检索结果-南通市图书馆

Adjuvant chemotherapy for early-stage cervical cancer

Chinese Journal of Cancer Research 2016年第2期28卷 228-234页

作者： hiroshi asano Yukiharu Todo Hidemichi Watari Department of Obstetrics and Gynecology Hokkaido University School of Medicine Division of Gynecologic Oncology National Hospital OrganizationHokkaido Cancer Center

The aim of this review is to address the current status of adjuvant chemotherapy alone in early-stage cervical cancer treatments in the literature. At present, the therapeutic effect of adjuvant chemotherapy alone after radical surgery （RS） has not yet been established, and radiation therapy （RT） or concurrent chemoradiotherapy （CCRT） is recommended as the standard adjuvant therapy after RS for early-stage cervical cancer in various guidelines. The main purpose of adjuvant therapy after RS, however, should be to reduce extrapelvic recurrence rather than local recurrence, although adjuvant RT or CCRT has survival benefits for patients with intermediate- or high-risk factors for recurrence. Moreover, several studies reported that adjuvant therapies including RT were associated with a higher incidence of complications, such as lymphedema, bowel obstruction and urinary disturbance, and a lower grade of long-term quality of life （QOL） or sexual functioning than adjuvant chemotherapy alone. The effect of adjuvant chemotherapy alone for early-stage cervical cancer with intermediate- or high-risk factors for recurrence were not fully investigated in prospective studies, but several retrospective studies suggest that the adjuvant effects of chemotherapy alone are at least similar to that of RT or CCRT in terms of recurrence rate, disease-free survival, or overall survival （OS） with lower incidence of complications. Whereas cisplatin based combination regimens were used in these studies, paclitaxel/cisplatin （TP） regimen, which is currently recognized as a standard chemotherapy regimen for patients with metastatic, recurrent or persistent cervical cancer by Gynecologic Oncology Group （GOG）, had also survival benefit as an adjuvant therapy. Therefore, it may be worth considering a prospective randomized controlled trial （RCT） of adjuvant chemotherapy alone using TP regimen versus adjuvant RT as an alternative adjuvant therapy. Because early-stage cervical cancer is a curable condition, it is necessary that the therapeutic s

关键词： Adjuvant chemotherapy cervical cancer quality of life （QOL） survival intermediate-risk disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Relapse of both small cell lung cancer and Lambert-Eaton myasthenic syndrome after a 13-year disease-free survival period

引用

Chinese Journal of Cancer 2016年第11期35卷 632-636页

作者： Fumio asano Keisuke Watanabe Masaharu Shinkai Yoshitaka Tei Kei Mishina Mikiko Tanabe hiroshi Ishii Masahiro Shinoda Tadasuke Shimokawaji Makoto Kudo Takeshi Kaneko Respiratory Disease Center Yokohama City University Medical Center4-57 Urafune-choMinami-kuYokohamaKanagawa 232-0024Japan. Department of Pathology Yokohama City University Medical Center4-57 Urafune-choMinami-kuYokohamaKanagawa 232-0024Japan. Com-prehensive Cancer Center Yokohama City University Medical Center4-57 Urafune-choMinami-kuYokohamaKanagawa 232-0024Japan. Depart-ment of Pulmonology Yokohama City University Graduate School of Medicine3-9 FukuuraKanazawa-kuYokohamaKanagawa 236-0004Japan. Department of Medicine McMaster UniversityHamiltonONCanada.

Lambert-Eaton myasthenic syndrome(LEMS) is a paraneoplastic syndrome and only 3%of small cell lung carcinoma(SCLC) patients have LEMS.Moreover,the recurrence of SCLC after a disease-free survival(DFS) of more than 10 years is rare.We report a patient who had a recurrence of both SCLC and LEMS after a 13-year DFS period.A 69-year-old man was diagnosed with LEMS and SCLC(cT0N2M0,stage ⅢA) 13 years ago.Chemoradiotherapy was performed and a complete response was achieved.With anticancer treatment,the LEMS symptoms was alleviated.At the age of 82 years,gait disturbance appeared followed by left supraclavicular lymphadenopathy and further examination revealed the recurrence of SCLC.Careful screening for the recurrence of SCLC might be needed when the patient has recurrent or secondary paraneoplastic neurological syndrome even after a long DFS period.

