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尼可地尔改善首选经皮冠状动脉介入治疗的急性心肌梗死患者的心脏功能和临床预后——抑制活性氧生成的作用

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首都食品与医药 2017年第8期24卷 144-144页

作者： hirotsugu ono Tomohiro Osanai Hiroshi Ishizaka Hiroyuki Hanada 高万峰北京四环科宝制药有限公司 100070

（接3月下）在PCI手术后持续进行48小时静脉注射肝素以维持活化凝血时间超过180秒。对于所有患者,该程序是在获准入院后60分钟内,最终的冠状动脉造影显示残余狭窄小于管腔直径的25%。对于串行尿液取样,在所有患者的膀胱插入球囊导管完... 详细信息

（接3月下）在PCI手术后持续进行48小时静脉注射肝素以维持活化凝血时间超过180秒。对于所有患者,该程序是在获准入院后60分钟内,最终的冠状动脉造影显示残余狭窄小于管腔直径的25%。对于串行尿液取样,在所有患者的膀胱插入球囊导管完成。尿液样本为PCI手术之前,直到初始PCI手术后150分钟后,每30分钟连续获得（基线）,并收集到含抗氧化剂丁基羟基茴香醚（0．1％）的聚乙烯管中。样品在收集期间保持冷藏,并储存在零下80℃直至测定分析。

关键词：尼可地尔急性心肌梗死活化凝血时间管腔直径活性氧球囊导管心脏功能介入治疗梗死相关动脉肺毛细血管楔压

尼可地尔改善首选经皮冠状动脉介入治疗的急性心肌梗死患者的心脏功能和临床预后——抑制活性氧生成的作用

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首都食品与医药 2017年第14期24卷 160-160页

作者： hirotsugu ono Tomohiro Osanai Hiroshi Ishizaka Hiroyuki Hanada 高万峰北京四环科宝制药有限公司 100070

侧支血管通过Rentrop定义成灌注等级2级或3级，梗死相关动脉镜内观察6组1例和8组有2例（PNS）。基利普和Forrester分类的程度在入院两组之间是相似的。

关键词：经皮冠状动脉介入治疗心肌梗死患者活性氧生成临床预后心脏功能尼可地尔急性梗死相关动脉

Can control of gut microbiota be a future therapeutic option for inflammatory bowel disease?

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World Journal of Gastroenterology 2021年第23期27卷 3317-3326页

作者： Atsushi Nishida Kyohei Nishino Keitaro Sakai Yuji Owaki Yoshika Noda hirotsugu Imaeda Department of Gastroenterology and Hepatology Nagahama City HospitalNagahama 5268580ShigaJapan

Inflammatory bowel disease(IBD)is a chronic inflammatory condition of the gastrointestinal tract encompassing two main clinical entities,Crohn’s disease and ulcerative *** evidence indicates that an aberrant immune activation caused by the interplay of genetic susceptibility and environmental impact on the gut microbiota may be involved in the pathogenesis of *** advances in next-generation sequencing technology have enabled a number of studies to identify the alteration of the gut microbiota,termed dysbiosis,in ***,the alteration in the metabolites derived from the gut microbiota in IBD has also been described in many ***,microbiota-based interventions such as fecal microbiota transplantation(FMT)have attracted attention as a novel therapeutic option in ***,in clinical trials,the efficacy of FMT for IBD remains *** basic and clinical studies are required to validate whether FMT can assume a complementary role in the treatment of *** present review provides a synopsis on dysbiosis in IBD and on the association between the gut microbiota and the pathogenesis of *** addition,we summarize the use of probiotics in IBD and the results of current clinical trials of FMT for IBD.

关键词： Inflammatory bowel disease Dysbiosis Fecal microbiota transplantation Short chain fatty acid Probiotics

Isolated pancreatic metastasis from a malignant pleural mesothelioma diagnosed using endoscopic ultrasonography-guided fne needle aspiration biopsy

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 196-198页

作者： Yuki Ishikawa-Kakiya hirotsugu Maruyama Kojiro Tanoue Shusei Fukunaga Yasuaki Nagami Yasuhiro Fujiwara Department of Gastroenterology Osaka City University Graduate School of Medicine1-4-3AsahimachiAbeno-kuOsaka 545-8585Japan

To the Editor:Malignant pleural mesothelioma is a rare and aggressive form of cancer with a poor prognosis [1].Its progression is mainly a direct invasion from the primary lesion,and metastasis to distant regions rarely *** was found that metastasis of malignant pleural mesothelioma may occur in the liver,adrenal glands,and kidneys in autopsy cases [2].

