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Transmembrane serine protease 4 expression in the prognosis of radical resection for biliary tract cancer

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2555-2564页

作者： Yoshiyuki Shibata Takeshi Sudo Sho Tazuma Naoki Tanimine Takashi Onoe Yosuke Shimizu Atsushi Yamaguchi Kazuya Kuraoka Shinya Takahashi hirotaka Tashiro Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterHiroshima 737-0023Japan Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterHiroshima 737-0023Japan Department of Diagnostic Pathology National Hospital Organization Kure Medical Centerand Chugoku Cancer CenterHiroshima 737-0023Japan Department of Surgery Graduate School of Biochemical and Health ScienceHiroshima UniversityHiroshima 734-8551Japan

BACKGROUND Recent advancements in biliary tract cancer(BTC)treatment have expanded beyond surgery to include adjuvant therapy,yet the prognosis remains *** prognostic biomarkers could enhance the assessment of patients who have undergone radical resection for *** To determine transmembrane serine protease 4(TMPRSS4)utility as a prognostic biomarker of radical resection for *** Medical records of patients who underwent radical resection for BTC,excluding intrahepatic cholangiocarcinoma,were retrospectively *** associations between TMPRSS4 expression and clinicopathological factors,overall survival,and recurrence-free survival were *** Among the 85 patients undergoing radical resection for BTC,46(54%)were *** TMPRSS4-positive group exhibited significantly higher preoperative carbohydrate antigen 19-9(CA19-9)values and greater lymphatic invasion than the TMPRSS4-negative group(P=0.019 and 0.039,respectively).Postoperative overall survival and recurrence-free survival were significantly worse in the TMPRSS4-positive group(median survival time:25.3 months vs not reached,P<0.001;median survival time:28.7 months vs not reached,P=0.043,respectively).Multivariate overall survival analysis indicated TMPRSS4 positivity,pT3/T4,and resection status R1 were independently associated with poor prognosis(P=0.032,0.035 and 0.030,respectively).TMPRSS4 positivity correlated with preoperative CA19-9 values≥37 U/mL and pathological tumor size≥30 mm(P=0.016 and 0.038,respectively).CONCLUSION TMPRSS4 is a potential prognostic biomarker of radical resection for BTC.

关键词： Biliary tract cancer Biomarker Prognosis Radical resection Transmembrane serine protease 4

Investigation on Effect of Composition on the Drying of Castables with Cement Binder

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China's Refractories 2024年第3期33卷 30-36页

作者： Bruno TOUZO hirotaka GOTO Uwe KLIPPEL Josh SAYRE Jeff BOGAN Calderys Paris 75016France Calderys Toyota 470-0308Japan Calderys Neuwied 56564Germany HWI West Mifflin 15122PAUSA

Monolithic refractory castables comprising a hydraulic bond are still used in a vast majority of cases because of their flexibility and robustness,despite many developments for chemical as well as non-cement castable *** drying can however be a challenge,in particular for deflocculated dense castables of the low cement castable *** publications have been released on this topic for the last ten years,but they often focused on the drying mechanisms or on the addition of drying *** paper presents some experimental results on the effect of the composition on the drying properties,especially on the effect of silicon carbide,used for its high thermal conductivity,and on the matrix *** also introduces two laboratory tests to study and iteratively improve the drying schedule of a given castable *** results show that the spalling resistance and the vapor pressure build-up are significantly influenced by the *** is also shown that the castable properties after drying can be altered if the heating rate is very high.

关键词： drying aggregate composition binding system heating rate

4-1BB transcriptomic expression patterns across malignancies:Implications for clinical trials of 4-1BB agonists

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Cancer Communications 2024年第10期44卷 1168-1172页

作者： Yuji Uehara Shumei Kato Daisuke Nishizaki hirotaka Miyashita Suzanna Lee Mary K.Nesline Sarabjot Pabla Jeffrey M.Conroy Paul DePietro Heidi Ko Jason K.Sicklick Razelle Kurzrock Department of Thoracic Oncology and Respiratory Medicine Tokyo Metropolitan Cancer and Infectious Diseases CenterKomagome HospitalTokyoJapan Department of Precision Cancer Medicine Center for Innovative Cancer TreatmentTokyo Medical and Dental UniversityTokyoJapan Center for Personalized Cancer Therapy and Division of Hematology and Oncology Department of MedicineUniversity of California San DiegoMoores Cancer CenterLa JollaCaliforniaUnited States Dartmouth Cancer Center Hematology and Medical OncologyLebanonNew HampshireUnited States Labcorp Oncology DurhamNorth CarolinaUnited States OmniSeq Incorporation BuffaloNew YorkUnited States Division of Surgical Oncology Department of SurgeryCenter for Personalized Cancer TherapyUniversity of California San DiegoLa JollaCaliforniaUnited States Medical College of Wisconsin Cancer Center and Genomic Sciences and Precision Medicine Center Medical College of WisconsinMilwaukeeWisconsinUnited States Department of Oncology Medical College of Wisconsin Cancer CenterMilwaukeeWisconsinUnited States Department of Oncology University of NebraskaOmahaNebraskaUnited States

4-1BB,a member of the tumor necrosis factor receptor superfamily,is an important co-stimulatory molecule regulating the activity of immune cells across a range of physiological and pathological processes,which culminates in a potent immune response(Figure 1A and B)[1,2].Numerous clinical trials have been conducted utilizing 4–1BB agonists(Supplemental Table S1);however,previous and ongoing 4-1BB agonist trials are being conducted without biomarker selection,which potentially explains their modest ***,several studies suggest the potential value of utilizing transcriptomics in addition to genomics to identify the unique immunologic signature of individual tumors[3–7].

