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High-grade pancreatic intraepithelial neoplasia diagnosed based on changes in magnetic resonance cholangiopancreatography findings:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1487-1496页

作者： Nao Furuya Atsushi Yamaguchi Naohiro Kato Syuhei Sugata Takuro Hamada Takeshi Mizumoto Yuzuru Tamaru Ryusaku Kusunoki Toshio Kuwai hirotaka Kouno Kazuya Kuraoka Yoshiyuki Shibata Sho Tazuma Takeshi Sudo Hiroshi Kohno Shiro Oka Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Gastroenterology Hiroshima University HospitalHiroshima 734-8551HiroshimaJapan Department of Pathology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan

BACKGROUND High-grade pancreatic intraepithelial neoplasia(PanIN)exhibits no mass and is not detected by any examination modalities.However,it can be diagnosed by pancreatic juice cytology from indirect findings.Most previous cases were diagnosed based on findings of a focal stricture of the main pancreatic duct(MPD)and caudal MPD dilatation and subsequent pancreatic juice cytology using endoscopic retrograde cholangiopancreatography(ERCP).We experienced a case of high-grade PanIN with an unclear MPD over a 20-mm range,but without caudal MPD dilatation on magnetic resonance cholangiopancreatography(MRCP).CASE SUMMARY A 60-year-old female patient underwent computed tomography for a follow-up of uterine cancer post-excision,which revealed pancreatic cysts.MRCP revealed an unclear MPD of the pancreatic body at a 20-mm length without caudal MPD dilatation.Thus,course observation was performed.After 24 mo,MRCP revealed an increased caudal MPD caliber and a larger pancreatic cyst.We performed ERCP and detected atypical cells suspected of adenocarcinoma by serial pancreatic juice aspiration cytology examination.We performed a distal pancreatectomy and obtained a histopathological diagnosis of high-grade PanIN.Pancreatic parenchyma invasion was not observed,and curative resection was achieved.CONCLUSION High-grade Pan-IN may cause MPD narrowing in a long range without caudal MPD dilatation.

关键词： Pancreatic cancer Pancreatic intraepithelial neoplasm High-grade pancreatic intraepithelial neoplasm Magnetic resonance cholangiopancreatography Carcinoma in situ Case report

Synthesis strategies of covalent organic frameworks: An overview from nonconventional heating methods and reaction media

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Green Energy & Environment 2023年第6期8卷 1596-1618页

作者： Jing Xiao Jia Chen Juewen Liu hirotaka Ihara Hongdeng Qiu CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Waterloo Institute for NanotechnologyUniversity of WaterlooWaterlooOntario N2L 3G1Canada Department of Applied Chemistry and Biochemistry Kumamoto University2-39-1 KurokamiChuo-ku Kumamoto 860-8555Japan College of Chemistry Zhengzhou UniversityZhengzhou 450001China

Covalent organic frameworks(COFs), as an emerging class of porous crystalline materials constructed by covalent links between the building monomers, have gained tremendous attention. Over the past 15 years, COFs have made rapid progress and substantial development in the chemistry and materials fields. However, the synthesis of COFs has been dominated by solvothermal methods for a long time and it usually involves high temperature, high pressure and toxic organic solvents, which created many challenges for environmental considerations. Recently,the exploration of new approaches for facile fabrication of COFs has aroused extensive interest. Hence, in this review, we comprehensively describe the synthetic strategies of COFs from the aspects of nonconventional heating methods and reaction media. In addition, the advantages,limitations and properties of the preparation methods are compared. Finally, we outline the main challenges and development prospects of the synthesis of COFs in the future and propose some possible solutions.

关键词： Covalent organic frameworks Heating methods Reaction media Synthesis strategy Formation mechanism

An Unusual Acceleration of Amination Reactivity by the Proximal Ester Groups in Catechol Diesters: An Efficient Way for Peptide Synthesis

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Precision Chemistry

Precision Chemistry 2023年第2期1卷 100-106页

作者： An Wu hirotaka Ikeda Hisashi Yamamoto Peptide Research Center Chubu UniversityKasugaiAichi 487-8501Japan Materials Science Department MOLSIS Inc.Chuo-kuTokyo 104-0032Japan

Peptide bond formation has drawn more and more attention due to its importance in medicinal chemistry and drug discovery.Using active esters to construct peptide bonds is an indispensable strategy in this field.We herein report a fast and efficient amination reaction to synthesize peptides from catechol diesters.Catechol monoesters are good active esters in peptide synthesis due to the anchimeric assistance effect.In previously reported work,the amination reaction was inactivated if the 2-hydroxyl group in the catechol esters was functionalized.However,we found an unusual acceleration of the amination reactivity when the 2-hydroxyl group was functionalized as an ester group.The reaction can be complete in 2−3 min in some cases.This acceleration was found through experimental studies to not result from the anchimeric assistance effect.We proposed aπ*−π*interaction pathway between the two proximal ester groups.Some computational studies were made to support this assumption.

