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Nutritional status in relation to lifestyle in patients with compensated viral cirrhosis

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World Journal of Gastroenterology 2012年第40期18卷 5759-5770页

作者： Fumikazu Hayashi Chika Momoki Miho Yuikawa Yuko Simotani Etsushi Kawamura Atsushi Hagihara Hideki Fujii Sawako Kobayashi Shuji Iwai hiroyasu morikawa Masaru Enomoto Akihiro Tamori Norifumi Kawada Satoko Ohfuji Wakaba Fukusima Daiki Habu Department of Medical Nutrition Graduate School of Life ScienceOsaka City University Department of Hepatology Graduate School of MedicineOsaka City University Department of Hepatology Graduate School of MedicineOsaka City UniversityOsaka 545-8585Japan Department of Public Health Graduate School of MedicineOsaka City University

AIM:To assess the nourishment status and lifestyle of non-hospitalized patients with compensated cirrhosis by using noninvasive ***:The subjects for this study consisted of 27 healthy volunteers,59 patients with chronic viral hepatitis,and 74 patients with viral cirrhosis,from urban *** assessed the biochemical blood tests,anthropometric parameters,diet,lifestyle and physical activity of the patients.A homeostasis model assessment-insulin resistance(HOMA-IR) value of ≥ 2.5 was considered to indicate insulin *** measured height,weight,waist circumference,arm circumference,triceps skin-fold thickness,and handgrip strength,and calculated body mass index,arm muscle circumference(AMC),and arm muscle area(AMA).We interviewed the subjects about their dietary habits and lifestyle using health assessment computer *** surveyed daily physical activity using a *** and multivariate logistic regression modeling were used to identify the relevant factors for insulin ***:The rate of patients with HOMA-IR ≥ 2.5(which was considered to indicate insulin resistance) was 14(35.9%) in the chronic hepatitis and 17(37.8%) in the cirrhotic ***(%)(control vs chronic hepatitis,111.9% ± 10.5% vs 104.9% ± 10.7%,P = 0.021;control vs cirrhosis,111.9% ± 10.5% vs 102.7% ± 10.8%,P = 0.001) and AMA(%)(control vs chronic hepatitis,128.2% ± 25.1% vs 112.2% ± 22.9%,P = 0.013;control vs cirrhosis,128.2% ± 25.1% vs 107.5% ± 22.5%,P = 0.001) in patients with chronic hepatitis and liver cirrhosis were significantly lower than in the control *** strength(%) in the cirrhosis group was significantly lower than in the controls(control vs cirrhosis,92.1% ± 16.2% vs 66.9% ± 17.6%,P < 0.001).The results might reflect a decrease in muscle *** total nutrition intake and amounts of carbohydrates,protein and fat were not significantly different amongst the *** activity levels(kcal/d)(control vs cirrhosis,210 ± 11

关键词： Hepatitis C virus Insulin resistance Livercirrhosis Nutrition assessment Obesity Lifestyle Ex-ercise

Effects of Cr and Cr/Mn Combined Additions on Semi-Solid Microstructures of Al-Mg-Si Alloys Produced by D-SSF Process

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Journal of Materials Science & Technology 2008年第1期24卷 21-24页

作者： Witthaya Eidhed hiroyasu Tezuka Tatsuo Sato Faculty of Engineering King Mongkut's Institute of Technology North Bangkok Thailand Department of Metallurgy and Ceramic Sciences Tokyo Institute of Technology Japan

The effects of Cr and Cr/Mn combined additions on the semi-solid microstructure of wrought Al-Mg-Si alloys are *** the Cr-added alloy,the Al-7Cr compound is formed with homogeneously distributed in theα-Al matrix after *** of the Al-7Cr andα-Al-（12）Mn3-Si-2 dispersiod particles are found in the homogenized microstructure of the Cr/Mn-added *** the semi-solid microstructures,the smallestα-Al grains are obtained in the 60% cold-rolled *** prolonged holding time,theα-Al grain size of the Cr/Mn-added alloy is smaller than that of the Cr-added *** deformation by cold-rolling accelerates spheroidization of theα-Al *** D-SSF process is found to be useful to modify the microstructures of both the Cr-added and Cr/Mn-added Al-Mg-Si alloys.

