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Effects of Neuroticism on Partial and Whole Body Reactions under Stress

Journal of Sports Science 2015年第4期3卷 155-164页

作者： Kanaka Yatabe Hiroto Fujiya Naoko Yui Keisuke Tateishi Yuka Murofushi Fumiko Terawaki Atsuhiro Yoshida hirotaka yoshioka Koh Terauchi Hajime Kobayashi Takaaki Kudo Mahiro Ohno Aya Uchino Hisao Miyano Tadasu Oyama Haruki Musha Department of Sports Medicine St. Marianna University School of Medicine Kawasaki 216-8511 Japan Department of Sports Medicine St. Marianna University Graduate School of Medicine Kawasaki 216-8511 Japan Research Division National Center for University Entrance Examinations Tokyo 153-8501 Japan Department of Psychology College of Humanities and Sciences Nihon University Tokyo 156-8550 Japan

Effects of neuroticism on partial and whole body reaction times were investigated under stress, or choking conditions in student participants （N = 127）. We measured simple and choice reaction times of parts of the body and choice reaction times of the whole body in the participants with high and low neuroticism such as depression, cyclic tendency, inferiority feelings, and nervousness under the controlled stress scenario of being in front of people. Results indicated significant differences in reaction times of partial body, discriminative decisions and choice reaction times of participants in the high neuroticism group. Results of whole body reaction times were opposite to that of partial body reactions. However, a two-way factorial analysis of variance indicated neither a significant main effect, nor interactions between reaction times and personality traits. Whole body reactions suggest that the effects of stimulus transduction process from motor commands to motor outputs via motor neurons has a greater effect in the central nervous system than recognition and decision-making. However, it is possible that changes in the intracortical mechanisms related to cognitions and emotions could be correlated in partial body movements with nearly no muscular activity. Our findings suggested that delays indiscrimination, decision-making, and choice times could affect the performance of individuals.

关键词： Personality traits stress reaction.

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Transmembrane serine protease 4 expression in the prognosis of radical resection for biliary tract cancer

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2555-2564页

作者： Yoshiyuki Shibata Takeshi Sudo Sho Tazuma Naoki Tanimine Takashi Onoe Yosuke Shimizu Atsushi Yamaguchi Kazuya Kuraoka Shinya Takahashi hirotaka Tashiro Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterHiroshima 737-0023Japan Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterHiroshima 737-0023Japan Department of Diagnostic Pathology National Hospital Organization Kure Medical Centerand Chugoku Cancer CenterHiroshima 737-0023Japan Department of Surgery Graduate School of Biochemical and Health ScienceHiroshima UniversityHiroshima 734-8551Japan

BACKGROUND Recent advancements in biliary tract cancer(BTC)treatment have expanded beyond surgery to include adjuvant therapy,yet the prognosis remains *** prognostic biomarkers could enhance the assessment of patients who have undergone radical resection for *** To determine transmembrane serine protease 4(TMPRSS4)utility as a prognostic biomarker of radical resection for *** Medical records of patients who underwent radical resection for BTC,excluding intrahepatic cholangiocarcinoma,were retrospectively *** associations between TMPRSS4 expression and clinicopathological factors,overall survival,and recurrence-free survival were *** Among the 85 patients undergoing radical resection for BTC,46(54%)were *** TMPRSS4-positive group exhibited significantly higher preoperative carbohydrate antigen 19-9(CA19-9)values and greater lymphatic invasion than the TMPRSS4-negative group(P=0.019 and 0.039,respectively).Postoperative overall survival and recurrence-free survival were significantly worse in the TMPRSS4-positive group(median survival time:25.3 months vs not reached,P<0.001;median survival time:28.7 months vs not reached,P=0.043,respectively).Multivariate overall survival analysis indicated TMPRSS4 positivity,pT3/T4,and resection status R1 were independently associated with poor prognosis(P=0.032,0.035 and 0.030,respectively).TMPRSS4 positivity correlated with preoperative CA19-9 values≥37 U/mL and pathological tumor size≥30 mm(P=0.016 and 0.038,respectively).CONCLUSION TMPRSS4 is a potential prognostic biomarker of radical resection for BTC.

