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International Journal of Modeling, Simulation, and Scientific Computing 2018年第3期9卷 115-130页

作者： Yuichi Sakano Yurina Kitaura Kyoko Hasegawa Roberto Lopez-Gulliver Liang Li hiroshi ando Satoshi Tanaka Center for Information and Neural Networks(CiNet)National Institute of Information and Communications Technology and Osaka University 2B6CiNet1-4 Yamadaoka SuitaOsaka 565-0871Japan Graduate School of Frontier Biosciences Osaka University 1-4 YamadaokaSuitaOsaka565-0871Japan Graduate School of Information Science and Engineering Ritsumeikan University 1-1-1 Noji-higashi KusatsuShiga 525-8577Japan College of Information Science and Engineering Ritsumeikan University 1-1-1 Noji-higashi KusatsuShiga 525-8577Japan

Transparent visualization is used in many fields because it can visualize not only the frontal object but also other important objects behind *** in many situations,it would be very important for the 3D structures of the visualized transparent images to be perceived as they are simulated,little is known quantitatively as to how such transparent 3D structures are *** address this question,in the present study,we conducted a psychophysical experiment in which the observers reported the perceived depth magnitude of a transparent object in medical images,presented with a multiview 3D *** the visualization,we employed a stochastic point-based rendering(SPBR)method,which was developed recently as a technique for efficient *** depth of the transparent object was smaller than the simulated *** found,however,that such depth underestimation can be alleviated to some extent by(1)applying luminance gradient inherent in the SPBR method,(2)employing high opacities,and(3)introducing binocular disparity and motion parallax produced by a multi-view 3D display.

关键词： Transparent visualization automultiscopic 3D image psychophysics.

Contact Resistance Characteristics of Relays Operated in Vapors Evaporated from Non-Silicone-Type Acryl-Based Polymeric Products Cured in Various Manners

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Contact Resistance Characteristics of Relays Operated in Vap...

The neutrophil–osteogenic cell axis promotes bone destruction in periodontitis

The 26th International Conference on Electrical contacts and the 4th International Conference on Reliability of Electrical Products & Electrical Contacts

作者： Makoto Hasegawa Nanae Kobayashi Yoshiyuki Kohno hiroshi ando Chitose Institute of Science and Technology Kaneka Corporation OsakaJapan

ISBN: (纸本)9781622763136

The authors have already reported that when relays were operated to break load currents in vapors evaporated from an acryl-based non-silicone-type polymeric cured product that can be used as replacement of conventional silicone-type products, the resultant contact resistance characteristics show no *** this paper,the acryl-based non-silicone-type product of UV-radiation-cured type was used,and influences of its vapors on contact resistance characteristics of relays at an ambient temperature of 120℃were ***,a commercially-available mechanical relay(AgSnIn contacts) was sealed into a metal can with the product,and placed in a heating chamber to operate,at an operating frequency of 1 Hz or 0.5 Hz, 40 000 break operations of an inductive DC 14V-1A or 14V-0.4A load *** resistance values were measured at every 50 *** a result,the relays showed no deterioration in contact resistances.

关键词： polyacrylate silicone siloxane contact resistance contact failure arc discharges

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International Journal of Oral Science 2024年第1期16卷 154-162页

作者： Yutaro ando Masayuki Tsukasaki Nam Cong-Nhat Huynh Shizao Zang Minglu Yan Ryunosuke Muro Kazutaka Nakamura Masatsugu Komagamine Noriko Komatsu Kazuo Okamoto Kenta Nakano Tadashi Okamura Akira Yamaguchi Kazuyuki Ishihara hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Department of Microbiology Tokyo Dental College2-1-14 Kanda-Misaki-choChiyoda-kuTokyoJapan Oral Health Science Center Tokyo Dental College2-9-18Kanda-Misaki-choChiyodakuTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of Tokyo7-3-1HongoBunkyo-kuTokyoJapan Unit of Prosthodontics Laboratory of Oral-Maxillofacial Biology Faculty of Odonto-StomatologyUniversity of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam Department of Oral and Maxillofacial Surgery Department of Sensory and Motor System MedicineGraduate School of MedicineThe University of TokyoTokyoJapan Division of Rheumatology Department of Internal MedicineKeio University School of MedicineTokyoJapan Department of Laboratory Animal Medicine Research InstituteNational Center for Global Health and MedicineTokyoJapan

