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中国城市研究 2013年 355-372页

作者： KENJI Kosaka ATSUSHI Ishida hiroshi hamada Kwansei Gakuin University Osaka University of Economics Tohoku University

Two kinds of 'China puzzle'are *** is named 'unhappy economic growth,'where rapid economic growth brought decrease rather than increase in happiness(Brockmann et al.).The other is concerned itself with differential subjective well-being felt among migrant workers in China where migrant workers in more developed cities feel more frustrated than those in less developed cities,though the former surely enjoy the better life objectively than the *** present paper attempts to formalize those situations mathematically to explain'why so'from a single theoretical framework of relative deprivation,which has been developed by Stouffer and others’ The American Soldier and further elaborated by Runciman and Yitzhaki.

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Postoperative complications of umbilical loop colostomy for anorectal malformations in neonates compared with the conventional abdominal stoma: a non-randomized study

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World Journal of Pediatric Surgery 2019年第1期2卷 21-23页

作者： Tatsuma Sakaguchi Yoshinori hamada Takeshi Shirai hiroshi hamada Yusuke Shigeta Yusuke Nakamura Takashi Doi Department of Surgery Kansai Medical UniversityOsakaJapan

background We previously reported a pilot study of temporary umbilical loop colostomy for neonates with intermediate-type anorectal malformations(ARM)and recommended this technique because of its cosmetic *** herein report the postoperative complications of umbilical stomas(US)compared with traditional abdominal stomas(AS).Methods From our institutional prospective database,we analyzed the patients with ARMs who underwent stoma creation at Kansai Medical University Hospital from January 1995 to November *** surgical technique used to create the US had been performed since *** US and AS were made for 12 and 27 patients with ARMs,*** postoperative complication rates in patients who underwent US and AS had no significant difference(17%and 11%,p=0.6).The complications comprised a wound infection(one case of US),ileus(one case each of US and AS),mucosal prolapse(one case of AS),and depression(one case of AS).No emergency surgery was required for these *** For patients with ARMs,the umbilicus appears to be a safe alternative site for temporary loop colostomy.

关键词： complications abdominal wound

High-grade pancreatic intraepithelial neoplasia diagnosed based on changes in magnetic resonance cholangiopancreatography findings:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1487-1496页

作者： Nao Furuya Atsushi Yamaguchi Naohiro Kato Syuhei Sugata Takuro hamada Takeshi Mizumoto Yuzuru Tamaru Ryusaku Kusunoki Toshio Kuwai Hirotaka Kouno Kazuya Kuraoka Yoshiyuki Shibata Sho Tazuma Takeshi Sudo hiroshi Kohno Shiro Oka Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Gastroenterology Hiroshima University HospitalHiroshima 734-8551HiroshimaJapan Department of Pathology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan

BACKGROUND High-grade pancreatic intraepithelial neoplasia(PanIN)exhibits no mass and is not detected by any examination ***,it can be diagnosed by pancreatic juice cytology from indirect *** previous cases were diagnosed based on findings of a focal stricture of the main pancreatic duct(MPD)and caudal MPD dilatation and subsequent pancreatic juice cytology using endoscopic retrograde cholangiopancreatography(ERCP).We experienced a case of high-grade PanIN with an unclear MPD over a 20-mm range,but without caudal MPD dilatation on magnetic resonance cholangiopancreatography(MRCP).CASE SUMMARY A 60-year-old female patient underwent computed tomography for a follow-up of uterine cancer post-excision,which revealed pancreatic *** revealed an unclear MPD of the pancreatic body at a 20-mm length without caudal MPD ***,course observation was *** 24 mo,MRCP revealed an increased caudal MPD caliber and a larger pancreatic *** performed ERCP and detected atypical cells suspected of adenocarcinoma by serial pancreatic juice aspiration cytology *** performed a distal pancreatectomy and obtained a histopathological diagnosis of high-grade *** parenchyma invasion was not observed,and curative resection was *** High-grade Pan-IN may cause MPD narrowing in a long range without caudal MPD dilatation.

