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Open Journal of Psychiatry 2015年第2期5卷 170-176页

作者： Akihiko Katsumi hiroshi hoshino Satoshi Fujimoto Shin-Ichi Niwa Katsumi Clinic Niigata Japan Department of Neuropsychiatry School of Medicine Fukushima Medical University Fukushima Japan Department of Psychiatry Aizu Medical Center Fukushima Medical University Fukushima Japan

Cognitive impairment is a symptom of schizophrenia and strongly associated with impaired social function. In recent years, cognitive interventions (cognitive remediation therapies) have been implemented and their results have also been reported. Intervention studies have been conducted using a variety of methods that differ in terms of terminology, approach, and targeted cognitive domains. In this study, we examined trends in recent cognitive remediation research conducted subsequent to the meta-analyses of McGurk et al. (2007) and Wykes et al. (2011). We identified studies conducted between 2009 and 2013 to examine computer-assisted cognitive remediation and collated and analyzed the literature describing their major results and trends. Our results indicated improved cognitive performance subsequent to cognitive remediation therapy using computer programs. We found promising outcomes, particularly in reasoning and problem solving, verbal learning and memory, verbal working memory, and attention and vigilance, which replicated the findings of Wykes et al. (2011).

关键词： Schizophrenia Cognitive Deficit Cognitive Remediation Variance Cognitive Domain

UBOM-4, a New Scale for Psychic Function and Energy: General Population Normative Values and Influencing Parameters

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Open Journal of Psychiatry 2018年第4期8卷 390-412页

作者： Daisuke Gotoh hiroshi hoshino Kumi Yoshida Yoshiko Akiyama Satoshi Fujimoto Emiko Yoshioka Yumiko Namae Shin-Ichi Niwa Fukushima Prefectural Mental Health and Welfare Center Fukushima Japan Department of Neuropsychiatry School of Medicine Fukushima Medical University Fukushima Japan Koriyama Institute of Health Sciences Fukushima Japan NPO Society of Utena’s Brief Objective Measures of 4 Axes for Psychic Function and Energy Fukushima Japan Niigata University of Rehabilitation Fukushima Japan Aizu Medical Center Fukushima Medical University Fukushima Japan

Objective: We introduce Utena’s Brief Objective Measures of 4 Axes for Psychic Function and Energy (UBOM-4), a new brief test battery for evaluating psychic function concerning intellect, emotion, volition, and imagination. To date, insufficient general population data on the UBOM have been collected. This study aimed to establish the normative values for the general population in UBOM-4 and examine the effects of age, sex, and mental health status on the values. Methods: The General Health Questionnaire, 12-item version (GHQ-12) and UBOM-4 were administered to 149 individuals working in or attending professional schools or universities (73 males, 76 females;age: 19 - 65 years). Participants were classified as healthy based on their GHQ-12 responses and psychiatrist interviews. Results: UBOM-4 measures (mean ± SD) were: pulse rate difference (PRD or UBOM-pulse), −0.72 ± 4.31 beats/min;ruler catching time (RCT or UBOM-ruler), 18.42 ± 3.73 cm;degree of randomness (DOR or UBOM-random), 0.94 ± 0.18;mean randomizing time (MRT or UBOM-time), 0.60 ± 0.31 sec. The Baum Test drawings were classified as usual (86%) and unusual patterns (14%). Sex effects were observed for RCT (UBOM-ruler) and DOR (UBOM-random), but not for PRD (UBOM-pulse) and MRT (UBOM-time). Therefore, the normative values for RCT (UBOM-ruler) (males: 17.37 ± 3.25 cm;females: 19.42 ± 3.90 cm) and DOR (UBOM-random) (males: 0.92 ± 0.18;females: 0.95 ± 0.18) should be differentiated by sex. The patterns of the Baum Test drawings were affected by age, with individuals over 51 years showing the unusual pattern more frequently (42%). Discussion: Compared to previous results for healthy individuals, the present results were similar for RCT (UBOM-ruler), DOR (UBOM-random), MRT (UBOM-time), and the drawing pattern, but different for PRD (UBOM-pulse). This difference is probably because PRD is sensitive to test situation habituation, sex of examiner, order of subtests, etc. Thus, PRD (UBOM-pulse) should be meas

关键词： UBOM-4 Psychic Function Normative Value GHQ-12 Shared Decision Making

Newly Admitted Psychiatric Inpatients after the 3.11 Disaster in Fukushima, Japan

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Open Journal of Psychiatry 2017年第3期7卷 131-146页