关键词： Lambert-Eaton myasthenic syndrome Paraneoplastic syndrome Paraneoplastic neurological syndrome P/Q-type anti-voltage-gated calcium channel antibody Small cell lung carcinoma

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Study on Distribution of Acinetobacter baumannii Complex in Dental Hospital Using Multiplex PCR

引用

Open Journal of Stomatology 2023年第7期13卷 212-221页

作者： Akira Fukatsu Osamu Tsuzukibashi hiroshi Yamamoto Yuji Takahashi Keisuke Usuda Mana Fuchigami Chiaki Komine Satoshi Uchibori Koji Umezawa Sachiyo Hayashi Takashi asano Masanobu Wakami hiroshi Murakami Taira Kobayashi Masahiko Fukumoto Department of Laboratory Medicine for Dentistry for the Compromised Patient School of Dentistry Nihon University Matsudo Japan Department of Oral Surgery School of Dentistry Nihon University Matsudo Japan Department of Oral Implantology School of Dentistry Nihon University Matsudo Japan Department of Fixed Prosthodontics School of Dentistry Nihon University Matsudo Japan Department of Special Needs Dentistry School of Dentistry Nihon University Matsudo Japan

Purpose: In recent years, multidrug-resistant Acinetobacter baumannii has appeared and caused outbreaks of hospital infections all over the world. Close monitoring of this pathogen and other A. baumanii complex species is considered of critical importance to public health organizations. The reliable identification method able to distinguish A. baumannii from genetically close Acinetobacter species is needed, because these species are unable to be differentiated by phenotypic or biochemical methods. The purpose of the present study was to design species-specific primers in order to identify and detect A. baumanii complex species, and Acinetobacter lwoffii which is frequently detected from the human specimens, and to investigate the distribution of these organisms in dental hospital using a multiplex PCR. Methods: Polymerase chain reaction (PCR) primers were designed based on partial sequences of the 16S ribosomal RNA (16S rRNA) gene and DNA gyrase subunit B (gyrB) of each species of A. baumanii complex species. Swab samples were collected from ten dental spittoon units in dental hospital, and the distribution of A. baumanii complex species was investigated using a multiplex PCR. Results: These primers were able to distinguish each species of A. baumanii complex species clearly. A. baumanii and A. calcoaceticus were detected at 20.0% and 10.0% in ten swab samples, respectively. On the other hand, A. nosocomialis, A. lowffii, and A. pittii were detected from no sample. Conclusion: Our developed one-step multiplex PCR method is accurate, specific, cost-effective, time-saving, and worked without requiring DNA extraction.

关键词： Acinetobacter baumannii Complex Multiplex PCR Hospital Infections

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Isolation and Identification Methods for Oral Klebsiella pneumoniae Involved in Onset of Inflammatory Bowel Disease

引用

Open Journal of Stomatology 2023年第7期13卷 197-211页

作者： Osamu Tsuzukibashi Akira Fukatsu hiroshi Yamamoto Yuji Takahashi Keisuke Usuda Mana Fuchigami Chiaki Komine Satoshi Uchibori Koji Umezawa Sachiyo Hayashi Takashi asano Masanobu Wakami hiroshi Murakami Taira Kobayashi Masahiko Fukumoto Department of Laboratory Medicine for Dentistry for the Compromised Patient School of Dentistry Nihon University Matsudo Japan Department of Oral Surgery School of Dentistry Nihon University Matsudo Japan Department of Oral Implantology School of Dentistry Nihon University Matsudo Japan Department of Fixed Prosthodontics School of Dentistry Nihon University Matsudo Japan Department of Special Needs Dentistry School of Dentistry Nihon University Matsudo Japan

