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Chemical Biology that Controls DNA Structure and Function:DNA Origami and Artificial Genetic Switch

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Chemical Biology that Controls DNA Structure and Function:DN...

Design of Pyrrole-Imidazole Polyamides Discriminating T/A

第八届全国化学生物学学术会议

作者： hiroshi sugiyama Department of Chemistry Graduate School of Science Institute for Integrated Cell-Material Sciences（iCeMS）Kyoto University

＜正＞Fifty years after the discovery of the double-helical structure of DNA,the complete sequence of the human genome has been *** diseases, including cancer,hereditary,and viral diseases,can now be understood at the DNA sequence ***,it has been revealed that epigenetic modification plays an important role in gene expression,which controls the gene expression through DNA methylation and histone *** is closely related to the cell reprogramming and differentiation.

关键词： DNA origami DNA nanotechnology Artificial Genetic Switch Epigenetics

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Design of Pyrrole-Imidazole Polyamides Discriminating T/A

2D and 3D refraction-based visualization of breast cancer for early clinical check

第四届全国化学生物学学术会议暨国际化学与生物/医学交叉研讨会

作者： hiroshi sugiyama Department of Chemistry Graduate School of Science Kyoto UniversityKyotoJapan

Polyamides, which are composed of several different types of heterocyclic rings, are currently the most promising synthetic compounds for the recognition of sequence-specific DNA and for use in chemotherapy and biosensing. N-methylpyrrole (Py) favors T, A and C bases excluding G;N-methylimidazole (Im) is G-reading

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Nuclear Science and Techniques 2006年第6期17卷 389-395页

作者： Masami ANDO Anton MAKSIMENKO Tetsuya YUASA Eiko HASHIMOTO Katsuhito YAMASAKI Shu IHIHARA hiroshi sugiyama Tokiko ENDO LI Gang CHEN Zhihua Kazuyuki HYODO Ei UENO DDS Center RIST Tokyo University of Science Chiba 278-8510 Japan Photon Factory IMSS KEK Oho I-1 Tsukuba Ibaraki 305-0801 Japan Department of Photo-Science GUAS Oho 1.1 Tsukuba Ibamki 305-0801 Japan Faculty of Engineering Yamagata University Yonezawa Yamagata 992-8510 Japan Clinical Genome Informatics Center School of Genome Science Kobe University Hyogo 650-0017 Japan Departramt of Pathology Nagoya Medical Center Nagoya 460-0001 Japan Department of Radiology Nagoya Medical Center Nagoya 460-0001 Japan BSRF IHEP CAS Yaquanlu Beijing 100049 China China-Japan Friendship Hospital Yinhua Donglu Beijing 100029 China Department of Breast-Thyroid-Endocrine Surgery University of Tsukuba Ibaraki 305-8573 Japan

Ductal carcinoma in-situ (DCIS) has been visualized by 2D XDFI (X-ray dark-field imaging) and further by a 3D X-ray CT, and the data was acquired by the X-ray optics DEI (diffraction-enhanced imaging). A newly made algorithm was used for CT. Data of 900 projections with interval of 0.2 degrees were used. Ductus lactiferi, microcalci-fication in a 3D form have been clearly visible. The spatial resolution available was approximately 30μm.

关键词：折射乳腺癌临床检查 CT

Non-destructive investigation of the 3D inner structure of Precambrian embryos fossil by synchrotron hard x-ray phase contrast micron CT

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Non-destructive investigation of the 3D inner structure of P...

The design and engineering strategies of metal tellurides for advanced metal-ion batteries

第十一届中国体视学与图像分析学术会议

作者： Paul Tafforeau Masami Ando hiroshi sugiyama European Synchrotron Radiation Facility France Tokyo University of Science Japan Photon Factory KEK Japan

The recent development of the synchrotron hard x-ray phase contrast imaging and CT with sub-micron and nano-meter resolution is. presented first. Then I will focus on this method’s application in paleontology. The Weng’an fauna from Precambrian Doushantuo phosphates in Weng ’ an, Guizhou Province, China, contains likely fossil representatives of the oldest known metazoans, radiometrically age-dated as at least 580 million years old. One of the main restriction to study these unique fossils is the scarcity of the non-destruc-

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Journal of Energy Chemistry 2024年第2期89卷 579-598,I0013页

