor of recurrence. The recurrence-free interval differed significantly among patients with ECI at positive nodes.CONCLUSION: Our results suggest that ECI at metastatic nodes can identify which cases are at high risk of short-term disease recurrence in colorectal cancer.

关键词：复发间隔大肠癌疾病危险因素入侵 ECI 淋巴结单因素分析

Propofol sedation during endoscopic treatment for early gastric cancer compared to midazolam

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第34期20卷 11985-11990页

作者： Shinsuke Kiriyama Hiroshi Naitoh hiroyuki kuwano Department of Surgery Gunma Chuo General HospitalMaebashiGunma 371-0025Japan Department of General Surgical Science Graduate School of MedicineGunma UniversityGunma 371-0025Japan

Endoscopic submucosal dissection(ESD)has been proposed as the gold standard in the treatment of early gastric cancer because it facilitates a more accurate histological assessment and reduces the risk of tumor recurrence.However,the time course of ESD for large gastric tumors is frequently prolonged because of the tumor size and technical difficulties and typically requires higher doses of sedative and pain-controlling drugs.Sedative or anesthetic drugs such as midazolam or propofol are used during the procedure.Therapeutic endoscopy of early gastric cancers can often be performed with only moderate sedation.Compared with midazolam,propofol has a very fast onset of action,short plasma half-life and time to achieve sedation,faster time to recovery and discharge,and results in higher patient satisfaction.For overall success,maintaining safety and stability not only during the procedure but also subsequently in the recovery room and ward is necessary.In obese patients,it is recommended that the injected dose be based on a calculated standard weight.Cooperation between gastroenterologists,surgeons,and anesthesiologists is imperative for a successful ESD procedure.

关键词： Sedation Gastric cancer Endoscopic submucosal diss

Nuclear heat shock protein 110 expression is associated with poor prognosis and hyperthermo-chemotherapy resistance in gastric cancer patients with peritoneal metastasis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第42期23卷 7541-7550页

作者： Akiharu Kimura Kyoichi Ogata Bolag Altan Takehiko Yokobori Erito Mochiki Mitsuhiro Yanai Norimichi Kogure Toru Yanoma Masaki Suzuki Tuya Bai hiroyuki kuwano Department of General Surgical Science Gunma University Graduate School of Medicine Department of Oncology Clinical Development Gunma University Graduate School of Medicine Department of Molecular Pharmacology and Oncology Gunma University Graduate School of Medicine Department of Digestive Tract and General Surgery Saitama Medical CenterSaitama Medical University

AIM To investigate the significance of heat shock protein 110(HSP110) in gastric cancer(GC) patients with peritoneal metastasis undergoing hyperthermochemotherapy.METHODS Primary GC patients(n = 14) with peritoneal metastasis or positive peritoneal lavage cytology who underwent distal or total gastrectomy between April 2000 and December 2011 were enrolled in this study. The patients underwent postoperative intraperitoneal hyperthermo-chemotherapy using a Thermotron RF-8 heating device two weeks after surgery. We analyzed nuclear HSP110 expression in surgically resected tumors using immunohistochemistry. Additionally, the effect of HSP110 suppression on hyptherthermochemosensitivity was assessed in vitro in the MKN45 GC cell line using the HSP inhibitor KNK437. RESULTS HSP110 immnohistochemical staining in 14 GC patients showed that five(35.7%) samples belonged to the low expression group, and nine(64.3%) samples belonged to the high expression group. Progression-free survival was significantly shorter in the HSP110 high-expression group than in the low-expression group(P = 0.0313). However, no significant relationships were identified between HSP110 expression and the clinicopathological characteristics of patients. Furthermore, high HSP110 expression was not an independent prognostic factor in GC patients with peritoneal metastasis(P = 0.0625). HSP110 expression in MKN45 cells was suppressed by KNK437 at the hyperthermic temperature of 43 ℃ in vitro. Comparison of MKN45 cell proliferation in the presence and absence of KNK437 at 43 ℃, revealed that proliferation was significantly decreased when HSP110 was inhibited by KNK437. Additionally, HSP110 suppression via HSP inhibitor treatment increased cellular sensitivity to hyperthermo-chemotherapy in vitro.CONCLUSION The expression of nuclear HSP110 in GC patients might be a new marker of chemosensitivity and a therapeutic target for patients who are tolerant to existing hyperthermo-chemotherapies.

