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Clinicopathological study of primary biliary cirrhosis with interface hepatitis compared to autoimmune hepatitis

World Journal of Gastroenterology 2014年第13期20卷 3597-3608页

作者： Mio Kobayashi Yuko Kakuda Kenichi harada Yasunori Sato Motoko Sasaki Hiroko Ikeda Mitsuhiro Terada Munenori Mukai Shuichi Kaneko Yasuni Nakanuma Department of Human Pathology Kanazawa University Graduate School of MedicineKanazawa 920-8640Japan Division of Pathology Kanazawa University HospitalKanazawa 920-8641Japan Department of Gastroenterology Kouseiren Takaoka HospitalTakaoka 933-8555Japan Department of Pathology Kouseiren Takaoka HospitalTakaoka 933-8555Japan Department of Gastroenterology Kanazawa University Graduate School of MedicineKanazawa 920-8640 Japan

AIM:To investigate histological and immunohistochemical differences in hepatitis between autoimmune hepatitis(AIH)and primary biliary cirrhosis(PBC)with AIH ***:Liver needle biopsies of 41 PBC with AIH features and 43 AIH patients were *** activity of periportal and lobular inflammation was scored0(none or minimal activity)to 4(severe),and the degree of hepatitic rosette formation and emperipolesis was semiquantatively scored *** infiltration of mononuclear cells positive for CD20,CD38,CD3,CD4,and CD8 and positive for immunoglobulins(IgG,IgM,and IgA)at the periportal areas(interface hepatitis)and in the hepatic lobules(lobular hepatitis)were semiquantitatively scored in immunostained liver sections(score 0-6).Serum aspartate aminotransferase(AST),immunoglobulins,and autoantibodies at the time of liver biopsy were correlated with the histological and immunohistochemical scores of individual ***:Lobular hepatitis,hepatitic rosette formation,and emperipolesis were more extensive and frequent in AIH than in ***3+,CD4+,and CD8+cell infiltration scores were higher in the hepatic lobules and at the interface in AIH but were also found in *** degree of mononuclear cell infiltration correlated well with the degree of interface and lobular hepatitis in PBC,but to a lesser degree in ***20+cells were mainly found in the portal tracts and,occasionally,at the interface in both *** AST correlated well with the hepatocyte necroinflammation and mononuclear cell infiltration,specifically CD38+cells in *** correlation existed between autoantibodies and inflammatory cell infiltration in PBC or *** most AIH cases were IgG-predominant at the interface,PBC cases were divided into IgM-predominant,IgM/IgGequal,and IgG-predominant types,with the latter sharing several features with ***:These results suggest that the hepatocellular injuries associated with interface and lobular hepatitis in AIH and PBC with inte

关键词： Primary biliary cirrhosis Autoimmune hepa-titis Interface hepatitis Lobular hepatitis Plasma cell subclass

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Feasibility of gastric endoscopic submucosal dissection with continuous low-dose aspirin for patients receiving dual antiplatelet therapy

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World Journal of Gastroenterology 2019年第4期25卷 457-467页

作者： Hideaki harada Satoshi Suehiro Daisuke Murakami Ryotaro Nakahara Takuya Nagasaka Tetsuro Ujihara Ryota Sagami Yasushi Katsuyama Kenji Hayasaka Yuji Amano Department of Gastroenterology New Tokyo Hospital Department of Endoscopy New Tokyo Hospital

BACKGROUND Endoscopic submucosal dissection(ESD) for gastric neoplasms during continuous low-dose aspirin(LDA) administration is generally acceptable according to recent guidelines. This retrospective study aimed to investigate the effect of continuous LDA on the postoperative bleeding after gastric ESD in patients receiving dual antiplatelet therapy(DAPT).AIM To investigate the feasibility of gastric ESD with continuous LDA in patients with *** A total of 597 patients with gastric neoplasms treated with ESD between January2010 and June 2017 were enrolled. The patients were categorized according to type of antiplatelet therapy(APT).RESULTS The postoperative bleeding rate was 6.9%(41/597) in all patients. Patients were divided into the following two groups: no APT(n = 443) and APT(n = 154). APT included single-LDA(n = 95) and DAPT(LDA plus clopidogrel, n = 59)subgroups. In the single-LDA and DAPT subgroups, 56 and 39 patients were received continuous LDA, respectively. The bleeding rate with continuous singleLDA(10.7%) was similar to that with discontinuous single-LDA(10.3%)(P >0.99). Although the bleeding rate with continuous LDA in patients receiving DAPT(23.1%) was higher than that with discontinuous LDA in patients receiving DAPT(5.0%), no significant difference was observed(P = 0.141).CONCLUSION The bleeding rate with continuous LDA in patients receiving DAPT was not statistically different from that with discontinuous LDA in patients receiving DAPT. Therefore, continuous LDA administration may be acceptable for ESD in patients receiving DAPT, although patients should be carefully monitored for possible bleeding.

