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Experimental study on slender buckling-restrained knee braces with round steel bar cores

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Frontiers of Structural and Civil Engineering 2023年第1期17卷 99-121页

作者： Togtokhbuyan MUNKHUNUR hiroshi TAGAWA Xingchen CHEN Graduate School of Engineering Hiroshima UniversityHigashi-Hiroshima 739-8527Japan Graduate School of Advanced Science and Engineering Hiroshima UniversityHigashi-Hiroshima 739-8527Japan

This study aimed to investigate a novel slender buckling-restrained knee brace damper (BRKB) for welded and weld-free steel framing systems. The proposed BRKB adopts steel bar cores connected by a central coupler and restrained by tube buckling restrainers with a cover tube supporter. The advantages of the proposed damper include easy assembly compared to conventional buckling restrained braces, and high architectural flexibility for the retrofitting of large-span weld-free or welded steel moment-resisting systems. Specifically, by increasing the number of contraction allowances, undesirable failure mechanisms that are global instability and local buckling of the restrainer ends can be effectively suppressed because the more uniform plastic deformation of the core bar can be achieved longitudinally. In this study, displacement-controlled compression and cyclic loading tests were carried out to investigate the deformation capacities of the proposed BRKBs. Structural performance metrics associated with both loading tests, such as strength capacities, strains at the cover tubes and buckling restrainers, and hysteretic behaviors of the proposed damper under cyclic loads, were measured and discussed. Test results revealed that the geometrical characteristics of the cover tubes and adopted contraction allowances at the dampers play essential roles in their load-bearing capacities.

关键词： weld-free beam-to-column connections moment-resisting frame cyclic and compression loading tests buckling-restrained knee brace cover tube

Matching of the Gray Whales of off Sakhalin and the Pacific Coast of Japan, with a Note on the Stranding at Wadaura, Japan in March, 2016

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Open Journal of Animal Sciences 2017年第2期7卷 168-178页

作者： Gen Nakamura hiroshi Katsumata Yujin Kim Minoru akagi Ayumi Hirose Kazutoshi Arai Hidehiro Kato Laboratory of Cetacean Biology Tokyo University of Marine Science and Technology Tokyo Japan Kamogawa Sea World Kamogawa Japan

The coast of Japan is a migratory corridor for the western stock of the gray whales (Eschrichtius robustus), which was once considered as extinct and remains endangered. According to the historical records, from 1955 to 2014, only 21 gray whales occurrence has been recorded in 59 years. However, from 2015 to 2016, intensive occurrence including the seven sightings and the two strandings were noted. In this paper, we found that those sightings were re-sightings of the same individual, which was initially sighted off Sakhalin during August, 2014. On 4 March, 2016, a young female gray whale (8.9 m in body length) was stranded at Wadaura beach, Chiba prefecture. We also conducted research on this animal including taking pictures and external measurements. In addition, we flensed this animal to observe the internal organs and collect a skeletal specimen. The reason for the death of this animal remains unclear;however, from its external characteristics, we identified that this animal was not an identical one, sighted off Sakhalin and the coast of Japan from 2014 to 2016. On 5 April, 2016, another young female gray whale (7 m in body length) was stranded at Arai beach, Shizuoka prefecture. We concluded that from 2015 to 2016, at least three distinct gray whales have migrated along the coast of Japan.

关键词： Gray Whale Eschrichtius robustus Stock Stranding

Network biology approach to epithelial–mesenchymal transition in cancer metastasis: three stage theory

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分子细胞生物学报:英文版 2015年第3期7卷 253-266页

作者： hiroshi Tanaka Soichi Ogishima Department of Bioinformatics Medical Research InstituteTokyo Medical and Dental UniversityTokyoJapan Department of Bioclinical Informatics Tohoku Medical Megabank OrganizationTohoku UniversitySendaiJapan

Epithelial–mesenchymal transition(EMT)plays a critical role in promoting cancer *** this study,cancer EMT is considered as an overall structural change in the gene regulatory network(GRN),and its essential features are elucidated by the network biology *** first defined the state space of GRN as a set of all possible activation patterns of GRN,and then introduced the quasipotential field into this space to show the relative stability distribution of each *** quasi-potential was determined empirically by collecting gene expression profiles from public *** of GRN states during the EMT process were traced in the state space,by using time-course data of gene expression profiles of a cell line inducingEMTfromthe *** wasfound that cancerEMT occurred in three sequential stable stages,each of which formed a potential basin along the EMT *** confirmation,structural changes of GRN were estimated by applying the ARACNe algorithm to the same time-course data,and then applying master regulator analysis to extract the main *** group of master regulators was found to be alternatively active in the subsequent three stages to cause overall structural changes of GRN during cancer EMT.