关键词： metastasis pleural needle

Butyrate stimulates IL-32α expression in human intestinal epithelial cell lines

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World Journal of Gastroenterology 2010年第19期16卷 2355-2361页

作者： Ayako Kobori Shigeki Bamba hirotsugu Imaeda Hiromitsu Ban Tomoyuki Tsujikawa Yasuharu Saito Yoshihide Fujiyama Akira Andoh Division of Gastroenterology Department of Internal Medicine Shiga University of Medical Science Seta Tukinowa Otsu 520-2192 Japan Division of Mucosal Immunology Graduate School of Medicine Shiga University of Medical Science Seta Tukinowa Otsu 520-2192 Japan

AIM: To investigate the effects of butyrate on interleukin (IL)-32α expression in epithelial cell lines. METHODS: The human intestinal epithelial cell lines HT-29, SW480, and T84 were used. Intracellular IL- 32α was determined by Western blotting analyses. IL- 32α mRNA expression was analyzed by real-time poly-merase chain reaction. RESULTS: Acetate and propionate had no effects on IL-32α mRNA expression. Butyrate significantly enhanced IL-32α expression in all cell lines. Butyrate also up-regulated IL-1β-induced IL-32α mRNA expression. Butyrate did not modulate the activation of phosphatidylinositol 3-kinase (PI3K), a mediator of IL- 32α expression. Like butyrate, trichostatin A, a histone deacetylase inhibitor, also enhanced IL-1β-induced IL- 32α mRNA ***: Butyrate stimulated IL-32α expression in epithelial cell lines. An epigenetic mechanism, such as histone hyperacetylation, might be involved in the action of butyrate on IL-32α expression.

关键词： Cytokine Histone acetylation Inflammatory bowel disease

Update on gut microbiota in gastrointestinal diseases

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World Journal of Clinical Cases 2022年第22期10卷 7653-7664页

作者： Atsushi Nishida Kyohei Nishino Masashi Ohno Keitaro Sakai Yuji Owaki Yoshika Noda hirotsugu Imaeda Department of Gastroenterology and Hepatology Nagahama City HospitalNagahama 526-8580Japan

The human gut is a complex microbial ecosystem comprising approximately 100 trillion microbes collectively known as the“gut microbiota”.At a rough estimate,the human gut microbiome contains almost 3.3 million genes,which are about 150 times more than the total human genes present in the human *** vast amount of genetic information produces various enzymes and physiologically active ***,the gut microbiota contributes to the maintenance of host health;however,when healthy microbial composition is perturbed,a condition termed“dysbiosis”,the altered gut microbiota can trigger the development of various gastrointestinal *** gut microbiota has consequently become an extremely important research area in *** is also expected that the results of research into the gut microbiota will be applied to the prevention and treatment of human gastrointestinal diseases.A randomized controlled trial conducted by a Dutch research group in 2013 showed the positive effect of fecal microbiota transplantation(FMT)on recurrent Clostridioides difficile infection(CDI).These findings have led to the development of treatments targeting the gut microbiota,such as probiotics and FMT for inflammatory bowel diseases(IBD)and other *** review focuses on the association of the gut microbiota with human gastrointestinal diseases,including CDI,IBD,and irritable bowel *** also summarize the therapeutic options for targeting the altered gut microbiota,such as probiotics and FMT.