Purpose: Recently, it was reported that Klebsiella pneumoniae is related to the onset of inflammatory bowel disease including the Crohn disease. It was frequently reported that K. pneumoniae was detected in human oral cavities. Regrettably, it currently remains unclear whether K. pneumoniae is part of the normal oral flora. The aim of this study was to establish the isolation and identification methods for K. pneumoniae from human oral cavities, and investigate its transmission pattern. Methods: A selective medium, OKPSM, for the isolation of K. pneumoniae from oral cavities was developed in this study. Also, PCR primer for the identification and detection at subspecies level of K. pneumoniae was designed. Results: OKPSM and PCR method using the primers designed in this study were useful for the isolation and identification of K. pneumoniae from human oral cavities. K. pneumoniae subsp. pneumoniae was detected at 10.0% in 30 saliva samples. On the other hand, K. pneumoniae subsp. ozaenae and K. pneumoniae subsp. rhinoscleromatis were detected from no sample. Moreover, K. pneumoniae subsp. pneumoniae isolates from same subject at 0 month and after 3 months showed same genotypes on AP-PCR using OPA-07 primer. Conclusion: These results indicated that human oral cavities were not suitable for the habitat of K. pneumoniae.

关键词： Klebsiella pneumoniae Selective Medium Oral Cavity Multiplex PCR

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Origin of Candida albicans in Human Oral Cavity

引用

Open Journal of Stomatology 2022年第4期12卷 137-145页

作者： Akira Fukatsu Osamu Tsuzukibashi Mana Fuchigami Yoshinori Ono Satoshi Uchibori Yuji Takahashi Chiaki Komine Koji Umezawa Sachiyo Hayashi Takashi asano Taira Kobayashi Masanobu Wakami hiroshi Murakami Masahiko Fukumoto Department of Laboratory Medicine for Dentistry for the Compromised Patient Nihon University School of Dentistry at Matsudo Chiba Japan Department of Laboratory Medicine for Dentistry Nihon University Graduate School of Dentistry at Matsudo Chiba Japan Department of Fixed Prosthodontics Nihon University School of Dentistry at Matsudo Chiba Japan Department of Special Needs Dentistry Nihon University School of Dentistry at Matsudo Chiba Japan Department of Oral Implantology Nihon University School of Dentistry at Matsudo Chiba Japan

Purpose: Candida albicans is regarded as a part of normal flora in the human oral cavity. However, it remains unclear whether the genus Candida, especially C. albicans, is an oral resident microorganism and causes marital infection or not. The purpose of the present study was to elucidate the origin of oral C. albicans by investigating the colonization and infection route to oral cavities of this organism with arbitrarily primed polymerase chain reaction (AP-PCR). Methods: After C. albicans was isolated from four subjects (average age: 42.2, range: 33 - 56), the isolations of this organism from them were performed six months later again. To investigate whether C. albicans is an oral resident microorganism, the genotype homology of each C. albicans isolates that were isolated twice from the same subjects was compared. Moreover, C. albicans was isolated from five pairs of married couples (average period of cohabitation: 12.4 years, range: 5 - 31). To investigate whether C. albicans causes marital infection, the genotype homology of C. albicans isolates that were isolated from each pair of married couples was compared. Results: AP-PCR patterns of C. albicans that were isolated from each subject at o month and after 6 months showed the identical genotypes among each individual. C. albicans isolates from five pairs of married couples showed the identical genotypes between a husband and wife of each pair on AP-PCR. Conclusion: These results indicated that C. albicans was an oral resident microorganism and caused the marital infection.

关键词： Candida albicans Oral Cavity AP-PCR Genotyping

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Investigation of Bacteria Species Most Involved in Peri-Implantitis

引用

口腔学期刊(英文) 2023年第10期13卷 353-366页

作者： hiroshi Murakami Osamu Tsuzukibashi Akira Fukatsu Yuji Takahashi Keisuke Idei Keisuke Usuda Mana Fuchigami Chiaki Komine Satoshi Uchibori Koji Umezawa Sachiyo Hayashi Takashi asano Masanobu Wakami Taira Kobayashi Masahiko Fukumoto Department of Oral Implantology Nihon University School of Dentistry at Matsudo Chiba Japan Department of Laboratory Medicine for Dentistry for the Compromised Patient Nihon University School of Dentistry at Matsudo Chiba Japan Department of Fixed Prosthodontics Nihon University School of Dentistry at Matsudo Chiba Japan Department of Special Needs Dentistry Nihon University School of Dentistry at Matsudo Chiba Japan

