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Behavioral Model of Molecular Gap-Type Atomic Switches and Its SPICE Integration

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Circuits and Systems 2022年第1期13卷 1-12页

作者： hiroshi kubota Tsuyoshi Hasegawa Megumi Akai-Kasaya Tetsuya Asai Graduate School of Information Science and Technology Hokkaido University Sapporo Japan School of Advanced Science and Engineering Waseda University Tokyo Japan

Atomic switches can be used in future nanodevices and to realize conceptually novel electronics in new types of computer architecture because of their simple structure, ease of operation, stability, and reliability. The atomic switch is a single solid-state switch with inherent learning abilities that exhibits various nonlinear behaviors with network devices. However, previous studies focused on experiments and nonvolatile memory applications, and studies on the application of the physical properties of the atomic switch in computing were nonexistent. Therefore, we present a simple behavioral model of a molecular gap-type atomic switch that can be included in a simulator. The model was described by three simple equations that reproduced the bistability using a double-well potential and was able to easily be transferred to a simulator using arbitrary numerical values and be integrated into HSPICE. Simulations using the experimental parameters of the proposed atomic switch agreed with the experimental results. This model will allow circuit designers to explore new architectures, contributing to the development of new computing methods.

关键词： Memristor Atomic Switch Behavioral Model SPICE

Cytosolic chaperonin CCT possesses GTPase activity

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American Journal of Molecular Biology 2011年第3期1卷 123-130页

作者： Susumu Noguchi Kazuyoshi Toyoshima Soh Yamamoto Toshio Miyazaki Michiro Otaka Sumio Watanabe Katsunori Imai Haruki Senoo Ryoji Kobayashi Mitsutoshi Jikei Yasushi Kawata hiroshi kubota Hideaki Itoh 不详

Cytosolic chaperonin CCT (also known as TRiC) is a hetero-oligomeric cage-like molecular chaperone that assists in protein folding by ATPase cycle-dependent conformational changes. However, role of the nucleo-tide binding and hydrolysis in CCT-assisted protein folding is still poorly understood. We purified CCT by using ATP-Sepharose and other columns, and found that CCT possesses ability to hydrolyze GTP, with an activity level very similar to the ATPase activity. CCT was more resistant to proteinase K treatment in the presence of GTP or ATP. These results suggest that the GTPase activity of CCT may play a role in chaperone-assisted protein folding.

关键词： Chaperonin Molecular Chaperone Protein Folding Gtp

The anti-oncogenic effect of 17-DMAG via the inactivation of HSP90 and MET pathway in osteosarcoma cells

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Oncology Research 2023年第5期31卷 631-643页

作者： MASANORI KAWANO KAZUHIRO TANAKA ICHIRO ITONAGA TATSUYA IWASAKI YUTA kubota hiroshi TSUMURA Department of Orthopaedic Surgery Faculty of MedicineOita UniversityOita879-5593Japan

Heat shock protein(HSP)90 plays a crucial role in correcting the misfolded three-dimensional structure of proteins,assisting them in folding into proper ***90 is critical in maintaining the normal functions of various proteins within cells,as essential factors for cellular ***,HSP90 simultaneously supports the maturation of cancer-related proteins,including mesenchymal epithelial transition factor(MET)within tumor *** osteosarcoma cell lines had elevated MET expression in the cDNA array in our ***,a tyrosine kinase receptor,promotes proliferation and an anti-apoptotic state through the activation of the MET pathway constructed by *** this study,we treated osteosarcoma cells with an HSP90 inhibitor,17-demethoxygeldanamycin hydrochloride(17-DMAG),and assessed the changes in the MET signaling pathway and also the antitumor effect of the *** cell cycle in osteosarcoma cells administered 17-DMAG was found to be halted at the G2/M ***,treatment with 17-DMAG inhibited cell proliferation and induced *** of tumor cell proliferation was also observed in an in vivo model system,mice that were treated with *** on the results of this study,we were able to confirm that 17-DMAG promotes inhibition of osteosarcoma cell proliferation and induction of apoptosis by inhibition of MET,a protein highly expressed in osteosarcoma *** approach may be useful for the establishment of a new treatment strategy for patients resistant to the standard treatment for osteosarcoma.