作者： Masaki Hisamura Arinobu Hori Akira Wada Itaru Miura hiroshi hoshino Shuntaro Itagaki Yasuto Kunii Junya Matsumoto Hirobumi Mashiko Craig Katz Shin-Ichi Niwa Department of Emergency Medicine Saitama Medical Center Saitama Medical University Saitama Japan Department of Disaster and Comprehensive Medicine Fukushima Medical University Fukushima Japan Department of Neuropsychiatry Fukushima Medical University Fukushima Japan Departments of Psychiatry and Medical Education Icahn School of Medicine at Mount Sinai New York USA Department of Psychiatry Aizu Medical Center Fukushima Medical University Fukushima Japan

Background: After the March 2011 “triple” disaster in Japan, the residents of Fukushima Prefecture suffered from serious psychological stress. Aims: This study aimed to elucidate the influence of stressful conditions on psychiatric disorders, as reflected in new psychiatric admissions. Methods: Diagnoses and background conditions among new psychiatric admissions during the 3 months immediately after the disaster in 2011 and the corresponding time periods of 2010 and 2012 were surveyed. Results: In 2011, more patients were admitted in confusional, manic, neurasthenic, and delirious states, whereas there were fewer admissions for depression. In 2012, more admissions pertained to depression. Twenty-four percent of the new admissions in 2011 were associated with concerns about radiation contamination and hospitalization, which declined to 4% in 2012. Conclusions: The diagnoses and background conditions among new psychiatric admissions were affected by the disaster;with the influence differing according to the time elapsed after the disaster.

关键词： Depression Fear of Radiation Fukushima Disaster Manic State Psychiatric Inpatients

Outcomes of endoscopic endonasal dacryocysto-rhinostomy for intractable lacrimal dacryostenosis and associated factors

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1471-1475页

作者： Tohru Tanigawa Hirokazu Sasaki hiroshi Nonoyama Yuichiro Horibe Kunihiro Nishimura Tetsuro hoshino Tetsuya Ogawa Kenta Murotani Hiromi Ueda Masahiro Kaneda Department of Otolaryngology Aichi Medical University Department of Otolaryngology Tono Kosei Hospital Division of Biostatistics Clinical Research CenterAichi Medical University Department of Ophthalmology Tono Kosei Hospital

AIM：To examine the effects of patient age,canalicular obstruction,mode of anesthesia,and duration of nasolacrimal intubation on the outcomes of endoscopic endonasal dacryocystorhinostomy（DCR）. METHODS： Totally 56 eyes of 46 patients with prolonged epiphora underwent minimally invasive endoscopic endonasal DCR.A successful surgical outcome was defined as a significant improvement in symptoms,adequate water passage from the puncta to the nasal cavity,and patency of the DCR *** outcomes were assessed at least 6mo after ***＇s exact test was used to discuss the factors,and then the logistic regression analysis was made by SAS9.4 ***： The overall success rate was 75.0%,and complete resolution was observed in 27 *** success rate was higher for patients with ≥6mo intubation than for those with 〈6mo ***,there were no significant differences in outcomes between groups stratified by age（〈65 or ≥65y）,presence or absence of canalicular obstruction,mode of anesthesia（local or general）,and use or nonuse of a radiowave *** patient developed subcutaneous emphysema around the eye and nose and one developed subcutaneous hemorrhage after surgery. CONCLUSION： Endoscopic endonasal DCR can be considered safe and minimally invasive with reasonable success rates,particularly when the duration of nasolacrimal intubation is ≥6mo.

关键词： dacryocystorhinostomy endoscopy,, intubation epiphora

First successful perinatal management of pregnancy after ABO-incompatible liver transplantation

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World Journal of Gastroenterology 2017年第3期23卷 547-550页

作者： Hisanobu Higashi Hideaki Obara Kei Miyakoshi Masahiro Shinoda Minoru Kitago Naoki Shimojima Yuta Abe Taizo Hibi hiroshi Yagi Kentaro Matsubara Yohei Yamada Osamu Itano Ken hoshino Tatsuo Kuroda Yuko Kitagawa Department of Surgery Keio University School of MedicineTokyo 160-8582Japan Department of Obstetrics and Gynecology Keio University School of MedicineTokyo 160-8582Japan Department of Pediatric Surgery Keio University School of MedicineTokyo 160-8582Japan

Many papers have reported on pregnancy and delivery after liver transplantation, but there have been no reports on pregnancy after ABO-incompatible liver transplantation. This paper reports the first successful pregnancy and delivery of a newborn after ABOincompatible liver transplantation for fulminant hepatic failure. The patient was a 39-year-old female. She had an ABO-incompatible liver transplantation, donated from her husband, due to subacute fulminant hepatitis of unknown etiology. She was taking tacrolimus, methylprednisolone, and mizoribine orally for the maintenance of immunosuppression at the time of discharge. She was discharged uneventfully on postoperative day 38 without any rejection episodes. At 1 year and 6 mo after transplantation, she indicated a wish to become pregnant. Therefore, treatment with mycophenolate mofetil was interrupted at that time. After two miscarriages, she finally became pregnant and delivered transvaginally 3 years after the transplantation. All of the pregnancies were conceived naturally. The newborn was female with a birth weight of 3146 g; the Apgar scores were 9 and 10. Delivery was performed smoothly, and the newborn exhibited no malformations. The mother and the newborn were discharged uneventfully. We suggest that pregnancy is possible for recipients after ABO-incompatible liver transplantation.