关键词： D-SSF process Semi-solid processing Thixoforming AI-Mg-Si alloy

Pharmacological characteristics of Kampo medicine as a mixture of constituents and ingredients

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Journal of Integrative Medicine 2013年第1期11卷 11-16页

作者： hiroyasu Satoh Health Life Science Shitennoji UniversityHabikino Osaka 583-8501 Japan

Herbal medicine in Japan is termed as Kampo medicine, which is derived from traditional Chinese medicine. Shakuyakukanzoto （Shao-Yao-Gan-Cao-Tang） as a kind of Kampo formulations is composed of just two components; Paeoniae Radix and Glycyrrhizae Radix, which produced marked relaxation of intestinal tract. Mokuboito （Mu-Fang-Ji-Tang） inhibited cardiac ionic channel currents, and as a mixture also produced great vasodilatation. Sinomenine （a main ingredient of Mokuboito） as a single compound also caused the vasodilatation, but decreased it along with ageing. Gypsum containing in Mokuboito and Chotosan （Diao-Teng-San） caused more marked effects, as compared with those without Gypsum. On the other hand, Rokumigan （Liu-Wei-Wan）, Hachimijiogan （Ba-Wei-Di-Huang-Wan） and Goshajinkigan （Niu- Che-Shen-Qi-Wan） increase in order the number of contained ingredients. The formulations with more herbs （ingredients） produced much more effective actions on rat aorta, presumably due to compensation of the decline of pharmacological sensitivity with ageing. Thus, there are some important differences between single chemical drugs and mixture drugs with many ingredients. The effects of Kampo medicine （mixture） are never just a sum of each effect induced by a lot of in qredients. For elder persons, furthermore, Kampo medicine exerts more effective actions.

关键词： Kampo medicine multiple compounds medicine, herbal anti-ageing drugs vasodilatation rats

Synthesis of Mesoporous, Nanocrystalline Lanthanum Phosphate in the Presence of Citric Acid and Stearic Acid

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Journal of Rare Earths 2007年第6期25卷 684-691页

作者： Li-Ngee Ho hiroyasu Nishiguchi Katsutoshi Nagaoka Yusaku Takita Department of Applied Chemistry Oita University Dannoharu 700 Oita 870-1192 Japan

Lanthanum phosphate was prepared in the presence of citric acid and stearic acid under methanolic conditions at pH 4.5 and pH 7, respectively. The samples obtained were intensively characterized using X-ray diffraction, nitrogen adsorption-desorption isotherm study, transmission electron microscopy （TEM）, thermal gravimetric and differential thermal analysis, and Fourier transform infrared （FTIR） analysis . The as-synthesized samples prepared at pH 4.5 showed lamellar mesostruroned form with high crystallinity. Results showed that the pore size and pore volume changed when the materials were prepared under different pH conditions. Morphology of the samples was observed by using TEM, which showed that the samples possessed relatively small particles closely packed together. The as-synthesized samples were investigated using FTIR, and the mesopore formation mechanism was discussed.

关键词： mesoporous lanthanum phosphate citric acid stearic acid nanocrystalline rare earths

Abemaciclib-induced lung damage leading to discontinuation in brain metastases from breast cancer: A case report

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World Journal of Clinical Cases 2023年第35期11卷 8425-8430页

作者： hiroyasu Yamashiro Nao Morii Department of Breast Surgery Tenri HospitalNaraTenri 632-8552Japan

BACKGROUND This case report addresses the dearth of effective therapeutic interventions for central nervous system metastases in patients with HER2-negative breast *** presents a unique case of a woman with estrogen receptor-positive,HER2-negative breast cancer who developed brain *** report highlights her initial favorable response to abemaciclib and letrozole therapy prior to the discon-tinuation due to drug-induced lung damage(DILD).CASE SUMMARY In this comprehensive case summary,we present the clinical course of a woman in her 60s,who 11 years following primary breast cancer surgery,was diagnosed with multiple brain *** a third-line systemic therapy,she underwent treatment with abemaciclib and *** treatment approach yielded a near-partial response in her metastatic brain ***,abemaciclib adminis-tration ceased due to the emergence of DILD,as confirmed by a computed tomography *** DILD improved after 1 mo of *** ongoing therapeutic efforts,the patient’s condition progressively deteriorated,ultimately resulting in death due to progression of the brain *** This case underscores the challenge of managing adverse events in responsive brain metastasis patients,given the scarcity of therapeutic options.

关键词： Breast cancer HER2 negative Brain metastasis Abemaciclib Drug-induced interstitial lung damage Case report

Chemoprevention of obesity-related liver carcinogenesis by using pharmaceutical and nutraceutical agents

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World Journal of Gastroenterology 2016年第1期22卷 394-406页

作者： hiroyasu Sakai Yohei Shirakami Masahito Shimizu Department of Gastroenterology/Internal Medicine Gifu University Graduate School of Medicine

Obesity and its related metabolic disorders are serious health problems worldwide,and lead to various healthrelated complications,including *** human cancers,hepatocellular carcinoma(HCC)is one of the most common malignancies affected by ***,obesity and its related disorders might be a key target for the prevention of ***,new research indicates that the molecular abnormalities associated with obesity,including insulin resistance/hyperinsulinemia,chronic inflammation,adipokine imbalance,and oxidative stress,are possible molecular mechanisms underlying the pathogenesis of obesityrelated *** tea catechins and branched-chain amino acids,both of which are classified as nutraceutical agents,have been reported to prevent obesity-related HCC development by improving metabolic *** administration of acyclic retinoid,a pharmaceutical agent,reduced the incidence of HCC in obese and diabetic mice,and was also associated with improvements in insulin resistance and chronic *** this article,we review the detailed molecular mechanisms that link obesity to the development of HCC in obese *** also summarize recent evidence from experimental and clinical studies using either nutraceutical or pharmaceutical agents,and suggest that nutraceutical and pharmaceutical approaches targeting metabolic abnormalities might be a promising strategy to prevent the development of obesity-related HCC.