关键词： Osteosarcoma MET HSP90 17-DMAG

Three cases of retroperitoneal schwannoma diagnosed by EUS-FNA

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World Journal of Gastroenterology 2011年第29期17卷 3459-3464页

作者： Taiki Kudo hiroshi Kawakami Masaki Kuwatani Nobuyuki Ehira Hiroaki Yamato Kazunori Eto Kanako kubota Masahiro Asaka Department of Gastroenterology Hokkaido University Graduate School of MedicineKita 15Nishi 7Kita-kuSapporo060-8638Japan Department of Surgical pathology Hokkaido University HospitalKita 14Nishi 5Kita-kuSapporo060-8638Japan

Schwannomas are peripheral nerve tumors that are typically solitary and *** diagnosis is largely based on surgically resected ***,a number of case reports have indicated that retroperitoneal schwannomas could be diagnosed with endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA).We report the diagnosis of three cases of schwannoma using *** were two males and one female,ages 22,40,and 46 years,respectively,all of whom were *** findings showed well-circumscribed round ***,as the tumors could not be diagnosed using these findings alone,EUS-FNA was ***-eosin staining of the resulting tissue fragments revealed bland spindle cells with nuclear *** was no disparity in nuclear *** revealed S-100 protein positivity and all cases were diagnosed as ***-67 indexes were 3%-15%,2%-3%,and 3%,*** case showed any signs of *** most schwannomas are benign tumors and seldom become malignant,we observed these patients without *** tumors demonstrated no enlargement and no change in *** are almost always benign and can be observed following diagnosis by EUS-FNA.

关键词： Schwannoma Endoscopic ultrasonography Fine-needle aspiration Retroperitoneal tumor S100 proteins Ki-67 index

Patellar dislocation following distal femoral replacement after extraarticular knee resection for bone sarcoma:A case report

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World Journal of Clinical Cases 2022年第11期10卷 3561-3572页

作者： Yuta kubota Kazuhiro Tanaka Masashi Hirakawa Tatsuya Iwasaki Masanori Kawano Ichiro Itonaga hiroshi Tsumura Orthopaedic Surgery Oita UniversityYufu City 879-5593OitaJapan

BACKGROUND For the treatment of bone sarcoma in the distal femur,wide-margin resection and knee reconstruction with tumor endoprosthesis are standard *** knee resection is required in cases of tumor invasion of the knee joint;however,the incidence of complications,such as aseptic loosening,prosthesis infection,and implant failure,is higher than that following intra-articular knee *** the best of our knowledge,there are three reports of patellar dislocations after replacement of a tumor *** SUMMARY A 36-year-old man with no significant past medical history was admitted to our institution with continuous pain in his left knee for 4 *** open biopsy was performed,and the patient was diagnosed with a left distal femoral malignant bone ***-articular knee resection and knee reconstruction with a tumor endoprosthesis were *** the alignment of the tumor prosthesis was acceptable,knee instability was noticed *** axial radiographic view of the patellar and computed tomography showed lateral patellar dislocation at 4 wk *** patient had to undergo a lateral release and proximal *** could perform his daily activities at 9 mo *** revealed no patellar *** Proximal realignment may be considered during primary surgery if there is an imbalance in the forces controlling the patellar tracking.

关键词： Bone tumor Distal femoral replacement Lateral release Patellar dislocation Proximal realignment Case report

Chemoprevention of colorectal cancer by targeting obesity-related metabolic abnormalities

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World Journal of Gastroenterology 2014年第27期20卷 8939-8946页

作者： Yohei Shirakami Masahito Shimizu Masaya kubota hiroshi Araki Takuji Tanaka Hisataka Moriwaki Mitsuru Seishima Department of Informative Clinical Medicine Gifu University Graduate School of Medicine Department of Gastroenterology Gifu University Graduate School of Medicine Department of Tumor Pathology Gifu University Graduate School of Medicine

Obesity and its related metabolic disorders, including insulin resistance and chronic inflammation, increase the risk of colorectal cancer(CRC). This observation suggests that the metabolic abnormalities associated with obesity can be effective targets for preventing the development of CRC in obese individuals. In recent years, many studies using obese and diabetic animal models have been conducted to investigate the chemoprevention of CRC using pharmaceutical or nutritional interventions. Pitavastatin, a medicine used to treat hyperlipidemia, prevents the development of obesityrelated colorectal carcinogenesis by attenuating chronic inflammation. Anti-hypertensive medicines, such as captopril and telmisartan, also suppress the formation of colonic preneoplastic lesions in obese and diabetic mice. In addition, several phytochemicals, including green tea catechins, have been reported to improve metabolic disorders and prevent the development of various cancers, including CRC. Moreover, the administration of branched-chain amino acids, which improves protein malnutrition and prevents the progression of hepatic failure, is effective for suppressing obesityrelated colon carcinogenesis, which is thought to be associated with improvements in insulin resistance. In the present article, we summarize the detailed relationship between metabolic abnormalities and the development of CRC. This review also outlines recent evidence, in particular drawing from basic and clinical examinations using either pharmaceutical or nutritional intervention that suggests that targeting metabolic alterations may be an effective strategy for preventing the development of CRC in obese individuals.