关键词： Dual antiplatelet therapy Endoscopic submucosal dissection Low-dose aspirin Postoperative bleeding Thienopyridine

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Ulcerative colitis patients in clinical remission demonstrate correlations between fecal immunochemical test results, mucosal healing, and risk of relapse

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World Journal of Gastroenterology 2016年第21期22卷 5079-5087页

作者： Asuka Nakarai Jun Kato Sakiko Hiraoka Shiho Takashima Daisuke Takei Toshihiro Inokuchi Yuusaku Sugihara Masahiro Takahara Keita harada Hiroyuki Okada Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Second Department of Internal Medicine Wakayama Medical University Department of Endoscopy Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences

AIM: To assess the risk of relapse in ulcerative colitis (UC) patients in clinical remission using mucosal status and fecal immunochemical test (FIT) ***: The clinical outcomes of 194 UC patients in clinical remission who underwent colonoscopy were based on evaluations of Mayo endoscopic subscores (MESs) and FIT ***: Patients with an MES of 0 (n = 94, 48%) showed a ten-fold lower risk of relapse than those with an MES of 1-3 (n = 100, 52%) (HR = 0.10, 95%CI: 0.05-0.19). A negative FIT result (fecal hemoglobin concentrations ≤ 100 ng/mL) was predictive of patients with an MES of 0, with a sensitivity of 0.94 and a specific of 0.76. Moreover, patients with a negative FIT score had a six-fold lower risk of clinical relapse than those with a positive score (HR = 0.17, 95%CI: 0.10-0.28). Inclusion of the distinguishing parameter, sustaining clinical remission > 12 mo, resulted in an even stronger correlation between negative FIT results and an MES of 0 with respect to the risk of clinical relapse (HR = 0.11, 95%CI: 0.04-0.23).CONCLUSION: Negative FIT results one year or more after remission induction correlate with complete mucosal healing (MES 0) and better prognosis. Performing FIT one year after remission induction may be useful for evaluating relapse risk.

关键词： Ulcerative colitis Clinical remission Mucosal healing Mayo endoscopic subscore Quantitative fecal immunochemical test

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Evolution of gastric surgery techniques and outcomes

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Chinese Journal of Cancer 2016年第8期35卷 410-415页

作者： Hironori Shiozaki Yusuke Shimodaira Elena Elimova Roopma Wadhwa Kazuki Sudo Kazuto harada Jeannelyn S.Estrella Prajnan Das Brian Badgwell Jaffer A.Ajani Department of Gastrointestinal Medical Oncology Unit 426The University of Texas MD Anderson Cancer Center1515 Holcombe BlvdHoustonTX 77030USA National Cancer Center Hospital Tokyo 104-0045Japan Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Radiation Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Surgical Oncology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA

Surgical management of gastric cancer improves ***,for some time,surgeons have had diverse opinions about the extent of *** have conducted many clinical studies,making slow but steady progress in determining the optimal surgical *** extent of lymph node dissection has been one of the major issues in surgery for gastric *** trials demonstrated that D2 dissection resulted in greater morbidity and mortality than D1 ***,long-term outcomes demonstrated that D2 dissection resulted in longer survival than D1 *** 2004,the Japan Clinical Oncology Group reported a pivotal trial which was performed to determine whether para-aortic lymph node dissection combined with D2 dissection was superior to D2 dissection alone and found no benefit of the additional *** with pancreatectomy,splenectomy,and bursectomy was initially recommended as part of the D2 ***,pancreas-preserving total gastrectomy with D2 dissection is standard,and ongoing trials are addressing the role of ***,the feasibility and safety of laparoscopic gastrectomy are well *** and quality of life are increasingly recognized as the most important *** this review,we present perspectives on surgical techniques and important trials of these techniques in gastric cancer patients.