关键词： Peritoneal metastasis Hyperthermia Hyperthermo-chemotherapy Heat shock protein 110 Gastric cancer Drug resistance

Cancer-associated fibroblasts in hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第30期22卷 6841-6850页

作者： Norio Kubo Kenichiro Araki hiroyuki kuwano Ken Shirabe Department of Hepatobiliary and Pancreatic Surgery Gunma University Graduate School of Medicine Department of General Surgical Science Gunma University Graduate School of Medicine

The hepatic stellate cells in the liver are stimulated sustainably by chronic injury of the hepatocytes, activating myofibroblasts, which produce abundant collagen. Myofibroblasts are the major source of extracellular proteins during fibrogenesis, and may directly, or secreted products, contribute to carcinogenesis and tumor progression. Cancer-associated fibroblasts(CAFs) are one of the components of the tumor microenvironment that promote the proliferation and invasion of cancer cells by secreting various growth factors and cytokines. CAFs crosstalk with cancer cells stimulates tumor progression by creating a favorable microenvironment for progression, invasion, and metastasis through the epithelial-mesenchymal transition. Basic studies on CAFs have advanced, and the role of CAFs in tumors has been elucidated. In particular, for hepatocellular carcinoma, carcinogenesis from cirrhosis is a known fact, and participation of CAFs in carcinogenesis is supported. In this review, we discuss the current literature on the role of CAFs and CAF-related signaling in carcinogenesis, crosstalk with cancer cells, immunosuppressive effects, angiogenesis, therapeutic targets, and resistance to chemotherapy. The role of CAFs is important in cancer initiation and progression. CAF-targeted therapy may be effective for suppression not only of fibrosis but also cancer progression.

关键词： Cancer associated fibroblast Hepatic stellate cell Hepatocellular carcinoma Immunosuppression Therap

Xanthogranulomatous cholecystitis:Difficulty in differentiating from gallbladder cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第35期21卷 10166-10173页

作者： Hideki Suzuki Satoshi Wada Kenichiro Araki Norio Kubo Akira Watanabe Mariko Tsukagoshi hiroyuki kuwano Department of General Surgical Science (Surgery I) Gunma University Graduate School of Medicine Gunma University

AIM: To compare cases of xanthogranulomatous cholecystitis(XGC) and advanced gallbladder cancer and discuss the differential diagnoses and surgical options.METHODS: From April 2000 to December 2013, 6 XGC patients received extended surgical resections. During the same period, 16 patients were proven to have gallbladder(GB) cancer, according to extended surgical resection. Subjects chosen for analysis in this study were restricted to cases of XGC with indistinct borders with the liver as it is often difficult to distinguish these patients from those with advanced GB cancer. We compared the clinical features and computed tomography findings between XGC and advanced GB cancer. The following clinical features were retrospectively assessed: age, gender, symptoms, and tumor markers. As albumin and the neutrophil/lymphocyte ratio(NLR) are prognostic in several cancers, we compared serum albumin levels and the NLR between the two groups. The computerized tomography findings were used to compare the two diseases, determine the coexistence of gallstones, the pattern of GB thickening(focal or diffuse), the presence of a hypoattenuated intramural nodule, and continuity of the mucosal line.RESULTS: Based on the preoperative image findings, we suspected GB carcinoma in all cases includingXGC in this series. In addition, by pathological examination, we found that the group of patients with XGC developed inflammatory disease after surgery. Patients with XGC tended to have abdominal pain(4/6, 67%). However, there was no significant difference in clinical symptoms, including fever, between the two groups. Serum albumin and NLR were also similar in the two groups. Serum tumor markers, such as carcinoembryonic antigen(CEA) and carbohydrate antigen 19-9(CA19-9), tended to increase in patients with GB cancer. However, no significant differences in tumor markers were identified. On the other hand, gallstones were more frequently observed in patients with XGC(5/6, 83%) than in patients with GB cancer(4/16, 33%)(P = 0.0116). A hypoattenu

关键词： Xanthogranulomatous cholecystitis Advanced gallbla

Gastrojejunostomy for pyloric stenosis after acute gastric dilatation due to overeating

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第5期21卷 1670-1674页

作者： Akiharu Kimura Norihiro Masuda Norihiro Haga Tomokazu Ito Kichirou Otsuka Jyunko Takita Hitoshi Satomura Yuji Kumakura hiroyuki Kato hiroyuki kuwano Department of Surgery Utsunomiya National HospitalTochigi 329-1193Japan Department of General Surgical Science Gunma UniversityGraduate School of MedicineMaebashiGunma 371-8511Japan Department of Surgery I Dokkyo Medical UniversityTochigi 321-0293Japan

A 34-year-old woman presented at our hospital withabdominal distention due to overeating.Acute gastric dilatation was diagnosed.The patient was hospitalized,and nasogastric decompression was initiated.On hospitalization day 3,she developed shock,and her respiratory state deteriorated,requiring intubation and mechanical ventilation.Nasogastric decompression contributed to the improvement in her clinical condition.She was discharged 3 mo after admission.During outpatient follow-up,her dietary intake decreased,and her body weight gradually decreased by 14 kg.An upper gastrointestinal series and endoscopy revealed pyloric stenosis; therefore,we performed gastrojejunostomy 18 mo after her initial admission.The patient was discharged from the hospital with no postoperative complications.Gastric necrosis and perforation due to overeating-induced gastric dilatation are life-threatening conditions.Surgical intervention may be required if delayed pyloric stenosis occurs after conservative treatment.We report a case of pyloric stenosis due to overeating-induced gastric dilatation treated by gastrojejunostomy 18 mo after the initial presentation.