关键词： Hepatocellular carcinoma Obesity Greentea catechins Branched-chain amino acids Acyclicretinoid

Dispersoid Formation and Recrystallization Behavior in an Al-Mg-Si-Mn Alloy

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Journal of Materials Science & Technology 2010年第3期26卷 237-243页

作者： Rong Hu Tomo Ogura hiroyasu Tezuka Tatsuo Sato Qing Liu Department of Materials-Science and Engineering Tsinghua University Beijing 100084 China Department of Metallurgy and Ceramics Science Tokyo Institute of Technology Tokyo Japan

The nucleation and precipitation of Mn-containing dispersoids in an Al-Mg-Si-Mn alloy （6082） have been studied by optical microscopy,EPMA （electron probe microanalysis） and TEM （transmission electron microscopy）.The influence of Mn-containing dispersoids on the recrystallization behavior was also *** size and distribution of dispersoids were strongly affected by both the homogenization process and the alloying element distribution formed in the direct chill cast *** Mn-containing dispersoids were observed to nucleate preferentially on the β-Mg 2 Si phase and to be aligned along the 〈100〉 direction of the *** cold deformation,the morphology of dispersoids greatly influences the recrystallization and grain growth behavior in the annealing process.

关键词： Mn-containing dispersoids Homogenization Recrystallization Grain refinement

Water Resource Development in the Quaternary Ryukyu Limestone Regions of Japan:Application of the GIS to the Site Selection of Underground Dams

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Acta Geologica Sinica(English Edition) 2001年第3期75卷 254-259页

作者： Kaijun JIANG hiroyasu FURUKAWA Yuji ONOYAMA Testuro ESAKI Underground Dam Research Group Showa-chika Kogyo Inc. Fukuoka Japan 815-0082Underground Dam Research Group Showa-chika Kogyo Inc. Fukuoka Japan 815-0082Underground Dam Research Group Showa-chika Kogyo Inc. Fukuoka Japan 815-0082Institute of Environmental Systems Kyushu University Fukuoka Japan 812-8581

Based on the natural and social conditions as well as hydrogeological characteristics of the Ryukyu limestone, a major aquifer in the Ryukyu Islands, a conception of underground dam, was proposed in the early 1970s in order to develop ground water resources in the Quaternary Ryukyu limestone regions of Japan. The practice of nearly thirty years has shown that the underground dam is an environment-friendly and effective way for developing ground water in these regions.

关键词： underground dam limestone Quaternary GIS ground water

Local regulator adrenomedullin contributes to the circulatory disturbance in cirrhotic rats

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World Journal of Gastroenterology 2006年第13期12卷 2095-2102页

作者： Shinya Sakurai Hideyuki Kojima Masahito Uemura hiroyasu Satoh Hiroshi Fukui Third Department of Internal Medicine Nara Medical University 840 Shijo-cho Kashihara-shiNara 634-8522Japan Department of Pharmacology Nara Medical University 840 Shijo-cho Kashihara-shiNara 634-8522Japan

AIM： To investigate whether adrenomedullin, a potent vasodilator peptide, plays a role in the circulatory disturbance in cirrhosis. METHODS： Cirrhosis was induced in rats by weekly gavage of carbon tetrachloride. Hemodynamic studies were performed in vivo using radioactive microspheres and in vitro using isolated aortic rings. The adrenomedullin concentrations were measured by radioimmunoassay. RESULTS： Acute administration of adrenomedullin to the control rats reduced the systemic arterial pressure along with an increase of serum levels of the stable metabolite of nitric oxide （NOx）, in a dose-dependent manner. Chronic infusion of adrenomedullin reduced the vascular resistance and increased the blood flow in the systemic and splanchnic circulation. Intravenous administration of anti-adrenomedullin antibody did not affect any hemodynamic parameters in the cirrhotic rats, whereas this antibody ameliorated the blunted contractile response to phenylephrine, o-adrenergic receptor agonist, in the aortic rings of the cirrhotic rats. The adrenomedullin concentrations in the aorta were higher in the cirrhotic rats than in the controls, and correlated with the mean arterial pressure in the cirrhotic rats. Moreover, adrenomedullin blunted the contractile response to phenylephrine in both of the control aorta and cirrhotic aorta, but not in the presence of NG-nitro L-arginine methyl ester, an NO synthase inhibitor. CONCLUSION： Adrenomedullin overproduced in the vascular wall may contribute to the circulatory disturbance in cirrhosis as a local regulator of the vascular tonus rather than a circulating hormone.

关键词： Adrenomedullin Liver cirrhosis Vasodilation Circulatory disturbance Vascular tonus Circulating hormone