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Role of Sphingosine 1-Phosphate (S1P) Receptor 1 in Experimental Autoimmune Encephalomyelitis —II

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Pharmacology & Pharmacy 2013年第8期4卷 638-646页

作者： Noriyasu Seki hirotoshi Kataoka Kunio Sugahara Atsushi Fukunari Kenji Chiba Advanced Medical Research Laboratories Research Division Mitsubishi Tanabe Pharma Corporation Yokohama Japan. Pharmacology Research Laboratories I Research Division Mitsubishi Tanabe Pharma Corporation Yokohama Japan Pharmacology Research Laboratories I Research Division Mitsubishi Tanabe Pharma Corporation Yokohama Japan Pharmacology Research Laboratories I Research Division Mitsubishi Tanabe Pharma Corporation Yokohama Japan Advanced Medical Research Laboratories Research Division Mitsubishi Tanabe Pharma Corporation Yokohama Japan.

Therapeutic administration of fingolimod hydrochloride (FTY720), the functional antagonist at sphingosine 1-phosphate (S1P) receptor 1 (S1P1) shows a marked improving effect on experimental autoimmune encephalomyelitis (EAE) induced by myelin oligodendrocyte glycoprotein (MOG) in C57BL/6 mice. However, this treatment showed an only partial inhibition of Th1/Th17 cell infiltration into the central nervous system (CNS), suggesting that down-regulation of lymphocytic S1P1 is insufficient to explain the therapeutic effect of FTY720 on EAE. On the other hand, the therapeutic administration of FTY720 reduced the mRNA expressions of IL-6, CCL2, and glial fibrillary acidic protein, an activation marker of astrocytes, in the CNS of EAE mice. In human astrocytic glyoma, U373MG cells, mRNA expression of S1P1 was higher as compared with those of the other S1P receptor subtypes and phosphorylation of Akt was induced by S1P, FTY720-phosphate (FTY720-P), or an S1P1-selective agonist, SEW2871. FTY720-P appeared to induce down-regulation of S1P1 in U373MG cells, implying a functional antagonism at S1P1 on astrocytes. S1P but not FTY720-P induced production of IL-6, IL-8, and CCL2 significantly and treatment with FTY720-P or SEW2871 inhibited production of these pro-inflammatory cytokines from U373MG cells stimulated with S1P. These results suggest that S1P-S1P1 axis induces production of pro-inflammatory cytokines by astrocytes. Consequently, it is highly probable that the therapeutic effects of FTY720 on EAE are caused by inhibiting not only egress of myelin-specific Th cells from the draining lymph nodes but also activation of astrocytes in the CNS.

关键词： Sphingosine 1-Phosphosphate Receptor 1 Fingolimod Hydrochloride (FTY720) Experimental Autoimmune Encephalomyelitis Astrocytes Pro-Inflammatory Cytokines

Comparative Cytological and Histopathological Study of Peri-Implantitis and Periodontitis

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Open Journal of Stomatology 2023年第11期13卷 385-395页

作者： Masaaki Suemitsu Yoshikazu Nakayama Mao Yamamoto Mitsuko Nakayama Tadahiko utsunomiya Kayo Kuyama Department of Pathology School of Dentistry at Matsudo Nihon University Chiba Japan Department of Oral Pathology Nihon University Graduate School Dentistry at Matsudo Chiba Japan

Peri-implant diseases, such as peri-implant mucositis and peri-implantitis, pose significant challenges to the long-term prognosis of dental implants. This study aimed to comprehensively compare peri-implantitis with periodontitis from cytological and histopathological perspectives, shedding light on the morphological characteristics associated with peri-implantitis. Thirteen patients, including six with peri-implantitis and seven with periodontitis, were included in the study. Cytological examination of affected gingival mucosa revealed distinct differences between the two conditions. Peri-implantitis exhibited an inflammatory background predominantly composed of neutrophils with lobulated nuclei, accompanied by stratified squamous epithelial cells showing signs of keratinization. In contrast, periodontitis showed a similar neutrophilic inflammatory background but with non-keratinized epithelial cells. Histopathological examination further confirmed these differences, with peri-implantitis showing keratinized epithelium in the inner epithelial layer. This histological finding aligns with the notion that peri-implantitis has a distinct mucosal profile compared to periodontitis. Additionally, cytological analysis revealed that peri-implantitis had a lower occurrence rate of Light green-positive cells, indicating a tendency toward keratinization. This finding suggests that the presence of keratinized mucosa might be associated with peri-implant health, although further research is needed to clarify this relationship. Overall, this study demonstrates the potential of cytological examination and Papanicolaou staining for assessing mucosal inflammatory conditions and distinguishing between keratinized and non-keratinized cells. These findings underscore the utility of oral mucosal smears as a valuable tool for diagnosing peri-implantitis and enhancing our understanding of its pathogenesis.