关键词： Acute gastric dilatation Bulimia Pyloric stenosis

Mechanism of gastrointestinal abnormal motor activity induced by cisplatin in conscious dogs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第42期20卷 15691-15702页

作者： hiroyuki Ando Erito Mochiki Tetsuro Ohno Mitsuhiro Yanai Yoshitaka Toyomasu Kyoichi Ogata Yuichi Tabe Ryuusuke Aihara Toshihiro Nakabayashi Takayuki Asao hiroyuki kuwano Department of General Surgical Science Gunma University Graduate School of Medicine

AIM: To investigate whether 5-hydroxytryptamine(serotonin; 5-HT) is involved in mediating abnormal motor activity in dogs after cisplatin administration.METHODS: After the dogs had been given a 2-wk recovery period, all of them were administered cisplatin, and the motor activity was recorded using strain gauge force transducers. Blood and intestinal fluid samples were collected to measure 5-HT for 24 h. To determine whether 5-HT in plasma or that in intestinal fluids is more closely related to abnormal motor activity we injected 5-HT into the bloodstream and the intestinal tract of the dogs.RESULTS: Cisplatin given intravenously produced abnormal motor activity that lasted up to 5 h. From 3 to 4 h after cisplatin administration, normal intact dogs exhibited retropropagation of motor activity accompanied by emesis. The concentration of 5-HT in plasma reached the peak at 4 h, and that in intestinal fluids reached the peak at 3 h. In normal intact dogs with resection of the vagus nerve that were administered kytril, cisplatin given intravenously did not produce abnormal motor activity. Intestinal serotonin administration did not produce abnormal motor activity, but intravenous serotonin administration did.CONCLUSION: After the intravenous administration of cisplatin, abnormal motor activity was produced in the involved vagus nerve and in the involved serotonergic neurons via another pathway. This study was the first to determine the relationship between 5-HT and emesis-induced motor activity.

关键词： Cisplatin Emesis 5-hydroxytryptamine Abnormal moto

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第11期12卷 1805-1809页

作者： Yoshimi Nakajima Hitoshi Takagi Naondo Sohara Ken Sato Satoru Kakizaki Kenichi Nomoto Hideki Suzuki Taketoshi Suehiro Tatsuo Shimura Takayuki Asao hiroyuki kuwano Masatomo Mori Ken Nishikura Department of Medicine and Molecular Science Gunma University Graduate School of Medicine MaebashiGunma 371-8511Japan Department of Surgery Gunma University Graduate School of Medicine MaebashiGunma 371-8511Japan Division of Molecular and Functional Pathology Department of Cellular Function Niigata University Graduate School of Medicine and Dental SciencesNiigataNiigata 951-8510Japan

因为 ultrasonography 检测的多重肝肿瘤，一个 42 岁的女人进入我们的医院。结肠镜检查在直肠揭示了粘膜下层肿瘤，它被认为梅毒初期损害。组织病理学说的检查跟随的内视镜的粘膜切除术表明肿瘤是良性肿瘤。肿瘤的 resected 边缘为恶... 详细信息

因为 ultrasonography 检测的多重肝肿瘤，一个 42 岁的女人进入我们的医院。结肠镜检查在直肠揭示了粘膜下层肿瘤，它被认为梅毒初期损害。组织病理学说的检查跟随的内视镜的粘膜切除术表明肿瘤是良性肿瘤。肿瘤的 resected 边缘为恶意的房间是积极的。二堂功课到 transcatheter 为肝转移的动脉的化疗是无效的。因此，直肠的肿瘤和变形淋巴结是通过手术 resected。在操作以后的一个月，她从她的儿子收到了肝移植(左侧面的片断和有尾的脑叶) 。没有周期性的损害在肝移植以后在二年被观察了。肝移植应该甚至在良性肿瘤转移的先进情况中被看作一种治疗选择到肝。我们也为变形良性肿瘤肿瘤在肝移植上讨论文学。

关键词：肝移植肝位移直肠癌病理