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Induction heating for desorption of surface contamination for high-repetition laser-driven carbon-ion acceleration

Matter and Radiation at Extremes 2023年第5期8卷 19-25页

作者： Sadaoki Kojima Tatsuhiko Miyatake Hironao Sakaki hiroyoshi kuroki Yusuke Shimizu Hisanori Harada Norihiro Inoue Thanh Hung Dinh Masayasu Hata Noboru Hasegawa Michiaki Mori Masahiko Ishino Mamiko Nishiuchi Kotaro Kondo Masaharu Nishikino Masaki Kando Toshiyuki Shirai Kiminori Kondo Kansai Institute for Photon Science National Institutes for Quantum Science and Technology(QST)8-1-7 UmemidaiKizugawaKyoto 619-0215Japan Interdisciplinary Graduate School of Engineering Sciences Kyushu University6-1Kasuga-KoenKasugaFukuoka 816-8580Japan Hitachi Zosen Corporation 7-89 Nanko-Kita 1-chomeSuminoe-kuOsaka 559-8559Japan Department of Accelerator and Medical Physics Institute for Radiological ScienceNational Institutes for Quantum Science and Technology(QST)4-9-1 AnagawaInage-kuChiba 263-8555Japan

This study reports the first experimental demonstration of surface contamination cleaning from a high-repetition supply of thin-tape targets for laser-driven carbon-ion *** adsorption of contaminants containing protons,mainly water vapor and hydrocarbons,on the surface of materials exposed to low vacuum(>10^(−3)Pa)suppresses carbon-ion *** newly developed contamination cleaner heats a 5-μm-thick nickel tape to over 400℃in 100 ms by induction *** the future,this heating method could be scaled to laserdriven carbon-ion acceleration at rates beyond 10 *** contaminant hydrogen is eliminated from the heated nickel surface,and a carbon source layer—derived from the contaminant carbon—is spontaneously formed by the catalytic effect of *** species of ions accelerated from the nickel film heated to various temperatures have been observed *** the nickel film is heated beyond∼150℃,the proton signal considerably decreases,with a remarkable increase in the number and energy of carbon *** Langmuir adsorption model adequately explains the temperature dependence of desorption and re-adsorption of the adsorbed molecules on a heated target surface,and the temperature required for proton-free carbon-ion acceleration can be estimated.

关键词： acceleration heated nickel

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Nuclear physics with RI Beam Factory

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Frontiers of physics 2018年第6期13卷 145-159页

作者： hiroyoshi Sakurai Department of Physics University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan RIKEN Nishina Center for Accelerator-Based Science 2-1 Hirosawa Wako Saitama 351-0198 Japan

Research activities of nuclear physics at Radioactive Isotope Beam Factory over 10 years are reviewed and future directions are also discussed. Conceptual ideas in designing the facility as well as experimental device... 详细信息

关键词： radioactive isotope beams heavy-ion accelerator facility in-flight production experimental devices and techniques storage rings r-process path nuclear waste problems

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Use of family structure information in interaction with environments for leveraging genomic prediction models

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The Crop Journal 2020年第5期8卷 843-854页

作者： Reyna Persa hiroyoshi Iwata Diego Jarquin Department of Agronomy and Horticulture University of Nebraska-LincolnLincolnNE 68583USA Graduate School of Agricultural and Life Sciences The University of TokyoBunkyoTokyo 113-8657Japan

The characterization of genomes with great detail offered by the modern genotyping platforms have opened a venue for accurately predicting the genotype-by-environment interaction(GE)effects of untested genotypes in different environmental *** developed statistical models have shown the advantages of including the GE interaction component in the prediction context using molecular markers,pedigree,or *** order to leverage the family information of highly structured populations when pedigree data is not available,we developed a model that uses the family membership *** proposed model extends the reaction norm model by including the interaction between families and environments(FE).A representative fraction of a soybean Nested Association Mapping population(16,187 grain yield records)comprising 38 bi-parental families(1358 genotypes)observed in 18 environments(2011,2012,and 2013)was used to contrast the proposed model with three conventional prediction *** crossvalidation scenarios(prediction of tested[CV2]and untested[CV1]genotypes)with a twofold design(50%for training and testing sets)were used for mimicking prediction situations that breeders face in *** showed that the family factor in interaction with environments explains a sizable amount of the phenotypic *** helped to improve the predictive ability with respect to the main effects model(GBLUP)around 41%(CV2)and 49%(CV1),and about 17%with respect to the conventional reaction norm *** inclusion of the FE term not only improved the global results but also significantly increased the prediction accuracy of those environments where the conventional models showed a very poor *** results show the importance of taking into consideration the family structure existing in breeding programs for improving the selection strategies in multi-parental populations.

