检索结果-南通市图书馆

Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses

引用

Cellular & Molecular Immunology 2018年第11期15卷 953-962页

作者： Tomonori Yaguchi Asuka Kobayashi Takashi Inozume Kenji Morii Haruna Nagumo hiroshi nishio Takashi Iwata Yuyo Ka Ikumi Katano Ryoji Ito Mamoru Ito Yutaka Kawakami Division of Cellular Signaling Institute for Advanced Medical ResearchKeio University School of MedicineTokyo 160-8582Japan Department of Dermatology Yamanashi University School of MedicineYamanashi 409-3898Japan Department of Obstetrics and Gynecology Keio University School of MedicineTokyo 160-8582Japan Central Institute for Experimental Animals Kanagawa 210-0821Japan

Immunodeficient mice engrafted with human peripheral blood cells are promising tools for in vivo analysis of human patient individual immune ***,when human peripheral blood mononuclear cells(PBMCs)are transferred into NOG(NOD/Shi-scid,IL-2rg null)mice,severe graft versus host disease(GVHD)hinders long term detailed *** of human PBMCs into newly developed murine MHC class I-and class II-deficient NOG(NOG-dKO;NOG-Iab,B2m-double-knockout)mice showed sufficient engraftment of human immune cells with little sign of *** with influenza vaccine resulted in an increase in influenza-specific human IgG Ab,indicating induction of antigen-specific B cells in the NOG-dKO *** with human dendritic cells pulsed with HLA-A2 restricted cytomegalovirus peptide induced specific cytotoxic T cells,indicating the induction of antigen-specific T cells in the NOG-dKO *** cell therapies(ACTs)using melanoma antigen recognized by T cells(MART-1)-specific TCR-transduced activated T cells showed strong tumor growth inhibition in NOG-dKO mice without any sign of GVHD accompanied by preferential expansion of the transferred MART-1-specific T *** using cultured human melanoma infiltrating T cells also showed anti-tumor effects against autologous melanoma cells in NOG-dKO mice,in which changes in human cancer phenotypes by immune intervention,such as increased CD271 expression,could be ***,NOG-dKO mice are useful tools for more detailed analysis of both the induction and effector phases of T-cell and B-cell responses for a longer period than regular NOG mice.

关键词： adoptive cell therapy humanized mouse vaccine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neoadjuvant chemotherapy for locally advanced cervical cancer

引用

Chinese Journal of Cancer Research 2016年第2期28卷 235-240页

作者： Takashi Iwata Azumi Miyauchi Yukako Suga hiroshi nishio Masaru Nakamura Akiko Ohno Nobumaru Hirao Tohru Morisada Kyoko Tanaka Hiroki Ueyama Hidemichi Watari Daisuke Aoki Department of Obstetrics and Gynecology Keio University School of Medicine Department of Obstetrics and Gynecology Hokkaido University Graduate School of Medicine

Neoadjuvant chemotherapy followed by surgery （NCS） has not been fully evaluated clinically. Currently, the main regimen of neoadjuvant chemotherapy （NAC） used in NCS includes cisplatin. The antitumor effects of NAC reduce lymph node metastasis and the tumor diameter in patients prior to surgery, and this can reduce the number of high risk patients who require postoperative radiation therapy. Many randomized controlled trials （RCTs） have examined the long-term prognosis of NCS compared to primary surgery, but the utility of NCS remains uncertain. The advent of concurrent chemoradiotherapy （CCRT） has markedly improved the outcome of radiotherapy （RT）, and CCRT is now used as a standard method in many cases of advanced bulky cervical cancer. NCS gives a better treatment outcome than radiation therapy alone, but it is important to verify that NCS gives a similar or better outcome compared to CCRT.

关键词： Neoadjuvant chemotherapy (NAC) cervical cancer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Total Laparoscopic Hysterectomy for Diagnosis and Treatment of Cervical Cystic Lesions: A Case Series

引用

Open Journal of Obstetrics and Gynecology 2020年第3期10卷 357-364页

作者： Tohru Morisada Kohsei Tanaka Tomoko Iijima Azumi Nishizawa hiroshi nishio Yusuke Kobayashi Masaru Nakamura Shigenori Hayashi Fumio Kataoka Takashi Iwata Daisuke Aoki Department of Obstetrics and Gynecology Keio University School of Medicine Tokyo Japan