关键词： epithelial-mesenchymal transition(EMT) Waddington’s epigenetic landscape gene regulatory network GRN network stage space cancer metastasis

Differences in dinucleotide frequencies of thermophilic genes encoding water soluble and membrane proteins

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第6期12卷 419-427页

作者： hiroshi NAKASHIMA Yuka KURODA Department of Clinical Laboratory Science Graduate Course of Medical Science and TechnologySchool of Health SciencesKanazawa University

The occurrence frequencies of the dinucleotides of genes of three thermophilic and three mesophilic species from both archaea and eubacteria were investigated in this study. The genes encoding water soluble proteins were rich in the dinucleotides of purine dimers, whereas the genes encoding membrane proteins were rich in pyrimidine dimers. The dinucleotides of purine dimers are the counterparts of pyrimidine dimers in a double-stranded DNA. The purine/pyrimidine dimers were favored in the thermophiles but not in the mesophiles, based on comparisons of observed and expected frequencies. This finding is in agreement with our previous study which showed that purine/pyrimidine dimers are positive factors that increase the thermal stability of DNA. The dinucleotides AA, AG, and GA are components of the codons of charged residues of Glu, Asp, Lys, and Arg, and the dinucleotides TT, CT, and TC are components of the codons of hydrophobic residues of Leu, Ile, and Phe. This is consistent with the suitabilities of the different amino acid residues for water soluble and membrane proteins. Our analysis provides a picture of how thermophilic species produce water soluble and membrane proteins with distinctive characters: the genes encoding water soluble proteins use DNA sequences rich in purine dimers, and the genes encoding membrane proteins use DNA sequences rich in pyrimidine dimers on the opposite strand.

关键词： Water soluble and membrane proteins Purine/pyrimidine dimers Thermophilic and mesophilic species Dinucleotide frequencies

Contribution of Cyclic and Pseudo-cyclic Electron Transport to the Formation of Proton Motive Force in Chloroplasts

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Molecular Plant 2017年第1期10卷 20-29页

作者： Toshiharu Shikanai hiroshi Yamamoto Department of Botany Graduate School of Science Kyoto University Oiwake-cho Kitashirakawa Sakyo-ku Kyoto 606-8502 Japan CREST Japan Science and Technology Agency Chiyoda-ku Tokyo 102-0076 Japan

Photosynthetic electron transport is coupled to proton translocation across the thylakoid membrane, re- sulting in the formation of a trans-thylakoid proton gradient （△pH） and membrane potential （△ψ）. Ion trans-porters and channels localized to the thylakoid membrane regulate the contribution of each component to the proton motive force （pmf）. Although both △pH and △ψ contribute to ATP synthesis as pmf, only ~pH downregulates photosynthetic electron transport via the acidification of the thylakoid lumen by inducing thermal dissipation of excessive absorbed light energy from photosystem II antennae and slowing down of the electron transport through the cytochrome bsf complex. To optimize the tradeoff between efficient light energy utilization and protection of both photosystems against photodamage, plants have to regulate the pmf amplitude and its components, △pH and △ψ. Cyclic electron transport around photosystem I （PSI） is a major regulator of the pmf amplitude by generating pmf independently of the net production of NADPH by linear electron transport. Chloroplast ATP synthase relaxes pmf for ATP synthesis, and its activity should be finely tuned for maintaining the size of the pmf during steady-state photosynthesis. Pseudo-cyclic electron transport mediated by flavodiiron protein （FIv） forms a large electron sink, which is essential for PSI photoprotection in fluctuating light in cyanobacteria. FIv is conserved from cyanobacteria to gymno- sperms but not in angiosperms. The Arabidopsis proton gradient regulation 50（pgr5） mutant is defective in the main pathway of PSI cyclic electron transport. By introducing Physcomitrella patens genes encoding Flvs, the function of PSI cyclic electron transport was substituted by that of FIv-dependent pseudo-cyclic electron transport. In transgenic plants, the size of the pmf was complemented to the wild-type level but the contribution of △pH to the total pmf was lower than that in the wild type. In the pgr5 mutant, the size of

关键词： alternative electron transport cyclic electron transport around photosystem I ion channel flavodiironprotein proton motive force pseudo-cyclic electron transport

Rough set-based rule generation and Apriori-based rule generation from table data sets: a survey and a combination

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CAAI Transactions on Intelligence Technology 2019年第4期4卷 203-213页

作者： hiroshi Sakai Michinori Nakata Graduate School of Engineering Kyushu Institute of TechnologySensui 1-1TobataKitakyushu 804-8550Japan Faculty of Management and Information Science Josai International UniversityGumyoToganeChiba 283-0002Japan

The authors have been coping with new computational methodologies such as rough sets,information incompleteness,data mining,granular computing,etc.,and developed some software tools on association rules as well as new mathematical *** simply term this research Rough sets Non-deterministic Information Analysis(RNIA).They followed several novel types of research,especially Pawlak’s rough sets,Lipski’s incomplete information databases,Or?owska’s non-deterministic information systems,Agrawal’s Apriori *** are outstanding researches related to information incompleteness,data mining,and rule *** have been trying to combine such novel researches,and they have been trying to realise more intelligent rule generator handling data sets with information *** study surveys the authors’research highlights on rule generators,and considers a combination of them.