关键词： interaction structure instead

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Mucosal-associated invariant T cells from induced pluripotent stem cells:A novel approach for modeling human diseases

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World Journal of Stem Cells 2016年第4期8卷 158-169页

作者： Chie Sugimoto hiroyoshi Fujita Hiroshi Wakao Department of Hygiene and Cellular Preventive Medicine Graduate School of MedicineHokkaido University

Mice have frequently been used to model human diseases involving immune dysregulation such as autoimmune and inflammatory *** models help elucidatethe mechanisms underlying the disease and in the development of novel ***,if mice are deficient in certain cells and/or effectors associated with human diseases,how can their functions be investigated in this species?Mucosal-associated invariant T(MAIT)cells,a novel innate-like T cell family member,are a good *** cells are abundant in humans but scarce in laboratory *** cells harbor an invariant T cell receptor and recognize nonpeptidic antigens vitamin B2metabolites from bacteria and *** studies have shown that MAIT cells play a pivotal role in human diseases such as bacterial infections and autoimmune and inflammatory *** cells possess granulysin,a human-specific effector molecule,but granulysin and its homologue are absent in ***,MAIT cells show poor proliferation in *** overcome these problems and further our knowledge of MAIT cells,we have established a method to expand MAIT cells via induced pluripotent stem cells(iP SCs).In this review,we describe recent advances in the field of MAIT cell research and our approach for human disease modeling with iP SCderived MAIT cells.

关键词： Mucosal-associated invariant T cells Induced pluripotent stem cells Differentiation Adoptive transfer Inflammatory diseases Autoimmune diseases Disease modeling Infectious diseases Immunocompromised mouse

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Correlation of magnetic anisotropy with dielectric anisotropy in fluorinated phenyl bicyclohexane liquid crystal

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Chinese Physics B 2010年第7期19卷 414-419页

作者：马恒 Onnagawa hiroyoshi Sugimori Sigeru Toriyama Kazuhisa Department of Physics Henan Normal University Henan Key Laboratory of Photovoltaic Materials Liquid Crystal Research Group of Toyama

Temperature dependence of magnetic anisotropy of homologous nematic fluorinated phenyl bicyclohexane liquid crystals is measured by a magneto-electric method. The result shows that the diamagnetic property is slightly influenced by the positions and the numbers of fluorine atoms substituted at the phenyl ring. By investigating the correlation of the dielectric anisotropy with the magnetic anisotropy, a novel explanation is proposed for the behaviour of the molecular dipole-dipole dimerization in the polar liquid crystal compounds.

关键词： fluorine liquid crystal magnetic dielectric

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Role of androgen receptor in prostate cancer

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Asian Journal of Andrology 1999年第3期1卷 81-85页

作者： hiroyoshi Suzuki Haruo Ito Department of Urology Chiba University School of Medicine I-8-I Inohana Chuo-ku Chiba-shi Chiba 260-8670 JapanDepartment of Urology Chiba University School of Medicine I-8-I Inohana Chuo-ku Chiba-shi Chiba 260-8670 Japan

The growth of prostate cancer is sensitive to androgen, and hormonal therapy has been used for treatment of ad-vanced cancer. About 80% of prostate cancers initially respond to hormonal therapy, howerver, more than half of the re-sponders gradually become resistant to this therapy. Changes in tumors from an androgen-responsive to an androgen-unre-sponsive state have been widely discussed. Since androgen action is mediated by androgen receptor (AR), abnormalitiesof AR is believed to play an important role of the loss of androgen responsiveness in prostate cancer. This article focusedon the role of AR in the progression of prostate cancer. (Asian J Androl 1999 Sep; 1: 81-85)

关键词： androgen receptors prostatic neoplasms genetic change methylation

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Multispectral Phenotyping and Genetic Analyses of Spring Appearance in Greening Plant, Phedimus spp.

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Plant Phenomics 2023年第2期5卷 353-367页

作者： Taeko Koji hiroyoshi Iwata Motoyuki Ishimori Hideki Takanashi Yuji Yamasaki Hisashi Tsujimoto The United Graduate School of Agricultural Sciences Tottori University4-101 Koyamacho minamiTottori-shiTottori 680-8553Japan Graduate School of Agricultural and Life Sciences The University of Tokyo1-1-1 Yayoi-chouBunkyoTokyo 113-8657Japan Arid Land Research Center Tottori University1390 HamasakaTottori-shiTottori 680-0001Japan