Objective: Cervical cystic lesions are often observed in gynecological clinical practice. Many are caused by benign diseases such as lobular endocervical glandular hyperplasia (LEGH), and it is important to differentiate these lesions from those due to malignant diseases such as minimal deviation adenocarcinoma (MDA). In cases in which fertility preservation is not a concern, the final pathology is often confirmed by hysterectomy. To investigate the feasibility and safety of laparoscopic surgery for cervical cystic lesions, we retrospectively examined cases in which total laparoscopic hysterectomy (TLH) was performed for diagnosis and treatment. Methods: The subjects were 28 women who underwent TLH from April 2012 to March 2017 at Keio University Hospital. The pre- and post-operative courses of these patients were examined. Results: The average age was 49.4 (range 39 - 65) years and the mean body mass index was 21.7 (16.8 - 30.5) kg/m2. The average operation time was 159 (101 - 314) min and the average bleeding volume was 106.8 (0 - 600) g. There were no severe perioperative complications. The average hospital stay was 8.4 (7 - 14) days. In postoperative pathological diagnosis, 13 cases had benign diseases such as Nabot cysts, there were 14 cases of LEGH, and one patient was diagnosed with MDA. In the MDA case, additional bilateral salpingo-oophorectomy and pelvic lymph node dissection were performed at a later date. No metastasis was observed in these excised specimens. Conclusions: Our results suggest that TLH for cervical cystic lesions can be performed safely. However, it is important to consider the TLH indication before surgery based on the possibility of malignant disease.

关键词： Lobular Endocervical Glandular Hyperplasia Minimum Deviation Adenocarcinoma Total Laparoscopic Hysterectomy Uterine Cervix

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Improvement of aerodynamic stability of suspension bridges with H-shaped simplified stiffening girder

引用

Frontiers of Structural and Civil Engineering 2016年第1期10卷 93-102页

作者： hiroshi KATSUCHI Hitoshi YAMADA Mayuko nishio Yoko OKAZAKI Department of Civil Engineering Yokohama National University Yokohama 240-8501 Japan

Wind-tunnel study on the improvement of aerodynamic stability of simplified suspension-bridge girder structures was conducted with using a 1/40-scaled section model. Objective of the study is the development of an economically superior suspension bridge with 500-1,000 m center span length. The wind-tunnel test showed that an edge-girder type cross section exhibited large amplitude torsional vortex-induced vibration as well as torsional flutter at a low wind speed. Accordingly, aerodynamic countermeasures of open grating deck and triangular fating, and structural countermeasures of center stay, diagonal bracing and mass increase were tried to improve the aerodynamic stability. Finally, feasibility of the best combination to a full-scale bridge was examined by structural analysis.

关键词： suspension bridge aerodynamics simplified girder wind-tunnel test

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A wind tunnel study on control methods for cable dry-galloping

引用

Frontiers of Structural and Civil Engineering 2016年第1期10卷 72-80页

作者： Hung D. VO hiroshi KATSUCHI Hitoshi YAMADA Mayuko nishio Department of Civil Engineering Yokohama National University Yokohama 240-8501 Japan

The common vibration of cable caused by rain-wind combination has been known as most typical type and a lot kind of its countermeasures has been proposed for suppressing this phenomenon. Recently, stayed-cables were also proved that they could be excited in dry state （without rain）, which is called dry-galloping. Recently, its mechanisms have been explained by axial flow, Reynolds number and so on. To clarify the characteristics of this galloping, wind tunnel test of a cable model with various kinds of wind angle was conducted. Then, three types of countermeasure were examined to suppress dry- galloping of bridge cable. The tests confirmed that the occurrence of dry-galloping depends on relative wind attacked angles and onset reduced wind speed. Furthermore, single spiral wire, double spiral wire and circular ring were found to have high effectiveness in mitigating this galloping when those are installed properly.

关键词： dry-galloping wind-relative angle single spiral wire double spiral wire circular rings

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microstructure and Wear Behavior of Cermet/Iron Alloy Cladding Layers on A6061 Alloy Coated by Resistance Seam Welding Method

引用

Acta Metallurgica Sinica(English Letters) 2015年第4期28卷 414-423页

作者： Wen-Qin Wang Tomiko Yamaguchi Kazumasa nishio Faculty of Engineering Kyushu Institute of Technology Nishinippon Institute of Technology

Cermet/iron alloy cladding layers were coated on the surface of Al-Mg-Si alloy （A6061） plates by resistance seam welding method with tungsten carbide （WC） and high-carbon iron alloy （SHA） powders. The cladding layer consisted of WC reinforcement, SHA binder, A6061 and FeAl3. The effect of WC ratio （30 wt%, 50 wt% and 70 wt%） on the microstructure and wear behavior of the cladding layers was investigated in detail. Abrasive wear test was performed under two kinds of load condition by using a rubber wheel apparatus to evaluate wear resistance. The results showed that the wear resistance of the cladding layer was improved by 3.5-5 times than that of the substrate. At lower load, the wear resistances of the samples 30% and 70% WC were nearly the same, which suggested that FeAl3 played an important role in improvement of the wear resistance instead of WC. While at higher load, the amount of WC determined the wear resistance of the cladding layer. Furthermore, wear behavior of these cladding layers was explained with reference to the observed microstructure of the worn surface.

