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A study on sleep architecture in patients with chronic respiratory failure under long-term oxygen therapy—Focused on the influence of ventilatory failure (high CO<sub>2</sub>) elements on the patient’s sleep architecture

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Health 2013年第8期5卷 14-20页

作者： Tsuguo Nishijima Keisuke Hosokawa Fumitaka Mito Tetsuya Kizawa Susumu Takahashi hiroshi kagami Akira Suwabe Shigeru Sakurai Department of Laboratory Medicine Iwate Medical University School of Medicine Morioka Japan Department of Respirology Hachinohe Red Cross Hospital Hachinohe Japan Division of Behavioral Sleep Medicine Iwate Medical University School of Medicine Morioka Japan

Sleep disturbance related symptoms are common in patients with long-term oxygen therapy (LTOT). Essentially, there were only few previous reports about the sleep architecture in patients with respiratory disease, such as chronic obstructive pulmonary disease (COPD). This study aims to clarify the objective sleep state and the elements that affect sleep architecture in Chronic Respiratory Failure (CRF) patients with focus on clinical cases of chronic hypercapnia. 13 subjects with chronic respiratory failure were enrolled in the study. All the subjects were pre-evaluated by pulmonary function test and Arterial blood gas analysis (ABG) including exercise testing. Polysomnography (PSG) test was performed in each subject with supplemental oxygen. The estimated base line PaCO2 value that reflects overall PaCO2 including sleep period was calculated using equation of PaCO2[2.4×(HCOˉ3)-22]from obtained ABG value just before PSG test. 6 subjects were classified as hypercapnic group (base line PaCO2 ≥ 45 mmHg) and 7 subjects were non-hypercapnic group (base line PaCO2 < 45 mmHg). Latency persistent sleep of PSG data was significant higher in patients with hypercapnic than non-hypercapnic (p < 0.01). Periodic Limb Movement was seen in 23.6% of the subjects, however there was no contribution for arousals. Other PSG data include mean SpO2 were no significant difference. This study suggests that patients with estimated hypercapnia had more disturbed sleep architecture especially significant loss of sleep latency than non-hypercapnic patient with chronic respiratory failure under LTOT. Nocturnal PaCO2 level or ventilatory function may contribute to sleep disturbance in patients with estimated hypercapnia during LTOT.

关键词： Chronic Respiratory Failure Long-Term Oxygen Therapy Sleep Architecture Periodic Leg Movement Disorder

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Significant Association of Nightly Nasal Continuous Positive Airway Pressure Using Time with Weight Change in Japanese Patients with Obstructive Sleep Apnea-Hypopnea Syndrome

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Health 2014年第17期6卷 2295-2302页

作者： Tsuguo Nishijima Sayaka Ishitoya Tomomi Mikasa Tetsuya Kizawa Keisuke Hosokawa Susumu Takahashi hiroshi kagami Akira Suwabe Shigeru Sakurai Division of Behavioral Sleep Medicine School of Medicine Iwate Medical University Morioka Japan Department of Respirology Hachinohe Red Cross Hospital Aomori Japan Department of Laboratory Medicine School of Medicine Iwate Medical University Morioka Japan

Background: Obstructive sleep apnea syndrome (OSAS) is one of the representative sleep disorders believed to be associated with metabolic syndrome. Nasal continuous positive airway pressure (nCPAP) ventilation is the first choice therapy for OSAS, which has been reported to cause an improvement in body fat mass, hepatocellular damage and hypertension. Study Objectives: We evaluated whether the changes in the body weight observed in patients with OSAS may have potential associations with the sleep time during which the patients are under nCPAP. Method: A total of 194 patients (148 obese and 46 non-obese) in whom nCPAP use was present for more than 70% of the nights were enrolled in this study. Using the electronic records of the night use time for CPAP devices, we examined whether the habitual sleep time during nCPAP is associated with changes in body weight. Results: In the non-obese OSAS group, the patients with night time use of nCPAP devices for 6 to 7 hours showed the greatest and the most sustained decrease in body weight. In the obese patients with OSAS, on the other hand, a U-shaped relationship has been demonstrated between a percent weight gain over 9 years and a minimal weight gain in patients with habitual sleep for 5 to 6 hours. Conclusions: These results suggest that changes in body weight in patients with OSAS are associated with habitual sleep time.