The change in appearance during the seasonal transitions in ornamental greening plants is an important *** particular,the early onset of green leaf color is a desirable trait for a *** this study,we established a method for phenotyping leaf color change by multispectral imaging and performed genetic analysis based on the phenotypes to clarify the potential of the approach in breeding greening *** performed multispectral phenotyping and quantitative trait locus(QTL)analysis of an F1 population derived from 2 parental lines of Phedimus takesimensis,known to be a drought and heat-tolerant rooftop plant *** imaging was conducted in April of 2019 and 2020 when dormancy breakage occurs and growth extension *** component analysis of 9 different wavelength values showed a high contribution from the first principal component(PC1),which captured variation in the visible light *** high interannual correlation in PC1 and in the intensity of visible light indicated that the multispectral phenotyping captured genetic variation in the color of *** also performed restriction site-associated DNA sequencing and obtained the first genetic linkage map of Phedimus *** analysis revealed 2 QTLs related to early dormancy *** on the genotypes of the markers underlying these 2 QTLs,the F1 phenotypes with early(late)dormancy break,green(red or brown)leaves,and a high(low)degree of vegetative growth were *** results suggest the potential of multispectral phenotyping in the genetic dissection of seasonal leaf color changes in greening plants.

关键词： breeding cultivar visible

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Patient blinding with blunt tip placebo acupuncture needles:comparison between 1 mm and 2 mm skin press

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Journal of Integrative Medicine 2018年第3期16卷 164-171页

作者： Nobuari Takakura Miho Takayama Morihiro Nasu Masako Nishiwaki Akiko Kawase hiroyoshi Yajima Department of Acupuncture and Moxibustion Faculty of Health Sciences Tokyo Ariake University of Medical and Health Sciences Department of Physiology Showa University School of Medicine Japan School of Acupuncture Moxibustion and Physiotherapy

Objective： To investigate the influence of the depth of skin press in blunt tip placebo acupuncture needles on patient blinding and its relationship to needle ***： Forty healthy volunteers were enrolled as subjects for patient blinding. Four acupuncturists applied the following needles randomly at three points in each forearm： 0.18 mm and 0.25 mm diameter penetrating needles inserted to a depth of 5 mm, and 0.18 mm and 0.25 mm diameter skin-touch needles depressing the skin at the acupoint to a depth of 1 mm and 2 mm from the skin surface. The subjects reported their guesses at the nature of needles they received, and rated needle pain and de qi. A blinding index was calculated to define the success of blinding for ***： The blinding status of subjects for 1 mm press needles of 0.18 mm diameter was ＂random guess＂,but ＂unblinded＂ for 1 mm press needles of 0.25 mm diameter. For 2 mm press needles of both diameters,the blinding status was ＂opposite guess＂ and the blinding status for penetrating needles of both diameters was ＂unblinded.＂ The percentages of ＂felt pain＂ with 2 mm press needles of both diameters were similar to that with penetrating needles, but those were not similar for 1 mm press needles. The frequency of de qi occurrence with 2 mm press needles of 0.18 mm diameter was similar to that of penetrating needles of both ***： Placebo needles of 2 mm press made more subjects guess that the needles penetrated the skin than 1 mm press needles. The use of small diameter needles increased patient blinding.

关键词： Double-blind method Acupuncture Placebo Sham De qi

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Recent traction methods for endoscopic submucosal dissection

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World Journal of Gastroenterology 2016年第26期22卷 5917-5926页

作者： Kunihiro Tsuji Naohiro Yoshida hiroyoshi Nakanishi Kenichi Takemura Shinya Yamada Hisashi Doyama Department of Gastroenterology Ishikawa Prefectural Central Hospital

Endoscopic mucosal resection(EMR) is problematic with regard to en bloc and curable resection *** in endoscopic techniques have enabled novel endoscopic approaches such as endoscopic submucosal dissection(ESD), which has overcome some EMR problems, and has become the standard treatment for gastrointestinal tumors. However, ESD is technically difficult. Procedure time is longer and complications such as intraoperative perforation and bleeding occur more frequently than in EMR. Recently various traction methods have been introduced to facilitate ESD procedures, such as clip with line, external forceps, clip and snare, internal traction, double scope, and magnetic anchor. Each method must be used appropriately according to the anatomical characteristics. In this review we discuss recently proposed traction methods for ESD based on the characteristics of various anatomical sites.

关键词： Endoscopic submucosal dissection Traction Pharyngeal cancer Esophageal cancer Gastric cancer Colorectal cancer

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The difference of Park and Streitberger singleblind needles from Takakura double-blind needle

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Journal of Integrative Medicine 2015年第4期13卷 212-214页

作者： Nobuari Takakura Miho Takayama hiroyoshi Yajima Department of Acupuncture and Moxibustion Faculty of Health Sciences Tokyo Ariake University of Medical and Health Sciences Department of Physiology Showa University School of Medicine

In a recent study aimed at validating the Park sham needle for use as a double-blind control intervention,To and Alexander concluded that the practitioner who was performing acupuncture recognized the type of needle[1].This paper may lead the reader to misunderstand the design and purpose of placebo/sham acupuncture[2–6]which have been developed in recent decades for the purpose of acupuncture research.

关键词： acupuncture single blind double blind sham treatment

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