The immune-stromal cell interactions play a key role in health and diseases. In periodontitis, the most prevalent infectious disease in humans, immune cells accumulate in the oral mucosa and promote bone destruction by inducing receptor activator of nuclear factor-κB ligand (RANKL) expression in osteogenic cells such as osteoblasts and periodontal ligament cells. However, the detailed mechanism underlying immune–bone cell interactions in periodontitis is not fully understood. Here, we performed single-cell RNAsequencing analysis on mouse periodontal lesions and showed that neutrophil–osteogenic cell crosstalk is involved in periodontitis-induced bone loss. The periodontal lesions displayed marked infiltration of neutrophils, and in silico analyses suggested that the neutrophils interacted with osteogenic cells through cytokine production. Among the cytokines expressed in the periodontal neutrophils, oncostatin M (OSM) potently induced RANKL expression in the primary osteoblasts, and deletion of the OSM receptor in osteogenic cells significantly ameliorated periodontitis-induced bone loss. Epigenomic data analyses identified the OSM-regulated RANKL enhancer region in osteogenic cells, and mice lacking this enhancer showed decreased periodontal bone loss while maintaining physiological bone metabolism. These findings shed light on the role of neutrophils in bone regulation during bacterial infection, highlighting the novel mechanism underlying osteoimmune crosstalk.

关键词： period neutrophil destruction

Common parameters of acupuncture for the treatment of hypertension used in animal models

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Journal of Traditional Chinese Medicine 2015年第3期35卷 343-348页

作者： Lu Shengfeng Cao Xin hiroshi Ohara Yuji Nakamura Hiroko Izumi-Nakaseko Kentaro ando Liu Wanxin Atsushi Sugiyama Zhu Bingmei Key Laboratory of Acupuncture and Medicine Research of Ministry of Education Nanjing University of Chinese Medicine Department of Pharmacology Faculty of MedicineToho University

Hypertension is associated with at least 7.6 million annual deaths *** pharmacotherapy may provide good control for blood pressure,it sometimes induces adverse ***,acupuncture has been used for the treatment of cardiovascular diseases,such as hypertension,coronary artery disease,and stroke,but its mechanisms of actions remain poorly *** efficacy of acupuncture depends on multiple constituent elements including acupoints,manipulation skills,and implementation programs,which are termed as acupuncture *** review summarized the previous information of experimental use of acupuncture on animals including species,hypertension models,acupoints selection,acupoint location,stimulation protocols,and evaluation of effectiveness to provide useful guidance for researchers when performing acupuncture in animal experiments.

关键词： Acupuncture Animals Cardiovascular diseases Hypertension Drug therapy Review

Identification of an intronic enhancer regulating RANKL expression in osteocytic cells

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骨研究:英文版 2023年第3期11卷 607-616页

作者： Minglu Yan Masayuki Tsukasaki Ryunosuke Muro Yutaro ando Kazutaka Nakamura Noriko Komatsu Takeshi Nitta Tadashi Okamura Kazuo Okamoto hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoTokyoJapan Department of Microbiology Tokyo Dental CollegeTokyoJapan Department of Oral and Maxillofacial Surgery Department of Sensory and Motor System MedicineGraduate School of MedicineThe University of TokyoTokyoJapan Department of Laboratory Animal Medicine Research InstituteNational Center for Global Health and MedicineTokyoJapan

The bony skeleton is continuously renewed throughout adult life by the bone remodeling process,in which old or damaged bone is removed by osteoclasts via largely unknown *** regulate bone remodeling by producing the osteoclast differentiation factor RANKL(encoded by the TNFSF11 gene).However,the precise mechanisms underlying RANKL expression in osteocytes are still ***,we explored the epigenomic landscape of osteocytic cells and identified a hitherto-undescribed osteocytic cell-specific intronic enhancer in the TNFSF11 gene *** analyses showed that transcription factors involved in cell death and senescence act on this intronic enhancer ***-cell transcriptomic data analysis demonstrated that cell death signaling increased RANKL expression in osteocytic *** deletion of the intronic enhancer led to a high-bone-mass phenotype with decreased levels of RANKL in osteocytic cells and osteoclastogenesis in the adult stage,while RANKL expression was not affected in osteoblasts or *** data suggest that osteocytes may utilize a specialized regulatory element to facilitate osteoclast formation at the bone surface to be resorbed by linking signals from cellular senescence/death and RANKL expression.