关键词： Pancreatic cancer Pancreatic intraepithelial neoplasm High-grade pancreatic intraepithelial neoplasm Magnetic resonance cholangiopancreatography Carcinoma in situ Case report

Upregulation of epidermal growth factor receptor 4 in oral leukoplakia

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International Journal of Oral Science 2013年第1期5卷 14-20页

作者： hiroshi Kobayashi Kenichi Kumagai Akito Gotoh Takanori Eguchi Hiroyuki Yamada Yoshiki hamada Satsuki Suzuki Ryuji Suzuki Department of Oral and Maxillofacial Surgery Tsurumi University Department of Rheumatology and Clinical Immunology Clinical Research Center for Rheumatology and AllergySagamihara National HospitalNational Hospital Organization Section of Biological Science Research Center for Odontology Nippon Dental University School of Dentistry

In the present study,we investigate the expression profile of the epidermal growth factor receptor family,which comprises EGFR/ ErbBl,HER2/ErbB2,HER3/ErbB3 and HER4/ErbB4 in oral leukoplakia(LP).The expression of four epidermal growth factor receptor (EGFR) family genes and their ligands were measured in LP tissues from 14 patients and compared with levels in 10 patients with oral lichen planus(OLP) and normal oral mucosa(NOM) from 14 healthy donors by real-time polymerase chain reaction(PCR) and *** mRNA coexpression of ErbBl,ErbB2,ErbB3and ErbB4 was detected in LP *** of the receptors,only ErbB4 mRNA and protein was more highly expressed in LP compared with NOM *** were strongly expressed by epithelial keratinocytes in LP lesions,as shown by *** the ligands,the mRNA of Neuregulin2 and 4 were more highly expressed in OLP compared with NOM ***,enhanced ErbB4 on the keratinocytes and synchronous modulation of EGFR family genes may contribute to the pathogenesis and carcinogenesis of LP.

关键词： epidermal growth factor receptor immunohistochemistry oral leukoplakia quantitative real-time polymerase chain reaction

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Challenges for a reduced inertia power system due to the large-scale integration of renewable energy

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Global Energy Interconnection 2022年第3期5卷 266-273页

作者： Hiromu hamada Yoshitaka Kusayanagi Masamoto Tatematsu Masayuki Watanabe hiroshi Kikusato Tokyo Electric Power Company Holdings Inc.4-1Egasaki-choTsurumi-kuYokohama230-8510KanagawaJapan Kansai Electric Power Company Inc.3-11-20NakojiAmagasaki661-0974 HyogoJapan Kyushu Institute of Technology 1-1 Sensui-choTobata-kuKitakyushuFukuoka 804-8550Japan Fukushima Renewable Energy Institute AIST(FREA)2-2-9 MachiikedaiKoriyama963-0298 FukushimaJapan

This paper reports on the status of technology development under a national project launched in 2019 to address the problem of decreased system inertia associated with the large-scale integration of renewable *** project comprises two parts:the development of a system inertia observation technology using a continuous monitoring system to observe inertia and development of an inverter equipped with a function to provide virtual inertia as a countermeasure *** both these efforts,the project aims to facilitate the introduction of renewable energy in the future with minimum *** was confirmed that the trend of inertia observed with the developed method was generally the same as that of the total inertia of synchronous machines observed by an electric *** effectiveness of the countermeasure device in reducing the frequency swing during a disturbance was confirmed through evaluation tests.

关键词： Renewable energy System inertia Fast Fourier Transform(FFT) Inverter

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A Phase II Trial of Preoperative Chemoradiotherapy with Oral DPD-Inhibitory Fluoropyrimidines in Patients with Advanced Rectal Cancer

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Journal of Cancer Therapy 2012年第6期3卷 989-995页

作者： Masanori Hotchi hiroshi Okitsu Murato Miura Madoka hamada Yasuhide Sonaka Yoh Fukuda Tsutomu Ando Shinji Kuratate Department of Surgery Kochi Health Sciences Center Kochi Japan Department of Surgery National Hospital Organization Kochi National Hospital Kochi Japan Department of Surgery Shikoku Central Hospital Ehime Japan Department of Surgery Takamatsu City Hospital Takamatsu Japan Department of Surgery Tokushima Municipal Hospital Tokushima Japan Department of Surgery Tokushima Prefectural Central Hospital Tokushima Japan Department of Surgery Tokushima Red Cross Hospital Tokushima Japan Department of Surgery Tokushima University Hospital Tokushima Japan

