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Acta Pharmaceutica Sinica B 2012年第1期2卷 23-27页

作者： Takashi Fukuda Ryuji Uchida hiroyo inoue Satoshi Ohte Hiroyuki Yamazaki Daisuke Matsuda Takenobu Katagiri Hiroshi Tomoda Graduate School of Pharmaceutical Sciences Kitasato UniversityTokyoJapan Research Center for Genomic Medicine Saitama Medical UniversitySaitamaJapan

Fibrodysplasia ossificans progressiva(FOP)is a rare autosomal dominant congenital disorder characterized by progressive heterotopic ossification in muscle tissues.A constitutively activated mutation of a bone morphogenetic protein(BMP)receptor,ALK2,has been identified in patients with *** report here that four structurally related compounds,lucilactaene,hydroxylucilactaene,NG-391 and NG-393,produced by fungal strain Fusarium sp.B88,inhibit BMP signaling in *** phosphatase activity,a marker enzyme of osteoblastic differentiation,was decreased in C2C12 myoblasts stably expressing mutant ALK2 by treatment with those compounds with IC_(50) values of 5.7,6.8,6.9 and 6.1 mM,***,NG-391 and NG-393 inhibited BMP-specific luciferase reporter activity,which is directly regulated by transcription factor Smads,with IC50 values of 1.4 and 2.1 mM,*** findings suggest that these fungal metabolites may provide a new direction in the development of FOP therapeutics.

关键词： Lucilactaenes Fungal metabolites C2C12 myoblasts Fibrodysplasia ossificans progressiva

Synthesis,structure and mechanical properties of Zr-Cu-based bulk metallic glass composites

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International Journal of Minerals,Metallurgy and Materials 2010年第2期17卷 208-213页

作者： Akihisa inoue Institute for Materials Research Tohoku University

The unusual glass-forming ability（GFA） of the Zr48Cu36Ag8Al8 alloy and the high ductility of the Zr48Cu36Ag8Al8 metallic glass-matrix composites containing Ta powder were *** bulk metallic glass rod with a diameter of 25 mm was successfully synthesized using copper mold casting for the Zr48Cu36Ag8Al8 *** GFA of this alloy was found to be related to a large supercooled liquid region and a quaternary eutectic point with low melting *** bulk metallic glass matrix composites were prepared by introducing extra Ta particles into the Zr48Cu36Ag8Al8 *** composites consist of Ta particles homogenously distributed in the Zr48Cu36Ag8Al8 metallic glass *** optimum content of Ta powder is 10at%for the composite with the highest plasticity,which shows a plastic strain of 31%.

关键词： bulk metallic glass composites glass forming ability Zr-Cu-based alloy plastic strain

Stress Dependence of Transformation Plastic Behavior

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材料热处理学报 2004年第5期25卷 208-213页

作者： Tatsuo inoue Fukuyama University Fukuyama/Himshima Japan

Transformation plasticity is known to play an important role in the course of heat treatment processes, and so affect the results of heat treatment simulations, which means that the transformation plasticity coefficient is necessary to be identifies. The authors developed a new method by use of four-point bending system of a beam to identify transformation plasticity coefficient taking advantage of its easiness and high accuracy compared with other conventional methods like tension test, etc., and identified the coefficient for four kinds of steels; plane carbon steel, Cr-steel, Cr-Mo steel and bearing steel. In this paper, further experimental data are presented for the steels if the coefficient Kp during pearlite transformation depend on the applied stress. Obtained results reveals that the stress dependence of Kp is rather trivial except for uncertain tendency detected in plane carbon steel. The relation between the Kp and carbon content included is discussed in comparison with other data referred from references.

