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High-grade pancreatic intraepithelial neoplasia diagnosed based on changes in magnetic resonance cholangiopancreatography findings:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1487-1496页

作者： Nao Furuya Atsushi Yamaguchi Naohiro Kato Syuhei Sugata Takuro Hamada Takeshi Mizumoto Yuzuru Tamaru Ryusaku Kusunoki Toshio Kuwai Hirotaka Kouno Kazuya Kuraoka Yoshiyuki Shibata Sho Tazuma Takeshi Sudo hiroshi Kohno Shiro Oka Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Gastroenterology Hiroshima University HospitalHiroshima 734-8551HiroshimaJapan Department of Pathology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan

BACKGROUND High-grade pancreatic intraepithelial neoplasia(PanIN)exhibits no mass and is not detected by any examination ***,it can be diagnosed by pancreatic juice cytology from indirect *** previous cases were diagnosed based on findings of a focal stricture of the main pancreatic duct(MPD)and caudal MPD dilatation and subsequent pancreatic juice cytology using endoscopic retrograde cholangiopancreatography(ERCP).We experienced a case of high-grade PanIN with an unclear MPD over a 20-mm range,but without caudal MPD dilatation on magnetic resonance cholangiopancreatography(MRCP).CASE SUMMARY A 60-year-old female patient underwent computed tomography for a follow-up of uterine cancer post-excision,which revealed pancreatic *** revealed an unclear MPD of the pancreatic body at a 20-mm length without caudal MPD ***,course observation was *** 24 mo,MRCP revealed an increased caudal MPD caliber and a larger pancreatic *** performed ERCP and detected atypical cells suspected of adenocarcinoma by serial pancreatic juice aspiration cytology *** performed a distal pancreatectomy and obtained a histopathological diagnosis of high-grade *** parenchyma invasion was not observed,and curative resection was *** High-grade Pan-IN may cause MPD narrowing in a long range without caudal MPD dilatation.

关键词： Pancreatic cancer Pancreatic intraepithelial neoplasm High-grade pancreatic intraepithelial neoplasm Magnetic resonance cholangiopancreatography Carcinoma in situ Case report

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Lithium Ion Transport Environment by Molecular Vibrations in Ion-Conducting Glasses

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Energy & Environmental Materials 2024年第3期7卷 133-142页

作者： Hiroki Yamada Koji Ohara Satoshi Hiroi Atsushi Sakuda Kazutaka lkeda Takahiro Ohkubo Kengo Nakada Hirofumi Tsukasaki hiroshi Nakajimai Laszlo Temleitner Laszlo Pusztai Shunsuke Ariga Aoto Matsuo Jiong Ding Takumi Nakano Takuya Kimura Ryo Kobayashi Takeshi Usuki Shuta Tahara Koji Amezawa Yoshitaka Tateyama Shigeo Mori Akitoshi Hayashi Diffraction and Scattering Division Japan Synchrotron Radiation Research Institute(JASRI)1-1-1 KoutoSayo-choSayo-gun Hyogo 679-5198Japan Faculty of Materials for Energy Shimane University1060Nishi-Kawatsu-ChoMatsue Shimane 690-8504Japan Department of Applied Chemistry Graduate School of EngineeringOsaka Metropolitan University1-1 Gakuen-choSakaiOsaka 599-8531Japan Institute of Materials Structure Science High Energy Accelerator Research Organization(KEK)203-1 ShirakataTokai-muraNaka-gunlbaraki 319-1106Japan Graduate School of Engineering Chiba University 1-33 Yayoi-cho Inage-kuChiba 263-8522Japan Department of Materials Science Graduate School of EngineeringOsaka Metropolitan University1-1 Gakuen-choSakaiOsaka 599-8531Japan Wigner Research Centre for Physics Konkoly Thegeút 29-33 H-1121Budapest Hungary International Research Organisation of Advanced Science and Technology(IROAST) Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan Department of Applied Physics Nagoya Institute of TechnologyGokisoShowaNagoya 466-8555Japan Faculty of Science Yamagata University1-4-12 KojirakawaYamagata-shiYamagata 990-5860Japan Faculty of Science University of the Ryukyus1 SenbaruNishihara-choOkinawa 903-0213Japan Institute of Multidisciplinary Research for Advanced Materials Tohoku University2-1-1 KatahiraAoba-kuSendai 980-8577Japan Center for Green Research on Energy and Environmental Materials(GREEN)and International Center for Materials Nanoarchitectonics(MANA) National Institute for Materials Science(NIMS)TsukubaIbaraki 305-0044Japan

