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Expression of mucosal addressin cell adhesion molecule 1 on vascular endothelium of gastric mucosa in patients with nodular gastritis

引用

World Journal of Gastroenterology 2003年第12期9卷 2701-2705页

作者： HiroshiOhara HajimeIsomoto Chun-YangWen ChiekoEjima MasahiroMurata MasanobuMiyazaki FuminaoTakeshima YoheiMizuta IkuoMurata TakehikoKoji hiroshinagura ShigeruKohno SecondDepartmentofInternalMedicine 1-7-1SakamotoNagasakiJapan DepartmentofMolecularPathology AtomicBombDiseaseInstitute1-12-4SakamotoNagasakiJapan DepartmentofPathology TohokuUniversitySchoolofMedicineAobakuSendalJapan DepartmentofHistologyandCellBiology NagasakiUniversitySchoolofMedicineNagasaki1-12-4SakamotoNagasakiJapan

AIM:The interaction of mucosal addressin cell adhesion molecule 1 (MAdCAM-1) with integrin α4β7 mediates lymphocyte recruitment into mucosa-associated lymphoid tissue (MALT).Nodular gastritis is characterized by a unique military pattern on endoscopy representing increased numbers of lymphoid follicles with germinal center,strongly associated with H pylori *** purpose of this study was to address the implication of the MAdCAM-1/integrin β7 pathway in NG. METHODS:We studied 17 patients with NG and H pylori infection and 19 H pylori-positive and 14 H pylori-negative controls.A biopsy sample was taken from the antrum and snap-frozen for immunohistochemical analysis of MAdCAM- 1 and integrin β*** simultaneous viewing of serial sections, the percentage of MAdCAM-1-positive to von Willebrand factor-positive vessels was *** also performed immunostaining with anti-CD20,CD4,CD8 and CD68 antibodies to determine the lymphocyte subsets co- expressing integrin β7. RESULTS:Vascular endothelial MAdCAM-1 expression was more enhanced in gastric mucosa with than without H pylori *** note,the percentages of MAdCAM-1-positive vessels were significantly higher in the lamina propria of NG patients than in H pylori-positive *** expression of MAdCAM-1 was identified adjacent to lymphoid follicles and dense lymphoid *** β7-expressing mononuclear cells,mainly composed of CD20 and CD4 lymphocytes,were associated with vessels lined with MAdCAM-1-expressing ***: Our results suggest that the MAdCAM一1/ integrin a4p7 homing system may participate in gastric inflammation in response to H py/o}i-infection and contributes to MALT formation, typically leading to the development of NG.

关键词： Base Sequence Comparative Study DNA Primers Endothelium, Vascular Gastric Mucosa Gastritis Helicobacter Infections Helicobacter pylori Humans Immunoglobulins Immunohistochemistry Lymphoma, Mucosa-Associated Lymphoid Tissue Mucoproteins Reverse Transcriptase Polymerase Chain Reaction

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