关键词： Pregnancy Liver transplantation Delivery Fulminant hepatic failure ABO-incompatible Living donor

A System to Depict the Cognitive Process of Trainees Based on Multiple Skill Parameters： System Validation Involving Normal Individuals with an Electrician＇s License

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通讯和计算机（中英文版） 2017年第2期14卷 73-83页

作者： Norikatsu Fujita hiroshi Takeshita Sho Aoki Hirotada Fukae Kazushige Matsumoto Tomohiro Murakami Minoru hoshino Ability Development Dept. Polytechnic University of Japan

Colon perforation due to antigenemia-negative cytomegalovirus gastroenteritis after liver transplantation: A case report and review of literature

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World Journal of Gastroenterology 2019年第15期25卷 1899-1906页

作者： Takahiro Yokose Hideaki Obara Masahiro Shinoda Yutaka Nakano Minoru Kitago hiroshi Yagi Yuta Abe Yohei Yamada Kentaro Matsubara Go Oshima Shutaro Hori Sho Ibuki Hisanobu Higashi Yuki Masuda Masanori Hayashi Miho Kawaida Takehiko Mori Takumi Fujimura Ken hoshino Kaori Kameyama Tatsuo Kuroda Yuko Kitagawa Department of Surgery Keio University School of Medicine Department of Pathology Keio University School of Medicine Division of Hematology Department of Medicine Keio University School of Medicine

BACKGROUND Cytomegalovirus(CMV) remains a critical complication after solid-organ transplantation. The CMV antigenemia(AG) test is useful for monitoring CMV infection. Although the AG-positivity rate in CMV gastroenteritis is known to be low at onset, almost all cases become positive during the disease course. We treated a patient with transverse colon perforation due to AG-negative CMV gastroenteritis, following a living donor liver transplantation(LDLT).CASE SUMMARY The patient was a 52-year-old woman with decompensated liver cirrhosis as a result of autoimmune hepatitis who underwent a blood-type compatible LDLT with her second son as the donor. On day 20 after surgery, upper and lower gastrointestinal endoscopy(GE) revealed multiple gastric ulcers and transverse colon ulcers. The biopsy tissue immunostaining confirmed a diagnosis of CMV gastroenteritis. On day 28 after surgery, an abdominal computed tomography revealed transverse colon perforation, and simple lavage and drainage were performed along with an urgent ileostomy. Although the repeated remission and aggravation of CMV gastroenteritis and acute cellular rejection made the control of immunosuppression difficult, the upper GE eventually revealed an improvement in the gastric ulcers, and the biopsy samples were negative for CMV. The CMV-AG test remained negative, therefore, we had to evaluate the status of the CMV infection on the basis of the clinical symptoms and *** This case report suggests a monitoring method that could be useful for AGnegative CMV gastroenteritis after a solid-organ transplantation.

关键词： Cytomegalovirus gastrointestinal disease Colon perforation Antigenemia negative Liver transplantation Case report

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日本高灌蓝莓采收最适线锯振动速度(摘选)

农业工程 2012年第2期2卷 119-121,118页

作者： Longsheng Fu hiroshi Okamoto Yoichiro hoshino Takashi Kataoka Youichi Shibata 北海道大学农业研究院札幌0608589 北海道大学北方生物圈研究中心札幌0600811

高灌蓝莓的成熟期不一致,在3～4周时间内需要有选择地采收3～5次。现在日本的蓝莓收获方式是采用一种具有5个速度调节挡的18mm线锯对树枝进行变速振动。为了能够找到采收效率最高且采收效果最好的振动速度,利用高速摄像机对蓝莓采收过... 详细信息

高灌蓝莓的成熟期不一致,在3～4周时间内需要有选择地采收3～5次。现在日本的蓝莓收获方式是采用一种具有5个速度调节挡的18mm线锯对树枝进行变速振动。为了能够找到采收效率最高且采收效果最好的振动速度,利用高速摄像机对蓝莓采收过程进行记录。之后利用数据统计,回放分析采收过程中的细节,以确定最佳振动速度和振动时间。通过对5种速度的分析,发现Ⅱ挡即频率为1670次min,在果枝周围振动2s是采收的最佳方式。在这种条件下,与3个高速挡同样可以分离87%成熟的蓝莓。同时仅分离了24%未成熟的蓝莓,该结果与Ⅰ挡无显著差异。

关键词：高速摄像机成熟蓝莓未成熟蓝莓统计分析