Controlling Li ion transport in glasses at atomic and molecular levels is key to realizing all-solid-state batteries,a promising technology for electric *** this context,Li_(3)PS_(4)glass,a promising solid electrolyte candidate,exhibits dynamic coupling between the Li^(+)cation mobility and the PS_(4)^(3-)anion libration,which is commonly referred to as the paddlewheel *** addition,it exhibits a concerted cation diffusion effect(i.e.,a cation-cation interaction),which is regarded as the essence of high Li ion ***,the correlation between the Li^(+)ions within the glass structure can only be vaguely determined,due to the limited experimental information that can be ***,this study reports that the Li ions present in glasses can be classified by evaluating their valence oscillations via Bader analysis to topologically analyze the chemical *** is found that three types of Li ions are present in Li_(3)PS_(4)glass,and that the more mobile Li ions(i.e.,the Li3-type ions)exhibit a characteristic correlation at relatively long distances of ***,reverse Monte Carlo simulations combined with deep learning potentials that reproduce X-ray,neutron,and electron diffraction pair distribution functions showed an increase in the number of Li3-type ions for partially crystallized glass structures with improved Li ion transport *** results show order within the disorder of the Li ion distribution in the glass by a topological analysis of their ***,considering the molecular vibrations in the glass during the evaluation of the Li ion valences is expected to lead to the development of new solid electrolytes.

关键词： electrolytes ionic conductors modeling molecular dynamics

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A Case Report of Kissing Molars Class II

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Open Journal of Stomatology 2024年第5期14卷 249-254页

作者： Toshiyuki Inou Keiichi Uchida Keiko Kaneko Anna Fuji Nina Wakimoto Tatsuo Takaya Hiroyuki Kitamura hiroshi Mori Yuji Kurihara Department of Oral Diagnostics and Comprehensive Dentistry Matsumoto Dental University Hospital Shiojiri Japan Department of Oral and Maxillofacial Surgery School of Dentistry Matsumoto Dental University Shiojiri Japan

Kissing molars (KMs) is a condition of occlusal molar surfaces in a single follicular space with roots extending in opposite directions. Here, we have reported a case of KMs in a 58-year-old woman. The patient complained of pain in the right mandibular molar region and was diagnosed with KMs consisting of the right mandibular second and third molars. Because of the patient’s pain having subsided at the time of the visit and her unwillingness to undergo tooth extraction, the patient was followed up. KMs is classified into three classes (I-III) and is either true-KMs or pseudo-KMs and presents with or without cystic variants of dental follicles. The presents as true-KMs class II without a cystic variant. With reference to the literature and based on our analysis, the mean age of patients affected by this specific case of KMs is 31.7 years and unilateral KMs is relatively more common (85.7%). Histopathological findings of dentigerous cysts are more often indicated (42.9%). The treatment policy for KMs should therefore be based on the classification of KMs. Importantly, the focus should be on preserving the first and second molars as much as possible. The treatment approach, such as the employment of surgical removal or orthodontics, should be determined by considering the associated factors such as the crowns, tissues, and age of the patient.