关键词： Biliary tract cancer Biomarker Prognosis Radical resection Transmembrane serine protease 4

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Investigation on Effect of Composition on the Drying of Castables with Cement Binder

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China's Refractories 2024年第3期33卷 30-36页

作者： Bruno TOUZO hirotaka GOTO Uwe KLIPPEL Josh SAYRE Jeff BOGAN Calderys Paris 75016France Calderys Toyota 470-0308Japan Calderys Neuwied 56564Germany HWI West Mifflin 15122PAUSA

Monolithic refractory castables comprising a hydraulic bond are still used in a vast majority of cases because of their flexibility and robustness,despite many developments for chemical as well as non-cement castable *** drying can however be a challenge,in particular for deflocculated dense castables of the low cement castable *** publications have been released on this topic for the last ten years,but they often focused on the drying mechanisms or on the addition of drying *** paper presents some experimental results on the effect of the composition on the drying properties,especially on the effect of silicon carbide,used for its high thermal conductivity,and on the matrix *** also introduces two laboratory tests to study and iteratively improve the drying schedule of a given castable *** results show that the spalling resistance and the vapor pressure build-up are significantly influenced by the *** is also shown that the castable properties after drying can be altered if the heating rate is very high.

关键词： drying aggregate composition binding system heating rate

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High-grade pancreatic intraepithelial neoplasia diagnosed based on changes in magnetic resonance cholangiopancreatography findings:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1487-1496页

作者： Nao Furuya Atsushi Yamaguchi Naohiro Kato Syuhei Sugata Takuro Hamada Takeshi Mizumoto Yuzuru Tamaru Ryusaku Kusunoki Toshio Kuwai hirotaka Kouno Kazuya Kuraoka Yoshiyuki Shibata Sho Tazuma Takeshi Sudo Hiroshi Kohno Shiro Oka Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Gastroenterology Hiroshima University HospitalHiroshima 734-8551HiroshimaJapan Department of Pathology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan

BACKGROUND High-grade pancreatic intraepithelial neoplasia(PanIN)exhibits no mass and is not detected by any examination ***,it can be diagnosed by pancreatic juice cytology from indirect *** previous cases were diagnosed based on findings of a focal stricture of the main pancreatic duct(MPD)and caudal MPD dilatation and subsequent pancreatic juice cytology using endoscopic retrograde cholangiopancreatography(ERCP).We experienced a case of high-grade PanIN with an unclear MPD over a 20-mm range,but without caudal MPD dilatation on magnetic resonance cholangiopancreatography(MRCP).CASE SUMMARY A 60-year-old female patient underwent computed tomography for a follow-up of uterine cancer post-excision,which revealed pancreatic *** revealed an unclear MPD of the pancreatic body at a 20-mm length without caudal MPD ***,course observation was *** 24 mo,MRCP revealed an increased caudal MPD caliber and a larger pancreatic *** performed ERCP and detected atypical cells suspected of adenocarcinoma by serial pancreatic juice aspiration cytology *** performed a distal pancreatectomy and obtained a histopathological diagnosis of high-grade *** parenchyma invasion was not observed,and curative resection was *** High-grade Pan-IN may cause MPD narrowing in a long range without caudal MPD dilatation.

关键词： Pancreatic cancer Pancreatic intraepithelial neoplasm High-grade pancreatic intraepithelial neoplasm Magnetic resonance cholangiopancreatography Carcinoma in situ Case report

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Synthesis strategies of covalent organic frameworks: An overview from nonconventional heating methods and reaction media

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Green Energy & Environment 2023年第6期8卷 1596-1618页

作者： Jing Xiao Jia Chen Juewen Liu hirotaka Ihara Hongdeng Qiu CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Waterloo Institute for NanotechnologyUniversity of WaterlooWaterlooOntario N2L 3G1Canada Department of Applied Chemistry and Biochemistry Kumamoto University2-39-1 KurokamiChuo-ku Kumamoto 860-8555Japan College of Chemistry Zhengzhou UniversityZhengzhou 450001China

