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Re-Evaluation of the Safety of Laser-Assisted Subepithelial Keratectomy

Open Journal of Ophthalmology 2014年第3期4卷 79-85页

作者： Yuji Kumano Yumi Soejima Shinichiro Numa hiroyasu matsui Ikuko Zushi Masahito Shigematsu Takaaki matsui Teruo Nishida Department of Oral and Maxillofacial Surgery Saga University Saga Japan Ohshima Hospital of Ophthalmology Fukuoka Japan Zushi Eye Clinic Fukuoka Japan

Purpose: Additional analyses of outcomes of laser-assisted subepithelial keratectomy (LASEK) are still necessary to improve the safety of LASEK. Therefore, in our study, outcomes were assessed retrospectively in 561 eyes that underwent LASEK treatment. Methods: Uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA) and residual spherical equivalent were analyzed at 3 and 6 months postoperatively. We assessed four subgroups based on the degree of preoperative myopia considering mean BSCVA and loss of two or more lines. Results: Mean UCVAs and BSCVAs were obtained at 3 and 6 months postoperatively (1.23/1.35 and 1.23/1.37, respectively). The mean predictability was within ±0.125 diopters. Conversely, the safety indexes were 0.94 and 0.96 respectively, and the efficacy indexes were 0.86 and 0.86 at 3 and 6 months postoperatively, respectively. 8.4% eyes and 5.2% eyes lost two or more lines of BSCVA at 3 and 6 months postoperatively, respectively. The mean BSCVAs of the high or ultra-high groups were significantly lower than those of the low or mild groups both 3 months and 6 months postoperatively. The incidence rates of losing two or more lines of BSCVA in the high or ultra-high myopia groups were significantly greater than in the low or mild groups at 3 months and 6 months postoperatively. Conclusion: LASEK predictably corrected myopia achieving >1.2 in UCVA and BSCVA. However, the safety and efficacy indexes were <1.0, which were related to the loss of two or more lines of BSCVA. Since the incidence rates of losing two or more lines of BSCVA were greater in the high or ultra-high myopia groups, we consider LASEK as more safely performed in patients with low to mild preoperative myopia.

关键词： BSCVA LASEK Loss of Two or More Lines Preoperative Myopia Re-Evaluation

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Abemaciclib-induced lung damage leading to discontinuation in brain metastases from breast cancer: A case report

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World Journal of Clinical Cases 2023年第35期11卷 8425-8430页

作者： hiroyasu Yamashiro Nao Morii Department of Breast Surgery Tenri HospitalNaraTenri 632-8552Japan

BACKGROUND This case report addresses the dearth of effective therapeutic interventions for central nervous system metastases in patients with HER2-negative breast *** presents a unique case of a woman with estrogen receptor-positive,HER2-negative breast cancer who developed brain *** report highlights her initial favorable response to abemaciclib and letrozole therapy prior to the discon-tinuation due to drug-induced lung damage(DILD).CASE SUMMARY In this comprehensive case summary,we present the clinical course of a woman in her 60s,who 11 years following primary breast cancer surgery,was diagnosed with multiple brain *** a third-line systemic therapy,she underwent treatment with abemaciclib and *** treatment approach yielded a near-partial response in her metastatic brain ***,abemaciclib adminis-tration ceased due to the emergence of DILD,as confirmed by a computed tomography *** DILD improved after 1 mo of *** ongoing therapeutic efforts,the patient’s condition progressively deteriorated,ultimately resulting in death due to progression of the brain *** This case underscores the challenge of managing adverse events in responsive brain metastasis patients,given the scarcity of therapeutic options.

关键词： Breast cancer HER2 negative Brain metastasis Abemaciclib Drug-induced interstitial lung damage Case report

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Regional neuromuscular regulation within rectus femoris muscle following three-month limb-loaded walking in older adults

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Sports Medicine and Health Science 2022年第1期4卷 38-43页

作者： Shideh Narouei hiroyasu Akatsu Kohei Watanabe Laboratory of Neuromuscular Biomechanics Faculty of Liberal Studies and Sciences and School of International Liberal StudiesChukyo UniversityNagoyaJapan Department of Community-based Medical Education Nagoya City University Graduate School of Medical ScienceNagoyaJapan

Limb-loaded walking using ankle weights has been widely applied to increase exercise intensity in older *** changes in the activation pattern between proximal(RFP)and distal(RFD)regions of the rectus femoris(RF)muscle is key to clarifying gait deficits in older *** aim of this study was to determine regional neuromuscular regulation within the RF muscle following three-month limb-loaded walking in older *** study participants were 22 healthy older adults(696.3 years)who walked at least 160 min per *** electromyography(EMG)and motion capture were used to measure the neuromuscular activities of RFP and RFD and generate kinematic data on the left lower extremity on walking for 240 s at the preferred gait speed on a treadmill at pre-and post-intervention,*** rectified values(ARV)of RFP and RFD were normalized by maximum values of ARV during a gait cycle within ten consecutive gait *** ARV of RFP was greater than RFD at 30%–40%and 70%–90%of the gait cycle and hip joint flexion at 0%–100%,and the walking speed and swing timing at post-were greater than at pre-intervention(p0.05).The activity of RFP compared with RFD and hip joint flexion were increased following limb-loaded walking intervention in older adults.