关键词： Kissing Molars Mandibular Second Molar Mandibular Third Molar Cone-Beam Computed Tomography

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Accuracy and Utility of Vessel Analysis Using Non-Contrast CT for Planning Endovascular Aortic Repair

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Open Journal of Medical Imaging 2024年第3期14卷 96-105页

作者： Midori Komita-Moriya Yukihisa Ogawa Akiyuki Kotoku Shintaro Nawata Kenji Kuramochi Yasuyoshi Ogawa Kiyoshi Chiba hiroshi Nishimaki Hidefumi Mimura Department of Radiology St. Marianna University School of Medicine Kanagawa Japan Department of Radiology Tokai University School of Medicine Hachioji Hospital Tokyo Japan Radiological Technology St. Marianna University School of Medicine Kanagawa Japan Department of Cardiovascular Surgery St. Marianna University School of Medicine Kanagawa Japan

Objectives: This study aimed to determine whether errors in vascular measurements would affect device selection in endovascular aortic repair (EVAR) by comparing measurements obtained using non-contrast computed tomography (NCT) with those obtained using contrast-enhanced CT (CECT). Materials and Methods: This single-center, retrospective study included 25 patients who underwent EVAR for abdominal aortic aneurysm at our institution. A 1-mm horizontal cross-sectional slice of NCT and CECT from each patient was retrospectively reviewed. The area from the abdominal aorta to the common iliac artery was divided into four zones. A centerline was created using the NCT by manually plotting the center points. Subsequently, the centerlines were automatically extracted and manually corrected during the arterial phase of CECT. The diameter and length of each zone were measured for each modality. The mean diameters and lengths of the target vessels were compared between NCT and CECT. Results: The measurements obtained using both methods were reproducible and demonstrated good agreement. The mean differences in vessel length and diameter measurements for each segment between NCT and CECT were not statistically significant, indicating good consistency. Conclusion: NCT may be useful for preoperative EVAR evaluation in patients with renal dysfunction or allergies to contrast agents.

关键词： Non-Contrast CT Vessel Analysis EVAR Contrast-Enhanced CT Abdominal Aortic Aneurysm

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日本服务型老年公寓入住者的入住理由及位置选择分析——基于岐阜县、爱知县和东京都入住老人的调研数据

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西部人居环境学刊 2024年第1期39卷 75-80页

作者：王吉彤铃木博志苏州科技大学社会发展与公共管理学院日本名城大学理工学部

通过对日本岐阜县、爱知县、东京都三个区域的服务型老年公寓的入住老人进行问卷调研,解析老人的入住理由和服务型老年公寓位置选择模式,提出合理规划建设服务型老年公寓的策略建议。结果显示老人在选择服务型老年公寓时,重视离自己及... 详细信息

通过对日本岐阜县、爱知县、东京都三个区域的服务型老年公寓的入住老人进行问卷调研,解析老人的入住理由和服务型老年公寓位置选择模式,提出合理规划建设服务型老年公寓的策略建议。结果显示老人在选择服务型老年公寓时,重视离自己及子女居住地近的要素,并在实际入住时,呈现相同趋势。城市化水平不同的区域,入住老人的护理等级,入住理由和服务型老年公寓位置选择模式呈现差异性。根据区域特征差异,分别提出相应规划建设策略。在我国老龄化程度日益严峻的社会背景之下,探讨日本服务型老年公寓的规划建设策略,从中汲取经验,对完善我国老年公寓规划建设,实现老年人居住环境高质量发展具有重要的启示意义。

关键词：服务型老年公寓选址老人居住地子女居住地区域差异规划策略

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Novel procedure for hepatic venous outflow block after liver resection:A case report

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World Journal of Clinical Cases 2024年第29期12卷 6320-6326页

作者： Hisanobu Higashi Yuta Abe Kodai Abe Yutaka Nakano Masayuki Tanaka Shutaro Hori Yasushi Hasegawa hiroshi Yagi Minoru Kitago Yuko Kitagawa Department of Surgery National Hospital Organization Saitama HospitalWako 351-0102Japan Department of Surgery Keio University School of MedicineTokyo 160-8582Japan