作者： Wenmiao Zhao Xiaoyuan Shi Bo Liu hiroshi Ueno Ting Deng Weitao Zheng Key Laboratory of Automobile Materials of MOE School of Materials Science and EngineeringJilin Provincial International Cooperation Key Laboratory of High-Efficiency Clean Energy MaterialsJilin UniversityChangchun 130012JilinChina Key Laboratory of Polyoxometalate Science of Ministry of Education Northeast Normal UniversityChangchun 130024JilinChina Key Laboratory of Preparation and Application of Environmental Friendly Materials(Jilin Normal University) Ministry of EducationChangchun 130103JilinChina Creative Interdisciplinary Research Division The Frontier Research Institute for Interdisciplinary Sciences(FRIS)Department of ChemistryGraduate School of ScienceTohoku UniversitySendai 980-8578Japan

Owning various crystal structures and high theoretical capacity,metal tellurides are emerging as promising electrode materials for high-performance metal-ion batteries(MBs).Since metal telluride-based MBs are quite new,fundamental issues raise regarding the energy storage mechanism and other aspects affecting electrochemical *** volume expansion,low intrinsic conductivity and slow ion diffusion kinetics jeopardize the performance of metal tellurides,so that rational design and engineering are crucial to circumvent these ***,this review provides an in-depth discussion of recent investigations and progresses of metal tellurides,beginning with a critical discussion on the energy storage mechanisms of metal tellurides in various *** the following,recent design and engineering strategies of metal tellurides,including morphology engineering,compositing,defect engineering and heterostructure construction,for high-performance MBs are *** primary focus is to present a comprehensive understanding of the structural evolution based on the mechanism and corresponding effects of dimension control,composition,electron configuration and structural complexity on the electrochemical *** closing,outlooks and prospects for future development of metal tellurides are *** work also highlights the promising directions of design and engineering strategies of metal tellurides with high performance and low cost.

关键词： Metal tellurides Metal-ion battery Energy storage mechanism Material design and engineering

Dynamic ultrasonography for optimizing treatment position in superior mesenteric artery syndrome:Two case reports and review of literature

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World Journal of Gastroenterology 2024年第5期30卷 499-508页

作者： Nobuaki Hasegawa Akihiko Oka Muyiwa Awoniyi Yuri Yoshida hiroshi Tobita Norihisa Ishimura Shunji Ishihara Department of Internal Medicine II Shimane University Faculty of MedicineIzumo 693-8501ShimaneJapan Department of Gastroenterology Hepatology and NutritionDigestive Disease and Surgery InstituteHepatology SectionCleveland ClinicClevelandOH 44195United States Clinical Laboratory Division Shimane University HospitalIzumo 693-8501ShimaneJapan Division of Hepatology Shimane University HospitalIzumo 693-8501Japan

BACKGROUND Superior mesenteric artery(SMA)syndrome is a rare cause of duodenal obstruction by extrinsic compression between the SMA and the aorta(SMA-Ao).Although the left lateral recumbent position is considered effective in the treatment of SMA syndrome,individual variations in the optimal patient position have been *** this report,we present two elderly cases of SMA syndrome that exhibited rapid recovery due to ultrasonographic dynamic evaluation of the optimal position for each *** SUMMARY Case 1:A 90-year-old man with nausea and *** diagnosis of SMA syndrome by computed tomography(CT),ultrasonography(US)revealed the SMA-Ao distance in the supine position(4 mm),which slightly improved in the lateral position(5.7–7.0 mm)without the passage of duodenal ***,in the sitting position,the SMA-Ao distance was increased to 15 mm accompanied by improved content ***,US indicated enhanced passage upon abdominal massage on the right *** day 2,the patient could eat comfortably with the optimal position and *** 2:An 87-year-old woman with *** the diagnosis of SMA syndrome and aspiration pneumonia by CT,dynamic US confirmed the optimal position(SMA-Ao distance was improved to 7 mm in forward-bent position,whereas it remained at 5 mm in the supine position).By day 7 when her pneumonia recovered,she could eat with the optimal *** The optimal position for SMA syndrome varies among *** US appears to be a valuable tool in improving patient outcomes.

关键词： Superior mesenteric artery syndrome Wilkie’s syndrome Cast syndrome Aorto-mesenteric compass syndrome Ultrasonography Case report

Correction: MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

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Oncology Research 2024年第8期32卷 1369-1370页

作者： HUI SUN MASANORI KAWANO TATSUYA IWASAKI ICHIRO ITONAGA YUTA KUBOTA hiroshi TSUMURA KAZUHIRO TANAKA Department of Orthopaedic Surgery Faculty of MedicineOita UniversityOita879-5503Japan

In the article‘MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1’(Oncology Research,2024,Vol.32,No.3,pp.463−***:10.32604/or.2023.044085),there was an error in the compilation of *** have revised Fig.8D to correct this error.A corrected version of Fig.8 is *** correction does not change any results or conclusions of the *** apologize for any inconvenience caused.