关键词： Older adults Limb-loaded walking Surface electromyography Proximal to distal region activity ratio Hip joint angle Swing phase

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Mechanical properties and corrosion resistance of powder metallurgical Mg-Zn-Ca/Fe bulk metal glass composites for biomedical application

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Journal of Materials Science & Technology 2022年第8期103卷 73-83页

作者： Kun Li Luxin Liang Peng Du Zeyun Cai Tao Xiang hiroyasu Kanetaka Hong Wu Guoqiang Xie School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Graduate School of Biomedical Engineering Tohoku UniversitySendai980-8579Japan Graduate School of Dentistry Tohoku UniversitySendai 980-8575Japan State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China

Magnesium(Mg)alloys can be regarded as the most promising biodegradable implant materials for orthopedic and stent applications due to their good biocompatibility and low Young’s modulus which is near to that of natural ***,its applicability is hindered because it exhibits a high corrosion rate in the physiological *** this work,we fabricated Mg_(66)Zn_(30)Ca_(4)/Fe bulk metallic glass composites via spark plasma sintering(SPS).We studied the influence of different contents of Fe on the properties of the *** results indicated that Fe was uniformly distributed on the surface of Mg_(66)Zn_(30)Ca_(4) metallic glass(MG)as a second phase,which led to an improvement in the corrosion resistance and mechanical *** standard potential of Mg_(66)Zn_(30)Ca_(4)/Fe bulk metallic glass(BMG)composites increased as compared to Mg_(66)Zn_(30)Ca_(4),while their mechanical strength improved from 355 MPa to 616 ***,cytotoxicity was investigated via the CCK-8 assay and calcein-AM staining,which revealed that the extraction mediums diluted 6 times(EM×6)of the Mg_(66)Zn_(30)Ca_(4) and Mg_(66)Zn_(30)Ca_(4)/Fe did not cause cell toxicity on day 3 and 5,while the EM×6 of the Mg_(66)Zn_(30)Ca_(4) showed cytotoxicity on day 1,3 and ***,Mg_(66)Zn_(30)Ca_(4)/Fe BMG composites exhibit significant potential for fabricating implants with good mechanical strength and corrosion resistance.

关键词： Mg_(66)Zn_(30)Ca_(4)/Fe bulk metallic glass composites Spark plasma sintering Corrosion behaviour Mechanical strength

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A Hybrid Vision Method for Autonomous Guided Vehicle Navigation

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自动化学报 2006年第6期32卷 988-998页

作者： IKEDA hiroyasu HAMAJIMA Kyoko National Institute of Industrial Safety 1-4-6UmezonoKiyoseTokyo 204-0024Japan

For the autonomous guided vehicle (AGV) used mainly in unfixed work fields, a machine vision method was proposed for the navigation system, in which a series of navigation-signs are placed along the travel route. The navigation system detects and recognizes these signs, and accordingly informs the travel control system. In order for the navigation to have balanced ability of 1) covering a large area and 2) recognizing details of the sign, the proposed vision method was designed to be a hybrid one, using both the stereo vision and the traditional 2D template matching. The former implemented a coarse recognition function for above 1), and the later implemented a fine recognition function for above 2). The results from the coarse recognition were used in the fine recognition for the gaze control to input suitable 2D image of the signs. Experiments on a prototype system show the feasibility of the proposed hybrid method in achieving the objective specifications for a typical AGV.

关键词： AGV navigation machine vision disparity image stereo vision template matching

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中桥

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城市环境设计 2024年第1期147卷 168-173页

作者：宫原贤次名城俊树田中浩介今井博康 Adrien Fritz 堀越圭晋中尾孝佑 SS

中桥是一座步行桥，代表了隈研吾事务所自2013年开始参与南三陆市复兴设计的努力。桥身连接南三陆市Sun Sun商业街和复兴祈愿公园（前身是防灾办公室），成为一个祈祷的场所。中桥以不同形式连接了不同空间。从前防灾办公室穿过桥梁，...

中桥是一座步行桥，代表了隈研吾事务所自2013年开始参与南三陆市复兴设计的努力。桥身连接南三陆市Sun Sun商业街和复兴祈愿公园（前身是防灾办公室），成为一个祈祷的场所。中桥以不同形式连接了不同空间。从前防灾办公室穿过桥梁，会到达上山八幡宫神社。在日本神社中，道路与神社之间的桥梁被用来区分和联系人界与神界。中桥优雅的桥拱与神社前典型的太鼓桥相似。

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南三陆311纪念馆

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城市环境设计 2024年第1期147卷 132-137页

作者：名城俊树田中浩介今井博康堀越圭晋·中尾孝佑堀越圭晋中尾孝佑 SS

自2013年以来，我一直参与南三陆町的重建计划，该地在2011年3月11日的东日本大地震中遭受了严重破坏。我们为抬高了10米的人造地面制定了一个总体规划，包括三个概念：（1）将城镇与大海重新连接起来，（2）将山脉与神社重新连接起来...