关键词： Bodyweight Obesity CPAP OSAS Sleep Time during CPAP

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鸡鸭异种间嵌合体的制备

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动物学报 2002年第4期48卷 543-548页

作者：李赞东刘春海黄劲松沙金危华孙明军赵晨姜盛花 hiroshi kagami 中国农业大学生物学院北京100094 Faculty of Agriculture

本研究采集孵化 14期鸡胚血液中的原始生殖细胞 ,在液氮中冷冻保存三个月后 ,解冻成活率达 80 %以上。以Ficoll密度梯度离心将其从血液中分离纯化 ,分离获得纯度为 2 7 5 % ,平均每枚胚胎可获得近 5 0个PGCs。将分离的鸡PGCs10 0～ 2 0 ... 详细信息

本研究采集孵化 14期鸡胚血液中的原始生殖细胞 ,在液氮中冷冻保存三个月后 ,解冻成活率达 80 %以上。以Ficoll密度梯度离心将其从血液中分离纯化 ,分离获得纯度为 2 7 5 % ,平均每枚胚胎可获得近 5 0个PGCs。将分离的鸡PGCs10 0～ 2 0 0个以微注射法转移至 15期早期麻鸭胚胎中制备了鸡鸭种间嵌合体 ,孵出 8(6♂ ,2♀ )只雏鸭 ,总孵化率为 7 3% (8/110 )。以鸡W染色体特异性DNA探针原位杂交法在早期鸭胚性腺中检测鸡PGCs ,在被检测的 2 1个鸭胚的性腺中 ,16个有不同程度的阳性信号 ,嵌合率达 76 2 % (16 /2 1)。实验结果表明鸡原始生殖细胞能够迁移并定居到鸭胚性腺中 ,并有可能在鸭性腺中增殖分化成有功能的配子。

关键词：鸡鸭异种间嵌合体制备原始生殖细胞

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Specific Surface Free Energy of As-Grown and Polished Faces of Synthetic Quartz

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Journal of Crystallization Process and Technology 2014年第4期4卷 177-184页

作者： Takaomi Suzuki Keiko Takahashi Masayuki Kawasaki Toshihiko kagami Faculty of Engineering Shinshu University Nagano Japan Nihon Dempa Kogyo Co. Ltd. (NDK) Sayama Japan

Contact angles of water droplet on as-grown Z, +X, –X, and m faces of synthetic quartz crystals with growth term of 20 and 48 days, and polished Z, +X, –X, Y, and 45° cut faces of synthetic quartz crystal were observed. The average of the contact angles on as-grown Z, +X, and –X faces increased with the growth term, and they were larger than that on polished Z, +X, and –X faces. On the other hand, the average of the contact angles of water on m face decreased with the growth term, and they were smaller than that on polished Y cut face. Growth rate of the faces of synthetic crystals was measured and the order of growth rate was, m < –X < +X < Z. Specific surface free energy (SSFE) was calculated using Neumann’s equation. The SSFE of polished face was in the order of, m < –X < +X < Z, which corresponds to the order of the growth rate. The SSFE was larger for the face with larger growth rate.

关键词： Surface Free Energy Quartz Crystals

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Change in Filler Network and Nonlinear Viscoelasticity of Rubbers

Change in Filler Network and Nonlinear Viscoelasticity of Ru...

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The 4th Pacific Rim Conference on Rheology

作者： Youji Satoh Shigeru kagami Sheiichi Kawahara Yoshinobu Isono Department of Chemistry Nagaoka University of Technology 1603-1 Kamitomioka Nagaoka Niigata 940-2188 Japan The Yokohama Rubber Co. Ltd Hiratsuka Kanagawa 254-8601 Japan Department of Chemistry Nagaoka University of Technology 1603-1 Kamitomioka Nagaoka Niigata 940-2188 Japan Department of Chemistry Nagaoka University of Technology 1603-1 Kamitomioka Nagaoka Niigata 940-2188 Japan

＜正＞ Uncured, filled rubbers show remarkable nonlinear viscoelasticity as well as cured, filled rubbers. The nonlinearity may come from change in entanglement and filler network structures. Many people use dynamic modulus to characterize rubber materials. However, dynamic modulus cannot be defined at large strain amplitude. Hence we must study a viscoelastic function to be defined at large strain. In addition, we need another information to separate the effects of the change in entanglement and filler network structures on nonlinear viscoelasticity. In this work, we have measured relaxation modulus G（γ,t） and electrical resistivity p（γ,t） simultaneously for carbon black （CB）-filled, uncured SBRs in a wide range of strain. Electrical resistivity at equilibrium, p（0,t）, showed step-off like change at the threshold of CB loading based on particle size. The threshold of N330 CB exists between 20 and 35phr, indicating threshold for filler network formation should exist in the range of values in CB loading. Both G（γ,t） and p（γ,t） for the samples having CB loading to be higher than the threshold showed nonlinearity at the strain larger than shear strain γ=0.1, indicating rupture in filler network at large strain. The threshold shifted to lower CB content for fine CB（N220）, and no threshold was observed for coarse CB（N660） in the range measured from 20 to 50phr, indicating that the threshold depends on primary particle size. Moreover it has been found that filler network structures rupture easily when the CB content close to the threshold. Furthermore, recovery rate in filler network has been found to be very slow in comparison with that in entanglement structure.

