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大气中CO_2等微量物质对全球变暖的影响

世界环境 1989年第2期 9-10,8页

作者： hirotoshi GOTO 张立军 Chief Atmospheric Protection Section Air Protection Department Environmental Protection Agency Japan

二氧化碳（CO2）、氧化亚氮（N2O）、甲烷（CH4）、氟氯烃类（CFCs,即氟里昂气体）、对流层中的臭氧（O3,即产生光化学雾的物质）等,在大气中存在的量尽管很少,但具有在地表附近将太阳能以热的形式截留下来的作用。这种作用称作“温室... 详细信息

二氧化碳（CO2）、氧化亚氮（N2O）、甲烷（CH4）、氟氯烃类（CFCs,即氟里昂气体）、对流层中的臭氧（O3,即产生光化学雾的物质）等,在大气中存在的量尽管很少,但具有在地表附近将太阳能以热的形式截留下来的作用。这种作用称作“温室效应”,具有这种作用的气体,即上述的CO2、N2O、CH4、CFCs、O3等称作温室气体。当前,温室气体在大气中的浓度虽然很低,但观测到其浓度有增加的趋势（见表1）。而这种增加已使地表及包围地球的大气下层逐渐变暖,其结果很可能使气候发生变化。

关键词：光化学雾气候变化全球变暖 CO2 微量物质 CFCs 氟氯烃氧化亚氮气中氟里昂

Steroid Sulfatase Inhibitor Reduces Proliferation of Ishikawa Endometrial Cancer Cells in Co-Culture Systems

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Open Journal of Endocrine and Metabolic Diseases 2016年第9期6卷 193-204页

作者： Mitsuo Nishimoto Masafumi Toyoshima Naomi Shiga Hiroki utsunomiya Fumihiko Suzuki Satoru Nagase Hidekazu Nishigori Takashi Suzuki Hironobu Sasano Kiyoshi Ito Nobuo Yaegashi Department of Obstetrics and Gynecology Tohoku University School of Medicine Sendai Japan Department of Obstetrics and Gynecology Iwate Prefectural Iwai Hospital Iwate Japan Department of Obstetrics and Gynecology Yamagata University School of Medicine Yamagata Japan Department of Pathology Tohoku University School of Medicine Sendai Japan Department of Disaster Obstetrics and Gynecology International Research Institute of Disaster Science Tohoku University Sendai Japan

Objectives: Estrogens significantly contribute toward the growth and development of endometrial cancers. Two principal pathways have been implicated in the final steps of estrogen synthesis: the steroid sulfatase (STS) and aromatase pathways. In this study, we aimed to evaluate the possible effects of tumor-stromal interactions on local estrogen biosynthesis in endometrial cancer. We also assessed the biological effects of inhibitors of steroid sulfatase and aromatase in the co-culture system compared with usual monocultures. Methods/Materials: We isolated stromal cells from endometrial cancer patients to examine local biosynthesis of estrogens and tumor-stromal interactions. Next we examined the effects of steroid sulfatase inhibitor and aromatase inhibitor in monoculture of endometrial cancer cell line (Ishikawa) and in a co-culture system involving an Ishikawa cells and stromal cells. Results: Estrogen receptor and steroid sulfatase mRNA levels in cancer cells were significantly higher in the co-cultures compared with the monocultures of endometrial cancer cells. Estradiol and androstenediol concentrations were also significantly higher in the co-cultured cells. Proliferation of the cancer cells was significantly increased through the steroid sulfatase pathway, which metabolizes androgens, estrone sulfate, and estradiol sulfate as its substrates. However, its proliferation was significantly decreased by the treatment of steroid sulfatase or aromatase inhibitors. The significant growth inhibition by the steroid sulfatase and aromatase inhibitors were also observed in the co-culture system. Conclusions: We evaluated the effects of STS inhibitor and aromatase inhibitors on the proliferation of estrogen-dependent endometrial cancer cells. Considering that intratumoral estrogen metabolism plays an important role, our co-culture systems provide an environment similar to that of the tumor in living patients in terms of metabolism and synthesis of intratumoral estrogens.