关键词： utilize removed linking

2D and 3D refraction-based visualization of breast cancer for early clinical check

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Nuclear Science and Techniques 2006年第6期17卷 389-395页

作者： Masami ando Anton MAKSIMENKO Tetsuya YUASA Eiko HASHIMOTO Katsuhito YAMASAKI Shu IHIHARA hiroshi SUGIYAMA Tokiko ENDO LI Gang CHEN Zhihua Kazuyuki HYODO Ei UENO DDS Center RIST Tokyo University of Science Chiba 278-8510 Japan Photon Factory IMSS KEK Oho I-1 Tsukuba Ibaraki 305-0801 Japan Department of Photo-Science GUAS Oho 1.1 Tsukuba Ibamki 305-0801 Japan Faculty of Engineering Yamagata University Yonezawa Yamagata 992-8510 Japan Clinical Genome Informatics Center School of Genome Science Kobe University Hyogo 650-0017 Japan Departramt of Pathology Nagoya Medical Center Nagoya 460-0001 Japan Department of Radiology Nagoya Medical Center Nagoya 460-0001 Japan BSRF IHEP CAS Yaquanlu Beijing 100049 China China-Japan Friendship Hospital Yinhua Donglu Beijing 100029 China Department of Breast-Thyroid-Endocrine Surgery University of Tsukuba Ibaraki 305-8573 Japan

Ductal carcinoma in-situ (DCIS) has been visualized by 2D XDFI (X-ray dark-field imaging) and further by a 3D X-ray CT, and the data was acquired by the X-ray optics DEI (diffraction-enhanced imaging). A newly made algorithm was used for CT. Data of 900 projections with interval of 0.2 degrees were used. Ductus lactiferi, microcalci-fication in a 3D form have been clearly visible. The spatial resolution available was approximately 30μm.

关键词：折射乳腺癌临床检查 CT

Non-destructive investigation of the 3D inner structure of Precambrian embryos fossil by synchrotron hard x-ray phase contrast micron CT

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Non-destructive investigation of the 3D inner structure of P...

Utility of “loco-check,” self-checklist for “locomotive syndrome” as a tool for estimating the physical dysfunction of elderly people

第十一届中国体视学与图像分析学术会议

作者： Paul Tafforeau Masami ando hiroshi Sugiyama European Synchrotron Radiation Facility France Tokyo University of Science Japan Photon Factory KEK Japan

The recent development of the synchrotron hard x-ray phase contrast imaging and CT with sub-micron and nano-meter resolution is. presented first. Then I will focus on this method’s application in paleontology. The Weng’an fauna from Precambrian Doushantuo phosphates in Weng ’ an, Guizhou Province, China, contains likely fossil representatives of the oldest known metazoans, radiometrically age-dated as at least 580 million years old. One of the main restriction to study these unique fossils is the scarcity of the non-destruc-

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Health 2013年第12期5卷 97-102页

作者： Yasumoto Matsui Marie Takemura Atsushi Harada Fujiko ando hiroshi Shimokata Department for Development of Preventive Medicine Center for Development of Advanced Medicine for Dementia National Center for Geriatrics and Gerontology Obu Japan Department of Health and Medical Sciences Aichi Shukutoku University Nagakute Japan Department for Development of Preventive Medicine Center for Development of Advanced Medicine for Dementia National Center Department of Health and Medical Sciences Aichi Shukutoku University Nagakute Japan Department of Orthopedic Surgery National Center for Geriatrics and Gerontology Obu Japan

Aim: A new concept of locomotive syndrome has been proposed by the Japanese Orthopaedic Association. The aim of this study is to clarify the utility of its self-checklist, “loco-check,” as a tool for estimating the physical dysfunction of elderly people. Methods: Subjects were 1124 community-dwelling Japanese people, 557 men and 567 women, aged 40-89 years. Information about the seven “loco-check” items was obtained from present inquiry sheets. Physical functions were examined by grip strength, knee extension strength, walking speed and one-leg standing time with open eyes. The averages of these test values, controlled for age and BMI, were compared between the “loco-check” (+) group and the “loco-check” (-) group. Also we examined about the trend of decline of physical function, together with SF36 physical function subscale score, as the number of the items chosen increased. Results: Adjusted average values of all four physical function examinations in the “lococheck” (+) group were significantly lower than those of the “loco-check” (-) group (all, p . Also the adjusted average values of the majority of four tests were significantly lower in those who checked each of the “loco-check” items than those who did not, for most of the items. It was also revealed that the more items subjects checked, the lower the adjusted average values were, except for one-leg standing time. It was also the case with SF36 physical function subscale score. Conclusion: We showed the utility of “loco-check” as a simple tool not only for noticing the physical dysfunction of elderly people, but also for estimating the extent of it, except for balancing ability, particularly by counting the number of checked items.