BACKGROUND Postoperative complications like remnant hepatic vein(HV)outflow block and liver torsion can occur after right *** falciform ligament fixation is typically used to prevent liver *** report a novel procedure to manage outflow *** SUMMARY An 80-year-old man developed HV outflow block after remnant right hepatectomy,despite liver fixation and intraoperative HV flow *** had a history of cholangiocellular carcinoma and had undergone posterior segmentectomy and *** falciform ligament fixation was inadequate to maintain liver *** surgery was performed,using an omental flap and mobilized right side colon with ileocecal region to prevent liver dislocation due to intraabdominal *** postoperative course was *** This is the first report providing a novel surgical procedure when the falciform ligament is insufficient for remnant liver fixation.

关键词： Hepatectomy Postoperative complications Budd-Chiari syndrome Hepatic vein outflow block Emergency surgery Case report

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Emergence of resistance to carbocyclic oxetanocin G in herpes simplex virus type 1 and genetic analysis of resistant mutants

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Acta Pharmacologica Sinica 2004年第7期25卷 75-80页

作者： hiroshi SHIOTA Department of Ophthalmology Japan School of Medicine The University of Tokushima Tokushima 770

AIM: To elucidate the potentiality of emergence of drug-resistance to carbocyclic oxetanocin G (***-G ), a new effective antiviral drug for herpetic keratitis during treatment and the mechanism of this drug resistance. METHODS: A ***-G resistant strain (***-Gr) was established by serially propagating the herpes simplex virus (HSV) -1 in African green monkey kidney (VERO) cells in the presence of ***-G. After the drug sensitiv- ity assay and the thymidine kinase (TK) activity assay, the molecular basis for the drug resistance was studied using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis and PCR direct se- quencing technology. RESULTS: After the 10th passage in 10 μm ***-G, the ED50 of the ***-Gr was 17.08-fold greater than that of the original strain on the average and the TK activities of these resistant strains were extremely reduced. PCR-SSCP analysis on TK gene of the wild HSV-1 and the ***-Gr showed altered migration patterns in part 3 and part 4, while PCR-SSCP analysis on DNA polymerase gene showed no difference among the viruses. Sequence analysis revealed a deletion of G at position of 430 that caused frameshift, resulting in premature termination in the TK gene. CONCLUSION: The drug resistance to ***-G may appear during the treatment due to the deficiency of TK activity caused by a single mutation in the TK gene of HSV-1.

关键词： carbocyclic oxetanocin G human herpesvirus 1 viral drug resistance thymidine kinase

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Chiral ligand-protected gold nanoclusters: Considering the optical activity from a viewpoint of ligand dissymmetric field

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Progress in Natural Science:Materials International 2016年第5期26卷 428-439页

作者： hiroshi Yao Graduate School of Material Science University of Hyogo

Chirality is a geometric property of a physical, chemical, or biological object, which is not superimposable on its mirror image. Its significant presence has led to a strong demand in the development of chiral drugs, sensors,catalysts, and photofunctional materials. In recent years, chirality of nanoscale organic/inorganic hybrids has received tremendous attention owing to potential applications in chiral nanotechnology. In particular, with the recent progress in the syntheses and characterizations of atomically precise gold nanoclusters protected by achiral thiolates, atomic level origins of their chirality have been unveiled. On the other hand, chirality or optical activity in metal nanoclusters can also be introduced via the surface chiral ligands, which should be universal for the nanosystems. This tutorial review presents some optically-active metal(gold) nanoclusters protected by chiral thiolates or phosphines, and their chiroptical(or circular dichroism; CD) properties are discussed mostly from a viewpoint of the ligand dissymmetric field scheme. The examples are the gold nanoclusters protected by(R)-/(S)-2-phenylpropane-1-thiol,(R)-/(S)-mercaptosuccinic acid, phenylboronateD/L-fructose complexes, phosphine sulfonate-ephedrinium ion pairs, or glutathione. Some methodologies for versatile asymmetric transformation and chiroptical controls of the nanocluster compounds are also *** the dissymmetric field model as the origin of optical activity, the chiroptical responses of the gold nanoclusters are strongly associated with coupled oscillator and/or CD stealing mechanisms based on the concept of induced CD(ICD) derived from a perturbation theory, so on this basis, some characteristic features of the observed CD responses of chiral ligand-protected gold nanoclusters are presented in detail. We believe that various kinds of origins of chirality found in ligand-protected gold nanoclusters may provide models for understanding those of many related nanomater