关键词： Peri-Implant Disease Peri-Implantitis Oral Cytology

Risk factors for bleeding after endoscopic mucosal resection

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World Journal of Gastroenterology 2005年第46期11卷 7335-7339页

作者： Masatsugu Shiba Kazuhide Higuchi Kaori Kadouchi Ai Montani Kazuki Yamamori hirotoshi Okazaki Makiko Taguchi Tomoko Wada Atsushi Itani Toshio Watanabe Kazunari Tominaga Yoshihiro Fujiwara Tomoshige Hayashi Kei Tsumura Tetsuo Arakawa Department of GastroenterologyOsaka City University Medical School OsakaJapan Department of GastroenterologyOsaka City University Medical School OsakaJapan Department of Preventive Medicine and Environmental HealthOsaka City University Medical SchoolOsakaJapan Department of GastroenterologyOsaka City University Medical School OsakaJapan Department of CardiologyOsaka City University Medical SchoolOsakaJapan

AIM： To clarify the risk factors for bleeding after endoscopic mucosal resection （EMR）. METHODS： A total of 297 consecutive patients who underwent EMR were enrolled. Some of the patients had multiple lesions. Bleeding requiring endoscopic treatment was defined as bleeding after EMR. Odds ratios （OR） with 95% confidence intervals （CI）, calculated by logistic regression with multivariate adjustments for covariates, were the measures of association. RESULTS： Of the 297 patients, 57 （19.2%） patients with bleeding after EMR were confirmed. With multivariate adjustment, the cutting method of EMR, diameter, and endoscopic pattern of the tumor were associated with the risk of bleeding after EMR. The multivariate-adjusted OR for bleeding after EMR using endoscopic aspiration mucosectomy was 3.07 （95%CI, 1.59-5.92） compared with strip biopsy. The multiple-adjusted OR for bleeding after EMR for the highest quartile （16-50 mm） of tumor diameter was 5.63 （95%CI, 1.84-17.23） compared with that for the lowest （4-7 mm）. The multiple-adjusted OR for bleeding after EMR for depressed type of tumor was 4.21 （95%CI, 1.75-10.10） compared with elevated type. CONCLUSION： It is important to take tumor charactedstics （tumor size and endoscopic pattern） and cutting method of EMR into consideration in predicting bleeding after EMR.

关键词： Endoscopic mucosal resection Bleeding Tumor characteristics Cutting method

Computer Predictions and Experimental Verification of Residual Stresses and Distortion in Carburizing-Quenching of Steel

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Journal of Shanghai Jiaotong university(Science) 2000年第1期5卷 165-172页

作者： Dong- Ying Ju, Michiharu Narazaki , Hirofumi Kamisugi , Haruyoshi Hirano 1 . Department of Mechanical Engineering, Saitama Institute of Technology, Saitama, Japan 2 . Department of Mechanical Systems Engineering, utsunomiya University, utsunomiya, Japan 3

In this paper, the carburizing-quenching process of carbon steel is analyzed with computer simulation which is based on the metallo-thermo-mechanical theory and finite element analysis coupled temperature, phase transformation and stress/strain fields. The residual stresses and distortion of a steel cylinder during carburizing quenching process were predicted and compared with experimental data. From the prediction results, improvement of hardness and strength of the cylinder component in carburizing-quenching process was verified.

关键词： Carburizing-quenching process Carbon diffusion Residual stresses and distortion

Immunohistochemical Localization of Versican, Link Protein and Hyaluronic Acid Binding Protein in the Human Periodontal Ligament

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Open Journal of Stomatology 2014年第9期4卷 446-451页

作者： Tadahiko utsunomiya Aki Otsuka Rei Sato Masaru Yamaguchi Kazutaka Kasai Hirotsugu Yamamoto Kayo Kuyama Department of Oral Pathology Nihon University School of Dentistry at Matsudo Matsudo Japan Department of Orthodontics Nihon University School of Dentistry at Matsudo Matsudo Japan Nihon University Tokyo Japan

The purpose of the present study was to histopathologically and immunohistochemically investigate the distribution of proteoglycans in human periodontal ligament (PDL). Specimens from osteotomy and tooth extraction having healthy PDL were studied. Histologically, PDL consisted of fibrous tissues, involving a compact arrangement area and edematous or myxoid area. Immuno-histochemically, versican binding region (12C5), versican link protein (8A4) and biotinylated hyaluronic acid binding protein (B-HABP) were distributed in PDL. In addition, positive immunore-activity for 12C5 and 8A4 was stronger in the compact arrangement area than in the edematous or myxoid area. Reactivity for B-HABP was stronger in the edematous or myxoid area than in the compact fibrous area. These results suggest that versican and link protein are associated with fibrous tissues, whereas hyaluronic acid is related to the formation of edematous and/or myxoid tissue in human PDL. These substances may play a role in periodontal homeostasis by protecting against mechanical stress.