关键词： clinical utilizing Figure

High-grade pancreatic intraepithelial neoplasia diagnosed based on changes in magnetic resonance cholangiopancreatography findings:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1487-1496页

作者： Nao Furuya Atsushi Yamaguchi Naohiro Kato Syuhei Sugata Takuro Hamada Takeshi Mizumoto Yuzuru Tamaru Ryusaku Kusunoki Toshio Kuwai hirotaka Kouno Kazuya Kuraoka Yoshiyuki Shibata Sho Tazuma Takeshi Sudo Hiroshi Kohno Shiro Oka Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Gastroenterology Hiroshima University HospitalHiroshima 734-8551HiroshimaJapan Department of Pathology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan

BACKGROUND High-grade pancreatic intraepithelial neoplasia(PanIN)exhibits no mass and is not detected by any examination ***,it can be diagnosed by pancreatic juice cytology from indirect *** previous cases were diagnosed based on findings of a focal stricture of the main pancreatic duct(MPD)and caudal MPD dilatation and subsequent pancreatic juice cytology using endoscopic retrograde cholangiopancreatography(ERCP).We experienced a case of high-grade PanIN with an unclear MPD over a 20-mm range,but without caudal MPD dilatation on magnetic resonance cholangiopancreatography(MRCP).CASE SUMMARY A 60-year-old female patient underwent computed tomography for a follow-up of uterine cancer post-excision,which revealed pancreatic *** revealed an unclear MPD of the pancreatic body at a 20-mm length without caudal MPD ***,course observation was *** 24 mo,MRCP revealed an increased caudal MPD caliber and a larger pancreatic *** performed ERCP and detected atypical cells suspected of adenocarcinoma by serial pancreatic juice aspiration cytology *** performed a distal pancreatectomy and obtained a histopathological diagnosis of high-grade *** parenchyma invasion was not observed,and curative resection was *** High-grade Pan-IN may cause MPD narrowing in a long range without caudal MPD dilatation.

关键词： Pancreatic cancer Pancreatic intraepithelial neoplasm High-grade pancreatic intraepithelial neoplasm Magnetic resonance cholangiopancreatography Carcinoma in situ Case report

A rare presentation of appendiceal diverticulitis associated with pelvic pseudocyst

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World Journal of Gastroenterology 2008年第8期14卷 1293-1295页

作者： hirotaka Niwa Takeyuki Hiramatsu Department of Surgery Yaizu City Hospital Yaizu-City Shizuoka Japan

We report a case of a 32-year-old woman with episodic right lower quadrant abdominal pain. With the diagnosis of either acute appendicitis or tubo-ovarian abscess, she was treated with antibiotics, which successfully relieved the pain and the inflammatory findings. She repeated the clinical condition a few times and antibiotics worked each time. In a year, her subjective symptoms became milder, however, a giant pelvic cyst appeared. She had an exploratory laparotomy to confirm this diagnosis. Histopathological studies revealed herniated appendiceal mucosa through the muscular layer associated with chronic inflammation and marked fibrosis. Gynecological disorders such as endometriosis or lutein cyst rupture was denied. These findings represent appendiceal diverticulitis. We discuss the clinical features of the disease and its relation with the pelvic pseudocyst.

关键词： Appendiceal diverticulitis Perforation Pelvic pseudocyst

Synthesis strategies of covalent organic frameworks: An overview from nonconventional heating methods and reaction media

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Green Energy & Environment 2023年第6期8卷 1596-1618页

作者： Jing Xiao Jia Chen Juewen Liu hirotaka Ihara Hongdeng Qiu CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Waterloo Institute for NanotechnologyUniversity of WaterlooWaterlooOntario N2L 3G1Canada Department of Applied Chemistry and Biochemistry Kumamoto University2-39-1 KurokamiChuo-ku Kumamoto 860-8555Japan College of Chemistry Zhengzhou UniversityZhengzhou 450001China

Covalent organic frameworks(COFs), as an emerging class of porous crystalline materials constructed by covalent links between the building monomers, have gained tremendous attention. Over the past 15 years, COFs have made rapid progress and substantial development in the chemistry and materials fields. However, the synthesis of COFs has been dominated by solvothermal methods for a long time and it usually involves high temperature, high pressure and toxic organic solvents, which created many challenges for environmental considerations. Recently,the exploration of new approaches for facile fabrication of COFs has aroused extensive interest. Hence, in this review, we comprehensively describe the synthetic strategies of COFs from the aspects of nonconventional heating methods and reaction media. In addition, the advantages,limitations and properties of the preparation methods are compared. Finally, we outline the main challenges and development prospects of the synthesis of COFs in the future and propose some possible solutions.