关键词： Aromatase Inhibitors Co-Culture System Endometrial Cancer Estrogen Estrogen Sulfatase Inhibitor

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甜菜红色素的色谱行为及其波谱表征

中国食品学报 2007年第5期7卷 139-144页

作者：霍光华杨树林 hirotoshi Tamura 江西农业大学生物科学与工程学院南昌330045 中南京理工大学化工学院南京210094 日本香川大学农学部

目的:分离与分析甜菜红色素成分。方法:通过HPLC法探讨甜菜红色素在不同洗脱液(乙腈-甲酸、乙腈-乙酸)浓度、不同柱温下ODS柱上的色谱行为;通过LC-ESI-MS和UV光谱鉴定甜菜红色素成分。结果:推导出甜菜主要红色素成分间分辨率与酸浓度、... 详细信息

目的:分离与分析甜菜红色素成分。方法:通过HPLC法探讨甜菜红色素在不同洗脱液(乙腈-甲酸、乙腈-乙酸)浓度、不同柱温下ODS柱上的色谱行为;通过LC-ESI-MS和UV光谱鉴定甜菜红色素成分。结果:推导出甜菜主要红色素成分间分辨率与酸浓度、乙腈浓度、柱温间的相互关系方程为YRe=6.3931-0.3868Xc-0.2155Xac-0.0384Xt(乙酸)和YRe=5.0501-0.0249Xc-0.1444Xac-0.0236Xt(甲酸);获得了甜菜红色素主要单组分制备物,其主成分为甜菜苷和异甜菜苷,此外,还鉴定出17-脱羧-新甜菜苷等组分。结论:色谱分离关系方程和主成分表征对甜菜红色素具有质控意义。

关键词：甜菜红色素色谱行为波谱表征

Comparative Study of Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry and Culture Test for <i>Candida</i>Identification

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Open Journal of Stomatology 2019年第12期9卷 295-306页

作者： Yoriko Kubota Chieko Taguchi Masanori Saito Noriko Shinozaki-Kuwahara Tomoko Suzuki Masaaki Suemitsu Mitsuko Nakayama Tadahiko utsunomiya Hiroyasu Endo Kayo Kuyama Department of Pathology Nihon University School of Dentistry at Matsudo Chiba Japan Department of Microbiology and Immunology Nihon University School of Dentistry at Matsudo Chiba Japan Department of Community Oral Health Nihon University School of Dentistry at Matsudo Chiba Japan Department of Oral Diagnosis Nihon University School of Dentistry at Matsudo Chiba Japan

Background: A new microorganism identification method using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF MS) has been developed, however, reports on its use for delineating Candida spp. are scarce. Objectives: The purpose of this study was to compare the identification accuracy of mixed infection between culture test and MALDI-TOF MS. Materials and Methods: Eighty-nine denture wearers (average 74.0 ± 9 years) were selected. Specimens were immediately inoculated onto selective medium for CHROMagarTM Candida, and were also carried out using MALDI-TOF MS. The distribution frequencies of them were analyzed. Results: The numbers and rates of detection/non-detection by MALDI-TOF MS of genus Candida were 58/31 (65.2%/34.8%), respectively. Infection types were single infection in 34 (38.2%), mixed infection in 24 (27.0%), and non-infection in 31 (34.8%) cases. Concerning the single infection, C. albicans was the most predominant (58.8%), followed by C. parapsilosis (17.6%), C. glabrata (14.7%), C. tropicalis (5.9%), and C. krusei (2.9%). As for the mixed infection, the most frequent combination was C. albicans and C. glabrata (50.0%), followed by C. albicans and C. parapsilosis (29.2%), C. albicans and C. tropicalis (8.3%), C. glabrata and C. tropicalis (4.2%), C. albicans, C. glabrata, and C. parapsilosis (4.2%), and C. albicans, C. parapsilosis, and C. glabrata (4.2%). There were four MALDI-TOF MS positive results that were negative by the culture test. Conversely, there were six MALDI-TOF MS negative results that were positive by the culture test. The sensitivity and specificity of MALDI-TOF MS were 0.929 and 0.840, respectively. The concordance rate of genus Candida was 0.644, indicating substantial agreement. Conclusion: Candida infection is complicated by disease type and oral cavity environment changes due to aging. A rapid microorganism detection method, such as MALDI-TOF MS, will be helpful to quickly determine the causative pathogen in