关键词： Gastric cancer Gastrectomy Laparoscopic gastrectomy Lymph node dissection

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Inactivation of severe fever with thrombocytopenia syndrome virus for improved laboratory safety

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Journal of Biosafety and Biosecurity 2020年第1期2卷 31-35页

作者： Toshihiko harada Shuetsu Fukushi Takeshi Kurosu Tomoki Yoshikawa Masayuki Shimojima Kiyoshi Tanabayashi Masayuki Saijo Division of Biosafety Control and Research National Institute of Infectious DiseasesTokyoJapan Department of Virology 1 National Institute of Infectious DiseasesTokyoJapan

Severe fever with thrombocytopenia syndrome(SFTS),a tick-borne infectious disease with high mortality,is diagnosed by the serological testing of serum samples from patients in the acute and convalescent phases and/or by direct detection of the SFTS virus(SFTSV).Conventionally,heat and UV treatments have been used to inactivate the viruses present in serum samples before performing the serological ***,we examined the inactivation conditions optimal for SFTSV-containing serum samples to ensure the safety of laboratory workers while maintaining the accuracy of serological assay results *** human serum samples spiked with SFTSV to 60C for 30 min or exposing them to UV irradiation for 30 min,reduced the infectious virus titer below the limit of *** in sera from patients in the acute phase of SFTS was completely inactivated by heating to 60C for 30 min,followed by UV irradiation for 10 *** inactivation procedure had minimal impact on the performance of SFTSV antibody detection *** data provided herein can serve as a guide for laboratory workers and researchers working with SFTS serological tests.

关键词： Biosafety Inactivation Severe fever with thrombocytopenia syndrome(SFTSV) Serology

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Studying Human Leukemic Stem Cells in Mice

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中国实用内科杂志 2007年第S1期27卷 9-9页

作者： Mine harada Department of Medicine and Biosystemic Science Kyushu University Graduate School of Medical Sciences

Transplantation of human leukemic cells into severe combined immunodeficiency(SCID)mice has been attempted to study leukemogenesis and to develop *** models,however,were limited in efficient initiation orlong-term engraftment of leukemic cells following the transplantation of primaryhuman leukemic *** insufficient engraftment of primary leukemic cells couldbe caused by the residual innate immunity in CB-17/SCID or NOD/SCID ***

关键词： Studying Human Leukemic Stem Cells in Mice SCID

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利用固体潮研究岩石天体的深部结构

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地球与行星物理论评（中英文） 2024年第5期55卷 537-551页

作者：肖驰李斐鄢建国叶茂原田雄司郝卫峰邓青云中国地震局地震研究所地震大地测量重点实验室武汉430071 武汉引力与固体潮国家野外科学观测研究站武汉430071 武汉大学测绘遥感信息工程国家重点实验室武汉430079 武汉大学中国南极测绘研究中心武汉430079 澳门科技大学创新工程学院中国澳门999078

经过地球物理学的长足发展,我们有着丰富的手段来研究地球的内部结构.然而对于地球之外的其他天体,研究其内部结构的手段却仍然十分有限,往往依赖于轨道探测器、着陆器以及天文观测获取的大地测量数据.在这之中,固体潮对研究其内部结构... 详细信息

经过地球物理学的长足发展,我们有着丰富的手段来研究地球的内部结构.然而对于地球之外的其他天体,研究其内部结构的手段却仍然十分有限,往往依赖于轨道探测器、着陆器以及天文观测获取的大地测量数据.在这之中,固体潮对研究其内部结构有着重要的意义.固体潮汐形变和其带来的潮汐耗散提供了关于行星内部结构,尤其是深部核幔边界及核心部分的关键信息.本文将全面地对利用固体潮汐参数(包括潮汐勒夫数及潮汐品质因子)研究岩石天体的深部结构进行综述.首先对固体潮的基本理论、潮汐参数以及黏弹性模型进行了介绍,建立了天体内部结构参数与其外部固体潮汐响应之间的关系.之后对现有利用固体潮汐参数研究水星、金星、火星及月球这些岩石天体的内部结构的工作进行了回顾与总结,可以发现固体潮汐参数是一种对天体深部结构进行约束的有效手段.本文进一步提供了未来探测任务获取的高精度数据对研究天体深部结构的贡献.然而,目前固体潮汐参数对天体深部结构研究中也存在一些问题.例如不同黏弹性模型之间耗散强度的差异性问题、黏弹性模型的短周期实验数据和宏观长周期理论计算结果之间的不匹配问题等.本文也针对这些问题进行了讨论和分析,并对未来的研究方向进行了展望.