关键词： Covalent organic frameworks Heating methods Reaction media Synthesis strategy Formation mechanism

Structural Health Monitoring by Using Fiber-Optic Distributed Strain Sensors With High Spatial Resolution

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Photonic Sensors 2013年第4期3卷 355-376页

作者： Hideaki MURAYAMA Daichi WADA hirotaka IGAWA School of Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan Japan Aerospace Exploration Agency 6-13-10hsawa Mitaka Tokyo 181-0015 Japan

In this paper, we review our researches on the topics of the structural health monitoring （SHM） with the fiber-optic distributed strain sensor. Highly-dense information on strains in a structure can be useful to identify some kind of existing damages or applied loads in implementation of SHM. The fiber-optic distributed sensors developed by the authors have been applied to the damage detection of a single-lap joint and load identification of a beam simply supported. We confirmed that the applicability of the distributed sensor to SHM could be improved as making the spatial resolution higher. In addition, we showed that the simulation technique considering both structural and optical effects seamlessly in strain measurement could be powerful tools to evaluate the performance of a sensing system and design it for SHM. Finally, the technique for simultaneous distributed strain and temperature measurement using the PANDA-fiber Bragg grating （FBG） is shown in this paper, because problems caused by the cross-sensitivity toward strain and temperature would be always inevitable in strain measurement for SHM.

关键词： Structural health monitoring fiber-optic distributed sensor strain monitoring damage detection load identification

Valproic acid as a micro RNA modulator to promote neurite outgrowth

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Neural Regeneration Research 2016年第10期11卷 1564-1565页

作者： hirotaka Oikawa Judy C.G.Sng Neuroepigenetics Laboratory Singapore Institute for Clinical Sciences Agency for Science and Technology (A*STAR) Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore

Valproic acid （VPA） has been a first-choice drug for clinical treatment of epilepsy and manic disorder. For decades, its phar- macological action was believed to act on inhibition of gam- ma-aminobutyric acid （GABA） transaminase, in turn, increas- ing GABA in inhibitory synapses. However, in recent years, VPA has been investigated on other therapeutic actions. Those investigations demonstrate that VPA shows neuroprotective ef- fects by promoting neurogenesis, neuronal differentiation, and neuroregeneration （Foti et al., 2013）.

关键词： VPA RNA Valproic acid as a micro RNA modulator to promote neurite outgrowth acid

Efficacy of balloon-occluded retrograde transvenous obliteration, percutaneous transhepatic obliteration and combined techniques for the management of gastric fundal varices

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World Journal of Gastroenterology 2006年第24期12卷 3866-3873页

作者： hirotaka Arai Takehiko Abe Hitoshi Takagi Masatomo Mori Department of Gastroenterology Maebashi Red Cross Hospital 3-20-14 Asahi-choMaebashi 371-0014Japan Department of Medicine and Molecular Science Gunma University Graduate School of Medicine (previously known as the First Department of Internal Medicine Gunma University School of Medicine)MaebashiGunma 371-8511Japan

AIM： To evaluate the effect of three interventional treatments involving transvenous obliteration for the treatment of gastric varices, and to compare the efficacy and adverse effects of these methods, METHODS： From 1995 to 2004, 93 patients with gastric fundal varices underwent interventional radiologic embolotherapy at our hospital. Of the 93 patients, 75 were treated with the balloon-occluded retrograde transvenous obliteration （BRTO） procedure; 8 were with the percutaneous transhepatic obliteration （PTO） procedure; and 10 were with the combined BRTO and PTO therapy. A follow-up evaluation examined the rates of survival, recurrence and rebleeding of the gastric varices, worsening of esophageal varices and complications in each group. RESULTS： The BRTO, PTO, and combined therapy were technically successful in 81% （75/93）, 44% （8/18）, and 100% （10/10） patients, respectively. Recurrence of gastric varices was found in 3 patients in the BRTO group and in 3 patients in the PTO group. Rebleeding was observed in 1 patient in the BRTO group and in 1 patient in the PTO group. The 1- and 3-year survival rates were 98% and 87% in the patients without hepatocellular carcinoma （HCC） in the BRTO group, 100% and 100% in the PTO group, and 90% and 75% in the combined therapy group, respectively. CONCLUSION： Combined BRTO and PTO therapy may rescue cases with uncontrollable gastric fundal varices that remained even after treatment with BRTO and/or PTO, though there were limitations of our study, including retrospective nature and discrepancy in sample size between the BRTO, PTO and combined therapy groups.

关键词： Gastric varices Balloon-occluded retrogradetransvenous obliteration Percutaneous transhepaticobliteration Combined therapy