关键词： Candida Culture Test MALDI-TOF MS Non-C. Albicans Candida (NCAC)

Improved visibility of colorectal tumor by texture and color enhancement imaging with indigo carmine

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World Journal of Gastrointestinal Endoscopy 2023年第12期15卷 690-698页

作者： Takuma Hiramatsu Toshihiro Nishizawa Yosuke Kataoka Shuntaro Yoshida Tatsuya Matsuno Hiroya Mizutani Hideki Nakagawa hirotoshi Ebinuma Mitsuhiro Fujishiro Osamu Toyoshima Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Gastroenterology and Hepatology International University of Health and WelfareNarita HospitalNarita 286-8520Japan Department of Gastroenterology Toyoshima Endoscopy ClinicTokyo 157-0066Japan

BACKGROUND Accurate diagnosis and early resection of colorectal polyps are important to prevent the occurrence of colorectal ***,technical factors and morphological factors of polyps itself can lead to missed *** endoscopy and chromoendoscopy(CE)have been developed to facilitate an accurate *** have been no reports on visibility using a combination of texture and color enhancement imaging(TXI)and CE for colorectal *** To investigate the visibility of margins and surfaces with the combination of TXI and CE for colorectal *** This retrospective study included patients who underwent lower gastrointestinal endoscopy at the Toyoshima Endoscopy *** extracted polyps that were resected and diagnosed as adenomas or serrated polyps(hyperplastic polyps and sessile serrated lesions)from our endoscopic *** expert endoscopist performed the lower gastrointestinal endoscopies and observed the lesion using white light imaging(WLI),TXI,CE,and TXI+CE *** carmine dye was used for *** expert endoscopists rated the visibility of the margin and surface patterns in four ranks,from 1 to *** primary outcomes were the average visibility scores for the margin and surface patterns based on the WLI,TXI,CE,and TXI+CE *** scores between the four modalities were compared by the Kruskal-Wallis and Dunn *** A total of 48 patients with 81 polyps were *** histological subtypes included 50 tubular adenomas,16 hyperplastic polyps,and 15 sessile serrated *** visibility scores for the margins based on WLI,TXI,CE,and TXI+CE were 2.44±0.93,2.90±0.93,3.37±0.74,and 3.75±0.49,*** visibility scores for the surface based on WLI,TXI,CE,and TXI+CE were 2.25±0.80,2.84±0.84,3.12±0.72,and 3.51±0.60,*** visibility scores for the detection and surface on TXI were significantly lower than that on CE but higher than that on WLI(P<0.001).The visibility sco

关键词： Texture and color enhancement imaging Indigo carmine Adenoma Colonoscopy Sessile serrated lesion

Role of targeted therapy in metastatic colorectal cancer

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World Journal of Gastrointestinal Oncology 2016年第9期8卷 642-655页

作者： Yoshihito Ohhara Naoki Fukuda Satoshi Takeuchi Rio Honma Yasushi Shimizu Ichiro Kinoshita hirotoshi Dosaka-Akita Department of Medical Oncology Hokkaido University Graduate School of MedicineSapporoHokkaido 060-8638Japan