自2013年以来，我一直参与南三陆町的重建计划，该地在2011年3月11日的东日本大地震中遭受了严重破坏。我们为抬高了10米的人造地面制定了一个总体规划，包括三个概念：（1）将城镇与大海重新连接起来，（2）将山脉与神社重新连接起来，以及（3）创建一条可步行的、赏心悦目的街道。我们设计了三个设施，都是重建计划的核心：太阳购物村（2017年）、中桥大桥（2020年）和311纪念馆（2022年）。311纪念馆代表了重建计划的高潮，成为衔接海洋、山脉和城镇（街道）的枢纽，同时也是连接过去和未来记忆的一种方式。

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Effects of Cr and Cr/Mn Combined Additions on Semi-Solid Microstructures of Al-Mg-Si Alloys Produced by D-SSF Process

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Journal of Materials Science & Technology 2008年第1期24卷 21-24页

作者： Witthaya Eidhed hiroyasu Tezuka Tatsuo Sato Faculty of Engineering King Mongkut's Institute of Technology North Bangkok Thailand Department of Metallurgy and Ceramic Sciences Tokyo Institute of Technology Japan

The effects of Cr and Cr/Mn combined additions on the semi-solid microstructure of wrought Al-Mg-Si alloys are *** the Cr-added alloy,the Al-7Cr compound is formed with homogeneously distributed in theα-Al matrix after *** of the Al-7Cr andα-Al-（12）Mn3-Si-2 dispersiod particles are found in the homogenized microstructure of the Cr/Mn-added *** the semi-solid microstructures,the smallestα-Al grains are obtained in the 60% cold-rolled *** prolonged holding time,theα-Al grain size of the Cr/Mn-added alloy is smaller than that of the Cr-added *** deformation by cold-rolling accelerates spheroidization of theα-Al *** D-SSF process is found to be useful to modify the microstructures of both the Cr-added and Cr/Mn-added Al-Mg-Si alloys.

关键词： D-SSF process Semi-solid processing Thixoforming AI-Mg-Si alloy

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Pharmacological characteristics of Kampo medicine as a mixture of constituents and ingredients

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Journal of Integrative Medicine 2013年第1期11卷 11-16页

作者： hiroyasu Satoh Health Life Science Shitennoji UniversityHabikino Osaka 583-8501 Japan

Herbal medicine in Japan is termed as Kampo medicine, which is derived from traditional Chinese medicine. Shakuyakukanzoto （Shao-Yao-Gan-Cao-Tang） as a kind of Kampo formulations is composed of just two components; Paeoniae Radix and Glycyrrhizae Radix, which produced marked relaxation of intestinal tract. Mokuboito （Mu-Fang-Ji-Tang） inhibited cardiac ionic channel currents, and as a mixture also produced great vasodilatation. Sinomenine （a main ingredient of Mokuboito） as a single compound also caused the vasodilatation, but decreased it along with ageing. Gypsum containing in Mokuboito and Chotosan （Diao-Teng-San） caused more marked effects, as compared with those without Gypsum. On the other hand, Rokumigan （Liu-Wei-Wan）, Hachimijiogan （Ba-Wei-Di-Huang-Wan） and Goshajinkigan （Niu- Che-Shen-Qi-Wan） increase in order the number of contained ingredients. The formulations with more herbs （ingredients） produced much more effective actions on rat aorta, presumably due to compensation of the decline of pharmacological sensitivity with ageing. Thus, there are some important differences between single chemical drugs and mixture drugs with many ingredients. The effects of Kampo medicine （mixture） are never just a sum of each effect induced by a lot of in qredients. For elder persons, furthermore, Kampo medicine exerts more effective actions.

关键词： Kampo medicine multiple compounds medicine, herbal anti-ageing drugs vasodilatation rats

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Synthesis of Mesoporous, Nanocrystalline Lanthanum Phosphate in the Presence of Citric Acid and Stearic Acid

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Journal of Rare Earths 2007年第6期25卷 684-691页

作者： Li-Ngee Ho hiroyasu Nishiguchi Katsutoshi Nagaoka Yusaku Takita Department of Applied Chemistry Oita University Dannoharu 700 Oita 870-1192 Japan

Lanthanum phosphate was prepared in the presence of citric acid and stearic acid under methanolic conditions at pH 4.5 and pH 7, respectively. The samples obtained were intensively characterized using X-ray diffraction, nitrogen adsorption-desorption isotherm study, transmission electron microscopy （TEM）, thermal gravimetric and differential thermal analysis, and Fourier transform infrared （FTIR） analysis . The as-synthesized samples prepared at pH 4.5 showed lamellar mesostruroned form with high crystallinity. Results showed that the pore size and pore volume changed when the materials were prepared under different pH conditions. Morphology of the samples was observed by using TEM, which showed that the samples possessed relatively small particles closely packed together. The as-synthesized samples were investigated using FTIR, and the mesopore formation mechanism was discussed.

关键词： mesoporous lanthanum phosphate citric acid stearic acid nanocrystalline rare earths

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