Covalent organic frameworks(COFs), as an emerging class of porous crystalline materials constructed by covalent links between the building monomers, have gained tremendous attention. Over the past 15 years, COFs have made rapid progress and substantial development in the chemistry and materials fields. However, the synthesis of COFs has been dominated by solvothermal methods for a long time and it usually involves high temperature, high pressure and toxic organic solvents, which created many challenges for environmental considerations. Recently,the exploration of new approaches for facile fabrication of COFs has aroused extensive interest. Hence, in this review, we comprehensively describe the synthetic strategies of COFs from the aspects of nonconventional heating methods and reaction media. In addition, the advantages,limitations and properties of the preparation methods are compared. Finally, we outline the main challenges and development prospects of the synthesis of COFs in the future and propose some possible solutions.

关键词： Covalent organic frameworks Heating methods Reaction media Synthesis strategy Formation mechanism

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Structural Health Monitoring by Using Fiber-Optic Distributed Strain Sensors With High Spatial Resolution

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Photonic Sensors 2013年第4期3卷 355-376页

作者： Hideaki MURAYAMA Daichi WADA hirotaka IGAWA School of Engineering The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan Japan Aerospace Exploration Agency 6-13-10hsawa Mitaka Tokyo 181-0015 Japan

In this paper, we review our researches on the topics of the structural health monitoring （SHM） with the fiber-optic distributed strain sensor. Highly-dense information on strains in a structure can be useful to identify some kind of existing damages or applied loads in implementation of SHM. The fiber-optic distributed sensors developed by the authors have been applied to the damage detection of a single-lap joint and load identification of a beam simply supported. We confirmed that the applicability of the distributed sensor to SHM could be improved as making the spatial resolution higher. In addition, we showed that the simulation technique considering both structural and optical effects seamlessly in strain measurement could be powerful tools to evaluate the performance of a sensing system and design it for SHM. Finally, the technique for simultaneous distributed strain and temperature measurement using the PANDA-fiber Bragg grating （FBG） is shown in this paper, because problems caused by the cross-sensitivity toward strain and temperature would be always inevitable in strain measurement for SHM.

关键词： Structural health monitoring fiber-optic distributed sensor strain monitoring damage detection load identification

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Magnetic Micromanipulation for In Vivo Measurement of Stiffness Heterogeneity and Anisotropy in the Mouse Mandibular Arch

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Research 2020年第1期2020卷 1409-1419页

作者： Min Zhu Kaiwen Zhang hirotaka Tao Sevan Hopyan Yu Sun Department of Mechanical and Industrial Engineering University of TorontoCanada M5S 3G8 Program in Developmental and Stem Cell Biology Research InstituteThe Hospital for Sick ChildrenTorontoONCanada M5G 0A4 Department of Molecular Genetics University of TorontoCanada M5S 1A8 Division of Orthopaedic Surgery The Hospital for Sick Children and University of TorontoCanada M5G 1X8 Institute of Biomaterials and Biomedical Engineering University of TorontoCanada M5S 3G9 Department of Electrical and Computer Engineering University of TorontoCanada M5S 3G4

The mechanical properties of tissues are pivotal for morphogenesis and disease *** approaches have enabled measurements of the spatial distributions of viscoelastic properties among embryonic and pathological model systems and facilitated the generation of important hypotheses such as durotaxis and tissue-scale phase *** likely are many unexpected aspects of embryo biomechanics we have yet to discover which will change our views of mechanisms that govern development and *** area in the blind spot of even the most recent approaches to measuring tissue stiffness is the potentially anisotropic nature of that ***,we report a magnetic micromanipulation device that generates a uniform magnetic field gradient within a large workspace and permits measurement of the variation of tissue stiffness along three orthogonal *** applying the device to the organ-stage mouse embryo,we identify spatially heterogenous and directionally anisotropic stiffness within the mandibular *** properties correspond to the domain of expression and the angular distribution of fibronectin and have potential implications for mechanisms that orient collective cell movements and shape tissues during *** of anisotropic properties extends the repertoire of current methods and will enable the generation and testing of hypotheses.