关键词： Resistance seam welding A6061 WC Cladding layer Wear resistance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimal calibration scheme for map-based control of diesel engines

引用

Science China(Information Sciences) 2018年第7期61卷 68-81页

作者： Yui nishio Yutaka MURATA Yukihisa YAMAYA Masato KIKUCHI Automobile R & D Center Honda R & D Co. Ltd.

Map-based control has the advantage of a simple control structure. However, in the case of a complex plant, calibrating the map is difficult. Calibration methodology using plant model is increasing in engine calibration industries. However, the models are for steady-state operation and cannot simulate at transient operation well. This study introduces the dynamic empirical model and applies the transient corrective function of an electronic control unit to simulate more realistic behavior. The optimization problem for calibrating maps of diesel engines is constructed, and the formulation of cost function and constraints is discussed. Consequently, the proposed calibration scheme can find an optimal map in satisfied ***, the optimized maps are validated using mass production diesel engines.

关键词： optimization Gaussian SQP Diesel engine calibration DoE

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Commonalities and differences between Brassica and Arabidopsis self-incompatibility

引用

Horticulture Research 2014年第1期1卷 40-44页

作者： Masaya Yamamoto Takeshi nishio Graduate School of Agricultural Science Tohoku UniversitySendai 981-8555Japan

In higher plants,the self-incompatibility mechanism is important for inhibition of self-fertilization and facilitation of *** Brassicaceae,the self-incompatibility response is mediated by allele-specific interaction of the stigma-localized S-locus receptor kinase(SRK)with the pollen coat-localized ligand(SCR/SP11).All self-incompatible Brassicaceae plants analyzed have been found to have the SRK and SCR/SP11 genes in the S-locus *** Arabidopsis thaliana is self-compatible,transformation with functional SRK-SCR genes from self-incompatible Arabidopsis species confers the self-incompatibility phenotype to *** allele-specific interaction between SRK and SCR activates the downstream signaling cascade of *** two-hybrid analysis with a kinase domain of SRK as bait and genetic analysis suggested several candidate components of self-incompatibility signaling in ***,*** genes orthologous to the identified genes for Brassica self-incompatibility signaling were evaluated by using a self-incompatible transgenic *** plant and these orthologous genes were found not to be involved in self-incompatibility signaling in the transgenic *** this review,we describe common and different aspects of S-locus genomic regions and self-incompatibility signaling between Brassica and Arabidopsis.

关键词： Arabidopsis interaction analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research on High Pressure Gas Injection As a Method of Fueling, Disruption Mitigation and Plasma Termination for Future Tokamak Reactors

引用

Plasma Science and Technology 2005年第5期7卷 3057-3061页

作者：宋云涛 S.nishio Institute of Plasma Physics Chinese Academy of Sciences Department of Fusion Plasma Research of Japan Atomic Energy Research InstituteNaka-machi Naka-gun Ibaraki-ken 311-0193 Japan

High-pressure gas injection has proved to be an effective disruption mitigation tech- nique in DIII-D tokamak experiments. If the method can be applied in future tokamak reactors not only for disruption mitigation but also for plasma termination and fueling, it will have an attractive advantage over the pellet and liquid injection from the viewpoint of economy and engineering design. In order to investigate the feasibility of this option, a study has been carried out with relevant parameters for conveying tubes of different geometrical sizes and for different gases. These parameters include pressure drop, lagger time after the valve＇s opening, gas diffusion in an ultra-high vacuum condition, and particle number contour.

关键词： tokamak reactor disruption mitigation fueling gas injection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Buckling Analysis of TF Coil Inner Leg for Central Solenoidless Tokamak

引用

Plasma Science and Technology 2006年第4期8卷 468-472页

作者：宋云涛杨庆喜 Satoshi nishio Institute of Plasma Physics Chinese Academy of SciencesHefei 230031China Department of Fusion Plasma Research Japan Atomic Energy Research InstituteNaka-machiNaka-gunIbaraki-ken 311-0193Japan

The central post is one of the critical components for the low aspect ratio tokamak, which endures not only a tremendous ohmic heating because it carries a rather high current, but also a large neutron heating and irradiation owing to the plasma operation. The DS copper alloy Glidcop AL-25[8] was chosen as the conductor material for its adequate mechanical properties and physics properties. The central post has a cylindrical structure with lots of cooling channels. The length of the central post for the next generation of nuclear fusion spherical tokamaks will be more than 10 m or 20 m. The structural stability is very crucial. When the applied load is larger than the structure critical buckling load, the device will lose its stability and collapse. In order to calculate the critical buckling load, a 1/6-segment finite element model was used and the force acting on the central post was simulated. The results showed that the vertical compressive stresses mainly affect the stability of the central post. The linear buckling analysis results with finite element method based on small deformation theory were given in this paper. The relation curves and functions for buckling factor, depending on the different lengths and the radius of the central post, the diameter of cooling channel and the maximum allowable current density, were also shown.

关键词： low aspect ratio tokamak toroidal field coil central post buckling analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：