关键词： catechol diesters peptide synthesis amination π*−π*interaction proximal ester groups

Reproducible reformation of a bilayer lipid membrane using microair bubbles

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液滴(英文) 2023年第3期2卷 90-98页

作者： Izumi Hashimoto Toshihisa Osaki hirotaka Sugiura Hisatoshi Mimura Sho Takamori Norihisa Miki Shoji Takeuchi Artificial Cell Membrane Systems Group Kanagawa Institute of Industrial Science and TechnologyKanagawaJapan Department of Mechanical Engineering Keio UniversityKanagawaJapan Institute of Industrial Science The University of TokyoTokyoJapan Graduate School of Information Science and Technology The University of TokyoTokyoJapan

Planar bilayer lipid membranes(BLMs)are widely used as models for cell membranes in various applications,including drug discovery and biosensors.However,the nanometer-thick bilayer structure,assembled through hydrophobic interactions of amphiphilic lipid molecules,makes such BLM systems mechanically and electrically unstable.In this study,we developed a device to reform BLMs using a microair bubble.The device consists of a double well divided by a separator with a microaperture,where a BLM was formed by infusing a lipiddispersed solvent and an aqueous droplet into each well in series.When the BLM ruptured,a microair bubble was injected from the bottom of the well to split the merged aqueous droplet at the microaperture,which resulted in the reformation of two lipid monolayers on the split droplets.By bringing the two droplets into contact,a new BLM was formed.An angled step design was introduced in the BLM device to guide the bubble and ensure the splitting of the merged droplet.We also elucidated the optimal bubble inflow rate for the reproducible BLM reformation.Using a 4-channel parallel device,we demonstrated the individual and repeatable reformation of BLMs.Our approach will aid the development of automated and arrayed BLM systems.

关键词： bubble bringing unstable

Alloyed nanostructures integrated metal-phenolic nanoplatform for synergistic wound disinfection and revascularization

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Bioactive Materials 2022年第10期7卷 95-106页

作者： Yi Xie Shengqiu Chen Xu Peng Xiaoling Wang Zhiwei Wei Joseph J.Richardson Kang Liang hirotaka Ejima Junling Guo Changsheng Zhao College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengduSichuan610065China BMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and EngineeringSichuan UniverisityChengduSichuan610065China Laboratory Animal Center Sichuan UniversityChengduSichuan610065China School of Chemical Engineering Graduate School of Biomedical Engineeringand Australian Centre for NanoMedicineUniversity of New South WalesSydneyNSW2052Australia Department of Materials Engineering School of EngineeringThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo113􀀀8656Japan Bioproducts Institute Departments of Chemical and Biological EngineeringThe University of British ColumbiaVancouverBCV6T 1Z4Canada School of Chemical Engineering Sichuan UniversityChengduSichuan610065China

New materials for combating bacteria-caused infection and promoting the formation of microvascular networks during wound healing are of vital importance.Although antibiotics can be used to prevent infection,treatments that can disinfect and accelerate wound healing are scarce.Herein,we engineer a coating that is both highly compatible with current wound dressing substrates and capable of simultaneously disinfecting and revascularizing wounds using a metal-phenolic nanoplatform containing an alloyed nanostructured architecture(Ag@Cu-MPNNC).The alloyed nanostructure is formed by the spontaneous co-reduction and catalytic disproportionation reaction of multiple metal ions on a foundation metal-phenolic supramolecular layer.This synergistic presence of metals greatly improves the antibacterial activity against both Gram-negative and Gram-positive pathogenic bacteria,while demonstrating negligible cytotoxicity to normal tissue.In infected rat models,the Ag@Cu-MPNNC could kill bacteria efficiently,promoting revascularization and accelerate wound closure with no adverse side effects in infected in vivo models.In other words,this material acts as a combination therapy by inhibiting bacterial invasion and modulating bio-nano interactions in the wound.

关键词： Metal-phenolic network Wound healing Antibacterial activity Revascularization

Magnetic Micromanipulation for In Vivo Measurement of Stiffness Heterogeneity and Anisotropy in the Mouse Mandibular Arch

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Research 2020年第1期2020卷 1409-1419页

作者： Min Zhu Kaiwen Zhang hirotaka Tao Sevan Hopyan Yu Sun Department of Mechanical and Industrial Engineering University of TorontoCanada M5S 3G8 Program in Developmental and Stem Cell Biology Research InstituteThe Hospital for Sick ChildrenTorontoONCanada M5G 0A4 Department of Molecular Genetics University of TorontoCanada M5S 1A8 Division of Orthopaedic Surgery The Hospital for Sick Children and University of TorontoCanada M5G 1X8 Institute of Biomaterials and Biomedical Engineering University of TorontoCanada M5S 3G9 Department of Electrical and Computer Engineering University of TorontoCanada M5S 3G4

