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CD14 upregulation as a distinct feature of non-alcoholic fatty liver disease after pancreatoduodenectomy

World Journal of Hepatology 2013年第4期5卷 189-195页

作者： Daisuke Satoh Takahito Yagi Takeshi Nagasaka Susumu Shinoura Yuzo Umeda Ryuichi Yoshida Masashi Utsumi Takehiro Tanaka hiroshi sadamori Toshiyoshi Fujiwara Department of Gastroenterological Surgery Transplantand Surgical OncologyOkayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Department of Pathology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan

AIM:To investigate the pathogenesis of non-alcoholic fatty liver disease(NAFLD)after pancreatoduodenectomy(PD).METHODS:A cohort of 82 patients who underwent PD at Okayama University Hospital between 2003 and 2009 was enrolled and the clinicopathological features were compared between patients with and without NAFLD after *** tomography(CT)images were evaluated every 6 mo after PD for *** steatosis was diagnosed on CT when hepatic attenuation values were 40 Hounsfield *** biopsy was performed for 4 of 30 patients with NAFLD after PD who consented to undergo *** compare NAFLD after PD with NAFLD associated with metabolic syndrome,liver samples were obtained from 10 patients with NAFLD associated with metabolic syndrome [fatty liver,n = 5;non-alcoholic steatohepatitis(NASH),n = 5] by percutaneous ultrasonography-guided liver ***-fluorescence immunohistochemistry was applied to examine CD14 expression as a marker of lipopolysaccharide(LPS)-sensitized macrophage cells(Kupffer cells)in liver biopsy ***:The incidence of postoperative NAFLD was 36.6%(30/82).Univariate analysis identified cancer of the pancreatic head,sex,diameter of the main pancreatic duct,and dissection of the nerve plexus as factors associated with the development of NAFLD after *** patients who developed NAFLD after PD demonstrated significantly decreased levels of serum albumin,total protein,cholesterol and triglycerides compared to patients without NAFLD after PD,but no glucose intolerance or insulin *** biopsy was performed in four patients with NAFLD after *** four patients showed moderate-to-severe steatosis and NASH was diagnosed in *** of cells positive for CD68(a marker of Kupffer cells)and CD14(a marker of LPSsensitized Kupffer cells)were counted in all biopsy *** number of CD68+ cells in specimens of NAFLD after PD was significantly increased from that in specimens of NAFLD associated with meta

关键词： Non-alcoholic fatty liver disease Pancreatoduodenectomy CD14 Endotoxin Kupffer cells

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