Purpose: Currently, bacteriological examinations of implant treatments target periodontopathic bacteria such as red complex bacteria, including Porphyromonas gingivalis, and detect them qualitatively or quantitatively. However, it seems that those examinations do not reflect the peri-implant tissue conditions precisely, because periodontopathic bacteria are also frequently detected from healthy peri-implant sites. The purpose of the present study was to investigate bacteria species most involved in peri-implantitis using a PCR method. Methods: Polymerase chain reaction (PCR) primers in this study were designed based on partial sequences of 16S rDNA of bacteria species involved in peri-implantitis that were described in numerous previous studies. Peri-implant sulcus fluid (PISF) samples were collected from thirty periodontally healthy patients with implants (HI) and thirty patients with peri-implantitis (PI). Each detection frequency of bacteria species in PISFs of both groups was investigated using a PCR method, and was compared using Fisher’s exact test. Results: In PI group, detection frequencies of Corynebacterium durum, Fretibacterium fastidiosum and Slackia exigua were significantly higher than those of HI group (p P. gingivalis and Tannerella forsythia belonging to red complex were frequently detected in the PISF samples of HI group (p > 0.05). Conclusion: It was suggested that monitoring C. durum and F. fastidiosum levels in PISF samples was useful as a clinical indicator for the evaluation of peri-implant tissue conditions.

关键词： Peri-Implantitis PCR Method Bacteria Flora in Peri-Implant Sulcus Red Complex

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

<i>In Vitro</i>Evaluation System of Pharmacokinetics and Irradiation Effect in Boron Neutron Capture Therapy (BNCT) Using Three-Dimensional Artificial Human Tumor Tissue Model

引用

Journal of Cancer Therapy 2019年第10期10卷 835-845页

作者： Shintaro Ishiyama Yoshiya asano Minoru Suzuki Mitsuru Akashi hiroshi Shimoda

Boron neutron capture therapy (BNCT) is based on the incorporation of boron-containing drugs to cancer cells and the nuclear reaction of 10B atoms by thermal neutron irradiation results in tumor degeneration. For the development of this therapy, currently, long time and high cost consuming experiments using many animals are required. In this study, we constructed a new in vitro evaluation system for BNCT by combination of an artificial tumor tissue model, comprised of normal human dermal-derived fibroblast (NHDF) and human pancreatic cancer cell line BxPC3, and the optical plastic material CR-39 as a solid state nuclear track detector. Administration of boronophenylalanine (10BPA) as a boron-containing drug and neutron irradiation up to 2.52 × 1012 n/cm2 to the control tissue constructed by NHDF (NHDF3D) and BxPC3 cell loaded tissue (NHDF3D/BxPC3) resulted in detection of 1.6 times higher number of α-ray/recoiled Li particle tracks in NHDF3D/BxPC3 in comparison to NHDF3D, demonstrating that putative irradiation damage to cancer cells can be evaluated by this system. On a cellular level, the hit number of α-ray/recoiled Li particle tracks per single BxPC3 cells and NHDF was evaluated as 5.46 and 1.71, respectively. The tumor and normal tissue ratio (T/N ratio) was 3.19, which was corresponded with those of BPA as 2 - 4 that reported in the previous studies. This new in vitro evaluation system may provide a useful tool for a low cost, labor-saving, and non-animal method for the development of new boron-containing drugs or improvement of BNCT conditions.

关键词： Boron Neutron Capture Therapy (BNCT) Boronophenylalanine (10BPA) Artificial Human Tumor Tissue Model Cell Accumulation Method

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rainfall and Runoff Observations in the Subtropical Forest of Okinawa Island, Japan

引用

Journal of Water Resource and Protection 2014年第6期6卷 625-634页

作者： Naoki Kabeya Akira Shimizu Takanori Shimizu Hitoshi Ikuzawa Takuya Arakaki hiroshi Furugen Yashuhiro Ohnuki Shiho asano Forestry and Forest Products Research Institute Tsukuba Japan Incorporated Okinawa Prefecture Environment Science Centre Urazoe Japan Kyushu Research Centre Forestry and Forest Products Research Institute Kumamoto Japan Okinawa Prefecture Forest Resource Research Centre Nago Japan