关键词： transition. stiffness anisotropic

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An Unusual Acceleration of Amination Reactivity by the Proximal Ester Groups in Catechol Diesters: An Efficient Way for Peptide Synthesis

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Precision Chemistry 2023年第2期1卷 100-106页

作者： An Wu hirotaka Ikeda Hisashi Yamamoto Peptide Research Center Chubu UniversityKasugaiAichi 487-8501Japan Materials Science Department MOLSIS Inc.Chuo-kuTokyo 104-0032Japan

Peptide bond formation has drawn more and more attention due to its importance in medicinal chemistry and drug *** active esters to construct peptide bonds is an indispensable strategy in this *** herein report a fast and efficient amination reaction to synthesize peptides from catechol *** monoesters are good active esters in peptide synthesis due to the anchimeric assistance *** previously reported work,the amination reaction was inactivated if the 2-hydroxyl group in the catechol esters was ***,we found an unusual acceleration of the amination reactivity when the 2-hydroxyl group was functionalized as an ester *** reaction can be complete in 2−3 min in some *** acceleration was found through experimental studies to not result from the anchimeric assistance *** proposed aπ*−π*interaction pathway between the two proximal ester *** computational studies were made to support this assumption.

关键词： catechol diesters peptide synthesis amination π*−π*interaction proximal ester groups

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Aerodynamic Study on Supersonic Flows in High-Velocity Oxy-Fuel Thermal Spray Process

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Journal of Thermal Science 2005年第2期14卷 126-129页

作者： Hiroshi KATANODA Takeshi MATSUOKA Seiji KURODA Jin KAWAKITA hirotaka FUKANUMA Kazuyasu MATSUO The University of Kitakyushu 1-1 Hibikino Wakamatsu-kuKitakyushuFukuoka808-0135 JapanTakagi Precision Dies Co. Ltd.2-4-1 IshidaminamiKokuraminami-kuKitakyushuFukuoka802-0836 JapanNational Institute for Materials Science 1-2-1SengenTsukubaIbaraki305-0047 JapanNational Institute for Materials Science 1-2-1SengenTsukubaIbaraki305-0047 JapanPlasma Giken Co. Ltd.2-1-12BijogiTodaSaitama335-0031 JapanThe University of Kitakyushu 1-1 HibikinoWakamatsu-kuKitakyushuFukuoka808-0135 Japan

To clarify the characteristics of gas flow in high velocity oxy-fuel (HVOF) thermal spray gun, aerodynamic research is performed using a special gun. The gun has rectangular cross-sectional area and sidewalls of optical glass to visualize the internal flow. The gun consists of a supersonic nozzle with the design Mach number of 2.0 followed by a straight passage called barrel. Compressed dry air up to 0.78 MPa is used as a process gas instead of combustion gas which is used in a commercial HVOF gun. The high-speed gas flows with shock waves in the gun and jets are visualized by schlieren technique. Complicated internal and external flow-fields containing various types of shock wave as well as expansion wave are visualized.

关键词：超声流冲击波热喷涂内流热处理

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The role of exosomal microRNAs;focus on clinical applications in breast cancer

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Cancer Drug Resistance 2019年第3期2卷 847-861页

作者： Aiko Sueta Yutaka Yamamoto hirotaka Iwase Department of Breast and Endocrine Surgery Kumamoto University Graduate School of Medical Sciences1-1-1HonjoChuo-kuKumamoto 860-8556Japan

Despite several advances in targeted therapies for breast cancer,breast-cancer-associated death remains high in *** is partially due to the lack of reliable markers predicting metastatic disease or recurrence after initial *** research into the clinical validity of circulating cancer-specific biomarkers as a“liquid biopsy”is of growing *** these,exosomal microRNAs(miRNAs)are promising candidate biomarkers for clinical use in breast *** addition to their diagnostic value,exosomal miRNAs play an important role in predicting clinical outcome or treatment *** this review,it is focused on the findings concerning exosomal miRNAs in relation to disease detection,prognostic impact and therapeutic effect in breast cancer,and discuss their clinical utility.

关键词： Exosomal miRNA breast cancer liquid biopsy

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