关键词：固体潮潮汐响应黏弹性内部结构岩石天体

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Glutathione Production by Yarrowia lipolyticaShowing Both Methyglyoxal Resistance and a High Activity of Glutathione Synthetase

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Advances in Microbiology 2012年第2期2卷 171-180页

作者： Naofumi Shiomi Emi harada Risako Nabeshima Graduate School of Human Sciences Kobe College Kobe Japan

Although Yarrowia lipolytica is an important host strain, there have so far been few studies on the production of glutathione by the strain. We therefore performed a study to obtain an improved strain of Y. lipolytica ATCC20688, which could produce a high yield of glutathione. First, the capability of glutathione production in the ATCC20688 strain was estimated. In comparison with other yeasts, the yield of this strain was higher than those in Pichia strains. Furthermore, this strain could produce glutathione by assimilating sodium oleate. We next performed mutation and gene cloning to improve the yield. After the yield of glutathione was improved in the isolated methylglyoxal-resistant mutant (MGR3), the glutathione synthetase gene was cloned into the MGR3 strain. By using this recombinant strain, we could reach the maximum yield and intracellular content of glutathione of 54 mg/L-medium and 30 mg/g-dry cell weight, respectively.

关键词： Glutathione Yarrowia lipolytica Glutathione Synthetase GSH2 Methylglyoxal

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Assessment of the Water Quality in the Ariake Sea Using Principal Component Analysis

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Journal of Water Resource and Protection 2015年第1期7卷 41-49页

作者： Toshinori Tabata Kazuaki Hiramatsu Masayoshi harada Department of Agro-Environmental Sciences Graduate School of Bioresource and Bioenvironmental Sciences Kyushu University Fukuoka Japan Department of Agro-Environmental Sciences Faculty of Agriculture Kyushu University Fukuoka Japan

The aim of this study is to investigate the condition of the Ariake Sea, Japan, which has been suffering from severe environmental issues for the past few decades. Water quality data have been generated from several points in this area for over 30 years by the Fukuoka, Saga, Kumamoto, and Nagasaki prefectures. In order to understand the characteristics of this sea, principal component analysis (PCA) was utilized using 11 water quality parameters;transparency, temperature, salinity, dissolved oxygen (DO), chemical oxygen demand (COD), dissolved inorganic nitrogen (DIN), ammonium-nitrogen (NH4+-N), nitrate-nitrogen (NO3--N), nitrite-nitrogen (NO2--N), phosphate-phosphorus, (PO43--P) and silica. PCA conveyed the amount of nutrients originating from the river, the organic pollution level, and seasonal changes. Subsequently, principal component scores were calculated for each point. It was concluded that the Ariake Sea environment has been affected by two main factors, which are the nutrients from the Chikugo River and anticlockwise tidal residual flow. These two factors must be considered for the environmental restoration of the Ariake Sea.

关键词： Ariake Sea Principal Component Analysis Nutrients Anticlockwise Tidal Residual Flow

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Diastereoselective Catalytic Hydrogenation of Schiff Bases of N-Pyruvoyl-(S)-Proline Esters

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International Journal of Organic Chemistry 2014年第1期4卷 29-39页

作者： Toratane Munegumi Shokichi Ohuchi Kaoru harada Department of Chemistry University of Tsukuba Tsukuba Japan Department Science Education Naruto University of Education Naruto Japan

Diastereoselective catalytic hydrogenation of pyruvic acid esters, amides, and their Schiff bases has been well studied over a long period to show that proline is one of the most effective chiral auxiliaries. Proline derivatives have been used as auxiliaries in the diastereoselective catalytic hydrogenation of pyruvamide Schiff bases. The diastereoselective hydrogenation resulted in up to a 78% enantiomeric excess of the amino acid derived from the hydrolysis of the dipeptide products. The chelation hypothesis explains the stereochemistry of the catalytic hydrogenation using (S)-proline esters in the amide moiety and the two chiral centers in the amide and Schiff base moieties.

关键词： Diastereoselective Catalytic Hydrogenation Proline Pyruvamide Schiff Base

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