关键词： Chiral ligand Monolayer-protected gold nanoclusters Dissymmetric field model Induced CD Asymmetric transformation Alloying effect

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考虑温度作用的岩石统计损伤本构模型及验证

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中南大学学报（自然科学版） 2024年第3期55卷 1056-1067页

作者：魏超赵程赵春风松田浩森田千寻同济大学地下建筑与工程系上海200092 同济大学岩土与地下工程教育部重点实验室上海200092 长崎大学构造工学研究科日本长崎852-8521

为了预测和评估深部高温岩体的稳定性,运用理论推导的方法研究温度作用下(后)岩石的本构关系。首先,基于已有的岩石统计损伤本构模型,考虑温度对岩石损伤变量的影响,引入了损伤变量修正系数、损伤起裂应力和起裂应变等参数;其次,假设微... 详细信息

为了预测和评估深部高温岩体的稳定性,运用理论推导的方法研究温度作用下(后)岩石的本构关系。首先,基于已有的岩石统计损伤本构模型,考虑温度对岩石损伤变量的影响,引入了损伤变量修正系数、损伤起裂应力和起裂应变等参数;其次,假设微元体强度服从幂函数分布,并符合Hoek-Brown(H-B)强度准则,针对统计损伤本构模型无法反映峰前较强的微裂纹压密效应的弊端,引入了相应的模型修正系数;再次,建立了考虑温度作用的岩石统计损伤本构模型,并确定了模型参数的表达式;最后,对比不同温度作用下(后)的花岗岩在单轴和常规三轴压缩试验条件下所得的结果与文献中模型的计算结果,验证本文模型的准确性。研究结果表明:所提出的模型的计算结果与文献的试验结果在数值、分布规律和趋势上具有良好的一致性;对于全过程σ-ε曲线的各阶段,本文模型的计算效果较文献中本构模型计算效果更好,与试验曲线的贴合度更高,能够更好地反映高温作用下(后)岩石的损伤本构特征。该模型的参数具有常规性,适用于各类温-压组合作用工况下的岩石。

关键词：岩石力学幂函数温度 Hoek-Brown强度准则微裂纹压密效应本构模型

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Microglial cathepsin B as a key driver of inflammatory brain diseases and brain aging

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Neural Regeneration Research 2020年第1期15卷 25-29页

作者： hiroshi Nakanishi Department of Pharmacology Faculty of Pharmacy Yasuda Women’s University

Interleukin-1βis a potent proinflammatory cytokine that plays a key role in the pathogenesis of the brain aging and diverse range of neurological diseases including Alzheimer’s disease,Parkinson’s disease,stroke and persistent *** microglia are the main cellular source of interleukin-1βin the *** B is associated with the production and secretion of interleukin-1βthrough pyrin domain-containing protein 3 inflammasome-independent processing of procaspase-3 in the *** leakage of cathepsin B from the endosomal-lysosomal system during aging is associated with the proteolytic degradation of mitochondrial transcription factor A,which can stabilize mitochondrial ***,microglial cathepsin B could function as a major driver for inflammatory brain diseases and brain *** active and blood-brain barrier-permeable specific inhibitors for cathepsin B can be potentially effective new pharmaceutical interventions against inflammatory brain diseases and brain aging.

关键词： brain aging caspase-1 cathepsin B inflammatory brain diseases interleukin-1β microglia mitochondrial transcription factor A neuroinflammation nuclear factor-κB oxidative stress

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