关键词： Inflammatory bowel disease Clostridioides difficile(Clostridium)infection Irritable bowel syndrome Probiotics Fecal microbiota transplantation

Safety and efficacy of transpapillary bridged bilateral side-by-side stenting for unresectable malignant hilar biliary obstruction

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Hepatobiliary & Pancreatic Diseases International 2017年第6期16卷 659-661页

作者： hirotsugu Maruyama Kazunari Tominaga Kunihiro Kato Satoshi Sugimori Masatsugu Shiba Toshio Watanabe Yasuhiro Fujiwara Department of Gastroenterology Osaka City University Graduate School of Medicine 1-4-3 Asahimachi Abeno-ku Osaka 545-8585 Japan

To the Editor:Biliary drainage is most frequently performed among endoscopic procedures using pancreatobiliary endoscopy.A large-diameter metallic stent can significantly extend the patency period rather than a plastic stent for extrahepatic biliary stricture.;However,the optimal drainage for the hilar biliary obstruction is still controversial.

关键词： Safety and efficacy of transpapillary bridged bilateral side-by-side stenting for unresectable malignant hilar biliary obstruction

Impact of fecal occult blood on obscure gastrointestinal bleeding:Observational study

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World Journal of Gastroenterology 2015年第1期21卷 326-332页

作者： Yuka Kobayashi hirotsugu Watabe Atsuo Yamada Hirobumi Suzuki Yoshihiro Hirata Yutaka Yamaji Haruhiko Yoshida Kazuhiko Koike Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan

AIM: To elucidate the association between small bowel diseases(SBDs) and positive fecal occult blood test(FOBT) in patients with obscure gastrointestinal bleeding(OGIB).METHODS: Between February 2008 and August 2013, 202 patients with OGIB who performed both capsule endoscopy(CE) and FOBT were enrolled(mean age; 63.6 ± 14.0 years, 118 males, 96 previous overt bleeding, 106 with occult bleeding). All patients underwent immunochemical FOBTs twice prior to CE. Three experienced endoscopists independently reviewed CE videos. All reviews and consensus meeting were conducted without any information on FOBT results. The prevalence of SBDs was compared between patients with positive and negative ***: CE revealed SBDs in 72 patients(36%). FOBT was positive in 100 patients(50%) and negative in 102(50%). The prevalence of SBDs was significantly higher in patients with positive FOBT than those with negative FOBT(46% vs 25%, P = 0.002). In particular, among patients with occult OGIB, the prevalence of SBDs was higher in positive FOBT group than negative FOBT group(45% vs 18%, P = 0.002). On the other hand, among patients with previous overt OGIB, there was no significant difference in the prevalence of SBDs between positive and negative FOBT group(47% vs 33%, P = 0.18). In disease specific analysis among patients with occult OGIB, the prevalence of ulcer and tumor were higher in positive FOBT group than negative FOBT group. In multivariate analysis, only positive FOBT was a predictive factors of SBDs in patients with OGIB(OR = 2.5, 95%CI: 1.4-4.6, P = 0.003). Furthermore, the trend was evidentam on g patients with occult OGIB who underwent FOBT on the same day or a day before CE. The prevalence of SBDs in positive vs negative FOBT group were 54% vs 13% in patients with occult OGIB who underwent FOBT on the same day or the day before CE(P = 0.001), while there was no significant difference between positive and negative FOBT group in those who underwent FOBT two or more d

关键词： Capsule endoscopy Fecal occult blood test Obscure

Large stereoscopic LED display by use of parallax barrier of aperture grille type(Invited Paper)

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Chinese Optics Letters 2014年第6期12卷 21-25页

作者： hirotsugu Yamamoto Hayato Nishimura Tetsuya Abe Yoshio Hayasaki Department of Optical Science and Technology University of Tokushima2-1 Minamijosanjima Tokushima CityTokushima 7708506 Japan Center for Optical Research and Education Utsunomiya University7-1-2 Yoto Utsunomiya City Tochigi 3218585 Japan

We propose a large parallax barrier by use of aperture grille. Main advantages of using aperture grille include no reflection and no absorption in apertures, as well as wide viewing angle. These advantages are investigated with theoretical calculations and experiments by use of several kinds of LED panels, such as a fine-pitch LED panel and a 140-inch large LED panel. Limitations of viewing angle by parallax barrier are analyzed in conventional black stripes on a transparent substrate type and in aperture grille type. Experimental results straw use of aperture grille increases contrast and reduce reflection on the aperture surface.

关键词： LED Large stereoscopic LED display by use of parallax barrier of aperture grille type