关键词： uncured styrene-butadiene rubber filler-network nonlinear viscoelasticity electrical resistivity.

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重新想象重新设计重新架构

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中国广告 2011年第10期 68-69页

作者： AKIRA kagami 镜明 Dentsu株式会社

业内流传这样一个笑话,就是戛纳本身就是一个创意,因为它每年都在找寻一些创意。研讨会绝对是本次戛纳节上最精彩的部分,甚至在将来10年也是。

关键词：想象设计架构创意

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日本岛弧西南部白垩纪-早第三纪花岗岩类岩石中Sr、Nd同位素的空间变化

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世界地质 1993年第1期 45-46页

作者： Hirov kagami 刘志宏

白垩纪-早第三纪花岗岩类和与之同时形成的火山岩在日本西南部的内带中广泛分布。人们认为中新世时,在日本岛弧西南部从大陆分开,导致日本海扩张之前,这种强烈的中性-长英质岩浆作用已经取代了欧亚大陆东部边缘的特征。花岗岩类岩石的... 详细信息

白垩纪-早第三纪花岗岩类和与之同时形成的火山岩在日本西南部的内带中广泛分布。人们认为中新世时,在日本岛弧西南部从大陆分开,导致日本海扩张之前,这种强烈的中性-长英质岩浆作用已经取代了欧亚大陆东部边缘的特征。花岗岩类岩石的放射性年龄和岩石中的Sr、Nd和O同位素比率都表现出区域性变化。在中央构造线和日本海之间,按照Sr和Nd同位素比率,将花岗岩类岩石分成三个带(南带、过渡带、北带)。北带的花岗岩类和与之伴生的辉长岩,具有较低的初始Sr同位素比率(0.7048～0.7068)和较高

关键词：花岗岩类岩石早第三纪老第三纪西南部同位素 Nd Sr

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Asymptomatic Anisakiasis of the Colon Diagnosed and Treated by Colonoscopy

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Case Reports in Clinical Medicine 2020年第9期9卷 288-294页

作者： Tomoshi Takeda Kenji Niwa Akie Sano Atsunori Kodama Kuninori Hatasa Yasunari Matsuno Masao kagami Motoki Takenaka Kohjiro Niwa Takuji Tanaka Department of Internal Medicine Gujo City Hospital Shimadani Gujo City Gifu Japan Section of Laboratory Medicine and Obstetrics & Gynecology Gujo City Hospital Shimadani Gujo City Gifu Japan Sano Internal Medicine Clinic Naka-fukuno-cho Seki City Gifu Japan Department of Obstetrics & Gynecology Gifu University School of Medicine Yanagido Gifu City Japan Department of Internal Medicine Kizawa Memorial Hospital Shimokobi Kobicho Minokamo City Japan Department of Diagnostic Pathology & Research Center of Diagnostic Pathology Gifu Municipal Hospital Gifu City Japan

Anisakiasis can involve any part of the digestive tract, but most cases reported have involved the stomach;few reports have described colonic anisakiasis. Furthermore, asymptomatic colonic anisakiasis has been reported to be very rare. A 58-year-old Japanese male asymptomatically received colonoscopy due to a fecal occult blood testing positive, and an Anisakis larva was removed in the ascending colon. After colonoscopy, an detailed questionings concerning eating raw fish revealed that the patient ate the liver of raw filefish 21 days before the colonoscopy. Thus, questionings concerning eating the raw fish were very important and helpful for correct diagnosis. This case report demonstrated that colonic anisakiasis can be diagnosed by colonoscopy before severe complications (intestinal obstruction, perforation, and cancer development) occur. Also, biopsy forceps could be used to remove the Anisakis worms, demonstrating that diagnosis and treatment can be simultaneously performed.

关键词： Asymptomatic Anisakiasis Ascending Colon Colonoscopy Risk Factor for Cancer

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