关键词： Proteoglycan Periodontal Ligament Immunohistochemistry

Commissioning of laser electron gamma beamline SLEGS at SSRF

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Nuclear Science and Techniques 2022年第7期33卷 103-114页

作者： Hong-Wei Wang Gong-Tao Fan Long-Xiang Liu Hang-Hua Xu Wen-Qing Shen Yu-Gang Ma Hiroaki utsunomiya Long-Long Song Xi-Guang Cao Zi-Rui Hao Kai-Jie Chen Sheng Jin Yu-Xuan Yang Xin-Rong Hu Xin-Xiang Li Pan Kuang Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai201800China University of Chinese Academy of Science Beijing100049China Fudan University Shanghai200433China Department of Physics Konan UniversityKobe658-8501Japan ShanghaiTech University Shanghai201210China Zhengzhou University Zhengzhou450001China

The Shanghai Laser Electron Gamma Source(SLEGS)is a powerful gamma source that provides MeV gamma-ray beams for nuclear science and *** was developed as one of the 16 beamline stations in the Phase Ⅱ Project of the Shanghai Synchrotron Radiation *** slant-scattering mode is for the first time systematically employed in laser Compton scattering at SLEGS to produce energy-tunable quasi-monoenergetic gamma-ray *** SLEGS officially completed its commissioning from July to December *** rays in the energy range of 0.25-21.7 MeV with a flux of 2.1×10^(4)-1.2×10^(7) photons/s and an energy spread of 2-15% were produced during the *** paper reports the results from commissioning the SLEGS beamline.

关键词： SLEGS Laser Compton scattering Slant-scattering mode Backscattering mode

Surgical Treatment of Scarring Alopecia Associated with Acne Keloidalis Nuchae

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Modern Plastic Surgery 2019年第1期9卷 14-17页

作者： Keiichi Tamagawa Daichi Morioka Rikako Suminaga Zhuo Zhang Ayako Aoki Yuka Shibuya Hiroki utsunomiya Department of Plastic Surgery Showa University Tokyo Japan

Acne keloidalis nuchae (AKN) is a relatively rare chronic inflammatory condition that leads to alopecia on the occipital scalp. Multiple large keloids and alopecia associated with long-lasting folliculitis impair the psychosocial functioning of patients. We report successful treatment of alopecia associated with AKN. When a 23-year-old male was referred to us, a large area of alopecia and multiple keloids associated with AKN were found. Following total excision of the lesion, the defect was reconstructed with two rotation flaps elevated bilaterally. Most patients with AKN undergo conservative treatments including oral antibiotics and local steroid injections. As surgical treatments, excision followed by skin grafting or second-intention healing has been reported. However, all of the previously-reported treatments have left alopecia on the occipital region. Although long scars might be left in the scalp, local flap reconstruction would be an option for the treatment of large areas of alopecia associated with AKN.

关键词： Acne Keloidalis Nuchae Alopecia Rotation Flap

Computed tomography attenuation values of ascites are helpful to predict perforation site

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World Journal of Gastroenterology 2015年第5期21卷 1573-1579页

作者： Ryo Seishima Koji Okabayashi hirotoshi Hasegawa Masashi Tsuruta Hiroki Hoshino Toru Yamada Yuko Kitagawa Department of Surgery Keio University School of MedicineTokyo 1608582Japan

AIM:To evaluate the effect of computed tomography(CT) attenuation values of ascites on gastrointestinal(GI) perforation site ***:The CT attenuation values of the ascites from 51 patients with GI perforations were measured by volume rendering to calculate the mean *** effect of the CT attenuation values of the ascites on perforation site prediction and postoperative complications was ***:Of 24 patients with colorectal perforations,the CT attenuation values of ascites were significantly higher than those in patients with perforations at other sites [22.5 Hounsfield units(HU) vs 16.5 HU,respectively,P = 0.006].Colorectal perforation was significantly associated with postoperative complications(P = 0.038).The prediction rate of colorectal perforation using attenuation values as an auxiliary diagnosis improved by 9.8% compared to that of CT findings alone(92.2% vs 82.4%).CONCLUSION:The CT attenuation values of ascites could facilitate the prediction of perforation sites and postoperative complications in GI perforations,particularly in cases in which the perforation sites are difficult to predict by CT findings alone.

关键词： Perforation site prediction Gastrointestinal perfo

The Urban Problems,Underground Solutions

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The Urban Problems,Underground Solutions