关键词：相变塑性四点弯曲试验应力关系金属热机械性能

Potential significance of CX3CR1 dynamics in stress resilience against neuronal disorders

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Neural Regeneration Research 2022年第10期17卷 2153-2156页

作者： Koichi inoue Department of Integrative Anatomy Nagoya City University Graduate School of Medical SciencesNagoyaJapan

Recent findings have implicated inflammatory responses in the central nervous system in a variety of neuropsychiatric and neurodegenerative diseases,and the understanding and control of immunological responses could be a major factor of future therapeutic strategies for neurological ***,derived from myelogenous cells,respond to a number of stimuli and make immune responses,resulting in a prominent role as cells that act on inflammation in the central nervous ***(FKN or CX3CL1)signaling is an important factor that influences the inflammatory response of *** receptor for FKN,CX3CR1,is usually expressed in microglia in the brain,and therefore the inflammatory response of microglia is modified by ***,FKN often suppresses inflammatory responses in microglia and activation of its receptor may be effective in the treatment of inflammatory neurological ***,it has also been suggested that inflammatory responses facilitated by FKN signaling aggravate neurological ***,further studies are still required to resolve the conflicting interpretation of the protective or deleterious contribution of microglial FKN *** notably,regulation of FKN signaling has recently been shown to be beneficial in the treatment of human diseases,although not neurological *** addition,a CX3CR1 inhibitor has been developed and successfully tested in animal models,and it is expected to be in human clinical trials in the *** this review,I describe the potential therapeutic consideration of microglial CX3CR1 dynamics through altered FKN signaling.

关键词： Alzheimer’s disease CX3CR1 fractalkine inflammation knockout mice microglia resilience SARS-CoV-2 stress stroke

Culm form analysis for bamboo, Phyllostachys pubescens

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Journal of Forestry Research 2013年第3期24卷 525-530页

作者： Akio inoue Laboratory of Forest Ecology Faculty of Environmental and Symbiotic Sciences Prefectural University of KumamotoKumamoto 862-8502 Japan

We investigated the culm form for one of the largest bamboo species, Phyllostachys pubescens Mazel ex Houz. in relation to the me- chanical constraint principles, i.e., elastic, stress and geometric similarity. The fine-resolution analysis of the culm taper indicated that the culm for P. pubescens consisted of three or four segments with various forms, except for the butt swell. This implied that the taper of the whole culm for P. pubescens could be expressed by neither of these principles. The regression slope between culm height and diameter at breast height on the double logarithmic coordinates was 0.629, which was significantly different from the values predicted from these principles. In conclusion, none of these mechanical constraint principles can express the culm taper and height-diameter relationship, and there may be a need for a more complicated model to express the culm form for P. pubescens.

关键词： culm taper fine-resolution analysis height-diameter rela-tionship mechanical constraint principle Phyllostachys pubescens

The Chloroplast Outer Envelope Membrane:The Edge of Light and Excitement

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Journal of Integrative Plant Biology 2007年第8期49卷 1100-1111页

作者： Kentaro inoue Department of Plant Sciences College of Agricultural & Environmental SciencesUniversity of CaliforniaOne Shields AvenueDavisCA 95616USA

The chloroplast is surrounded by a double-membrane envelope at which proteins, ions, and numerous metabolites including nucleotides, amino acids, fatty acids, and carbohydrates are exchanged between the two aqueous phases, the cytoplasm and the chloroplast stroma. The chloroplast envelope is also the location where the biosynthesis and accumulation of various lipids take place. By contrast to the inner membrane, which contains a number of specific transporters and acts as the permeability barrier, the chloroplast outer membrane has often been considered a passive compartment derived from the phagosomal membrane. However, the presence of galactoglycerolipids and β-barrel membrane proteins support the common origin of the outer membranes of the chloroplast envelope and extant cyanobacteria. Furthermore, recent progress in the field underlines that the chloroplast outer envelope plays important roles not only for translocation of various molecules, but also for regulation of metabolic activities and signaling processes. The chloroplast outer envelope membrane offers various interesting and challenging questions that are relevant to the understanding of organelle biogenesis, plant growth and development, and also membrane biology in general.