关键词： Locomotive Syndrome Loco-Check Physical Dysfunction Estimation Elderly People

Homogeneity tests on neutron shield concrete

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Nuclear Science and Techniques 2014年第A1期25卷 57-61页

作者： Koichi Okuno hiroshi Iikura HAZAMA ando Technical Research Institute 515-1 Karima Tsukuba Ibaraki 305-0822 Japan JAEA Quantum Beam Science Directorate 2-4 Shirakata Tokai-mura Naka-gun Ibaraki 319-1195 Japan

In recent years, neutrons have been studied for application in fields such as material analysis and boron neutron capture therapy. To create a compact shield for these facilities, a neutron shield concrete is developed. Verifying the homogeneity of the concrete is important to ensure adequate shielding performance. In this research, neutron radiography images of the concrete are taken using the Thermal Neutron Radiography Facility (TNRF) of the JRR-3 research reactor, and the transmission ratio of the thermal neutrons were estimated. The results showed that the transmission ratio of the concrete was almost the same at each depth. © 2014, Science Press. All rights reserved.

关键词：中子屏蔽同质性测试研究反应堆中子俘获屏蔽性能照相设备中子照相

A Phase II Trial of Preoperative Chemoradiotherapy with Oral DPD-Inhibitory Fluoropyrimidines in Patients with Advanced Rectal Cancer

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Journal of Cancer Therapy 2012年第6期3卷 989-995页

作者： Masanori Hotchi hiroshi Okitsu Murato Miura Madoka Hamada Yasuhide Sonaka Yoh Fukuda Tsutomu ando Shinji Kuratate Department of Surgery Kochi Health Sciences Center Kochi Japan Department of Surgery National Hospital Organization Kochi National Hospital Kochi Japan Department of Surgery Shikoku Central Hospital Ehime Japan Department of Surgery Takamatsu City Hospital Takamatsu Japan Department of Surgery Tokushima Municipal Hospital Tokushima Japan Department of Surgery Tokushima Prefectural Central Hospital Tokushima Japan Department of Surgery Tokushima Red Cross Hospital Tokushima Japan Department of Surgery Tokushima University Hospital Tokushima Japan

Background: Preoperative chemoradiotherapy (CRT) with 5-FU has been widely used to improve local control of disease and to preserve anal sphincter in the treatment of rectal cancer. UFT and S-1 as oral dihydropyrimidine dehydrogenase (DPD)-inhibitory fluoropyrimidines enhance the therapeutic effect of 5-FU by modulating its metabolic pathways. The purpose of this study was to evaluate the efficacy and toxicity of CRT using UFT versus S-1 in patients with locally advanced rectal cancer. Methods: Fifty-nine patients who received preoperative CRT (40 Gy radiotherapy) were randomly assigned to either UFT or S-1 groups. UFT and S-1 were administered during the radiotherapy course. Response to CRT was determined using a histopathologic examination and RECIST of surgically resected specimens and classified as responders (CR, PR and grade 2, 3) or nonresponders (SD, PD and grade 0, 1). Results: All patients were randomly allocated to S-1 group (n = 30) or UFT group (n = 29). Pathological response rate (Grade2 and Grade3) was 57% in the S-1 group and 45% in the UFT group (p = 0.36). Pathological complete response (CR) rate (Grade3) was 7% in the S-1 group and 4% in the UFT group (p = 0.98). There was no statistically significant difference between the two groups in regard to the response rate of RECIST (p = 0.52). There was no statistically significant difference between the groups based on the downstaging rate, resection of tumor, sphincter preservation and marginal invasion. The incidence of Grade 3 diarrhea was significantly more frequent in the S-1 group (7%) compared with the UFT group (0%) (p = 0.02). Conclusion: The results supported the conclusion that CRT using UFT or S-1 is effective and feasible for patients with locally advanced rectal cancer.

关键词： S-1 UFT Chemoradiation Rectal Cancer