关键词： Apriori rule incomplete

Revealing the diversity of neutrophil functions and subsets

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Cellular & Molecular Immunology 2021年第4期18卷 781-783页

作者： Kiyoharu Fukushima hiroshi Nabeshima hiroshi Kida Department of Respiratory Medicine National Hospital Organization Osaka Toneyama Medical CenterOsakaJapan Department of Respiratory Medicine and Clinical immunology Osaka University Graduate School of MedicineOsakaJapan Laboratory of Host Defense World Premier Institute Im m unology Frontier Research Center(WPIIFReC)Osaka UniversityOsakaJapan Fujii Memorial Research Institute Otsuka Pharmaceutical CompanyLtdShigaJapan

Several recent studies have shown that diverse neutrophil subsets exhibit distinct phenotypic and functional properties in terms of disease onset and progression.1,2 In a study published in Nature Immunology,Sas et al.3 discovered a new neutrophil subset that promotes neuronal survival and axonal regeneration in the central nervous system(CNS).

关键词： neutrophil Immunology

Endoscopic management of chronic radiation proctitis

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World Journal of Gastroenterology 2011年第41期17卷 4554-4562页

作者： Tarun Rustagi hiroshi Mashimo Department of Internal Medicine University of Connecticut Gastroenterology Section 111 VA Boston Healthcare SystemBrigham and Women’s HospitalHarvard Medical School

Chronic radiation proctopathy occurs in 5%-20% of patients following pelvic radiotherapy. Although many cases resolve spontaneously,some lead to chronic symptoms including diarrhea,tenesmus,urgency and persistent rectal bleeding with iron deficiency anemia requiring blood transfusions. Treatments for chronic radiation proctitis remain unsatisfactory and the basis of evidence for various therapies is generally insuff icient. There are very few controlled or prospective trials,and comparisons between therapies are limited because of different evaluation methods. Medical treatments,including formalin,topical sucralfate,5-amino salicylic acid enemas,and short chain fatty acids have been used with limited *** management is associated with high morbidity and mortality. Endoscopic therapy using modalities such as the heater probe,neodymium:yttrium-aluminium-garnet laser,potassium titanyl phosphate laser and bipolar electrocoagulation has been reported to be of some benef it,but with frequent *** plasma coagulation is touted to be the preferred endoscopic therapy due to its eff icacy and safety *** methods of endoscopic ablation such as radiofrequency ablation and cryotherapy have been recently described which may afford broader areas of treatment per application,with lower rate of *** review will focus on endoscopic ablation therapies,including such newer modalities,for chronic radiation proctitis.

关键词： Chronic Radiation proctitis Endoscopic Argon plasma coagulation Radiofrequency Cryoablation

SH-wavefield simulation for a laterally heterogeneous whole-Earth model using the pseudospectral method

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Science China Earth Sciences 2011年第12期54卷 1940-1947页

作者： WANG YanBin TAKENAKA hiroshi Department of Geophysics School of Earth and Space Sciences Peking University Beijing 100871 China Department of Earth and Planetary Sciences Kyushu University Hakozaki 6-10-1 Fukuoka 812-8581 Japan

We present a scheme to simulate SH-wave propagation in a whole-Earth model with arbitrary lateral heterogeneities employing the Fourier pseudospectral method. Wave equations are defined in two-dimensional cylindrical coordinates and the model is taken through a great circle of the Earth. Spatial derivatives in the wave equations are calculated in the wavenumber domain by multiplication, and the transformation between spatial and wavenumber domains is performed via fast Fourier transformation. Because of the high accuracy and high speed of the Fourier pseudospectral method, the scheme enables us to calculate a short-wavelength global SH-wavefield with accurate waveforms and arrival times for models with heterogeneities that can be approximated as azimuthally symmetric. Comparing with two-dimensional simulation methods based on an axisymmetric model, implementing the seismic source in the present scheme is more convenient. We calculated the global SH-wavefield for the preliminary reference Earth model to identify the generation, reflection and refraction of various seismic phases propagating in the Earth. Applications to a heterogeneous global model with low-velocity perturbation above the core-mantle boundary were conducted to analyze the effect of lateral heterogeneity on global SH-wave propagation.

关键词： wave propagation computational seismology pseudospectral method global seismology core-mantle boundary