关键词： osteosarcoma correction revised

Expression levels of K_(ATP)channel subunits and morphological changes in the mouse liver after exposure to radiation

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World Journal of Experimental Medicine 2024年第2期14卷 103-113页

作者： Ming Zhou Tao-Sheng Li hiroshi Abe Hideo Akashi Ryoji Suzuki Yoshio Bando Department of Anatomy Akita University Graduate School of MedicineAkita 010-8543Japan Department of Stem Cell Biology Atomic Bomb Disease InstituteNagasaki UniversityNagasaki 852-8523Japan Sendai Old Age Refresh Station A Long-term Care Health FacilitySendai 981-1105Japan

BACKGROUND ATP sensitive K+(K_(ATP))channels are ubiquitously distributed in various of cells and tissues,including the *** play a role in the pathogenesis of myocardial and liver *** To evaluate the radiation-induced changes in the expression of K_(ATP)channel subunits in the mouse liver to understand the potential role of K_(ATP)channels in radiation *** Adult C57BL/6 mice were randomly exposed toγ-rays at 0 Gy(control,n=2),0.2 Gy(n=6),1 Gy(n=6),or 5 Gy(n=6).The livers were removed 3 and 24 h after radiation *** and eosin staining was used for morphological observation;immunohistochemical staining was applied to determine the expression of K_(ATP)channel subunits in the liver *** Compared with the control group,the livers exposed to 0.2 Gyγ-ray showed an initial increase in the expression of Kir6.1 at 3 h,followed by recovery at 24 h after *** to a high dose of 5.0 Gy resulted in decreased expression of Kir6.1 and increased expression of SUR2B at 24 ***,the expression of Kir6.2,SUR1,or SUR2A had no remarkable changes at 3 and 24 h after exposure to any of these *** The expression levels of Kir6.1 and SUR2B in mouse liver changed differently in response to different radiation doses,suggesting a potential role for them in radiation-induced liver injury.

关键词： Radiation exposure ATP-sensitive K^(+)channel Mouse Liver

Natural history of asymptomatic gallbladder stones in clinic without beds:A long-term prognosis over 10 years

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World Journal of Clinical Cases 2024年第1期12卷 42-50页

作者： Yuji Sakai Toshio Tsuyuguchi hiroshi Ohyama Junichiro Kumagai Takashi Kaiho Masayuki Ohtsuka Naoya Kato Tadao Sakai Department of Gastroenterology Sakai ClinicKimistu 299-1162Japan Department of Gastroenterology Graduate School of MedicineChiba UniversityChiba 260-8677Japan Department of Gastroenterology Chiba Prefectural Sawara HospitalChiba Prefectural Sawara HospitalSawara 287-0003Japan Department of Gastroenterology Kimitsu Central HospitalKisarazu 292-8535Japan Department of Surgery Kimitsu Central HospitalKisarazu 292-8535Japan Department of General Surgery Graduate School of MedicineChiba UniversityChiba 260-8677Japan

BACKGROUND Several studies have explored the long-term prognosis of patients with asymp-tomatic gallbladder *** reports were primarily conducted in facilities equipped with beds for addressing symptomatic *** To report the long-term prognosis of patients with asymptomatic gallbladder stones in clinics without bed *** We investigated the prognoses of 237 patients diagnosed with asymptomatic gallbladder stones in clinics without beds between March 2010 and October *** symptoms developed,patients were transferred to hospitals where appropriate treatment was *** investigated the asymptomatic and survival periods during the *** Among the 237 patients,214(90.3%)remained asymptomatic,with a mean asymptomatic period of 3898.9279±46.871 d(50-4111 d,10.7 years on average).Biliary complications developed in 23 patients(9.7%),with a mean survival period of 4010.0285±31.2788 d(53-4112 d,10.9 years on average).No patient died of biliary *** The long-term prognosis of asymptomatic gallbladder stones in clinics without beds was *** the condition became symptomatic,the patients were transferred to hospitals with beds that could address it;thus,no deaths related to biliary complications were *** finding suggests that follow-up care in clinics without beds is possible.

关键词： Gallbladder stone Acute cholangitis Acute cholecystitis Asymptomatic gallbladder stone Symptomatic gallbladder stone