关键词： Colorectal cancer Obesity Green tea catechin Branched-chain amino acid Chemoprevention

Safety and efficacy of carbon dioxide insufflation during gastric endoscopic submucosal dissection

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World Journal of Gastroenterology 2015年第26期21卷 8195-8202页

作者： Jun Takada hiroshi Araki Fumito Onogi Takayuki Nakanishi Masaya kubota Takashi Ibuka Masahito Shimizu Hisataka Moriwaki Department of Gastroenterology Gifu University Graduate School of Medicine

AIM: To compare the safety and efficacy of carbon dioxide(CO2) and air insufflation during gastric endoscopic submucosal dissection(ESD).METHODS: This study involved 116 patients who underwent gastric ESD between January and December *** eliminating 29 patients who fit the exclusion criteria,87 patients,without known pulmonary dysfunction,were randomized into the CO2 insufflation(n = 36) or air insufflation(n = 51) *** ESD was performed with a CO2 regulation unit(constant rate of 1.4 L/min) used for patients undergoing CO2 *** received diazepam for conscious sedation and pentazocine for *** CO2 tension(Ptc CO2) was recorded 15 min before,during,and after ESD with *** CO2,the correlation between Ptc CO2 and procedure time,and ESD-related complications were compared between the two *** blood gases were analyzed after ESD in the first 30 patients(12 with CO2 and 18 with air insufflation) to assess the correlation between arterial blood CO2 partial pressure(Pa CO2) and Ptc ***: There were no differences in respiratoryfunctions,median sedative doses,or median procedure times between the ***,there was no significant difference in post-ESD blood gas parameters,including Pa CO2,between the CO2 and air groups(44.6 mm Hg vs 45 mm Hg).Both groups demonstrated median p H values of 7.36,and none of the patients exhibited *** significant differences were observed between the CO2 and air groups with respect to baseline Ptc CO2(39 mm Hg vs 40 mm Hg),peak Ptc CO2 during ESD(52 mm Hg vs 51 mm Hg),or median Ptc CO2 after ESD(50 mm Hg vs 50 mm Hg).There was a strong correlation between Pa CO2 and Ptc CO2(r = 0.66; P < 0.001).The incidence of Mallory-Weiss tears was significantly lower with CO2 insufflation than with air insufflation(0% vs 15.6%,P = 0.013).CO2 insufflation did not cause any adverse events,such as CO2 narcosis or gas ***: CO2 insufflation durin

关键词： Carbon dioxide Gastric endoscopic submucosaldissection Insufflation Mallory-Weiss tear Randomizedcontrolled trial

Correction: MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

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Oncology Research 2024年第8期32卷 1369-1370页

作者： HUI SUN MASANORI KAWANO TATSUYA IWASAKI ICHIRO ITONAGA YUTA kubota hiroshi TSUMURA KAZUHIRO TANAKA Department of Orthopaedic Surgery Faculty of MedicineOita UniversityOita879-5503Japan

In the article‘MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1’(Oncology Research,2024,Vol.32,No.3,pp.463−***:10.32604/or.2023.044085),there was an error in the compilation of *** have revised Fig.8D to correct this error.A corrected version of Fig.8 is *** correction does not change any results or conclusions of the *** apologize for any inconvenience caused.

关键词： osteosarcoma correction revised

Recent advances in endoscopic ultrasonography-guided biliary interventions

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World Journal of Gastroenterology 2015年第32期21卷 9494-9502页

作者： Kazumichi Kawakubo hiroshi Kawakami Masaki Kuwatani Shin Haba Shuhei Kawahata Yoko Abe Yoshimasa kubota Kimitoshi Kubo Hiroyuki Isayama Naoya Sakamoto Department of Gastroenterology and Hepatology Hokkaido University Graduate School of Medicine Department of Gastroenterology Graduate School of Medicine The University of Tokyo

Interventional endoscopic ultrasonography(EUS) based on EUS-guided fine-needle aspiration has rapidly spread as a minimally invasive procedure. Especially in patients with failed endoscopic retrograde cholangiopancreatography, EUS-guided biliary intervention is reported to be useful as salvage therapy. EUS-guided biliary interventions are carried out using three techniques: EUS-guided bilioenteric anastomosis, EUS-guided rendezvous procedure, and EUS-guided antegrade treatment. Although interventional EUS is not yet a standardized procedure, there have been recent advances in this field that address various biliary diseases. Here, we summarize the indications, techniques, clinical results of previous studies, and future perspectives.

关键词： Endosonography-guided biliary intervention Choledo