The mechanical properties of tissues are pivotal for morphogenesis and disease progression.Recent approaches have enabled measurements of the spatial distributions of viscoelastic properties among embryonic and pathological model systems and facilitated the generation of important hypotheses such as durotaxis and tissue-scale phase transition.There likely are many unexpected aspects of embryo biomechanics we have yet to discover which will change our views of mechanisms that govern development and disease.One area in the blind spot of even the most recent approaches to measuring tissue stiffness is the potentially anisotropic nature of that parameter.Here,we report a magnetic micromanipulation device that generates a uniform magnetic field gradient within a large workspace and permits measurement of the variation of tissue stiffness along three orthogonal axes.By applying the device to the organ-stage mouse embryo,we identify spatially heterogenous and directionally anisotropic stiffness within the mandibular arch.Those properties correspond to the domain of expression and the angular distribution of fibronectin and have potential implications for mechanisms that orient collective cell movements and shape tissues during development.Assessment of anisotropic properties extends the repertoire of current methods and will enable the generation and testing of hypotheses.

关键词： transition. stiffness anisotropic

A Cyborg Insect Reveals a Function of a Muscle in Free Flight

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Cyborg and Bionic Systems 2022年第1期2022卷 98-108页

作者： T.Thang Vo-Doan V.Than Dung hirotaka Sato Nanyang Technological University School of Mechanical and Aerospace EngineeringSingapore University of Freiburg Institute of Biology I Germany

While engineers put lots of effort,resources,and time in building insect scale micro aerial vehicles(MAVs)that fly like insects,insects themselves are the real masters of flight.What if we would use living insect as platform for MAV instead?Here,we reported a flight control via electrical stimulation of a flight musde of an insect-computer hybrid robot,which is the interface of a mountable wireless backpack controller and a living beetle.The beetle uses indirect flight muscles to drive wing flapping and three major direct flight muscles(basalar,subalar,and third axilliary(3Ax)muscles)to control the kinematics of the wings for flight maneuver.While turning control was already achieved by stimulating basalar and 3Ax muscles,electrical stimu lation of subalar musdes resulted in braking and elevation control in flight.We also demonstrated around 20 degrees of contralateral yaw and roll by stimulating individual subalar muscle.Stimulating both subalar muscles lead to an increase of 20 degrees in pitch and decelerate the flight by 1.5 m/s2 as well as an induce in elevation of 2m/s.

关键词： robot computer mount

Structural Health Monitoring by Using Fiber-Optic Distributed Strain Sensors With High Spatial Resolution

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Photonic Sensors 2013年第4期3卷 355-376页

作者： Hideaki MURAYAMA Daichi WADA hirotaka IGAWA School of Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan Japan Aerospace Exploration Agency 6-13-10hsawa Mitaka Tokyo 181-0015 Japan

In this paper, we review our researches on the topics of the structural health monitoring (SHM) with the fiber-optic distributed strain sensor. Highly-dense information on strains in a structure can be useful to identify some kind of existing damages or applied loads in implementation of SHM. The fiber-optic distributed sensors developed by the authors have been applied to the damage detection of a single-lap joint and load identification of a beam simply supported. We confirmed that the applicability of the distributed sensor to SHM could be improved as making the spatial resolution higher. In addition, we showed that the simulation technique considering both structural and optical effects seamlessly in strain measurement could be powerful tools to evaluate the performance of a sensing system and design it for SHM. Finally, the technique for simultaneous distributed strain and temperature measurement using the PANDA-fiber Bragg grating (FBG) is shown in this paper, because problems caused by the cross-sensitivity toward strain and temperature would be always inevitable in strain measurement for SHM.

关键词：结构健康监测光纤应变传感高空间分辨率光纤分布式分布式光纤传感器光纤布拉格光栅器具分布式传感器

Valproic acid as a micro RNA modulator to promote neurite outgrowth

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Neural Regeneration Research 2016年第10期11卷 1564-1565页

作者： hirotaka Oikawa Judy C.G.Sng Neuroepigenetics Laboratory Singapore Institute for Clinical Sciences Agency for Science and Technology (A*STAR) Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore

Valproic acid （VPA） has been a first-choice drug for clinical treatment of epilepsy and manic disorder. For decades, its phar- macological action was believed to act on inhibition of gam- ma-aminobutyric acid （GABA） transaminase, in turn, increas- ing GABA in inhibitory synapses. However, in recent years, VPA has been investigated on other therapeutic actions. Those investigations demonstrate that VPA shows neuroprotective ef- fects by promoting neurogenesis, neuronal differentiation, and neuroregeneration （Foti et al., 2013）.

关键词： VPA RNA Valproic acid as a micro RNA modulator to promote neurite outgrowth acid