Colorectal cancer(CRC) is a significant cause of cancer-related morbidity and mortality all over the *** of cytotoxic and biologic agents have prolonged the survival in metastatic CRC(mC RC),with a median overall survival of approximately 2 years and more in the past two *** biologic agents that have proven clinical benefits in m CRC mainly target vascular endothelial growth factor(VEGF) and epidermal growth factor receptor(EGFR).In particular,bevacizumab targeting VEGF and cetuximab and panitumumab targeting EGFR have demonstrated sig-nificant survival benefits in combination with cytotoxic chemotherapy in the first-line,second-line,or salvage ***,ramucirumab,and regorafenib are also used in second-line or salvage *** retrospective analyses have shown that KRAS or NRAS mutations were negative predictive markers for anti-EGFR *** on the evidence from large rand-omized clinical trials,personalized therapy is necessary for patients with m CRC according to their tumor biology and *** aim of this paper was to summarize the results of the major randomized clinical trials and highlight the benefits of the molecular targeted agents in patients with mC RC.

关键词： Metastatic colorectal cancer Aflibercept Ramucirumab Regorafenib Cetuximab Panitumumab Targeted therapy Bevacizumab

吲哚菁绿荧光强度分析在颅内动脉瘤术中的应用

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中华神经外科杂志 2011年第12期27卷 1198-1201页

作者：陈四方王占祥谭国伟郭剑峰陈东汉 Yoko Kato hirotoshi Sano 厦门大学附属第一医院神经外科 361003 日本藤田保健卫生大学神经外科

目的探讨吲哚菁绿血管造影及荧光强度分析在颅内动脉瘤夹闭术中的作用.方法回顾性分析吲哚菁绿血管造影及荧光强度分析在47例颅内动脉瘤患者夹闭术中的作用.术中行吲哚菁绿荧光血管造影,观察动脉瘤、载瘤动脉及分支血管的血流情况,并... 详细信息

目的探讨吲哚菁绿血管造影及荧光强度分析在颅内动脉瘤夹闭术中的作用.方法回顾性分析吲哚菁绿血管造影及荧光强度分析在47例颅内动脉瘤患者夹闭术中的作用.术中行吲哚菁绿荧光血管造影,观察动脉瘤、载瘤动脉及分支血管的血流情况,并通过荧光强度分析软件进行分析.结果47例中有4例通过吲哚菁绿血管造影检测到动脉瘤夹闭不全,术中荧光强度分析为3例动脉瘤的夹闭提供了重要信息.结论吲哚菁绿血管造影能在术中对术野血流情况进行实时的分析,而通过荧光强度分析可进一步提高吲哚菁绿血管造影对血流分析的准确性.

关键词：颅内动脉瘤吲哚菁绿血管造影显微外科手术

贝加尔湖KUKUY地区两种结构气体水合物的形成过程

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海洋地质动态 2008年第11期24卷 41-43页

作者： Akihiro Hachikubo hirotoshi Sakagami Hirotsugu Minami 孙萍（编译）

贝尔加湖首次发现气体水合物是1997年贝加尔钻探计划（BDP）在盆地南部海底深度121m和161m处，气体成分主要是甲烷，8δC值范围为-68．2‰～-57．6‰，表明这些气体水合物是微生物成因的。最近，在盆地南部的Malenky泥火山和盆地中部的K... 详细信息

贝尔加湖首次发现气体水合物是1997年贝加尔钻探计划（BDP）在盆地南部海底深度121m和161m处，气体成分主要是甲烷，8δC值范围为-68．2‰～-57．6‰，表明这些气体水合物是微生物成因的。最近，在盆地南部的Malenky泥火山和盆地中部的Kukuy K-2地区海底发现气体水合物，这些站点位于抬升地形带上，并且具有流体溢出口特征。

关键词：气体水合物贝加尔湖结构微生物成因钻探计划贝尔加湖气体成分盆地

Occludin modulates perijunctional actin at a discrete apico-lateral membrane domain in a rat endothelial cell line (RLE)

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Occludin modulates perijunctional actin at a discrete apico-...