关键词： chloroplast envelope lipid biosynthesis outer membrane protein import putative solute channel

Detection of small delamination in mullite/Si/SiC model EBC system by pulse thermography

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Journal of Advanced Ceramics 2019年第3期8卷 438-447页

作者： Yutaro ARAI Ryo inoue Department of Materials Science and Technology Tokyo University of Science6-3-1NiijyukuKatsushika-kuTokyo125-8585Japan Department of Mechanical Engineering Tokyo University of Science6-3-1NiijyukuKatsushika-kuTokyo125-8585Japan

The pulse thermography(PT) technique was applied to the detection of the delamination of a multi-layered coating system composed of mullite/Si onto a reaction-bonded Si C substrate. The potential evaluation was carried out in order to detect internal delamination in multi-layered material system. Moreover, the observation of the cross sections and 3D views obtained by X-ray computed tomography(CT) indicated that the delamination occurred at the interface between the top coat and the bond coat layers. The changes in the temperature distribution obtained by PT indicated the existence of a delamination area in the top coat layer of the mullite. In particular, the lower temperature region corresponded to the delamination area. The experimental results confirmed that the PT technique is effective with respect to the internal delamination of multi-layered coating system.

关键词： environmental barrier coatings (EBCs) delamination pulse thermography (PT) multi-layer image processing

River system in Japan from a landscape ecological aspect

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Journal of Environmental Sciences 2003年第2期15卷 160-166页

作者： Nobukazu NAKAGOSHI Masahito inoue Graduate School for International Development and Cooperation Hiroshima UniversityGraduate School for International Development and Cooperation Hiroshima University 1-5-1 Kagamiyama Higashi-Hiroshima 739-8529 Japan1-5-1 Kagamiyama Higashi-Hiroshima 739-8529 Japan

The objective of this study was to elucidate characteristics associated with rivers by classification of major rivers in Japan into several types based on riparian conditions. As the results of principal component analysis (PCA) with use of parameters reflecting forms and artificial alterations of respective rivers, four major components such as “comprehensive riparian size', “intactness of water front', “continuity of streams' and “simplicity of landform in river basin' were extracted. Subsequently, cluster analysis was performed based on principal component scores, leading to successful classification of major rivers into 6 types. These findings disclosed that (1) the extracted principal components provide effective viewpoint for classification of rivers; (2) distribution of respective classes indicates area properties; and (3) the employed quantitative procedures were found effective for classification of major rivers.

关键词： river system landscape ecological aspect Japan

Robust Stability of Nonlinear Plants with a Non-symmetric Prandtl-Ishlinskii Hysteresis Model

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International Journal of Automation and computing 2010年第2期7卷 213-218页

作者： Akira inoue Graduate School of Natural Science and Technology Okayama University

In this paper, robust stability of nonlinear plants represented by non-symmetric Prandtl-Ishlinskii （PI） hysteresis model is studied. In general, PI hysteresis model is the weighted superposition of play or stop hysteresis operators, and the slopes of the operators are considered to be the same. In order to make a hysteresis model, a modified form of non-symmetric play hysteresis operator with unknown slopes is given. The hysteresis model is described by a generalized Lipschitz operator term and a bounded parasitic term. Since the generalized Lipschitz operator is unknown, a new condition using robust right coprime factorization is proposed to guarantee robust stability of the controlled plant with the hysteresis nonlinearity. As a result, based on the proposed robust condition, a stabilized plant is obtained. A numerical example is presented to validate the effectiveness of the proposed method.

关键词： Prandtl-Ishlinskii (PI) hysteresis model robust stability right coprime factorization non-symmetric play hysteresis operator nonlinear plants.

Cast bulk glassy alloys:fabrication,alloy development and properties

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China Foundry 2010年第3期7卷 278-286页

作者： Akihisa inoue WPI Advanced Institute for Materials Research Tohoku University

Metallic glasses represent an interesting group of materials as they possess outstanding physical, chemical and mechanical properties compared to their crystalline ***, with well designed compositions it is possible to cast liquid alloys into the glassy state at low critical cooling rates from 100 K·s-1 to 1 K·s-1 and in large critical sample sizes up to several centimeters, which significantly enhances the promise for possible applications as advanced engineering *** paper reviews the development of (ZrCu)-based bulk metallic glasses with large sizes by copper mold casting and their unique ***, the ex-situ and in-situ second phases reinforced BMG composites with large plasticity are also presented.

关键词： bulk metallic glasses copper mold casting properties