We set up two experimental catchments to provide an improved understanding of hydrological processes in a subtropical forested area in the northern part of Okinawa Island, Japan. We calculated runoff using water level data (recorded by a pressure-type water level gauge installed in a box culvert) and a discharge rating curve (derived from in situ observations). Water balance calculations for 2010 showed that the rainfall, runoff and evapotranspiration losses (= rainfall – runoff) were 3403.6 mm, 2285.7 mm and 1117.4 mm, respectively. This result was in agreement with previous results from other forested experimental catchments in this region. Direct runoff, as a proportion of event total rainfall, can be expressed by the empirical equation (Qdirect = 0.0048, Pevent 1.7971, R2 = 0.9599). When Pevent was 100 mm or less, the ratios of Qdirect to Pevent were less than 15% in general. When Pevent exceeded 100 mm, the ratios were 20% - 30%.

关键词： Direct Runoff Forested Watershed Okinawa Island Rainfall-Runoff Observation Sub-Tropical Forest Water Balance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A novel visual test for hydrogen sulfide on the tongue dorsum

引用

Open Journal of Stomatology 2012年第4期2卷 314-321页

作者： Takashi Kanehira Hirohisa Hongo Junji Takehara Kozo asano Kazumi Osada hiroshi Izumi Yoshihiro Fujii Wataru Sakamoto Applied Microbiology Applied Bioscience Graduate School of Agricul-ture Hokkaido University Sapporo Japan Department of Physiology School of Dentistry Health Sciences University of Hokkaido Ishikari-Tobetsu Japan Division of Preventive Dentistry Graduate School of Dental Medicine Hokkaido University Sapporo Japan Institute of QOL Fuji Women’s University Ishikari Japan

Objective: The purpose of this study was to develop a novel colorimetric system for direct detection of hydrogen sulfide on the tongue dorsum from subjects with complaints of halitosis. Method: An assay system comprised of a cotton swab impregnated with zinc sulfate, attached chromatography paper, stabilizing solution, and coloring reagents for the methylene blue technique was developed. Using this system we investigated on the visualization of the hydrogen sulfide on the solid phase and possibility for evaluating the origin of oral malodor on the tongue dorsum. Results: The assay system made possible visualization of a linear curve ranging from 5.3 ng to 85 ng of hydrogen sulfide, with low reagent consumption and miniaturization. However, the sensitivity was different for gaseous and fluid samples. The biofilm of the tongue dorsum from subjects with complaints of halitosis showed different shades of methylene blue depending on the concentration of hydrogen sulfide. A positive correlation was found between hydrogen sulfide on the tongue dorsum and the concentration of VSC hydrogen sulfide in mouth breath as measured using an Oral Chroma semiconductor gas sensor. Conclusion: The results of this study suggest that the novel assay system can be used as a visual warning sensor for halitosis by measuring hydrogen sulfide on the tongue dorsum.

关键词： Halitosis Tongue dorsum VSC Hydrogen Sulfide Methylene Blue

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High Quality and High Speed Casting Technologies for Round Billet Caster

High Quality and High Speed Casting Technologies for Round B...

引用

2007中国钢铁年会

作者： Masaya asano Atsushi Hirata hiroshi Hayashi Katsuyoshi Iwata Yuichi Tsukaguchi Masayuki Kawamoto Sumikin Iron ＆ Steel Corporation 1850 Minato Wakayama-cityWakayama 640-8555Japan Sumikin Iron ＆ Steel Corporation 1850 Minato Wakayama-cityWakayama 640-8555Japan Sumikin Iron ＆ Steel Corporation 1850 Minato Wakayama-cityWakayama 640-8555Japan Sumikin Iron ＆ Steel Corporation 1850 Minato Wakayama-cityWakayama 640-8555Japan Sumitomo Metal Industries.Ltd. Sumitomo Metal Industries.Ltd.

＜正＞1 Introduction The advanced round billet casting technologies, mild cooling mold flux,short stroke oscillation,mold taper of multiple type and secondary cooling of short pitch ring header,etc.,have been developed at Wakayama Steel Works. Round billets are directly supplied to seamless pipe mill without blooming process. So, round billet casting is superior to bloom casting because of the lower cost,shorter lead time and higher quality.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：