Background: Preoperative chemoradiotherapy (CRT) with 5-FU has been widely used to improve local control of disease and to preserve anal sphincter in the treatment of rectal cancer. UFT and S-1 as oral dihydropyrimidine dehydrogenase (DPD)-inhibitory fluoropyrimidines enhance the therapeutic effect of 5-FU by modulating its metabolic pathways. The purpose of this study was to evaluate the efficacy and toxicity of CRT using UFT versus S-1 in patients with locally advanced rectal cancer. Methods: Fifty-nine patients who received preoperative CRT (40 Gy radiotherapy) were randomly assigned to either UFT or S-1 groups. UFT and S-1 were administered during the radiotherapy course. Response to CRT was determined using a histopathologic examination and RECIST of surgically resected specimens and classified as responders (CR, PR and grade 2, 3) or nonresponders (SD, PD and grade 0, 1). Results: All patients were randomly allocated to S-1 group (n = 30) or UFT group (n = 29). Pathological response rate (Grade2 and Grade3) was 57% in the S-1 group and 45% in the UFT group (p = 0.36). Pathological complete response (CR) rate (Grade3) was 7% in the S-1 group and 4% in the UFT group (p = 0.98). There was no statistically significant difference between the two groups in regard to the response rate of RECIST (p = 0.52). There was no statistically significant difference between the groups based on the downstaging rate, resection of tumor, sphincter preservation and marginal invasion. The incidence of Grade 3 diarrhea was significantly more frequent in the S-1 group (7%) compared with the UFT group (0%) (p = 0.02). Conclusion: The results supported the conclusion that CRT using UFT or S-1 is effective and feasible for patients with locally advanced rectal cancer.

关键词： S-1 UFT Chemoradiation Rectal Cancer

Pancreatic duct drainage using EUS-guided rendezvous technique for stenotic pancreaticojejunostomy

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World Journal of Gastroenterology 2013年第31期19卷 5182-5186页

作者： Tetsuya Takikawa Atsushi Kanno Atsushi Masamune Shin hamada Eriko Nakano Shin Miura Hiroyuki Ariga Jun Unno Kiyoshi Kume Kazuhiro Kikuta Morihisa Hirota hiroshi Yoshida Yu Katayose Michiaki Unno Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine Miyagi 980-8574 Japan Division of Hepato-biliary-Pancreatic Surgery Tohoku University Graduate School of Medicine Miyagi 980-8574 Japan

The patient was a 30-year-old female who had undergone excision of the extrahepatic bile duct and Rouxen-Y hepaticojejunostomy for congenital biliary dilatation at the age of ***,she suffered from recurrent acute pancreatitis due to pancreaticobiliary maljunction and received subtotal stomach-preserving *** developed a pancreatic fistula and an intra-abdominal abscess after the *** complications were improved by percutaneous abscess drainage and antibiotic *** ever,upper abdominal discomfort and the elevation of serum pancreatic enzymes persisted due to stenosis from the *** we could not accomplish dilation of the stenosis by endoscopic retrograde cholangiopancreatography,we tried an endoscopic ultrasonography(EUS) guided rendezvous technique for pancreatic duct *** transgastric puncture of the pancreatic duct using an EUS-fine needle aspiration needle,the guidewire was inserted into the pancreatic duct and finally reached to the jejunum through the stenotic *** changed the echoendoscope to an oblique-viewing endoscope,then grasped the guidewire and withdrew it through the *** stenosis of the pancreaticojejunostomy was dilated up to 4 mm,and a pancreatic stent was put in *** the pancreatic stent was removed after three months,the patient remained *** duct drainage using an EUS-guided rendezvous technique was useful for the treatment of a stenotic pancreaticojejunostomy after pancreaticoduodenectomy.

关键词： Balloon dilatation Endoscopic ultrasoundguided fine needle aspiration Pancreaticobiliary maljunction Pancreaticoduodenectomy Pancreatitis Postoperative complication

组织调整材料的操作时间及固化时间的测量方法

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首都医科大学学报 2005年第4期26卷 505-508页

作者：赵晶洪光李英爱村田比吕司滨田泰三金辰中日友好医院口腔科广岛大学大学院医齿药学综合研究科齿科补缀学研究室德山齿科材料有限公司

目的利用移位式流变仪(Displacementrheometer),开发适当的测量组织调整材料的操作时间和固化时间的方法。方法使用5种组织调整材料。每个材料在23℃和37℃条件下各测量3次。在23℃下发生最初弹性回复的时间定义为操作时间,在37℃下弹... 详细信息

目的利用移位式流变仪(Displacementrheometer),开发适当的测量组织调整材料的操作时间和固化时间的方法。方法使用5种组织调整材料。每个材料在23℃和37℃条件下各测量3次。在23℃下发生最初弹性回复的时间定义为操作时间,在37℃下弹性复原率表现为稳定数据的时间定义为固化时间。结果各个组织调整材料的操作时间和固化时间有显著性差异,显示出不同的固化行为。5种组织调整材料中SR的操作时间最短,为(2.7±0.2)min,VG的操作时间最长,为(15.7±0.5)min。VG的固化时间最长〔(25.0±0.8)min〕,SR的固化时间最短〔(7.7±1.9)min〕。结论移位式流变仪方法可以用于测量组织调整材料的操作时间和固化时间,并对分析组织调整材料的固化过程有重大意义。

关键词：组织调整材料操作时间固化时间移位式流变仪

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